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Tuberculosis screening among children and adolescents in China:insights from a mathematical model

Intelligent Medicine 2023年第3期3卷 157-163页

作者： Janne Estill Yangqin Xu Shouyuan Wu Lidong Hu Nan Yang Shu Yang Yaolong Chen Guobao Li Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhouGansu 730000China Institute of Global Health University of GenevaGenevaSwitzerland School of Public Health Lanzhou UniversityLanzhouGansu 730000China Department of Rheumatology and Immunology The First Medical CenterChinese PLA General HospitalBejing 100853China College of Medical Information Engineering Chengdu University of Traditional Chinese MedicineChengduSichuan 610000China Research Unit of Evidence-Based Evaluation and guidelines Chinese Academy of Medical Sciences(2021RU017)School of Basic Medical SciencesLanzhou UniversityLanzhouGansu 730000China Lanzhou University Institute of Health Data Science LanzhouGansu 730000China who collaborating centre for guideline implementation and knowledge translation LanzhouGansu 730000China Department of Lung Disease Shenzhen Third People's HospitalThe Second Affiliated HospitalSouthern University of Science and TechnologyShenzhen Guangdong 518112China

Background Tuberculosis(TB)continues to be prevalent in China also among children and adolescents in *** built a dynamic mathematical model for TB transmission in China,and applied it to compare the epidemic trends 2021–2030 under a range of screening interventions focusing on children and *** We developed a dynamic mathematical model with a flexible *** model can be applied either stochastically or deterministically,and can encompass arbitrary age structure and resistance *** the present version,we used the deterministic version excluding resistance but including age structure with six groups:0–5,6–11,12–14,15–17,18–64,and 65 years and *** parameterized the model by literature data and fitting it to case and death estimates provided by the World Health *** compared the new TB cases and TB-related deaths in each age group over the period 2021–2030 in 10 scenarios that involved intensified screening of particular age groups of children,adolescents,or young adults,or decreased or increased diagnostic accuracy of the *** Screening the entire age class of 18-year-old persons would prevent 517,000 TB cases and 14,600 TB-related deaths between years 2021 and 2030,corresponding to 6.6%and 5.5%decrease from the standard of care projection,*** screening of children aged 6–11 and,to a lesser extent,0–5 years,also reduced TB incidence and mortality,particularly among children of the respective ages but also in other age *** contrast,intensified screening of adolescents did not have a major *** with a simpler and less accurate method resulted in worsened outcomes,which could not be offset by more intensive *** accurate screening and better sensitivity to detect latent TB could prevent 2.3 million TB cases and 68,500 TB deaths in the coming 10 *** Routine screening in schools can efficiently reduce the burden of TB in *** should be intensifie

关键词： Tuberculosis China Children and adolescents Mathematical model Screening

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2019 Chinese Clinical Practice guidelines for the Prevention of Mother-to-child Transmission of Hepatitis B Virus

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Journal of Clinical and translational Hepatology 2020年第4期8卷 397-406页

作者： Caiyun NieJinfeng Liu Tianyan Chen Yaolong Chen Hong Ren Guiqiang Wang Wenhong Zhang Yingren Zhao The First Affiliated Hospital of Xi’an Jiaotong University Xi’anShaanxiChina Shaanxi Clinical Research Center of Infectious Diseases Xi’anShaanxiChina Evidence-Based Medicine Center Basic Medical SciencesLanzhou UniversityLanzhouGansuChina who collaborating centre for guideline implementation and knowledge translation LanzhouGansuChina Department of Infectious Diseases The Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina Hepatology Center Department of Infectious DiseasesPeking University First HospitalBeijingChina Department of Infectious Diseases Huashan Hospital Affiliated to Fudan UniversityShanghaiChina

To develop the evidence-based guidelines for managing mother-to-child transmission of hepatitis B virus in China, a multidisciplinary guideline development group was estab-lished. Clinical questions were identified from two rounds of surveys on the concerns of first-line clinicians. We conducted a comprehensive search and review of the literature. A grading of recommendations' assessment, development, and evaluation system was adopted to rate the quality of evidence and the strength of recommendations. Recommen-dations were formulated based on the evidence, overall balance of benefits and harms (at individual and population levels), patient/health worker values and preferences, re-sources available, cost-effectiveness, and feasibility. Even-tually, recommendations related to 13 main clinical concerns were developed, covering diagnostic criteria, treatment in-dications, antiviral therapy choice, timing to initiate and discontinue treatment, immunoprophylaxis strategy at birth, and how to deal with special situations, such as unintended pregnancy, assisted reproduction, and breastfeeding. The guidelines are intended to serve as guidance for clinicians and patients, to optimize the management of majority of pregnant women who are positive for hepatitis B surface antigen. guideline registration: International Practice Guide Registration Platform (IPGRP-2018CN040).

关键词： Hepatitis B virus Mother-to-child transmission Clinical practice guidelines Prevention GRADE

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Analysis of COVID-19 guideline Quality and Change of Recommendations:A Systematic Review

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Health Data Science 2021年第1期2021卷 88-109页

作者： Siya Zhao Shuya Lu Shouyuan Wu Zijun Wang Qiangqiang Guo Qianling Shi Hairong Zhang Juanjuan Zhang Hui Liu Yunlan Liu Xianzhuo Zhang Ling Wang Mengjuan Ren Ping Wang Hui Lan Qi Zhou Yajia Sun Jin Cao Qinyuan Li Janne Estill Joseph LMathew Hyeong Sik Ahn Myeong Soo Lee Xiaohui Wang Chenyan Zhou Yaolong Chen School of Public Health Lanzhou UniversityLanzhouChina Institute of Health Data Science Lanzhou UniversityLanzhouChina Department of Pediatric Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduChina Chinese Academy of Sciences Sichuan translational Medicine Research Hospital ChengduChina Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhouChina The First School of Clinical Medicine Lanzhou UniversityLanzhouChina National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChildren’s Hospital of Chongqing Medical UniversityChongqingChina Institute of Global Health University of GenevaGenevaSwitzerland Institute of Mathematical Statistics and Actuarial Science University of BernBernSwitzerland Advanced Pediatrics centre PGIMER ChandigarhChandigarhIndia Department of Preventive Medicine Korea UniversitySeoulRepublic of Korea Korea Cochrane centre SeoulRepublic of Korea Evidence Based Medicine SeoulRepublic of Korea Korea University School of Medicine SeoulRepublic of Korea Korea Institute of Oriental Medicine DaejeonRepublic of Korea University of Science and Technology DaejeonRepublic of Korea London Southbank University LondonUK Tianjin University of Traditional Chinese Medicine TianjinChina who collaborating centre for guideline implementation and knowledge translation LanzhouChina guideline International Network Asia China Key Laboratory of Evidence Based Medicine and knowledge translation of Gansu Province Lanzhou UniversityLanzhouChina Lanzhou University GRADE Center China

*** of coronavirus disease 2019(COVID-19)clinical practice guidelines(CPGs)and expert consensus statements have been developed and published since the outbreak of the ***,these CPGs are of widely variable ***,this review is aimed at systematically evaluating the methodological and reporting qualities of COVID-19 CPGs,exploring factors that may influence their quality,and analyzing the change of recommendations in CPGs with evidence *** searched five electronic databases and five websites from 1 January to 31 December 2020 to retrieve all COVID-19 *** assessment of the methodological and reporting qualities of CPGs was performed using the AGREE II instrument and RIGHT *** and evidence used to make recommendations in the CPGs regarding some treatments for COVID-19(remdesivir,glucocorticoids,hydroxychloroquine/chloroquine,interferon,and lopinavir-ritonavir)were also systematically *** the statistical inference was performed to identify factors associated with the quality of *** included a total of 92 COVID-19 CPGs developed by 19 ***,the RIGHT checklist reporting rate of COVID-19 CPGs was 33.0%,and the AGREE II domain score was 30.4%.The overall methodological and reporting qualities of COVID-19 CPGs gradually improved during the year *** associated with high methodological and reporting qualities included the evidence-based development process,management of conflicts of interest,and use of established rating systems to assess the quality of evidence and strength of *** recommendations of only seven(7.6%)CPGs were informed by a systematic review of evidence,and these seven CPGs have relatively high methodological and reporting qualities,in which six of them fully meet the Institute of Medicine(IOM)criteria of ***,a rapid advice CPG developed by the World Health Organization(who)of the seven CPGs got the highest overa

关键词： register formal transparency

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guideline for the diagnosis and treatment of rheumatoid arthritis with integrated traditional Chinese medicine and Western medicine to increase efficiency and reduce toxicity

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Traditional Medicine Research 2023年第3期8卷 19-35页

作者： Zhi-Jun Xie Wei Cao Lin Huang Yang-Qin Xun Nan Yang Ping Wang Qiao Wang Meng-Juan Ren Hai-Chang Li Yun-Lan Liu Yu-Jun Tang Yue Hu Hui Zheng Juan-Juan Zhang Hui Lan Shou-Yuan Wu Qiang-Qiang Guo Ya-Jia Sun Xian-Zhuo Zhang Xiao-Hui Wang Xu-Ping Song Yan-Fang Ma Yao-Long Chen Cheng-Ping Wen Basic Medical School Zhejiang Chinese Medical UniversityHangzhou 310053China Department of Rheumatology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Center for Evidence-Based Medicine School of Basic MedicineLanzhou UniversityLanzhou 730000China School of Public Health Lanzhou UniversityLanzhou 730000China The Institutes of Biology and Medical Sciences Soochow UniversitySuzhou 215123China The First Clinical Medical College Lanzhou UniversityLanzhou 730000China Hong Kong Chinese Medicine Clinical Study Center School of Chinese MedicineHong Kong Baptist UniversityHong Kong SARChina Institute of Health Data Science Lanzhou UniversityLanzhou 730000China Research Unit of Evidence-Based Evaluation and guidelines(2021RU017) Chinese Academy of Medical SciencesSchool of Basic Medical SciencesLanzhou UniversityLanzhou 730000China who collaborating centre for guideline implementation and knowledge translation Lanzhou 730000China

Rheumatoid arthritis imposes a huge disease *** practice guidelines do not meet the needs of integrated traditional Chinese medicine and Western medicine in the treatment of rheumatoid *** established a guideline working group consists of a steering committee,a secretary group,an evidence evaluation group,a consensus group and a review group and developed a guideline following the guidance of the World Health Organization Handbook and the Chinese Medical *** guideline includes 35 recommendations which reached consensus by the two rounds Delphi *** recommendations were formulated to address the following themes of most concern to clinician:diagnostic imaging,disease staging,traditional Chinese medicine syndromes,effectiveness and toxicity of integrated traditional Chinese medicine and Western medicine.

关键词： rheumatoid arthritis guideline traditional Chinese medicine toxicity

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Publishing clinical prActice guidelines(PAGE):Recommendations from editors and reviewers

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Chinese Journal of Traumatology 2022年第6期25卷 312-316页

作者： Nan Yang Wei Zhao Wen-An Qi Chen Yao Chong-Ya Dong Zhen-Guo Zhai Tong Chen En-Mei Liu Guo-Bao Li You-Lin Long Xin-Yi Wang Zi-Jun Wang Ruo-Bing Lei Qi Zhou Yao-Long Chen Liang Du on behalf of TERM working group Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou730000China Editor-in-Chief Office Chinese Medical Association Publishing HouseBeijing100052China Editorial Department British Medical Journal(Chinese Edition)Chinese Medical Association Publishing HouseBeijing100052China Department of Biostatistics Peking University First HospitalBeijing100034China Clinical Research Institute Peking UniversityBeijing100191China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing100029China Institute of Respiratory Medicine Chinese Academy of Medical SciencesBeijing100029China National Clinical Research Center for Respiratory Diseases Beijing100029China Department of Hematology Huashan HospitalFudan UniversityShanghai200040China Institute of Medicine Huashan HospitalFudan UniversityShanghai200040China Department of Respiratory Medicine Children's Hospital of Chongqing Medical UniversityChongqing400014China National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing400014China Chongqing Key Laboratory of Pediatrics Chongqing400014China National Clinical Research Center for Infectious Disease The Third People's Hospital of ShenzhenShenzhen518112China Medical Device Regulatory Research and Evaluation Center West China HospitalSichuan UniversityChengdu610041China Chinese Evidence-Based Medicine Center West China HospitalSichuan UniversityChengdu610041China Chevidence Lab of Child&Adolescent Health Department of Pediatric Research InstituteChildren's Hospital of Chongqing Medical UniversityChongqing400014China Research Unit of Evidence-Based Evaluation and guidelines(2021RU017) Chinese Academy of Medical SciencesSchool of Basic Medical SciencesLanzhou UniversityLanzhou730000China guidelines and Standards Research Center Chinese Medical Association Publishing HouseBeijing100052China W

Transparency Ecosystem for Research and Journals in Medicine(TERM)working group summarized the essential recommendations that should be considered to review and publish a high-quality *** recommendations from editors and reviewers included 10 components of essential requirements:systematic review of existing relevant guidelines,guideline registration,guideline protocol,stakeholders,conflicts of interest,clinical questions,systematic reviews,recommendation consensus,guideline reporting and external *** working group abbreviates them as PAGE(essential requirements for Publishing clinical prActice guidelines),and recommends guideline authors,editors,and peer reviewers to use them for high-quality guidelines.

关键词： guidelines Recommendations Editor Peer review Transparency

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Publishing clinical prActice guidelines(PAGE):Recommendations from Editors and Reviewers

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Infectious Diseases & Immunity 2022年第4期2卷 219-223页

作者： Nan Yang Wei Zhao Wenan Qi Chen Yao Chongya Dong Zhenguo Zhai Tong Chen Enmei Liu Guobao Li Youlin Long Xinyi Wang ZijunWang Ruobing Lei Qi Zhou Yaolong Chen Liang Du Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou 730000China Editor-in-Chief Office Chinese Medical Association Publishing HouseBeijing 100052China Editorial Department British Medical Journal(Chinese Edition)Chinese Medical Association Publishing HouseBeijing 100052China Department of Biostatistics Peking University First HospitalBeijing 100034China Clinical Research Institute Peking UniversityBeijing 100191China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Institute of Respiratory Medicine Chinese Academy of Medical SciencesBeijing 100029China National Clinical Research Center for Respiratory Diseases China-Japan Friendship HospitalBeijing 100029China Department of Hematology Huashan HospitalFudan UniversityShanghai 200040China Institute of Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Respiratory Medicine Children’s Hospital of Chongqing Medical UniversityChongqing 400014China National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and DisordersChongqing 400014China Chongqing Key Laboratory of Pediatrics Children’s Hospital of Chongqing Medical UniversityChongqing 400014China National Clinical Research Center for Infectious Disease the Third People’s Hospital of ShenzhenShenzhen 518112China Medical Device Regulatory Research and Evaluation Center West China HospitalSichuan UniversityChengdu 610041China Chinese Evidence-Based Medicine Center West China HospitalSichuan UniversityChengdu 610041China Chevidence Lab Child&Adolescent Health Department of Pediatric Research InstituteChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Research Unit of Evidence-Based Evaluation and guidelines(2021RU017) Chinese Academy of Medical SciencesSchool of Basic Medical SciencesLanzhou UniversityLanzhou 730000China guidelines and Standards Re

Transparency Ecosystemfor Research and Journals inMedicine(TERM)Working Group summarized the essential recommendations that should be considered to review and publish a high-quality *** recommendations fromeditors and reviewers included the 10 components of essential requirements:systematic review of existing relevant guidelines,guideline registration,guideline protocol,stakeholders,conflicts of interest,clinical questions,systematic reviews,recommendation consensus,guideline reporting,and external *** Group abbreviates them as PAGE(essential requirements for Publishing clinical prActice guidelines),recommends guideline authors,editors,and peer reviewers use them for high-quality guidelines.

关键词： Peer review guidelines Recommendations Editor Transparency

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The SUPER reporting guideline suggested for reporting of surgical technique

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Hepatobiliary Surgery and Nutrition 2023年第4期12卷 534-544,I0024-I0026页

作者： Kaiping Zhang Yanfang Ma Jinlin Wu Qianling Shi Leandro Cardoso Barchi Marco Scarci Rene Horsleben Petersen Calvin S.H.Ng Steven Hochwald Ryuichi Waseda Fabio Davoli Robert Fruscio Giovanni Battista Levi Sandri Michel Gonzalez Benjamin Wei Guillaume Piessen Jianfei Shen Xianzhuo Zhang Panpan Jiao Yulong He Nuria M.Novoa Benedetta Bedetti Sebastien Gilbert Alan D.L.Sihoe Alper Toker Alfonso Fiorelli Marcelo F.Jimenez Toni Lerut Aung Y.Oo Grace S.Li Xueqin Tang Yawen Lu Hussein Elkhayat Tomaz Stupnik Tanel Laisaar Firas Abu Akar Diego Gonzalez-Rivas Zhanhao Su Bin Qiu Stephen D.Wang Yaolong Chen Shugeng Gao Editorial Office AME Publishing CompanyHong KongChina School of Chinese Medicine Hong Kong Baptist UniversityHong KongChina Department of Cardiovascular Surgery Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouChina Evidence-based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhouChina Lanzhou University Institute of Health Data Science LanzhouChina Digestive Surgery Division Department of GastroenterologyUniversity of Sao Paulo School of MedicineSão PauloBrazil Department of Cardiothoracic Surgery Imperial College Healthcare NHS TrustLondonUK Department of Cardiothoracic Surgery University Hospital of CopenhagenRigshospitaletCopenhagenDenmark The Chinese University of Hong Kong Prince of Wales HospitalShatinNew TerritoriesHong KongChina Department of Surgical Oncology Roswell Park Cancer InstituteBuffaloNYUSA Department of General Thoracic Breast and Pediatric SurgeryFukuoka UniversityFukuokaJapan Department of Thoracic Surgery AUSL RomagnaS.Maria delle Croci Teaching HospitalRavennaItaly Clinic of Obstetrics and Gynecology University of Milan-BicoccaSan Gerardo HospitalMonzaItaly Division of General Surgery and Liver Transplantation S.Camillo HospitalRomeItaly Service of Thoracic Surgery Lausanne University Hospital(CHUV)LausanneSwitzerland Division of Cardiothoracic Surgery Department of SurgeryUniversity of Alabama BirminghamBirminghamALUSA University of Lille CNRSInsermCHU LilleUMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to TherapiesLilleFrance Department of Cardiothoracic Surgery Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhaiChina The First School of Clinical Medicine Lanzhou UniversityLanzhouChina Thoracic Surgery Service University Hospital of SalamancaBiomedical Institute of SalamancaSalamancaSpain Department of Thoracic Surgery Helios Clinic Bonn/Rhein SiegBonnGermany Division of Thoracic Surgery Department of SurgeryThe Ottawa

Background:Existing reporting guidelines pay insufficient attention to the detail and comprehensiveness reporting of surgical *** Surgical techniqUe rePorting chEcklist and standaRds(SUPER)aims to address this gap by defining reporting standards for surgical *** SUPER guideline intends to apply to articles that encompass surgical technique in any study design,surgical discipline,and stage of surgical ***:Following the EQUATOR(Enhancing the QUAlity and Transparency Of health Research)Network approach,16 surgeons,journal editors,and methodologists reviewed existing reporting guidelines relating to surgical technique,reviewed papers from 15 top journals,and brainstormed to draft initial items for the *** initial items were revised through a three-round Delphi survey from 21 multidisciplinary Delphi panel experts from 13 countries and *** final SUPER items were formed after an online consensus meeting to resolve disagreements and a three-round wording refinement by all 16 SUPER working group members and five SUPER ***:The SUPER reporting guideline includes 22 items that are considered essential for good and informative surgical technique *** items are divided into six sections:background,rationale,and objectives(items 1 to 5);preoperative preparations and requirements(items 6 to 9);surgical technique details(items 10 to 15);postoperative considerations and tasks(items 16 to 19);summary and prospect(items 20 and 21);and other information(item 22).Conclusions:The SUPER reporting guideline has the potential to guide detailed,comprehensive,and transparent surgical technique reporting for *** may also assist journal editors,peer reviewers,systematic reviewers,and guideline developers in the evaluation of surgical technique papers and help practitioners to better understand and reproduce surgical technique.

关键词： Surgical technique surgical innovation reporting guideline reporting checklist Surgical techniqUe rePorting chEcklist and standaRds(SUPER)

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基于国际实践指南报告规范的影像学临床实践指南质量评价

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中华放射学杂志 2022年第6期56卷 684-691页

作者：孙婧吕晗周奇刘文娟李佳杨正汉王振常首都医科大学附属北京友谊医院放射科北京100050 兰州大学基础医学院循证医学中心who指南实施与知识转化合作中心GRADE中国中心兰州730000

目的:采用国际实践指南报告规范(RIGHT)评价影像学临床实践指南的报告质量。方法:在中国知网数据库(CNKI)、万方数据库、中国生物医学文献数据库(CBM)、Web of Science、PubMed等数据库检索影像学指南。检索时间范围自2017年1月1日至202... 详细信息

目的:采用国际实践指南报告规范(RIGHT)评价影像学临床实践指南的报告质量。方法:在中国知网数据库(CNKI)、万方数据库、中国生物医学文献数据库(CBM)、Web of Science、PubMed等数据库检索影像学指南。检索时间范围自2017年1月1日至2022年2月26日。根据RIGHT清单条目内容,分别由两名评价者对纳入指南进行信息提取以及报告质量评价并交叉核对。结果:最终纳入18篇中文指南,报告率为(56.2±14.3)%;其中领域一基本信息(75.9%,82/108)和领域七其他方面(68.5%,37/54)报告率最高;领域六资助与利益冲突声明及管理(25.0%,18/72)报告率最低。本研究所纳入的指南在条目2对推荐意见的汇总(27.8%,5/18)、条目11a指南基于的系统评价类型(5.6%,1/18)、条目14a形成推荐意见是否考虑患者意愿和价值观(22.2%,4/18)、条目15形成推荐意见的方法(22.2%,4/18)及条目16指南是否经过独立评审(16.7%,3/18)方面报告率较低。结论:已发表影像学指南的总体报告质量有待提高。建议影像学指南制订者掌握相关指南研究和评价工具,如RIGHT等,充分报告指南制订的细节与关键内容,提升指南报告的透明性和全面性。

关键词：放射学临床实践指南报告质量

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解析中国血吸虫病预防性化疗方案演变历史提升who指南精准化实施水平

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中国血吸虫病防治杂志 2022年第3期34卷 223-229页

作者：许静李宜锋董毅赵正元闻礼永张世清林丹丹周杰梁松郭家钢李石柱周晓农中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心)、国家卫生健康委员会寄生虫病原与媒介生物学重点实验室、who热带病合作中心、国家级热带病国际联合研究中心上海200025 江西省寄生虫病防治研究所云南省地方病防治所湖南省血吸虫病防治所杭州医学院、浙江省血吸虫病防治中心安徽省血吸虫病防治研究所美国佛罗里达大学 who被忽视热带病控制司

预防性化疗是控制和消除血吸虫病的重要干预措施之一,可显著降低发病率和感染率。为推进联合国可持续发展目标和who《结束忽视,实现可持续发展目标:2021—2030年被忽视热带病路线图》中设定的血吸虫病防控目标,2022年who发布了《who控... 详细信息

预防性化疗是控制和消除血吸虫病的重要干预措施之一,可显著降低发病率和感染率。为推进联合国可持续发展目标和who《结束忽视,实现可持续发展目标:2021—2030年被忽视热带病路线图》中设定的血吸虫病防控目标,2022年who发布了《who控制和消除人体血吸虫病指南》,基于循证医学证据对血吸虫病化疗策略进行了较大调整。作为血吸虫病防控进程较快的流行国家,中国在70余年的血吸虫病防治历程中对化疗方案也进行了多次调整和修订。本文在回顾who和中国血吸虫病化疗策略演变过程的基础上,对中国现行化疗方案和《who控制和消除人体血吸虫病指南》中的化疗建议进行了比较分析,并对今后贯彻实施who指南的化疗策略提出相应建议,为从事血吸虫病公共卫生援外工作者和相关人员提供参考。

关键词：血吸虫病消除指南预防性化疗吡喹酮

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共享who指南努力实现我国消除血吸虫病目标

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中国血吸虫病防治杂志 2022年第3期34卷 235-240页

作者：汪天平吕山秦志强周艺彪刘阳闻礼永郭家钢许静李石柱张光明张世清安徽省血吸虫病防治研究所安徽合肥230601 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心)、国家卫生健康委员会寄生虫病原与媒介生物学重点实验室、who热带病合作中心、国家级热带病国际联合研究中心上海交通大学医学院-国家热带病研究中心全球健康学院复旦大学公共卫生学院、教育部公共卫生安全重点实验室、热带病研究中心四川省疾病预防控制中心浙江省血吸虫病防治中心 who被忽视热带病控制司

目前,我国血吸虫病防治工作正处于从传播阻断迈向消除的关键阶段,同时也面临进一步压缩钉螺面积难度大、传染源控制成果不牢固、监测体系不完善、防治管理有所松懈等诸多问题和挑战。本文依据《who控制和消除人体血吸虫病指南》核心建议... 详细信息

目前,我国血吸虫病防治工作正处于从传播阻断迈向消除的关键阶段,同时也面临进一步压缩钉螺面积难度大、传染源控制成果不牢固、监测体系不完善、防治管理有所松懈等诸多问题和挑战。本文依据《who控制和消除人体血吸虫病指南》核心建议,结合我国血吸虫病防治工作实际,对新时期我国血吸虫病监测体系建设、检测新技术研发、防治策略调整、防治能力维持和提高等提出了相应建议。要从全健康角度谋划我国血吸虫病防治策略和目标;要适时对血吸虫病传播阻断和消除进程开展验证;要在充分评估的基础上因时因地调整防治策略,精准实施血吸虫病防治措施;要重视和加强高敏感度、高特异度检测工具的开发和应用,为消除血吸虫病提供技术支撑;要借鉴和吸收《who控制和消除人体血吸虫病指南》精髓,充分发挥其引导作用,促进我国实现消除血吸虫病目标。

关键词：血吸虫病消除指南精准防治综合治理全健康

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