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众脑之力:通过开放神经影像数据和大规模协作催化神经精神疾病的创新发现

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Science Bulletin 2024年第10期69卷 1536-1555页

作者：鲁彬陈骁 Francisco Xavier Castellanos Paul m.Thompson 左西年臧玉峰严超赣 CAS Key laboratory of Behavioral Science Institute of PsychologyBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100101China Department of Child and Adolescent Psychiatry NYU Grossman School of MedicineNew York 10016USA d Nathan Kline Institute for Psychiatric Research Orangeburg 10962USA Imaging Genetics Center Mark&Mary Stevens Institute for Neuroimaging&InformaticsKeck School of MedicineUniversity of Southern CaliforniaLos Angeles 90033USA Developmental Population Neuroscience Research Center IDG/McGovern Institute for Brain ResearchBeijing Normal UniversityBeijing 100875China National Basic Science Data Center Beijing 100190China Centre for Cognition and Brain Disorders The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310004China Institute of Psychological Science Hangzhou Normal UniversityHangzhou 310030China Zhejiang Key laboratory for Research in Assessment of Cognitive Impairment Hangzhou 311121China International Big-Data Center for Depression Research Institute of PsychologyChinese Academy of SciencesBeijing 100101China magnetic Resonance Imaging Research Center Institute of PsychologyChinese Academy of SciencesBeijing 100101China

Recent advances in open neuroimaging data are enhancing our comprehension of neuropsychiatric *** pooling images from various cohorts,statistical power has increased,enabling the detection of subtle abnormalities and robust associations,and fostering new research *** collaborations in imaging have furthered our knowledge of the neurobiological foundations of brain disorders and aided in imaging-based prediction for more targeted ***-scale magnetic resonance imaging initiatives are driving innovation in analytics and supporting generalizable psychiatric *** also emphasize the significant role of big data in understanding neural mechanisms and in the early identification and precise treatment of neuropsychiatric ***,challenges such as data harmonization across different sites,privacy protection,and effective data sharing must be *** proper governance and open science practices,we conclude with a projection of how large-scale imaging resources and collaborations could revolutionize diagnosis,treatment selection,and outcome prediction,contributing to optimal brain health.

关键词： magnetic resonance imaging Neuropsychiatric disorders Big data Open science Artificial intelligence

Creep behavior and post-creep thermoelectric performance of the n-type Skutterudite alloy Yb_(0.3)Co_(4)Sb_(12)

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Journal of materiomics 2021年第1期7卷 89-97页

作者： muath m.Al malki Xun Shi Pengfei Qiu G.Jeffrey Snyder David C.Dunand Department of materials Science&Engineering Northwestern UniversityEvanstonIL60208USA mechanical Engineering Department King Fahd University of Petroleum and MineralsDhahran31261Saudi Arabia State Key laboratory of High-Performance Ceramics and Superfine microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China

Upon uniaxial compressive loading at 500℃(T/Tm=0.67,where Tm is the absolute melting point),the n-type Skutterudite alloy Yb03Co4Sb12 deforms plastically by creep via a power-law,with a stress exponent~3 consistent with dislocation viscous *** activation energy of 171 kJ/mol is measured over the temperature range of 500-587℃(T/Tm=0.67-0.75)at a stress of 30 ***_(0.3)Co_(4)Sb_(12)is ductile at 500℃,exhibiting a compressive strain of 25%when subjected to stresses ranging from 22 to 90 mPa for up to 28 *** the thermoelectric materials tested so far for creep,Yb_(0.3)Co_(4)Sb_(12)exhibits a creep resistance intermediate between low-melting(Bi2Te3,TAGS-85)and high-melting thermoelectrics(mg2Si and ZrNiSn).A relatively modest drop in the figure of merit zT,from 0.67 to 0.52,is displayed by Yb_(0.3)Co_(4)Sb_(12)after accumulating 3.7%compressive creep strain at 500℃,mostly due to a drop in electrical conductivity.

关键词： Filled Skutterudite CoSb_(3) Seebeck coefficient Electrical conductivity Creep

Partial anhysteretic remanent magnetization (pARm) of synthetic single-and multidomain magnetites and its paleoenvironmental significance

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Chinese Science Bulletin 2005年第20期50卷 2381-2384页

作者： LIU Qingsong YU Yongjae PAN Yongxin ZHU Rixiang ZHAO Xixi Institute for Rock magnetism and Department of Geology and Geophysics University of Minnesota Minneapolis MN 55455 USA Paleomagnetism and Geochronology laboratory (SKL-LE) Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Department of Earth Sciences and Institute of Geophysics and Planetary Physics University of California Santa Cruz CA95064 USA Geosciences Research Division Scripps Institution of Oceanography La Jolla CA USA

In order to isolate magnetic signals carried by single-domain (SD) ferrimagnetic (Fm) minerals from multi-domain (mD) Fm minerals, we developed a few pa- rameters using partial anhysteretic remanent magnetization (pARm). Because mD fraction contains only soft (easy to be demagnetized) coercivity spectrum, pARm(>20 mT) was sensitive in eliminating mD contributions. Ratio of pARm(5 mT, 10 mT)/pARm(0, 5 mT) is useful in quantifying a rela- tive abundance of mass ratio between SD and mD fractions. These new proxies can quickly characterize the details of grain size distribution of magnetic minerals in paleoclimatic and paleomagnetic studies.

关键词：磁铁矿 pARm 地质气候岩石磁学光谱

Characterizing microlensing planetary system OGLE-2014-BLG-0676Lb with adaptive optics imaging

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Research in Astronomy and Astrophysics 2021年第12期21卷 357-364页

作者： Xiao-Jia Xie Subo Dong Yossi Shvartzvald Andrew Gould Andrzej Udalski Jean-Philippe Beaulieu Charles Beichman Laird miller Close Calen BHenderson Jared Rmales Jean-Baptiste marquette Katie mmorzinski Christopher RGelino Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Department of Astronomy Peking UniversityBeijing 100871China Department of Particle Physics and Astrophysics Weizmann Institute of ScienceRehovot 76100Israel Department of Astronomy Ohio State University140 W.18th AvenueColumbusOH 43210USA max-Planck-Institute for Astronomy Koigstuhl 17D-69117 HeidelbergGermany Astronomical Observatory University of WarsawAl.Ujazdowskie 400-478 WarszawaPoland School of Natural Sciences University of TasmaniaPrivate Bag 37 HobartTasmania 7001Australia Sorbonne Universite UPMC Universite Paris 6 et CNRSUMR 7095Institut d'Astrophysique de Paris98 bis Bd AragoF-75014 ParisFrance Jet Propulsion laboratory California Institute of Technology4800 Oak Grove DrivePasadenaCA 91109USA Caltech/IPAC-NASA Exoplanet Science Institute 770 S.Wilson AvePasadenaCA 91106USA Steward Observatory University of ArizonaTucsonAZ 85721USA IPAC Mail Code 100-22Caltech1200 East California BoulevardPasadenaCA 91125USA Laboratoire d'Astrophysique de Bordeaux Univ.BordeauxCNRSB18Nallee Geoffroy Saint-HilaireF-33615 FessacFrance

we constrain the host-star flux of the microlensing planet OGLE-2014-BLG-0676 Lb using adaptive optics(AO)images taken by the magellan and keck *** measure the flux of the light blended with the microlensed source to be K=16.79±0.04 mag and J=17.76±0.03 *** that the blend is the lens star,we find that the host is a 0.73_(-0.29)^(+0.14)m_(⊙)star at a distance of2.67_(-1.41)^(+0.77)kpc,where the relatively large uncertainty in angular Einstein radius measurement is the major source of *** mass of m_(p)=3.68_(-1.44)^(+0.69)m_J,the planet is likely a"super Jupiter"at a projected separation of r_(⊥)=4.53_(-2.50)^(+1.49)AU,and a degenerate model yields a similar m_p=3.73_(-1.47)^(+0.73)m_(J)at a closer separation of r_(⊥)=2.56_(-1.41)^(+0.84)*** estimates are consistent with the previous Bayesian analysis based on a Galactic ***-2014-BLG-0676 Lb belongs to a sample of planets discovered in a"secondgeneration"planetary microlensing survey and we attempt to systematically constrain host properties of this sample with high-resolution imaging to study the distribution of planets.

关键词： gravitational lensing:micro instrumentation:adaptive optics instrumentation:high angular resolution (stars:)planetary systems

多发性一过性白点综合征的非典型表现——大小不一的颗粒状病变

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世界核心医学期刊文摘（眼科学分册） 2005年第9期1卷 25-25页

作者： Khurana R.N. Albini T. Dea m.K. J.I. Lim 韩静 Doheny Eye Institute University of Southern California Keck School of Medicine 1450 San Pablo Street No. 3612 Los Angeles CA 90033 United States Dr.

PURPOSE: To report an atypical presentation of multiple evanescent white dot syndrome (mEwDS). DESIGN: Observational case report. mETHODS: Review of the clinical, laboratory, photographic, and angiographic records of a patient with mEwDS. RESULTS: A 29-year-old woman presented with 20/400 vision in the right eye associated with multiple, granular lesions of varying sizes (100-1000 μm) in the outer retina, a prominent panuveitis, diffuse choroidal thickening and enlarged blindspot. The multiple lesions and visual disturbances resolved within 4 weeks with corticosteroid treatment, and the patient was diagnosed with mEwDS. CONCLUSIONS: Clinicians should be aware of atypical manifestations of mEwDS. The patient’s unusual fundoscopic changes and prominent intraocular inflammatory reaction are findings that have not been reported in patients with mEwDS.

关键词：颗粒状眼底改变视网膜外层右眼视力葡萄膜炎临床医生炎症反应血管造影糖皮质激素观察性

Application of Advanced Analytics and Visualization in mineral Systems

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Acta Geologica Sinica(English Edition) 2019年第S1期93卷 55-55页

作者： Shaunna m.mORRISON Anirudh PRABHU Ahmed ELEISH PAN Feifei ZHONG Hao HUANG Fang Peter FOX mA Xiaogang Jolyon RALPH Joshua J.GOLDEN Robert T.DOwNS LIU Chao Simone E.RUNYON Robert m.HAZEN Geophysical laboratory Carnegie Institution for Science1530 P Street NWWashington DC 20005USA Rensselaer Polytechnic Institute 1008th StTroyNY 12180USA University of Idaho 875 Perimeter DrMoscowID 83844USA *** University of Arizona TucsonAZ 85721USA University of wyoming 1000 E University AveLaramieWY 82071USA

The key to answering many compelling and complex questions in Earth,planetary,and life science lies in breaking down the barriers between scientific fields and harnessing the integrated,multi-disciplinary power of Earth,planetary,and bioscience data *** have a unique opportunity to integrate large and rapidly expanding"big data"resources,to enlist powerful analytical and visualization methods,and to answer multi-disciplinary questions that cannot be addressed by one field alone.

关键词： minerals network analysis data-driven discovery mineral evolution mineral ecology

Polarization Flipping of Even-Order Harmonics in monolayer Transition-metal Dichalcogenides

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Ultrafast Science 2021年第1期1卷 39-47页

作者： Yuki Kobayashi Christian Heide Hamed Koochaki Kelardeh Amalya Johnson Fang Liu Tony F.Heinz David A.Reis Shambhu Ghimire Stanford PULSE Institute SLAC National Accelerator LaboratoryMenlo ParkCA 94025USA Department of Applied Physics Stanford UniversityStanfordCA 94305USA max Planck Institute for the Physics of Complex Systems Nöthnitzer Str.3801187 DresdenGermany Department of materials Science and Engineering Stanford UniversityStanfordCA 94305USA Department of Chemistry Stanford UniversityStanfordCA 94305USA Department of Photon Science Stanford UniversityStanfordCA 94305USA

we present a systematic study of the crystal-orientation dependence of high-harmonic generation in monolayer transition-metal dichalcogenides,wS2 and moSe2,subjected to intense linearly polarized midinfrared laser *** measured spectra consist of both odd-and even-order harmonics,with a high-energy cutoff extending beyond the 15th order for a laser-field strength around~1 V/*** wS2,we find that the polarization direction of the odd-order harmonics smoothly follows that of the laser field irrespective of the crystal orientation,whereas the direction of the even-order harmonics is fixed by the crystal mirror ***,the polarization of the even-order harmonics shows a flip in the course of crystal rotation when the laser field lies between two of the crystal mirror *** numerically solving the semiconductor Bloch equations for a gapped-graphene model,we qualitatively reproduce these experimental features and find the polarization flipping to be associated with a significant contribution from interband *** contrast,high-harmonic signals from moSe2 exhibit deviations from the laser-field following of oddorder harmonics and crystal-mirror-plane following of even-order *** attribute these differences to the competing roles of the intraband and interband contributions,including the deflection of the electron-hole trajectories by nonparabolic crystal bands.

关键词： polarization harmonics mirror

Data-Driven Discovery in mineralogy: Recent Advances in Data Resources, Analysis, and Visualization

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Engineering 2019年第3期5卷 397-405页

作者： Robert m. Hazen Robert T. Downs Ahmed Eleish Peter Fox Olivier C. Gagné Joshua J. Golden Edward S. Grew Daniel R. Hummer Grethe Hystad Sergey V. Krivovichev Congrui Li Chao Liu Xiaogang ma Shaunna m. morrison Feifei Pan Alexander J. Pires Anirudh Prabhu Jolyon Ralph Simone E. Runyon Hao Zhong Geophysical laboratory Carnegie Institution for Science Washington DC 20015 USA Department of Geology and Geophysics University of Wyoming Laramie WY 82071-2000 USA Department of Geosciences The University of Arizona Tucson AZ 85721-0077 USA Tetherless world Constellation Rensselaer Polytechnic Institute Troy NY 12180 USA School of Earth and Climate Sciences University of Maine Orono ME 04469 USA Department of Geology Southern Illinois University Carbondale IL 62901 USA mathematics Statistics and Computer Science Purdue University Northwest Hammond IN 46323-2094 USA Kola Science Centre of the Russian Academy of Sciences Apatity Murmansk Region 184209 Russia Department of Computer Science University of Idaho Moscow ID 83844-1010 USA *** Mitcham CR4 4FD UK

Large and growing data resources on the diversity, distribution, and properties of minerals are ushering in a new era of data-driven discovery in mineralogy. The most comprehensive international mineral database is the ImA database, which includes information on more than 5400 approved mineral species and their properties, and the *** data source, which contains more than 1 million species/locality data on minerals found at more than 300 000 localities. Analysis and visualization of these data with diverse techniques—including chord diagrams, cluster diagrams, Klee diagrams, skyline diagrams, and varied methods of network analysis—are leading to a greater understanding of the co-evolving geosphere and biosphere. New data-driven approaches include mineral evolution, mineral ecology, and mineral network analysis—methods that collectively consider the distribution and diversity of minerals through space and time. These strategies are fostering a deeper understanding of mineral co-occurrences and, for the first time, facilitating predictions of mineral species that occur on Earth but have yet to be discovered and described.

关键词： mineral evolution ecology Skyline diagrams Network analysis Cluster Chord Klee

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皮质下小血管病诊断的共识声明

国际脑血管病杂志 2016年第6期24卷 481-496页

作者： Gary A Rosenberg Anders wallin Joanna m wardlaw Hugh S markus Joan montaner Leslie wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel martin Dichgans marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师张劼陈涵丰俞娅美徐子奇罗本燕 Department of Neurology University of New Mexico Albuquerque New Mexico USA Institute of Neuroscience and Physiology Sahlgrenska Academy Gothenburg University Gothenburg Sweden Centre for Clinical Brain Sciences University of Edinburgh Edinburgh UK Department of Clinical Neurosciences University of Cambridge Cambridge UK Neurovascular Research laboratory Vail d'Hebron Research Institute Universitat Auto'noma de Barcelona Barcelona Spain Department of Neurology University of Connecticut Health Center Farmington Connecticut USA Feil Family Brain and mind Research Institute Weill Cornell Medical College New York New York USA Department of Physiology and Biophysics Zilkha Neurogenetic Institute Keck School of Medicine University of Southern Califomia Los Angeles California USA INSERm U1161 Paris France Institute for Stroke and Dementia Research Klinikum der Universitat Mtinchen Munich Germany Department of Neurology Medical University of Graz Graz Austria Tel-Aviv University medical School Ramat Aviv Israel Department of Neurology Memory and Aging Center and Department of Pathology University of Califomia San Francisco California USA University of Sao Paulo medical School Sao Paulo Brazil Department of Neurology University of Southern California Medical School Los Angeles California USA Department of Clinical Neurological Sciences University Hospital University of Western Ontario London Ontario Canada 浙江大学医学院附属第一医院杭州310003

血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病（Binswanger＇s disease, BD）的进行性白质损害患者构成了从单纯血管性... 详细信息

血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病（Binswanger＇s disease, BD）的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组，存在缺氧缺血、腔隙性梗死和炎症，它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物，这将有助于诊断以及将来协作性治疗试验的患者选择。

关键词：宾斯旺格病血脑屏障通透性脑脊液炎症白质疏松