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17th World Conference on Non-Destructive Testing

作者： Goeran vogt Carsten KOEHLER vogt werkstoffpruefsysteme gmbh BurgwedelGermany Burgwedel.Lower Saxony Germany

＜正＞The ultrasonic testing with pulse echo method has been approved since many years as a user suitable and expressive non-destructive testing method for electron beam-and laser weld *** PROline-S system is used *** the inspection especially at transmission control gears for the automotive industry in *** the process of immersion technique the ultrasound will be beamed radially into the weld seam of the rotating transmission control gear by means of a fixed vertical *** further developed PROline-S ultrasonic inspection system now is provided with a waterless coupling by a rubber *** doing so with a gear inspector’s stamp there will be created a membrane-enclosed tank inside the coupler *** enables cost-efficient solutions with conventional and new designed immersion systems for control gears matched for short test cycles and easy *** focus is on scan functions by low hardware and control effort as well as simple handling mechanics for the testing in variable inspection systems for different *** can be leveraged for inline-and offline testing in mechanized and automatic processes as well as for monitoring in production and application in the aerospace-,aviation-, automotive-,railroad-,steel-,plastic-and ceramic industries as well as at universities and research *** application ranges from wall thickness measurement up to the integration into all kinds of production line systems for inline inspection as well as upgrading and retrofitting of existing ultrasonic testing systems and adaption of customer designed *** the PROline ultrasonic inspection system is designed for production with automatic data acquistion and *** multifunctional screen display shows the A-,B-or C-scan and at the same time the evaluation of the parts as well as the statistical process *** ultrasonic system communicates by digital I/O ports with the PLC of the inspection mechanics.

关键词： PROline ultrasonic system Electron beam welds Laser beam welds Inline production testing Ultrasound Waterless couplent Immersion tank

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AF4通道技术表征病毒样颗粒

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生命科学仪器 2010年第4期8卷 10-12页

作者： Rainer LANG Lorenz vogt Alexander ZüRCHER Gerhard WINTER Intervet International. gmbh UntershleissheimGermany Biopharmaceutics Ludwig-Maximilians-University Butenandtstr 581377 Munich. Germany

病毒样颗粒(VLP)是一种越来越受到广泛关注的抗体疫苗。为了对其进行质量控制,采用灵敏的分析方法非常重要。这项研究阐述了将非对称流分离(AF4)方法开发用于VLP研究。结果表明,AF4在研究VLP表达方面具有很大的潜力,超过了通常使用的动... 详细信息

病毒样颗粒(VLP)是一种越来越受到广泛关注的抗体疫苗。为了对其进行质量控制,采用灵敏的分析方法非常重要。这项研究阐述了将非对称流分离(AF4)方法开发用于VLP研究。结果表明,AF4在研究VLP表达方面具有很大的潜力,超过了通常使用的动态光散射和尺寸排阻高效液相色谱法。

关键词：病毒样颗粒通道技术高效液相色谱法表征动态光散射质量控制流分离非对称

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维普期刊数据库

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The roles of canonical Wnt/β-catenin signaling in the adult dopaminergic neurogenesis

The roles of canonical Wnt/β-catenin signaling in the adult...

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中国神经科学学会第十二届全国学术会议

作者： Jingzhong Zhang Daniela M.vogt Weisenhorn Makoto M.Taketo Nilima Prakash Wolfgang Wurst Suzhou Institute of Biomedical Engineering and Technology (SIBET) Chinese Academy of Sciences (CAS) Institute of Developmental Genetics Helmholtz Centre Munich German Research Centre for Environmental Health (GmbH) and Technical University Munich Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Standort München and Max-Planck-Institute of Psychiatry

Wnt/β-catenin signaling plays a critical role in the development of mesodiencephalic dopaminergic(md DA) neurons, but also in adult homeostasis and protection of these neurons. We have previously shown that Wnt1-mediated signaling is necessary and sufficient for the correct establishment of the md DA progenitor domain during early mouse embryonic development, and more recent data indicate a critical role of a precisely balanced Wnt/β-catenin signaling in the differentiation of these progenitor/precursor cells into mature md DA neurons. To assess the function of the Wnt/β-catenin pathway in the adult mouse brain under both basal and lesioned conditions, we constitutively activated the Wnt/β-catenin signaling pathway in Doublecortin(Dcx)-expressing adult neural precursor cells and newly generated neurons by crossing an inducible DCX-Cre ERT2 transgenic mouse with Catnblox(ex3)/lox(ex3) mice and CAG-CATEGFP reporter mice. The Wnt/β-catenin signaling pathway is constitutively activated in the Catnblox(ex3)/lox(ex3)) mice by the Cre-mediated removal of the 3 rd exon of the β-catenin(Catnb or Ctnnb1) gene encoding the phosphorylation sites that mediate its proteasomal degradation. We show here that constitutive activation of Wnt/β-catenin signaling in adult Dcx neural precursor cells did not lead to increased ubiquitous cell proliferation and/or tumorigenesis but increased the numbers of Tyrosine hydroxylase(Th, a marker for dopaminergic neurons) and EGFP double-positive cells in the olfactory bulbs(140% increase) and hypothalamus of adult DCX-Cre ERT2;Catnblox(ex3)/lox(ex3);CAG-CAT-EGFP mice relative to the control, and very few double-positive cells were also detected in the ventral midbrain(VM) of the mutant mice but not in the corresponding controls. By contrast, Th/EGFP double-positive cells were not detected in the cortex and dentate gyrus(hippocampus) of the mutant mice. To determine whether the β-catenin removed phosphorylation sites in Dcx neural precursor cells

关键词： Neural precursors Wnt/β-catenin DCX Transdifferentiation Dopaminergic neurons

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