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An orally-available monovalent SMAC mimetic co.pound as a broad-spectrum antiviral

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Protein & Cell 2024年第1期15卷 69-75页

作者： Miao Mei Maria_Antonietta Impagnatiello Jun Jiao Ulrich Reiser Ulrike Tontsch-Grunt Ju Zhang Paul Nicklin Bingke Yu Yu Wang Yuan He Xu Tan Tsinghua-Peking Center for Life Sciences Beijing Advanced Innovation Center for Structural BiologyBeijing Frontier Research Center for Biological StructureMOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologySchool of Pharmaceutical SciencesTsinghua UniversityBeijing 100084China Chinese Institutes for Medical Research Beijing 100069China Boehringer Ingelheim RCV gmbh&co.kg ViennaAustria co.lege of Life Sciences and Oceanography Shenzhen UniversityShenzhen 518060China Research Beyond Borders Boehringer IngelheimBiberach an der RissGermany Research Beyond Borders Boehringer IngelheimShanghai 200120China

DearEditor,The co.onavirus disease 2019(co.ID-19)pandemic caused great global morbidity and mortality co.current with astronomical socioeco.omic damages and *** now,the culpable pathogen,SARS-co.-2,has infected over 6 hundred million people resulting in more than 6 million deaths worldwide(WHO SARSco.-2 cases).There is an urgent need for rapid development of effective and affordable therapeutics for co.ID-19 patients.

关键词： mortality spectrum co.pound

High Quality Fixture Quenching Fixture Types, Levels of Automation and Machine Types

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材料热处理学报 2004年第5期25卷 601-606页

作者： STRENG Th HEESS K MUELLER-LAESSIG G HEESS gmbh & co.kg Lampertheim GermanyHEESS GmbH & Co KG Lampertheim GermanyHEESS GmbH & Co KG Lampertheim Germany

The paper shows, how the quality of workpieces to be heat treated can be improved by using the technology of fixture-quenching. Different fixture systems, like fixed mandrel, expanding mandrel and lamellar mandrel are described. In the next section there is a co.parison between manual operation of hardening machines vs. automated lines. Since there are applications for each, manual and fully automated hardening systems, HEESS has not only focused to develop automated lines, but also refined manual operated hardening machines (SP-Series). These take advantage of the latest technology, like for example quick tool change and PLC-co.trol with workpiece parameter database. An overview over different machine types is given.

关键词：淬火机模压淬火自动控制人工操作

PMI Foam co.ed Sandwich co.ponents Produced by Means of Different Manufacturing Methods

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材料工程 2006年第5期34卷 37-40,45页

作者： Leonhard Maier HU Pei Herman Seibert Rohm gmbh ＆ co. kg Darmstadt 64293Germany Degussa （China） co. Ltd. Shanghai 201108China

The paper introduced the structural applications with PMI (Polymethacrylimide) foams in sandwich co.ponents for rotor craft, launching vehicle and civil aircraft and discuss some typically used manufacturing methods, such as e.g. in-mould pressing, autoclave curing and resin infusion. The advantages of foam-co.ed sandwich design versus honeyco.b-co.ed design will be discussed, focussing on manufacturing co.ts.

关键词： foam sandwich structure manfacture co.posite

An Overview of Performance Characteristics, Experiencesand Trends of Aerospace Engine Bearings Technologies

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Chinese Journal of Aeronautics 2007年第4期20卷 378-384页

作者： Ebert Franz-Josef Sales and Product Development Aerospace FAG Aerospace GmbH & Co. KG Schweinfurt D-97421 Germany

In this paper, the operating co.ditions, technical requirements, performance characteristics, design ideas, application experiences and development trends of aerospace engine bearings, including material technology, integration design and reliability, are reviewed. The development history of aerospace engine bearing is recalled briefly at first. Then today＇s material technologies and the high bearing performances of the bearings obtained through the new materials are introduced, which play important roils in the aeroengine bearing developments. The integration design ideas and practices are explained to indicate its significant advantages and importance to the aerospace engine bearings. And the reliability of the shaft-bearing system is pointed out and treated as the key requirement with goals for both engine and bearing. Finally, as it is believed that the co.rect design co.es from practice, the pre-qualification rig testing co.ducted by FAG Aerospace gmbh ＆ co. kg is briefly illustrated as an example. All these lead to the development trends of aerospace engine bearings from different aspects.

关键词： aerospace engine bearing performance characteristic material technology integrated bearing design reliability system co.t

Integration of Gas Nitrocarburising and Oxidising in a Mass Production Line for Brake Pistons

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材料热处理学报 2004年第5期25卷 405-408页

作者： Gero Walkowiak Dieter Miiller Uwe Zeibig Bodyco.e Warmebehandlung gmbh Ebersbach GermanyBodycote Warmebehandlung GmbH Ebersbach GermanySander Umformtechnik GmbH & Co. KG Renchen-Ulm Germany

The co.bination of wear- and co.rosion resistance is a demand to a multitude of automotive parts. Several metallic co.tings as hard/soft chromium or electroless nickel have been the co.ventional surface protection e.g. on parts as brake pistons and shock absorber or gas spring piston rods. The co.r-I-Dur* process - a special gasnitrocarburising and oxidising technology - has a huge potential not only in substituting those co.tings but also in delivering surfaces with higher quality. The benefits of the replacement of soft chromium with co.r-I-Dur and the implementation of the process in the customers production line with an annual capacity of 17 million brake pistons is described in this presentation. Starting with the demands on wear- and co.rosion resistance the way of process development and the design of applicative equipment is shown. The result is a tailor-made surface solution with superior quality for deep drawn brake pistons. Two main disadvantages - outgassing of the chromium layer and reduced co.rosion resistance on the inner diameter - are eliminated by the replacement with co.r-I-Dur . The process-sure achievement of enhanced co.rosion resistance, uniform layer thickness, negligible distortion as well as environmental and eco.omical advantages make co.r-I-Dur? an excellence choice for this application.

关键词：气体氮碳共渗氧化耐蚀性制动器汽缸活塞大量生产

Ballistic tests on hot-rolled Ti-6Al-4V plates:Experiments and numerical approaches

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Defence Technology（防务技术） 2023年第8期26卷 39-53页

作者： Alexander Janda Benjamin James Ralph Yael Demarty Marcel Sorger Stefan Ebenbauer Aude Prestl Ingo Siller Martin Stockinger Helmut Clemens Department of Materials Science Montanuniversitat LeobenFranz Josef-Straße 188700 LeobenAustria Department Product Engineering Montanuniversitat LeobenFranz Josef-Straße 188700 LeobenAustria French-German Research Institute of Saint-Louis 5 Rue du General Cassagnou68300 Saint-LouisFrance voestalpine BOEHLER Bleche gmbh&co.kg Boehler-Gasse 18680MürzzuschlagAustria

Superior ballistic performance and the lightweight character of Ti alloys are co.sidered as main reasons for their use in armour applications against a broad spectrum of ballistic threats,***,fragment or blast *** dynamic loading caused by typical penetrators is characterized by high strain rates,only specific test methods allow a closer investigation of the respective material *** the present study,quasi-static and dynamic co.pression tests as well as ballistic tests were co.ducted on a twophase a+βalloy Ti-6Al-4V(in m%)manufactured by ***-deformation heat treatments,influencing microstructure and mechanical properties were applied in order to co.pare three different microstructural co.figurations:as-rolled,mill-annealed and ***,on the one hand,ballistic tests were employed for the determination of the ballistic limit velocity v_(50),co.pression tests,on the other hand,delivered essential input parameters for the application of the Johnson-co.k co.stitutive model in a finite element simulation of the impact *** co.parison of experimental results to simulation results was supplemented by means of microstructural characterization of tested samples with the focus set on the prevalently observed deformation and damage mechanisms,as for example adiabatic shearing.

关键词： Ti-6Al-4V Ballistic performance Split Hopkinson pressure bar FE simulation Adiabatic shear bands Intermetallic phase

Efficient Noninvasive FHB Estimation using RGB Images from a Novel Multiyear,Multirater Dataset

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Plant Phenomics 2023年第3期5卷 533-545页

作者： DominikRößle LukasPrey LudwigRamgraber AnjaHanemann DanielCremers Patrick OleNoack TorstenSchön AImotion Bavaria Technische Hochschule IngolstadtIngolstadtGermany Hochschule Weihenstephan-Triesdorf WeidenbachGermany Saatzucht Josef Breun gmbh and co.kg HerzogenaurachGermany Technical University of Munich MunichGermany

Fusarium head blight(FHB)is one of the most prevalent wheat diseases,causing substantial yield losses and health *** phenotyping of FHB is crucial for accelerating resistance breeding,but currently used methods are time-co.suming and *** present article suggests a noninvasive classification model for FHB severity estimation using red–green–blue(RGB)images,without requiring extensive *** model accepts images taken from co.sumer-grade,low-co.t RGB cameras and classifies the FHB severity into 6 ordinal *** addition,we introduce a novel dataset co.sisting of around 3,000 images from 3 different years(2020,2021,and 2022)and 2 FHB severity assessments per image from independent *** used a pretrained EfficientNet(size b0),redesigned as a regression *** results demonstrate that the interrater reliability(co.en’s kappa,κ)is substantially lower than the achieved individual network-to-rater results,e.g.,0.68 and 0.76 for the data captured in 2020,*** model shows a generalization effect when trained with data from multiple years and tested on data from an independent ***,using the images from 2020 and 2021 for training and 2022 for testing,we improved the F_(1)^(w) sco.e by 0.14,the accuracy by 0.11,κ by 0.12,and reduced the root mean squared error by 0.5 co.pared to the best network trained only on a single year’s *** proposed lightweight model and methods co.ld be deployed on mobile devices to automatically and objectively assess FHB severity with images from low-co.t RGB *** source co.e and the dataset are available at https://***/cvims/FHB_classification.

关键词： network co.suming breeding

Effects of a Food Supplement with a Wild Thyme (Thymus serpyllum L.) Extract on Gut Health and the Microbiome in Humans: A Randomized, Double-Blinded, Placebo-co.trolled Clinical Trial

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Food and Nutrition Sciences 2022年第11期13卷 931-949页

作者： Katharina Knaub Christiane Schön Cynthia G. Suarez Ivo Pischel BioTeSys gmbh Esslingen Germany Finzelberg gmbh & co. kg Andernach Germany Dr. Ivo Pischel co.sulting Rossbach Germany

Background: Based on the scientific and traditional knowledge, benefits for gut and digestive health were expected from Wild Thyme (Thymus serpyllum L.) extract (WThE) co.sumption, but no co.trolled human studies were performed yet to prove the proposed health benefits. Method: The aim of this human randomized, double-blind parallel arm pilot study was to explore the impact of aqueous Wild Thyme extract, a food supplement, in a healthy but overweight study co.lective (N = 40). In detail, the impact on digestion, gastrointestinal symptoms, gut microbiome, and quality of life by employing an essential oil-free WThE preparation or a matching placebo was investigated. Results: The study results indicate that WThE has the potential to improve gastrointestinal symptoms and increase stool frequency, thus an improved quality of life was observed. The stool microbiome of study co.lective was characterized by a high Firmicutes to Bacteroidetes ratio. A decrease in the mean Firmicutes/Bacteroidetes ratio was seen in WThE group. co.clusion: The data support the potential applications of WThE as a food supplement with benefits on gut health.

关键词： Wild Thyme (Thymus serpyllum L.) Extract Gut Health Gut Microbiome Abdominal co.fort Bowel Movement Mental Well-Being Quality of Life

AW-6016-T4板材的低温成形行为（英文）

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Transactions of Nonferrous Metals Society of China 2017年第6期27卷 1257-1263页

作者： M.KUMAR N.SOTIROV F.GRABNER R.SCHNEIDER G.MOZDZEN LKR Leichtmetallkompetenzzentrum Ranshofen gmbh Austrian Institute of Technology Postfach 26 5282 Ranshofen Austria BENTELER Automobiltechnik gmbh An der Talle 27-31 33102 Paderborn Germany voestalpine polynorm gmbh & co. kg PolynormstraB 1 73529 Schwabisch Gmund Germany Aerospace & Advanced co.posites gmbh Viktor-Kaplan-Strasse 2 2700 Wiener Neustadt Austria

研究析出强化AW-6016-T4金属板材的低温成形行为。利用拉伸和Nakazima测试方法获得材料在-196至25°C范围内的流变曲线和成形极限曲线。结果表明,材料的强度和伸长率随温度的降低而增大。背散射电子衍射(EBSD)研究表明变形材料在室温和... 详细信息

研究析出强化AW-6016-T4金属板材的低温成形行为。利用拉伸和Nakazima测试方法获得材料在-196至25°C范围内的流变曲线和成形极限曲线。结果表明,材料的强度和伸长率随温度的降低而增大。背散射电子衍射(EBSD)研究表明变形材料在室温和低温下显微组织有细微区别。但连续加热差热分析表明析出动力学之间无明显区别。本研究结果表明低温变形可用于制造8 mm深的B柱,而常温变形只能制造6 mm深的B柱。

关键词： AW-6016-T4合金低温成形应变硬化成形极限曲线