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Chinese Journal of Integrative Medicine 2025年第1期31卷 49-54页

作者： Fatemeh Zare Mehrjerdi Azadeh Shahrokhi Raeini Fatemeh Sadate Zebhi Zeynab Hafizi Reyhaneh Mirjalili Faezeh Afkhami Aghda Yazd Neuroendocrine Research Center School of MedicineShahid Sadoughi University of Medical Sciences and Health ServicesYazd***Iran

Objective: To determine the neuroprotective effects of berberine hydrochloride(BBR) against lead-induced injuries on the hippocampus of rats. Methods: Wistar rats were exposed orally to doses of 100 and 500 ppm lead acetate for 1 and 2 months to develop subchronic and chronic lead poisening models, *** treatment, BBR(50 mg/kg daily) was injected intraperitoneally to rats poisoned with lead. At the end of the experiment, the spatial learning and memory of rats were assessed using the Morris water maze test. Hippocampal tissue changes were examined by hematoxylin and eosin staining. The activity of antioxidant enzymes catalase,superoxide dismutase, glutathione peroxidase, and malondialdehyde levels as parameters of oxidative stress and antioxidant status of the hippocampus were evaluated. Results: BBR reduced cognitive impairment in rats exposed to lead(Phealthy cells in the hippocampus of leadexposed rats(P<0.05). Significant changes in tissue morphology and biochemical factors of the hippocampus were observed in rats that received lead for 2 months(P<0.05). Most of these changes were insignificant in rats that received lead for 1 month. Conclusion: BBR can improve oxidative tissue changes and hippocampal dysfunction in lead-exposed rats, which may be due to the strong antioxidant potential of BBR.

关键词： lead acetate berberine hippocampus oxidative stress Morris water maze

On load dependence of detachment rate of kinesin motor

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Chinese Physics B 2025年第1期34卷 498-505页

作者： Xiao-Xuan Shi Yao Wang Yu-Ru Liu Ping Xie school of Pharmaceutical Engineering Chongqing Chemical Industry Vocational CollegeChongqing 401220China Laboratory of Soft Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Kinesin is an archetypal microtubule-based molecular motor that can generate force to transport cargo in cells. The load dependence of the detachment rate is an important factor of the kinesin motor, the determination of which is critically related to the chemomechanical coupling mechanism of the motor. Here, we use three models for the load dependence of the detachment rate of the kinesin motor to study theoretically and numerically the maximal force generated and microtubuleattachment duration of the motor. By comparing the theoretical and numerical results with the available experimental data,we show that only one model can explain well the available experimental data, indicating that only this model can be applicable to the kinesin motor.

关键词： kinesin detachment rate generated force chemomechanical coupling mechanism optical trapping

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed services University of the health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

ICA-Net: improving class activation for weakly supervised semantic segmentation via joint contrastive and simulation learning

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Optoelectronics Letters 2025年第3期21卷 188-192页

作者： YE Zhuang LIU Ruyu SUN Bo school of Information Engineering Chengdu Aviation Vocational and Technical College school of Computer Science and Engineering Hangzhou Normal University Quanzhou Institute of Equipment Manufacturing Haixi Institutes Chinese Academy of Sciences

In the field of optoelectronics, certain types of data may be difficult to accurately annotate, such as high-resolution optoelectronic imaging or imaging in certain special spectral ranges. Weakly supervised learning can provide a more reliable approach in these situations. Current popular approaches mainly adopt the classification-based class activation maps (CAM) as initial pseudo labels to solve the task.

关键词： A

Elastohydrodynamic Lubrication Performance of Curvilinear Cylindrical Gears Based on Finite Element Method

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Computer Modeling in Engineering & Sciences 2025年第2期142卷 1585-1609页

作者： Xuegang Zhang Yingjie Dong Xian Wei Ruiqi Wang Qi Zhang school of Intelligent Manufacturing Panzhihua UniversityPanzhihua617000China Panzhihua Hangyu New Material Technology Co. Ltd.Panzhihua617000China school of Intelligent Manufacturing Chengdu Industrial Vocational Technical CollegeChengdu610218China

The fixed-setting face-milled curvilinear cylindrical gear features teeth that are arc-shaped along the longitudinal *** researchers hypothesize that this arc-tooth may enhance the lubrication conditions of the *** study focuses on this type of gear,employing both finite element analysis(FEA)and analytical methods to determine the input parameters required for elastohydrodynamic lubrication(EHL)*** effects of assembly errors,tooth surface modifications,load,and face-milling cutter radius on the lubrication performance of these gears are systematically *** finite element model(FEM)of the gear pair is utilized to calculate the coordinates of contact points on the tooth surface and the corresponding contact pressures at the tooth surface nodes throughout a meshing ***,the normal load on specific gear teeth is determined using a gradient-based *** speed,slip-to-roll ratio,and effective radius near the contact points on the tooth surface are derived through analytical *** data obtained from FEA serve as input parameters for EHL *** lubrication performance of the curvilinear cylindrical gear is evaluated through example *** findings indicate that using FEA to provide input parameters for EHL simulations can reveal the occurrence of edge contact phenomena during gear meshing,allowing for a more accurate representation of the gear’s lubrication *** lubrication performance of the curvilinear cylindrical gear is shown to be independent of the face-milling cutter radius but is significantly influenced by the size of the contact pattern on the tooth *** gears with larger contact patterns demonstrate superior lubrication performance.

关键词： FEM EHL curvilinear cylindrical gear lubrication performance analysis

Advances in phytochemistry, ananlysis methods and pharmacology of Eleutherococcus trifoliatus:A promising medicinal and edible resource with development value

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Chinese Herbal Medicines 2025年第1期17卷 19-30页

作者： Maofang Lu Bin Wang Ling Dai Jian Wu Jiao Luo Changsoo Yook Xiangqian Liu school of Pharmacy Hunan University of Chinese Medicine school of Pharmacy Hunan Vocational College of Science and Technology Instrumental Analysis Center Shanghai Institute of Organic Chemistry Chinese Academy of Sciences school of Pharmacy Kyung Hee University

Eleutherococcus trifoliatus(Araliaceae) is called Baile or Lecai in *** is a medicinal and edible plant widely used in folk *** a TCM,the dried herb of this species can remove damp heat and detoxicity,cure rheumatism,remove blood stasis,relieve pain,and alleviate cough and asthma *** chemical compounds have been reported including diterpenoids,triterpenoids,phenylpropanoids,flavonoids,lignans,caffeoyl quinic acids,steroids,essential oils,etc.,in which flavonoids,saponins,and caffeoyl quinic acids are the most bioactive *** vitro and in vivo pharmacological experiments demonstrated that *** has anti-inflammatory,hypoglycemic,anticancer,antioxidant,antibacterial,anti-hyperalgesic,anti-fatigue,analgesic,and hemostatic *** we reviewed *** in phytochemistry,analysis methods,and pharmacology.

关键词： Acanthopanax Miq. analysis methods anti-inflammatory Eleutherococcus trifoliatus (L.) S. Y. Hu pharmacology phytochemistry toxicity

Establishing and Sustaining Academic and Local health Collaborations: A Case Study of Practice-Based Teaching and Workforce Development

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health 2025年第1期17卷 23-48页

作者： Marissa Varrasso Stacey Cunnington Eva Nelson Alyson Codner Meredith Hurley Ami Mitchell Amanda Flanagan Donna McGrath Jacey Greece Department of Community health Sciences Boston University School of Public Health Boston MA USA Winthrop Department of Public health & Clinical services Winthrop MA USA Tennessee Department of health Columbia TN USA

The pandemic highlighted significant gaps in the public health infrastructure impacted by shortages of public health workers, an undertrained workforce, and years of disinvestment. These gaps required innovative problem-solving by public health agencies (PHAs), including local health departments (LHDs), to respond to rapidly changing community conditions during and after the pandemic. Many schools and programs of public health (SPPH) worked with PHAs to mobilize public health (PH) students through practice-based teaching (PBT). Current research indicates PBT benefits all stakeholders—PHAs, students, faculty, SPPH, and ultimately the community served. However, more research is needed on the utility of PBT in addressing a community’s systemic public health issues, the extent to which the academic-community collaboration enhances a PHA’s capacity, and the impact of the pedagogy on preparing the workforce for an evolving PH landscape. This paper examines the process of a semester-long PBT course, guided by the PBT STEPS framework, which includes five steps from collaboration to implementation to evaluation of a PBT course. The collaborating PHA and its student group addressed community trauma and resilience issues during the semester. Additionally, it examines the longer-term impacts after the semester for the PHA, community, and the workforce by 1) conducting a formative evaluation to understand needs and gaps in the community;2) redesigning an intervention that merged the results of the formative evaluation with the intervention developed during the semester;and 3) securing funding and resources for intervention sustainability. Through the documentation of a post-course partnership between an LHD and faculty at a large school of public health, this case study illustrates the potential for PBT to lay the foundation for ongoing research that supports more impactful interventions for PHAs while bolstering the workforce abilities of students as future practitioners.

关键词： Academic and Community Collaborations Practice-Based Teaching Public health Training Workforce Development Curriculum Design Community Trauma COVID-19

RE-SEGNN:recurrent semantic evidence-aware graph neural network for temporal knowledge graph forecasting

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Science China(Information Sciences) 2025年第2期68卷 103-119页

作者： Wenyu CAI Mengfan LI Xuanhua SHI Yuanxin FAN Quntao ZHU Hai JIN National Engineering Research Center for Big Data Technology and System Services Computing Technology and System LabCluster and Grid Computing LabSchool of Computer Science and TechnologyHuazhong University of Science and Technology

Temporal knowledge graph(TKG) reasoning, has seen widespread use for modeling real-world events, particularly in extrapolation settings. Nevertheless, most previous studies are embedded models, which require both entity and relation embedding to make predictions, ignoring the semantic correlations among different entities and relations within the same timestamp. This can lead to random and nonsensical predictions when unseen entities or relations occur. Furthermore, many existing models exhibit limitations in handling highly correlated historical facts with extensive temporal depth. They often either overlook such facts or overly accentuate the relationships between recurring past occurrences and their current counterparts. Due to the dynamic nature of TKG, effectively capturing the evolving semantics between different timestamps can be *** address these shortcomings, we propose the recurrent semantic evidenceaware graph neural network(RE-SEGNN), a novel graph neural network that can learn the semantics of entities and relations simultaneously. For the former challenge, our model can predict a possible answer to missing quadruples based on semantics when facing unseen entities or relations. For the latter problem, based on an obvious established force, both the recency and frequency of semantic history tend to confer a higher reference value for the current. We use the Hawkes process to compute the semantic trend, which allows the semantics of recent facts to gain more attention than those of distant facts. Experimental results show that RE-SEGNN outperforms all SOTA models in entity prediction on 6 widely used datasets, and 5 datasets in relation prediction. Furthermore, the case study shows how our model can deal with unseen entities and relations.

关键词： knowledge graph reasoning temporal knowledge graph Hawkes process semantic evidence

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Control upconversion decay dynamics from perspective of collective response

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Journal of Rare Earths 2025年第1期43卷 57-63,I0003页

作者： Yingdong Han Yutong Pan Tong Wei Yu Ma Xingxing Zhang Lei Jiang Kai Chen Liwei Wu Jiao Cui Chao Gao College of Science Civil Aviation University of ChinaTianjin300300China school of Inspection and Testing Certification Changzhou Vocational Institute of EngineeringChangzhou213164China school of Chemical and Physical Sciences Victoria University of WellingtonWellington6012New Zealand Robinson Research Institute Faculty of EngineeringVictoria University of WellingtonWellington6012New Zealand

Very recently,upconversion luminescence(UCL)lifetime,as a powerful optical dimension,has attracted tremendous research interest due to its advantages of high information capacity and high photophysical *** the implementation and emergence of endlessly fascinating UCL features,it is particularly meaningful to understand the photophysical mechanisms inside UCL materials to enable rational subdivision-level structure design,which is however currently far from *** this work,we take an ordinary upconversion nanoparticle as an example to prove that the UCL decay curves and corresponding lifetimes are indeed a collective response of the entire UCL system to excitations,that exhibits correlated,yet quite different properties from individual ions.A specially developed theoretical random walk model combined with an experimental lifetime control for Yb^(3+)/Er^(3+)UCL demonstrates that ene rgy diffusion principally alters the decay ***,the different extent of the influence of energy diffusion on the emissions of ^(2)H_(11/2)/^(4)S_(3/2)(green)and ^(4)F_(9/2)(red)leads to an extremely uncommon crossover comparison of decay *** work provides new ideas for understanding decay dynamics and practical UCL lifetime manipulation methods.

关键词： Upconversion Lifetime Collective response Decaycurves Random walk model Rare earths

Glial cell line-derived neurotrophic factor improves impaired colonic motility in experimental colitis mice through connexin 43

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World Journal of Gastroenterology 2025年第8期31卷 82-95页

作者： Wei Yang Rui Liu Feng Xu Department of Gastroenterology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Medical school Xiangyang Vocational and Technical CollegeXiangyang 441021Hubei ProvinceChina

BACKGROUND Colonic motility dysfunction is a common symptom of ulcerative colitis(UC),significantly affecting patients’quality of *** suggests that glial cell line-derived neurotrophic factor(GDNF)plays a role in restoring colonic *** To investigate whether GDNF enhances aberrant colonic motility in mice with experimental colitis via connexin 43(Cx43).METHODS An experimental colitis model was induced in male C57BL/6 mice using dextran sodium sulfate(DSS).The measurement of colonic transit time was conducted,and colon tissues were evaluated through transmission electron microscopy and hematoxylin and eosin *** mice were treated with exogenous GDNF and Gap 19,a selective Cx43 *** Cx43 and GDNF levels were detected via immunofluorescence,immunohistochemistry,and real-time polymerase chain *** levels of inflammatory markers,including interleukin-1β,tumor necrosis factor-α,interleukin-6,and C-reactive protein,were quantified using enzyme-linked immunosorbent *** Experimental colitis was successfully induced using DSS,and the findings exhibited that the colonic transit time was significantly delayed in colitis mice relative to the UC group(P<0.01).GDNF treatment improved colonic transit time and alleviated intestinal inflammation in DSS-induced colitis mice(P<0.05).In the UC+Gap19+GDNF group,colitis symptoms,colonic transit time,and inflammatory marker levels remained comparable to those in the UC group,indicating that the therapeutic effects of GDNF in UC mice were blocked by Gap *** GDNF improves colonic motility in mice with experimental colitis through a partially Cx43-mediated *** holds promise as a therapeutic option for improving colonic motility in patients with colitis.

关键词： Glial cell line-derived neurotrophic factor Ulcerative colitis Colonic motility Connexin 43 Dextran sodium sulfate model