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Gut liver brain axis in diseases:the implications for therapeutic interventions

Signal Transduction and Targeted Therapy 2024年第1期9卷 79-104页

作者： Mengyao Yan Shuli Man Benyue Sun Long Ma Lanping Guo Luqi Huang Wenyuan Gao State Key Laboratory of Food nutrition and Safety Key Laboratory of Industrial MicrobiologyMinistry of EducationTianjin Key Laboratory of Industry MicrobiologyNational and Local United Engineering Lab of Metabolic Control Fermentation TechnologyChina International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal ChemistryCollege of BiotechnologyTianjin University of Science&Technology300457 TianjinChina National Resource Center for Chinese Materia Medica China Academy of Chinese Medical Sciences100700 BeijingChina Tianjin Key Laboratory for Modern Drug Delivery&High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityWeijin Road300072 TianjinChina

Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract,liver,and nervous *** the past few decades,breakthrough progress has been made in the gut liver brain axis,mainly through understanding its formation mechanism and increasing treatment *** this review,we discuss various complex networks including barrier permeability,gut hormones,gut microbial metabolites,vagus nerve,neurotransmitters,immunity,brain toxic metabolites,β-amyloid(Aβ)metabolism,and epigenetic regulation in the gut-liver-brain *** therapies containing antibiotics,probiotics,prebiotics,synbiotics,fecal microbiota transplantation(FMT),polyphenols,low FODMAP diet and nanotechnology application regulate the gut liver brain ***,some special treatments targeting gut-liver axis include farnesoid X receptor(FXR)agonists,takeda G protein-coupled receptor 5(TGR5)agonists,glucagon-like peptide-1(GLP-1)receptor antagonists and fibroblast growth factor 19(FGF19)*** gut-brain axis embraces cognitive behavioral therapy(CBT),antidepressants and tryptophan metabolism-related *** liver-brain axis contains epigenetic regulation and Aβmetabolism-related *** the future,a better understanding of gut-liver-brain axis interactions will promote the development of novel preventative strategies and the discovery of precise therapeutic targets in multiple diseases.

关键词： metabolism therapeutic immunity

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Signal amplificated electrochemical immunosensor for β-lactoglobulin allergen detection in dairy products applying AuNPs/Prussian Blue/CMK-8 composite

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Food science and Human Wellness 2024年

作者： Jingying Yang Lin Li Xinmiao Ma Shuo Wang Mingfei Pan State Key Laboratory of Food nutrition and Safety Tianjin University of science and Technology Key Laboratory of Food Quality and Health of Tianjin Tianjin University of science & Technology Tianjin Key Laboratory of Food science and Health School of Medicine Nankai University

Herein， a novel label-free electrochemical immunosensor was fabricated via immobilizing specific anti-β-lactoglobulin （β-LG） antibodies （Abs） onto an integrated electrode of gold nanoparticles （AuNPs） / Prussian Blue （PB） / CMK-8. This immunosensor allowed for the quantitative detection of the major milk allergen β-LG. CMK-8 with excellent electrical conductivity and uniformly adjustable pore structure was modified on the glassy carbon electrode （GCE） and served as the sensitive substrate for the electro-polymerization of PB， forming the redox-active layer. AuNPs were subsequently electrochemically deposited on PB/CMK-8/GCE to improve the electrical conductivity and utilized as the connector for Abs immobilization. During β-LG detection， the Abs-modified AuNPs/PB/CMK-8/GCE exhibited a significant reduction in DPV current signal when exposed to β-LG， displaying an inverse dose-dependent relationship. The developed electrochemical immunosensor demonstrated good detection performance for β-LG， with a wider linear range of 0.01 - 100 ng mL-1and a lower detection limit of 4.72 pg mL-1. Meanwhile， the sensor exhibited remarkable repeatability， reproducibility， stability and anti-interference capabilities， which was further applied to detect β-LG in dairy food， achieving satisfactory recoveries （89.2% - 98.8%） and lower relative standard deviation （ ≤ 3.1%）. Therefore， this innovative electrochemical method for food allergens detection holds great potential application in food safety determination and evaluation.

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Lactose-free milk powder can effectively relieve diarrhea symptoms in weaning SD rats and children

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Food science and Human Wellness 2024年第3期13卷 1494-1502页

作者： Manman Liu Shiwen Han Boya Li Cheng Chen Lu Yao Jung-il Kwon Juan Jin Huilian Che Beijing Advanced Innovation Center for Food nutrition and Human Health College of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Maeil Innovation Center Maeil Dairies Co.Ltd.Seoul 03142South Korea

Diarrhea has become the leading cause of illness and death among infants and young children in developing ***,patients with diarrhea showed damaged intestinal epithelial villi,usually accompanied by lactase *** this study,we evaluated the therapeutic effects of lactose-free milk powder on rats and children with ***-associated diarrhea(AAD)model was established by gavage with antibiotic mixture in SD rats,followed by administration of milk powder containing lactose or *** results showed that lactose-free milk powder ameliorated A AD-related diarrhea symptoms,and accelerated the recovery from *** 16S sequencing results indicated lactose-free milk powder contributed to increase theα-andβ-diversity of intestinal flora,and restore the intestinal microbiota *** conclusion,our data demonstrate that lactose-free milk powder could alleviate diarrhea by restoring gut microbiota and intestinal barrier function.

关键词： Diarrhea Lactose-free Milk powder Intestinal barrier Gut microbiota

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Hepatic TRPC3 loss contributes to chronic alcohol consumption-induced hepatic steatosis and liver injury in mice

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life Metabolism 2024年第1期3卷 51-66页

作者： Qinchao Ding Rui Guo Liuyi Hao Qing Song Ai Fu Shanglei Lai Tiantian Xu Hui Zhuge Kaixin Chang Yanli Chen Haibin Wei Daxi Ren Zhaoli Sun Zhenyuan Song Xiaobing Dou Songtao Li School of Public Health Zhejiang Chinese Medical UniversityHangzhouZhejiang 310053China College of Animal science Zhejiang UniversityHangzhouZhejiang 310058China Department of Kinesiology and nutrition University of Illinois at ChicagoChicagoIL 60612United States School of life science Zhejiang Chinese Medical UniversityHangzhouZhejiang 310053China Department of Surgery Johns Hopkins University School of MedicineBaltimoreMD 21205United States

Emerging evidence discloses the involvement of calcium channel protein in the pathological process of liver *** receptor potential cation channel subfamily C member 3(TRPC3),a ubiquitously expressed non-selective cation channel protein,controls proliferation,inflammation,and immune response via operating calcium influx in various ***,our understanding on the biofunction of hepatic TRPC3 is still *** present study aims to clarify the role and potential mechanism(s)of TRPC3 in alcohol-associated liver disease(ALD).We recently found that TRPC3 expression plays an important role in the disease process of *** exposure led to a significant reduction of hepatic TRPC3 in patients with alcohol-related hepatitis(AH)and ALD ***(N-acetylcysteine and mitoquinone)intervention improved alcohol-induced suppression of TRPC3 via a miR-339-5p-involved ***3 loss robustly aggravated the alcohol-induced hepatic steatosis and liver injury in mouse liver;this was associated with the suppression of Ca^(2+)/calmodulin-dependent protein kinase kinase 2(CAMKK2)/AMP-activated protein kinase(AMPK)and dysregulation of genes related to lipid ***3 loss also enhanced hepatic inflammation and early fibrosis-like change in *** hepatic TRPC3 effectively reversed chronic alcohol-induced detrimental alterations in ALD ***,chronic alcohol exposure-induced TRPC3 reduction contributes to the pathological development of ALD via suppression of the CAMKK2/AMPK *** stress-stimulated miR-339-5p upregulation contributes to alcohol-reduced ***3 is the requisite and a potential target to defend alcohol consumption-caused ALD.

关键词： TRPC3 alcohol-associated liver disease miR-339-5p hepatic steatosis liver injury CAMKK2/AMPK

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Functional Lactiplantibacillus plantarum P10 screened from Chinese traditional pickle showing application potential in steamed bread for in-situ bio-preservation and GABA-enrichment

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Food science and Human Wellness 2024年

作者： Mengge Ma Yajuan Zhang Dongchun Zhang Yi Chen Zhixin Wang Yingmin Jia Yawei Ning Beijing Advanced Innovation Center for Food nutrition and Human Health Beijing Technology and Business University College of Food and Biology Hebei University of science and Technology

Mold spoilage and nutrition enrichment are major concerns of Chinese steamed bread， and using functional lactic acid bacteria as starter to play the role of in-situ preservation and nutritional fortification was a promising alternative. Hence， Lactiplantibacillus plantarum P10 capable of inhibiting spoilage microorganisms and producing GABA (380 mg/L) was screened from Chinese pickle. Metabolomics analysis showed that P10 produced key antimicrobial metabolites mainly including ten organic acids， aldehyde， alkaloid. Besides， P10 might exhibit health beneficial effects such as degrading cholesterol， lowering blood glucose and reducing uric acid due to the production of deoxycholic acid and Ile-Pro-Ile， and the degradation of purine. Finally， the promising application potential of P10 was evidenced in steamed bread with extended shelf life， excellent anti-aging effect， and 24.5-fold enrichment of GABA. Conclusively， this investigation could provide scientific basis for the application of P10 as a functional starter in steamed bread.

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膳食脂质干预在预防脑衰老中的作用（英文）

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Engineering 2024年第6期 128-137页

作者：熊炜方冰王晓玉张明杜敏孙佳增陈娟李依璇孙长颢雷欣根张学任发政 Key Laboratory of Precision nutrition and Food Quality Department of Nutrition and Health China Agricultural University Key Laboratory of Functional Dairy Co-Constructed by the Ministry of Education and Beijing Municipality College of Food Science and Nutritional Engineering China Agricultural University School of Food science and Chemical Engineering Beijing Technology and Business University Department of Animal science Washington State University Department of nutrition and Food Hygiene School of Public Health Harbin Medical University Department of Animal science Cornell University National Health Commission (NHC) and Chinese Academy of Medical sciences (CAMS) Key Laboratory of Molecular Probe and Targeted Theranostics Harbin Medical University

As people live longer, the burden of aging-related brain diseases, especially dementia, is increasing. Brain aging increases the risk of cognitive impairment, which manifests as a progressive loss of neuron function caused by the impairment of synaptic plasticity via disrupting lipid homeostasis. Therefore, supplemental dietary lipids have the potential to prevent brain aging. This review summarizes the important roles of dietary lipids in brain function from both structure and mechanism perspectives. Epidemiological and animal studies have provided evidence of the functions of polyunsaturated fatty acids(PUFAs) in brain health. The results of interventions indicate that phospholipids-including phosphatidylcholine, phosphatidylserine, and plasmalogen-are efficient in alleviating cognitive impairment during aging, with plasmalogen exhibiting higher efficacy than phosphatidylserine. Plasmalogen is a recognized nutrient used in clinical trials due to its special vinyl ether bonds and abundance in the postsynaptic membrane of neurons. Future research should determine the dose-dependent effects of plasmalogen in alleviating brain-aging diseases and should develop extraction and storage procedures for its clinical application.

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Fish Gelatin-Based Film Containing Maillard Reaction Products:Properties and Its Use as Bag for Packing Chicken Skin Oil

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Journal of Renewable Materials 2024年第6期12卷 1125-1143页

作者： Krisana Nilsuwan Yolanda Victoria Rajagukguk Umesh Patil Thummanoon Prodpran Soottawat Benjakul International Center of Excellence in Seafood science and Innovation Faculty of Agro-IndustryPrince of Songkla UniversitySongkhla90110Thailand Department of Food Safety and Quality Management PoznańUniversity of Life SciencesPoznań60-637Poland Center of Excellence in Bio-Based Materials and Packaging Innovation Faculty of Agro-IndustryPrince of Songkla UniversityHat YaiSongkhla90110Thailand Department of Food and nutrition Kyung Hee UniversitySeoul02447Republic of Korea

Maillard reaction is a non-enzymatic browning reaction and its products(MRPs)have been proven to possess antioxidant *** research aimed to produce a fish gelatin-based packaging incorporated with MRPs to retard lipid oxidation in chicken skin oil(CSO)during storage at ambient temperature(28℃–30℃).MRPs produced from fish gelatin and fructose(1:1,90℃,pH 11)showed the highest antioxidant properties compared to those prepared under other *** glycerol/MRPs ratios(30:0,25:5,20:10,15:15,10:20,5:25,0:30)were incorporated into the film and resulting films were ***/MRPs at 10:20 ratio was chosen to add into the film prior to bag preparation via heat sealing *** packed in the bag was monitored for lipid hydrolysis and oxidation during 15 days of storage(30℃±0.5℃,RH 52%±5%).After 15 days,quality deterioration was lower in CSO packed in the prepared gelatin bag as evidenced by lower FFA,TBARS,and volatile compounds in comparison with CSO packed in LDPE *** gelatin film added with MRPs possessed an excellent water vapor barrier property(WV-BP).This finding indicated that MRPs could be used to substitute glycerol and simultaneously could serve as antioxidants for the developed active *** novel packaging can be a potential alternative packaging for retarding lipid oxidation of lipid or fatty foods.

关键词： Active film antioxidant shelf-life extension Maillard reaction products fish gelatin

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Dietary supplementation of benzoic acid and essential oils combination enhances intestinal resilience against LPS stimulation in weaned piglets

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Journal of Animal science and Biotechnology 2024年第2期15卷 878-897页

作者： Chang Cui Yulong Wei Yibo Wang Wen Ma Xiaoyu Zheng Jun Wang Ziwei Ma Caichi Wu Licui Chu Shihai Zhang Wutai Guan Fang Chen Guangdong Provincial Key Laboratory of Animal nutrition Control College of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642China College of Animal science and National Engineering Research Center for Breeding Swine Industry South China Agricultural UniversityGuangzhou 510642China Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhou 510642China

Background The benefits of combining benzoic acid and essential oils(BAO)to mitigate intestinal impairment during the weaning process have been well established,while the detailed underlying mechanism has not been fully *** research has primarily focused on the reparative effects of BAO on intestinal injury,while neglecting its potential in enhancing intestinal stress *** In this study,we investigated the pre-protective effect of BAO against LPS-induced stress using a modified experimental *** were pre-supplemented with BAO for 14 d,followed by a challenge with LPS or saline to collect blood and intestinal *** Our findings demonstrated that BAO supplementation led to significant improvements in piglets’final weight,average daily gain,and feed intake/body gain ***,BAO supplementation positively influenced the composition of intestinal microbiota,increasing beneficial Actinobacteriota and Alloprevotella while reducing harmful Desulfobacterota,Prevotella and ***,BAO supplementation effectively mitigated oxidative disturbances and inflammatory responses induced by acute LPS *** was evidenced by elevated levels of T-AOC,SOD,and GSH,as well as decreased levels of MDA,TNF-α,and IL-6 in the ***,piglets subjected to LPS challenge and pre-supplemented with BAO exhibited significant improvements in intestinal morphological structure and enhanced integrity,as indicated by restored expression levels of Occludin and Claudin-1 compared to the non-supplemented *** analysis revealed that BAO supplementation enhanced the jejunal antioxidative capacity by increasing GSH-Px levels and decreasing MDA levels under the LPS challenge and stimulated the activation of the Nrf2 signaling ***,the reduction of TLR4/NF-κB/MAPK signaling pathways activation and proinflammatory factor were also observed in the jejunal of those piglets fed with ***

关键词： Anti-stress Benzoic acid Essential oils Intestine LPS Weaned piglets

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Functionalized selenium nanoparticles ameliorated acetaminophen-induced hepatotoxicity through synergistically triggering PKCδ/Nrf2 signaling pathway and inhibiting CYP 2E1

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Food science and Human Wellness 2024年第2期13卷 932-945页

作者： Si Zou Yetao Gong Xiujie Li Yanbin Wu Jinzhong Wu Jianguo Wu Ka-Hing Wong College of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Research Institute for Future Food The Hong Kong Polytechnic UniversityHong Kong 999077China Department of Food science and nutrition The Hong Kong Polytechnic UniversityHong Kong 999077China

Selenium nanoparticles(SeNPs)have been demonstrated potential for use in diseases associated with oxidative *** SeNPs with lower toxicity and higher biocompatibility could bring better therapeutic activity and clinical application ***,this work was conducted to investigate the protective effect of Pleurotus tuber-regium polysaccharide-protein complex funtionnalized SeNPs(PTR-SeNPs)against acetaminophen(APAP)-induced oxidative injure in HepG2 cells and C57BL/6J mouse *** elucidation of the underlying molecular mechanism,in particular their modulation of Nrf2 signaling pathway was also *** results showed that PTR-SeNPs could significantly ameliorate APAP-induced oxidative injury as evidenced by a range of biochemical analysis,histopathological examination and immunoblotting ***-SeNPs could hosphorylate and activate PKCδ,depress Keap1,and increase nuclear accumulation of Nrf2,resulting in upregulation of GCLC,GCLM,HO-1 and NQO-1 ***,PTR-SeNPs suppressed the biotransformation of APAP to generate intracellular ROS through CYP 2E1 inhibition,restoring the mitochondrial ***,the protective effect of PTR-SeNPs against APAP induced hepatotoxicity was weakened as Nrf2 was depleted in vivo,indicating the pivotal role of Nrf2 signaling pathway in PTR-SeNPs mediated hepatoprotective *** a potential hepatic protectant,PTR-SeNPs could serve as a new source of selenium supplement for health-promoting and biomedical applications.

关键词： PTR-SeNPs(polysaccharide-proteincomplex functionalized selenium nanoparticles) Acetaminophen-induced hepatotoxicity Nuclear factor erythroid 2-related factor 2 Cytochrome P450 enzyme 2E1 Mitochondria

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Phlorizin alleviates deltamethrin-induced oxidative stress in brine shrimp Artemia

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Journal of Oceanology and Limnology 2024年第1期42卷 163-173页

作者： Dandan MA Qingli ZHOU Liying SUI Qingbin GUO Huanhuan LIU Honghe LIANG Zhenjing LI Zhongna SANG School of Food science and Engineering Tianjin University of Science and TechnologyTianjin 300457China Asian Regional Artemia Reference Center Key Laboratory of Marine Resource Chemistry and Food Technology(TUST)Ministry of EducationTianjin University of Science and TechnologyTianjin 300457China Subtropical Crops Research Institute of Guangxi Zhuang Autonomous Region Nanning 530001China Department of nutrition and Food Hygiene School of Public HealthTianjin Medical UniversityTianjin 300070China

Deltamethrin(DEL),a commonly used pyrethroid pesticide,results in higher reactive oxygen species(ROS)levels in aquatic animals,which consequently unbalance the redox ***(PHL)is a flavonoid and a natural product promising to prevent or reduce pesticide-induced oxidative *** is a micro-crustacean widely used in marine hatcheries and an experimental aquatic organism for environmental toxicology *** research aimed to evaluate the toxicity of DEL on Artemia and the antioxidative effect of PHL against the *** show that 0.08-mg/mL PHL exerted its antioxidative effects on hatching percentage of the cysts in 24-h incubation and on body length and survival rate of Artemia in 12-d *** 12-d culture,12-,24-,and 36-h DEL exposure showed significant drops in SOD,CAT,and GSH-Px enzyme activities,and significant increases in ROS and malondialdehyde(MDA)levels in Artemia(P<0.05).On the contrary,0.08-mg/mL PHL application improved the enzyme activities and decreased the ROS and MDA levels(P<0.05).Moreover,0.08-mg/mL PHL significantly increased mRNA expression levels of Cu/Zn SOD,CAT,GST,HO-1,NQO1,and Nrf2,and decreased mRNA expression level of Keap1 in the DEL-exposed Artemia(P<0.05).Therefore,DEL is toxic to Artemia,while PHL alleviates DEL-induced oxidative damage by possibly regulating the Nrf2signaling *** study provided a theoretical basis for PHL to reduce pesticide-induced toxicity in aquatic animals.

关键词： Artemia deltamethrin phlorizin oxidative stress

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