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Different Starting Dominant Strain of Seasonal Influenza in China and Other Neighboring Asian Countries in 2019−2020 Winter Season

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China CDC weekly 2020年第4期2卷 57-60页

作者： Jing Yang Weijuan Huang Yanhui Cheng Tao Chen Minju Tan Qian Guo Hejiang Wei Fei Zhu Tomoko Kuwahara Xiyan Li Xiang Zhao Hideki Hasegawa George F.Gao Dayan Wang National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionWHO Collaborating Center for Reference and Research on InfluenzaKey Laboratory for Medical VirologyNational Health CommissionBeijingChina laboratory of Influenza virus Surveillance Influenza Virus Research CenterNational Institute of Infectious DiseasesWHO Collaborating Center for Reference and Research on InfluenzaTokyoJapan Chinese Center for Disease Control and Prevention BeijingChina.

Introduction:Seasonal influenza is a prevalent and highly contagious acute respiratory disease that causes a major global disease burden.New strains of influenza viruses also have the potential to cause an influenza pandemic.Due to the high variability and the consequent uncertainty about virus strains,the prevention and control of influenza are faced with many challenges.Surveillance is considered a key strategy to lead to the prevention and control of influenza,and influenza is one of first infectious diseases to be monitored globally.Methods:The Chinese National Influenza Surveillance Network conducts routine influenza surveillance and includes 410 network laboratories and 554 sentinel hospitals based on the requirements of National Influenza Surveillance Guidelines.China and other countries submit epidemiological and virological data to the WHO FluMart database,which can be viewed online.Results:Seasonal influenza H3N2 virus was the dominant subtype in China when entering the 2019–2020 winter influenza season,while neighboring countries such as Japan and Republic of Korea reported the dominance of H1N1pdm09 and Mongolia and Russia reported a higher proportion of type B virus than type A virus.Conclusions and Implications for Public Health Practice:Asian countries entered the 2019–2020 winter influenza season with different type/subtypes of influenza virus dominant in different areas.Influenza surveillance needs to be strengthened to closely monitor changes in the antigenicity and genetic characteristics of emerging viruses.

关键词： prevention strengthened submit

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Non-coding regions of the Ebola virus genome contain indispensable phylogenetic and evolutionary information

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Science China(Life Sciences) 2015年第7期58卷 682-686页

作者： JIANG XinQuan ZHANG ZhenJie ZHUANG DongMing CARR Michael J. ZHANG RuiLing LV Qiang SHI WeiFeng School of Public Health Taishan Medical College Institute of Pathogen Biology Taishan Medical College National virus Reference laboratory University College Dublin

We compared the numbers of nucleotide substitutions occurring in the non-coding regions and coding regions of Ebola virus genomes and found that non-coding regions contain indispensable phylogenetic and evolutionary information. The omission of genetic data from non-coding regions can lead to unreliable phylogenies and inaccurate estimates of evolutionary parameters.

关键词：非编码区病毒基因组系统发育进化信息核苷酸替换参数估计基因数据

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Complete genome sequence of a novel bacteriophage infecting Bradyrhizobium diazoefficiens USDA110

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Science China(Life Sciences) 2018年第1期61卷 118-121页

作者： Junjie Liu Hao Yu Yong Huang Zhenhua Yu Guoquan Fan Jian Jin Xiaobing Liu Guanghua Wang Key laboratory of Mollisols Agroecology Northeast Institute of Geography and Agroecology Chinese Academy of Sciences State Key laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology virus-free Seedling Heilongjiang Academy of Agricultural Sciences

Dear Editor,The nitrogen-fixing symbiotic bacteria, rhizobia are the most important beneficial bacteria in soil, as they form nodules with host legume plants to fix nitrogen to maintain soil fertility and facilitate plant growth. Although these bacteria are critically important to agriculture, bacteriophages of rhizobia (rhizobiophages) are commonly present in soils, rhizosphere,and nodules, which have major influences on the composition and population of rhizobia in soils and affect nodulation and nitrogen fixation. Despite the importance of rhizobiophages,only 23 phage full genomes have been sequenced.

关键词：染色体抗菌素感染共生细菌植物生长氮固定土壤噬菌体

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Detection and pathogenesis of a novel swine H3N2 influenza virus containing three genes from the 2009 pandemic H1N1 influenza viruses in Korea in 2015

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Virologica Sinica 2016年第6期31卷 513-516页

作者： Tran Bac Le In Hong Lee Byung Jun Kim Hyun Soo Kim Sang Heui Seo laboratory of Influenza Research College of Veterinary Medicine Chungnam National University Institute of Influenza virus College of Veterinary MedicineChungnam National University laboratory of Public Health College of Veterinary MedicineChungnam National University

Dear Editor,Influenza A viruses cause pandemics at an interval of approximately 10–40 years,and pigs are regarded as a'mixing vessel'because they are easily infected with avian and human influenza viruses(Ito et al.,... 详细信息

关键词： gene Detection and pathogenesis of a novel swine H3N2 influenza virus containing three genes from the 2009 pandemic H1N1 influenza viruses in Korea in 2015

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Identification and characterization of a novel group of natural antisense transcripts from RNA1.2 gene locus of human cytomegalovirus

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Chinese Medical Journal 2019年第13期132卷 1591-1598页

作者： Bing-Yang Liu Yan-Ping Ma Ying Qi Yu-Jing Huang Zhong-Yang Liu Meng-Qing Lu Qiang Ruan Department of Endocrinology Affiliated Shengjing HospitalChina Medical UniversityShenyangLiaoning 110004China Virus Laboratory Affiliated Shengjing HospitalChina Medical UniversityShenyangLiaoning 110004China

Background:Natural anti-sense transcripts(NATs),which are transcribed from the complementary DNA strand of annotated genes,exert regulatory function of gene expression.Increasing studies recognized anti-sense transcription widespread throughout human cytomegalovirus(HCMV)genome,whereas the anti-sense transcription of RNA1.2 gene locus has never been investigated.In this study,the transcription of the RNA1.2 anti-sense strand was investigated in clinically isolated HCMV strain.Methods:Strand-specific high-through RNA-sequencing(RNA-seq)was performed to find possible anti-sense transcripts(ASTs).For analyzing and visualization of RNA-seq data sets,Integrative Genomics Viewer software was applied.To confirm these possibilities,Northern blotting and rapid amplification of cDNA ends(RACE)were used.Results:Transcription of the opposite strand of RNA1.2 gene locus was detected by RNA-sequencing using RNAs extracted from human embryonic lung fibroblasts infected with HCMV clinical isolate HAN.At least three HCMV NATs,named RNA1.2 AST 1,RNA1.2 AST2,and RNA 1.2 AST3,were characterized by Northern blotting and RACE analyses.These RNA1.2 ASTs orientated from the complementary strand of RNA1.2 locus during the late phase of HCMV infection.The 5'-and 3'-termini of these transcripts were located within the opposite sequence of the predicted RNA1.2 gene.Conclusion:A cluster of novel NATs was transcribed from the opposite sequence of the HCMV RNA 1.2 gene region.

关键词： Human cytomegalovirus RNA1.2 Natural anti-sense transcript

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Dengue positivity among blood donors in hyper-endemic region of southern India

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Asian Pacific Journal of Tropical Medicine 2023年第4期16卷 190-192页

作者： Mahadevan Ganesan Robert Sudha Ganesan Sucila Thangam Sivathanu Lalitha virus Research and Diagnostic laboratory Department of MicrobiologyGovernment Theni Medical CollegeTheniTamil NaduIndia Department of Microbiology Government Theni Medical CollegeTheniTamil NaduIndia

Transfusion-transmitted infections(TTIs)impose meticulous screening protocols in blood banks.Emerging or re-emerging viruses with altered pathogenicity remains debatable whether or not to include those in TTI screening panel.Dengue infection is known to transmit via Aedes aegypti mosquito;however,the route of infection through blood transfusion is recently of greater importance.India with hyper-endemic and endemic dengue regions must guarantee the safety in transfusion-related products.The donor with asymptomatic dengue infection during viremic phase can act as a reservoir for transmission.The acute infection in dengue is ascertained by detecting either nonstructural-1 protein(NS1)or IgM antibody whereas the prevalence of dengue can be monitored by the presence of IgG.

关键词： transfusion reservoir guarantee

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Viromes of Haemaphysalis longicornis reveal different viral abundance and diversity in free and engorged ticks

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Virologica Sinica 2024年第2期39卷 194-204页

作者： Jian Xiao Xuan Yao Xuhua Guan Jinfeng Xiong Yaohui Fang Jingyuan Zhang You Zhang Abulimiti Moming Zhengyuan Su Jiayin Jin Yingying Ge Jun Wang Zhaojun Fan Shuang Tang Shu Shen Fei Deng Key laboratory of Virology and Biosafety and National virus Resource Center Wuhan Institute of VirologyChinese Academy of SciencesWuhan430071China Hubei Provincial Center for Disease Control and Prevention Wuhan430070China University of Chinese Academy of Sciences Beijing101408China Hubei Jiangxia laboratory Wuhan430200China Xinjiang Key laboratory of Vector-borne Infectious Diseases Urumqi830002China Current address:Department of Medical laboratory The Second Affiliated HospitalHainan Medical UniversityHaikou57000China

Haemaphysalis longicornis ticks,commonly found in East Asia,can transmit various pathogenic viruses,includingthe severe fever with thrombocytopenia syndrome virus(SFTSV)that has caused febrile diseases among humansin Hubei Province.However,understanding of the viromes of H.longicornis was limited,and the prevalence ofviruses among H.longicornis ticks in Hubei was not well clarified.This study investigates the viromes of bothengorged(fed)and free(unfed)H.longicornis ticks across three mountainous regions in Hubei Province from 2019to 2020.RNA-sequencing analysis identified viral sequences that were related to 39 reference viruses belonging tounclassified viruses and seven RNA viral families,namely Chuviridae,Nairoviridae,Orthomyxoviridae,Parvoviridae,Phenuiviridae,Rhabdoviridae,and Totiviridae.Viral abundance and diversity in these ticks were analysed,andphylogenetic characteristics of the Henan tick virus(HNTV),Dabieshan tick virus(DBSTV),Okutama tick virus(OKTV),and Jingmen tick virus(JMTV)were elucidated based on their full genomic sequences.Prevalenceanalysis demonstrated that DBSTV was the most common virus found in individual H.longicornis ticks(12.59%),followed by HNTV(0.35%),whereas JMTV and OKTV were not detected.These results improve our understanding of H.longicornis tick viromes in central China and highlight the role of tick feeding status and geographyin shaping the viral community.The findings of new viral strains and their potential impact on public health raisethe need to strengthen surveillance efforts for comprehensively assessing their spillover potentials.

关键词： Ticks Virome Haemaphysalis longicornis Phylogenetic analysis Viral abundance and diversity

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Genome sequencing and analysis of a granulovirus isolated from the Asiatic rice leafroller, Cnaphalocrocis medinalis

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Virologica Sinica 2015年第6期30卷 417-424页

作者： Shan Zhang Zheng Zhu Shifeng Sun Qijin Chen Fei Deng Kai Yang State Key laboratory of Biocontrol Sun Yat-sen University State Key laboratory of Virology and China Center for virus Culture Collection Wuhan Institute of Virology Chinese Academy of Sciences Guangdong Haina Agriculture Co. Ltd

The complete genome of Cnaphalocrocis medinalis granulovirus(CnmeGV) from a serious migratory rice pest, Cnaphalocrocis medinalis(Lepidoptera: Pyralidae), was sequenced using the Roche 454 Genome Sequencer FLX system(GS FLX) with shotgun strategy and assembled by Roche GS De Novo assembler software. Its circular double-stranded genome is 111,246 bp in size with a high A+T content of 64.8% and codes for 118 putative open reading frames(ORFs). It contains 37 conserved baculovirus core ORFs, 13 unique ORFs, 26 ORFs that were found in all Lepidoptera baculoviruses and 42 common ORFs. The analysis of nucleotide sequence repeats revealed that the CnmeGV genome differs from the rest of sequenced GVs by a 23 kb and a 17 kb gene block inversions, and does not contain any typical homologous region(hr) except for a region of non-hr-like sequence. Chitinase and cathepsin genes, which are reported to have major roles in the liquefaction of the hosts, were not found in the CnmeGV genome, which explains why CnmeGV infected insects do not show the phenotype of typical liquefaction. Phylogenetic analysis,based on the 37 core baculovirus genes, indicates that CnmeGV is closely related to Adoxophyes orana granulovirus. The genome analysis would contribute to the functional research of CnmeGV,and would benefit to the utilization of CnmeGV as pest control reagent for rice production.

关键词： baculovirus granulovirus Cnaphalocrocis medinalis granulovirus(CnmeGV) genome sequencing

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Cyanophage and Algal virus

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Virologica Sinica 2013年第5期28卷 251-252页

作者： Fei Deng Zhihong Hu State Key laboratory of Virology Virus Resource and Bioinformatics CenterWuhan Institute of VirologyChinese Academy of Sciences

Cyanobacteria and eukaryotic algae are abundant in freshwater and marine environments,and are fundamentally important in global biogeochemical cycles and for primary productivity.Under certain conditions,such as an ex... 详细信息

关键词：藻类病毒生物地球化学水生生态系统初级生产力海洋环境营养物质人类活动蓝藻

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Oridonin inhibits SARS-CoV-2 replication by targeting viral proteinase and polymerase

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Virologica Sinica 2023年第3期38卷 470-479页

作者： Zherui Zhang Hongqing Zhang Yanan Zhang Qiuyan Zhang Qiaojie Liu Yanyan Hu Xiaoling Chen Jing Wang Yujia Shi Chenglin Deng Peng Gong Bo Zhang Xiaodan Li Bing Zhu Hanqing Ye Virus Laboratory Institute of PediatricsGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou510623China Key laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Hunan Normal University School of MedicineChangsha410081China

COVID-19 has become a global public health crisis since its outbreak in China in December 2019.Currently there are few clinically effective drugs to combat SARS-CoV-2 infection.The main protein(M^(pro)),papain-like protease(PL^(pro))and RNA-dependent RNA polymerase(RdRp)of SARS-CoV-2 are involved in the viral replication,and might be prospective targets for anti-coronavirus drug development.Here,we investigated the antiviral activity of oridonin,a natural small-molecule compound,against SARS-CoV-2 infection in vitro.The time-of-addition analysis showed that oridonin efficiently inhibited SARS-CoV-2 infection by interfering with the genome replication at the post-entry stage.Mechanistically,the inhibition of viral replication by oridonin depends on the oxidation activity ofα,β-unsaturated carbonyl.Further experiments showed that oridonin not only effectively inhibited SARS-CoV-2 Mpro activity,but also had some inhibitory effects on PLpro-mediated deubiquitinating and viral polymerase-catalyzed RNA elongation activities at high concentrations.In particular,oridonin could inhibit the bat SARS-like CoV and the newly emerged SARS-CoV-2 omicron variants(BA.1 and BA.2),which highlights its potential as a pan-coronavirus antiviral agent.Overall,our data provide strong evidence that oridonin is an efficient antiviral agent against SARS-CoV-2 infection.

关键词： SARS-CoV-2 Oridonin Antiviral Protease inhibitor

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