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Liquid metal biomaterials: translational medicines,challenges and perspectives

National Science Review 2024年第2期11卷 264-284页

作者： Hanchi Xu Jincheng Lu Yikuang Xi Xuelin Wang Jing Liu Department of biomedical engineering School of Medicine Tsinghua University Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University Shanghai World Foreign Language Academy Beijing Advanced Innovation Center for biomedical engineering School of Engineering MedicineBeihang University Beijing Key Lab of Cryo-biomedical engineering and Key Lab of Cryogenics Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Until now, significant healthcare challenges and growing urgent clinical requirements remain incompletely addressed by presently available biomedical materials. This is due to their inadequate mechanical compatibility, suboptimal physical and chemical properties, susceptibility to immune rejection, and concerns about long-term biological safety. As an alternative, liquid metal(LM) opens up a promising class of biomaterials with unique advantages like biocompatibility, flexibility, excellent electrical conductivity,and ease of functionalization. However, despite the unique advantages and successful explorations of LM in biomedical fields, widespread clinical translations and applications of LM-based medical products remain limited. This article summarizes the current status and future prospects of LM biomaterials, interprets their applications in healthcare, medical imaging, bone repair, nerve interface, and tumor therapy, *** to translate LM materials into medicine and obstacles encountered in practices are *** that, we outline a blueprint for LM clinics, emphasizing their potential in making new-generation artificial organs. Last, the core challenges of LM biomaterials in clinical translation, including bio-safety,material stability, and ethical concerns are also discussed. Overall, the current progress, translational medicine bottlenecks, and perspectives of LM biomaterials signify their immense potential to drive future medical breakthroughs and thus open up novel avenues for upcoming clinical practices.

关键词： liquid metal biomaterials translational medicine clinical device healthcare therapeutics

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Cell Mechanics Regulates the Dynamic Anisotropic Remodeling of Fibril Matrix at Large Scale

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Research 2024年第3期2023卷 401-415页

作者： Mingxing Ouyang Yanling Hu Weihui Chen Hui Li Yingbo Ji Linshuo Qiu Linlin Zhu Baohua Ji Bing Bu Linhong Deng Institute of biomedical engineering and Health sciences School of Medical and Health Engineering and School of PharmacyChangzhou UniversityChangzhou213164China Institute of Biomechanics and Applications Department of Engineering MechanicsZhejang UniversityHangzhou310027China.

Living tissues often have anisotropic and heterogeneous organizations, in which developmental processes are coordinated by cells and extracellular matrix modeling. Cells have the capability of modeling matrix in long distance;however, the biophysical mechanism is largely unknown. We investigated the dynamic remodeling of collagen I (COL) fibril matrix by cell contraction with designed patterns of cell clusters. By considering cell dynamic contractions, our molecular dynamics simulations predicted the anisotropic patterns of the observed COL bundling in experiments with various geometrical patterns without spatial limitation. The pattern of COL bundling was closely related to the dynamic remodeling of fibril under cell active contraction. We showed that cell cytoskeletal integrity (actin filaments and microtubules), actomyosin contractions, and endoplasmic reticulum calcium channels acting as force generations and transductions were essential for fiber bundling inductions, and membrane mechanosensory components integrin and Piezo played critical roles as well. This study revealed the underlying mechanisms of the cell mechanics-induced matrix remodeling in large scales and the associated cellular mechanism and should provide important guidelines for tissue engineering in potential biomedical applications.

关键词： contraction Dynamic Matrix

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Characterization of cerebrovascular changes in Alzheimer's disease mice by photoacoustic imaging

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Journal of Innovative Optical Health sciences 2024年第6期17卷 29-40页

作者： Xi Li Zhongyang Zhang Hua Shi Feifan Zhou Key Laboratory of biomedical engineering of Hainan Province school of biomedical engineering Hainan university Sanya 572025P.R.China

The cerebral vasculature plays a significant role in the development of Alzheimer's disease(AD),however,the specific association between them remains *** this paper,based on the benefits of photoacoustic imaging(PAI),including label-free,high-resolution,in vivo imaging of vessels,we investigated the structural changes of cerebral vascular in wild-type(WT)mice and AD mice at different ages,analyzed the characteristics of the vascular in different brain regions,and correlated vascular characteristics with cognitive *** results showed that vascular density and vascular branching index in the cortical and frontal regions of both WT and AD mice decreased with ***,vascular lacunarity increased with age,and the changes in vascular structure were more pronounced in AD *** trend of vascular dysfunction aligns with the worsening cognitive dysfunction as the disease ***,we utilized in vivo PAI to analyze the changes in vascular structure during the progression of AD,elucidating the spatial and temporal correlation with cognitive impairment,which will provide more intuitive data for the study of the correlation between cerebrovascular and the development of AD.

关键词： Photoacoustic imaging Alzheimer's disease cerebrovascular vascular network cognitive impairment.

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Interface engineering on Constructing Physical and Chemical Stable Solid-State Electrolyte Toward Practical Lithium Batteries

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Energy & Environmental Materials 2024年第4期7卷 28-47页

作者： Honggang He Litong Wang Malek Al-Abbasi Chunyan Cao Heng Li Zhu Xu Shi Chen Wei Zhang Ruiqing Li Yuekun Lai Yuxin Tang Mingzheng Ge school of Textile and Clothing Nantong University school of Science Qingdao University of Technology Department of biomedical sciences City University of Hong Kong Institute of Applied Physics and Materials engineering University of Macau College of Chemical engineering Fuzhou University

Solid-state lithium batteries (SSLBs) with high safety have emerged to meet the increasing energy density demands of electric vehicles,hybrid electric vehicles,and portable electronic ***,the dendrite formation,high interfacial resistance,and deleterious interfacial reactions caused by solid-solid contact between electrode and electrolyte have hindered the commercialization of SSLBs.

关键词： dendrite formation high energy density interface instability interfacial resistance solid-state electrolyte

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Nanomedicine-mediated immunogenic cell death and its combination with immune checkpoint blockade therapy

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Science China(technological sciences) 2024年第8期67卷 2350-2362页

作者： CHEN JunBin ZHANG YuXi SU Miao ZHU YueQiang YANG XianZhu school of biomedical sciences and engineering South China University of TechnologyGuangzhou International CampusGuangzhou 511442China National engineering Research Center for Tissue Restoration and Reconstruction Guangdong Provincial Key Laboratory of Biomedical EngineeringKey Laboratory of Biomedical Materials and Engineering of the Ministry of EducationSouth China University of TechnologyGuangzhou 510006China

Cancer immunotherapies, which train the natural immune system to specifically kill tumor cells while sparing the healthy cells,have helped revolutionize cancer treatments and demonstrated promising clinical therapeutic benefits for decades. However, the therapeutic outcome of immunotherapies, even for the most successful immune checkpoint blockade(ICB) therapy, remains unsatisfactory in the clinical practice, mainly due to the low immunogenicity of solid tumors and its immunosuppressive tumor microenvironment(TME). Notably, several cancer treatment modalities, including chemotherapy, radiotherapy, and phototherapy, have been revealed to evoke tumor immunogenicity and reverse immunosuppressive TME via inducing immunogenic cell death(ICD) of tumor cells, which synergistically sensitized tumors to ICB therapy. Nanomedicines have been extensively applied to augment ICD-inducing treatment modalities and potentiate ICB therapeutic efficacy therapy due to the opportune convergence of immunotherapy and nanotechnology. Here, we discuss the recent advances in nanomedicine-mediated ICD and its combination with ICB therapy.

关键词： cancer immunotherapy nanomedicine immunogenic cell death immune checkpoint blockade

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Multi-focus non-periodic scanning method for femtosecond lasers based on DMD and galvanometer scanners[Invited]

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Chinese Optics Letters 2024年第5期22卷 89-94页

作者：李华明王雨胡庆磊张卓宇吕晓华曾绍群 Britton Chance Center for biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China MOE Key Laboratory for biomedical Photonics Collaborative Innovation Center for Biomedical EngineeringSchool of Engineering SciencesHuazhong University of Science and TechnologyWuhan 430074China

Multi-focus parallel scanning can effectively increase laser fabrication ***,the conventional approach of using a spatial light modulator(SLM)to generate multi-foci and scan this fixed number of foci with galvanometer scanners can only achieve a periodic scanning trajectory due to the low switching speed of the *** we demonstrate a multifocus non-periodic scanning method for femtosecond lasers by using,instead,a fast-switching digital micromirror device(DMD)to generate a dynamic number of *** number of effective foci is quickly switched by introducing aberration to the undesired *** this way,the intensity allocated to each focus will not be affected by the number of foci,and a uniformity of 98%with different numbers of foci is achieved without adjusting the total laser ***,we validate the effectiveness of this scanning method by demonstrating corneal flap fabrication of porcine cornea in vitro.

关键词： multi-focus non-periodic trajectory digital micromirror device aberration control corneal cutting

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Large-field objective lens for multi-wavelength microscopy at mesoscale and submicron resolution

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Opto-Electronic Advances 2024年第6期7卷 41-56页

作者： Xin Xu Qin Luo Jixiang Wang Yahui Song Hong Ye Xin Zhang Yi He Minxuan Sun Ruobing Zhang Guohua Shi school of biomedical engineering(Suzhou) Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China Jiangsu Key Laboratory of Medical Optics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of ScienceSuzhou 215163China

Conventional microscopes designed for submicron resolution in biological research are hindered by a limited field of view,typically around 1 *** restriction poses a challenge when attempting to simultaneously analyze various parts of a sample,such as different brain *** addition,conventional objective lenses struggle to perform consistently across the required range of wavelengths for brain imaging in *** we present a novel mesoscopic objective lens with an impressive field of view of 8 mm,a numerical aperture of 0.5,and a working wavelength range from 400 to 1000 *** achieved a resolution of 0.74μm in fluorescent beads *** versatility of this lens was further demonstrated through high-quality images of mouse brain and kidney sections in a wide-field imaging system,a confocal laser scanning system,and a two-photon imaging *** mesoscopic objective lens holds immense promise for advancing multi-wavelength imaging of large fields of view at high resolution.

关键词： mesoscopic objective lens large field-of-view high resolution multi-wavelength wide-field microscopy confocal laser scanning microscopy

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Controlling the dynamic behavior of decentralized cluster through centralized approaches

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Chinese Physics B 2024年第6期33卷 46-54页

作者：袁大明王培龙王鹏马星宇汪楚云王璟陈怀城王高叶方富 school of Ophthalmology and Optometry Eye HospitalSchool of Biomedical EngineeringWenzhou Medical UniversityWenzhou 325035China Postgraduate Training Base Alliance Wenzhou Medical UniversityWenzhou 325035China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325011China school of Physical sciences University of Chinese Academy of SciencesBeijing 100049China

How to control the dynamic behavior of large-scale artificial active matter is a critical concern in experimental research on soft matter, particularly regarding the emergence of collective behaviors and the formation of group patterns. Centralized systems excel in precise control over individual behavior within a group, ensuring high accuracy and controllability in task execution. Nevertheless, their sensitivity to group size may limit their adaptability to diverse tasks. In contrast, decentralized systems empower individuals with autonomous decision-making, enhancing adaptability and system robustness. Yet, this flexibility comes at the cost of reduced accuracy and efficiency in task execution. In this work, we present a unique method for regulating the centralized dynamic behavior of self-organizing clusters based on environmental interactions. Within this environment-coupled robot system, each robot possesses similar dynamic characteristics, and their internal programs are entirely identical. However, their behaviors can be guided by the centralized control of the environment, facilitating the accomplishment of diverse cluster tasks. This approach aims to balance the accuracy and flexibility of centralized control with the robustness and task adaptability of decentralized control. The proactive regulation of dynamic behavioral characteristics in active matter groups, demonstrated in this work through environmental interactions, holds the potential to introduce a novel technological approach and provide experimental references for studying the dynamic behavior control of large-scale artificial active matter systems.

关键词： self-organizing system centralized control dynamics regulation

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Preparation and Structure-Property Regulation Mechanism of Reversible Thermochromic Polydiacetylene

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Chinese Journal of Polymer Science 2024年第8期42卷 1111-1121页

作者： Zhi-Qing Ge Shuo Yan Zu-Xiong Pan Shan Lei Xuan-Zhi Mao Chu Zhao Mo-Zhen Wang Xue-Wu Ge Key Laboratory of Precision and Intelligent Chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China Marshall Laboratory of biomedical engineering International Cancer CenterLaboratory of Evolutionary Theranostics(LET)School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen UniversityShenzhen 518055China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China university of Chinese Academy of sciences Beijing 100049China

The thermochromic mechanism and the structure-property regulation principle of reversible thermochromic polydiacetylene(PDA)materials have always been a challenging *** this work,a series of diacetylene monomers(m-PCDA)containing phenyl and amide or carboxyl groups were synthesized from 10,12-pentacosadiynoic acid(PCDA)through the esterification or amidation *** effects of the number and the distribution of the functional groups in m-PCDA molecules on their solid-state polymerization capability,and the thermochromic mechanism of their corresponding polymers(m-PDA)were investigated and discussed in *** results show that the m-PCDA monomers containing both benzene ring and groups that can form hydrogen bonding interactions have strong intermolecular interaction,and are easy to carry out the solid phase polymerization under 254-nm UV irradiation to obtain the corresponding new thermochromic m-PDA *** thermochromic behavior of m-PDA depends on its melting *** initial color-change temperature(blue to red)is determined by the onset melting tem perature,and the temperature range in which reversible color recovery can be achieved by repeat heating-cooling treatment is determined by its melting *** to the proposed thermochromic mechanism of PDA,various new PDA materials with precise thermochromic temperatu res and reversible thermochromic temperature ra nges can be designed and synthesized through the appropriate introduction of benzene ring and groups that can form hydrogen bonding interactions into the molecular structure of linear diacetylene *** work provides a perspective to the precise molecular structure design and the property regulation of the reversible thermochromic PDA materials.

关键词： Polydiacetylene Thermochromism Hydrogen bonding Chemical modification

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Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs

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Chinese Chemical Letters 2024年第8期35卷 481-485页

作者： Jiaqi Huang Renjiang Kong Yanmei Li Ni Yan Yeyang Wu Ziwen Qiu Zhenming Lu Xiaona Rao Shiying Li Hong Cheng school of biomedical engineering&Guangdong Provincial Key Laboratory of Construction and Detection in Tissue engineering Southern Medical UniversityGuangzhou 510515China school of Pharmaceutical sciences Guangzhou Medical UniversityGuangzhou 511436China

Oxidative therapies receive a limited antitumor efficiency due to the insufficient reactive oxygen species(ROS)levels at focal sites and the evolvement of antioxidant defense ***,we develop an albumin-based nanomedicine to co-deliver chlorin e6(Ce6)and COH-SR4(CS),which can simultaneously enhance the yield and lethality of intracellular ROS for amplified photodynamic therapy(PDT).In which,CS acts as both an activator of AMP-activated protein kinase(AMPK)and an inhibitor of glutathione S-transferases(GSTs).Benefiting from it,the prepared HSA-Ce6@COH-SR4(HCCS)enables positive feed-back uptake by promoting AMPK phosphorylation,leading to rapid and extensive tumor accumulation of *** a result,HCCS obviously increases the ROS production to elevate intracellular oxidative ***,HCCS can inhibit GSTs to disturb the antioxidant defense system of tumor cells,intensifying the oxidative damage of ***,the PDT of HCCS is significantly strengthened by improving the ROS yield and lethality,which greatly declines the proliferation of breast cancer in *** study may open a window in the development of drug co-delivery system for enhanced oxidative therapy of tumors.

关键词： Human serum albumin Drug delivery Reactive oxygen species Positive feedback uptake Oxidative damage

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