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Evolution and host-specific adaptation of Pseudomonas aeruginosa

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四川生理科学杂志 2024年第7期46卷 1579-1579页

作者： Aaron Weimann victor phillip dahdaleh heart & lung research institute University of Cambridge Cambridge UK. University of Cambridge Molecular Immunity Unit MRC Laboratory of Molecular Biology Cambridge UK. Cambridge Centre for AI in Medicine University of Cambridge Cambridge UK. Department of Veterinary Medicine University of Cambridge Cambridge UK. Laboratory of Pathogens and Host Immunity (LPHI) UMR5235 CNRS/Université de Montpellier Montpellier France. Cambridge Centre for lung Infection Royal Papworth Hospital Cambridge UK. Department of Physiology Bioscience Institute University College Cork Cork Ireland. Department of Biochemistry University of Cambridge Cambridge UK. Department of Medicine University of Cambridge Cambridge UK. Wellcome Sanger institute Hinxton UK. Cambridge University Hospitals Trust Cambridge UK. Institut de Biologie Intégrative et des Systèmes (IBIS) Université Laval Québec City Québec Canada. Department of Science University Roma Tre Rome Italy. IRCCS Fondazione Santa Lucia Rome Italy. London School of Hygiene and Tropical Medicine London UK. Department of Clinical Infection Microbiology and Immunology University of Liverpool Liverpool UK.

The major human bacterial pathogen Pseudomonas aeruginosa causes multidrug-resistant infections in people with underlying immunodeficiencies or structural lung diseases such as cystic fibrosis(CF).We show that a few environmental isolates,driven by horizontal gene acquisition,have become dominant epidemic clones that have sequentially emerged and spread through global transmission networks over the past 200 years.

关键词： lung diseases sequentially

Diagnostic and therapeutic role of endoscopic ultrasound in liver diseases:A systematic review and meta-analysis

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World Journal of Gastroenterology 2024年第7期30卷 742-758页

作者： Eyad Gadour Abeer Awad Zeinab Hassan Khalid Jebril Shrwani Bogdan Miutescu Hussein Hassan Okasha Department of Gastroenterology and Hepatology King Abdulaziz Hospital-National GuardAhsa 31982Saudi Arabia Department of Internal Medicine Faculty of MedicineZamzam University CollegeKhartoum 11113Sudan Department of Hepatogastroenterology Kasar Alainy HospitalFaculty of MedicineCairo UniversityCairo 11451Egypt Department of Internal Medicine Stockport Hospitals NHS Foundation TrustManchester SK27JEUnited Kingdom Public Health Authority Saudi Center for Disease Prevention and ControlJazan 45142Saudi Arabia Department of Clinical Infection Microbiology and ImmunologyInstitute of Infection and Global HealthSchool of Medicine and Life SciencesUniversity of LiverpoolLiverpoolUnited Kingdom Department of Gastroenterology and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 300041Romania Advanced Regional research Center in Gastroenterology and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 30041Romania Department of Internal Medicine Division of Gastroenterology and HepatologyKasr Al-Aini School of MedicineCairo UniversityCairo 11562Egypt

BACKGROUND In hepatology,the clinical use of endoscopic ultrasound(EUS)has experienced a notable increase in recent *** applications range from the diagnosis to the treatment of various liver ***,this systematic review summarizes the evidence for the diagnostic and therapeutic roles of EUS in liver *** To examine and summarize the current available evidence of the possible roles of the EUS in making a suitable diagnosis in liver diseases as well as the therapeutic accuracy and *** PubMed,Medline,Cochrane Library,Web of Science,and Google Scholar databases were extensively searched until October *** methodological quality of the eligible articles was assessed using the Newcastle-Ottawa scale or Cochrane Risk of Bias *** addition,statistical analyses were performed using the Comprehensive Meta-Analysis *** Overall,45 articles on EUS were included(28 on diagnostic role and 17 on therapeutic role).Pooled analysis demonstrated that EUS diagnostic tests had an accuracy of 92.4%for focal liver lesions(FLL)and 96.6%for parenchymal liver ***-guided liver biopsies with either fine needle aspiration or fine needle biopsy had low complication rates when sampling FLL and parenchymal liver diseases(3.1%and 8.7%,respectively).Analysis of data from four studies showed that EUS-guided liver abscess had high clinical(90.7%)and technical success(90.7%)without significant ***,EUS-guided interventions for the treatment of gastric varices(GV)have high technical success(98%)and GV obliteration rate(84%)with few complications(15%)and rebleeding events(17%).CONCLUSION EUS in liver diseases is a promising technique with the potential to be considered a first-line therapeutic and diagnostic option in selected cases.

关键词： Focal liver lesion Liver abscess drainage Fine needle aspiration Gastric varices Endoscopic ultrasound

Floristic Diversity and Conservation Status of Guineo-Congolese Species in Southeastern Cameroon: The Case of the Gari-Gombo Communal Forest

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Open Journal of Forestry 2024年第1期14卷 87-97页

作者： Boris Nyeck Valery Noiha Noumi Nicole Maffo Maffo victor Awe Djongmo Cedric Djomo Chimi Louis Zapfack Department of Biological Sciences Faculty of Sciences University of Ngaoundéré Ngaoundéré Cameroon Agricultural research institute for Development (IRAD) Minko Agricultural Research Station Meyomessala Cameroon Department of live Sciences Higher Teacher Training College University of Bertoua Bertoua Cameroon Department of Plant Biology and Physiology Faculty of Sciences University of Yaoundé I Yaoundé Cameroon Agricultural research institute for Development (IRAD) Research Station of Yokadouma Yokadouma Cameroon

The conservation of plant biodiversity has become one of the most important objectives in the sustainable management of Guinean-Congolese ecosystems. However, in the south-east zone of Cameroon, there is a lack of rigor in the management of these forests, which can result in the loss of species of high conservation value. The study was carried out in communal forests in the south-east zone of Cameroon. Its aim was to carry out a floristic inventory and then compare the list of species with the IUCN catalog. Twenty-four plots, each with a surface area of 0.2 ha, were set up in the Gari-Gombo communal forest. All timbers with a DBH ≥ 5 cm were systematically counted. A total of 176 species, belonging to 144 genera and 45 families, were surveyed. Fabaceae (42.08%), Malvaceae (39%), Euphorbiaceae (24.64%), Moraceae (20.92%), Apocynaceae (18.64%), Cecropiaceae (16.60%), Ulmaceae (14.76%), Meliaceae (14.61%), Violaceae (14.08%), Combretaceae (12.67%), Theobroma cacao (21.17%), Baphia leptobotrys (18.06%), Rinorea sp. (14.09%), Musanga cecropioides (12.18%), Terminalia superba (10.32%), Neosloetiopsis kamerunensis (10.14%), Celtis zenkeri (8.29%) and Alstonia boonei (7.77%) were the most important taxa. Nearly 90% of the species in this forest are Guinean species, with a dominance of Guinean-Congolese species (66%). Fourteen (14) threatened species have been identified in the FCGG. This study, which highlights the rich biodiversity of communal forests, is important for guiding biodiversity conservation policies in ecosystems used for production.

关键词： Communal Forest Conservation Status Cameroon Floristic Diversity

A new oxidative pathway of nitric oxide production from oximes in plants

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Molecular Plant 2024年第1期17卷 178-198页

作者： Pedro Lopez-Gomez Javier Buezo Marina Urra Alfonso Cornejo Raquel Esteban Jorge Fernandez de los Reyes Estibaliz Urarte Estefania Rodriguez-Dobreva Alejandro Chamizo-Ampudia Alejandro Eguaras Sebastian Wolf Daniel Marino victor Martinez-Merino Jose F.Moran institute for Multidisciplinary research in Applied Biology(IMAB) Department of SciencesPublic University of Navarre(UPNA)Avda.de Pamplona 12331192 MutilvaSpain institute for Advanced Materials and Mathematics(INAMAT2) Department of SciencesPublic University of Navarre(UPNA)Campus de Arosadia31006 PamplonaSpain Department of Plant Biology and Ecology University of the Basque Country(UPV/EHU)Sarriena s/nApdo.64448080 BilbaoSpain Center for Plant Molecular Biology(ZMBP) University of TubingenGeschwister-Scholl-Platz72074 TubingenGermany institute of Natural Resources and Agrobiology of Salamanca(IRNASA) Department of Plant-Microorganism InteractionsSpanish National Research Council(CSIC)Cordel de Merinas40-5237008SalamancaSpain Department of Biochemistry Area of Molecular BiologyVeterinary FacultyUniversity of LeonCampus de Vegazanas/n.24071 LeonSpain

Nitric oxide(NO)is an essential reactive oxygen species and a signal molecule in *** several studies have proposed the occurrence of oxidative NO production,only reductive routes for NO production,such as the nitrate(NO_(3)^(-))-upper-reductase pathway,have been evidenced to date in land ***,plants grown axenically with ammonium as the sole source of nitrogen exhibit contents of nitrite and NO3−,evidencing the existence of a metabolic pathway for oxidative production of *** hypothesized that oximes,such as indole-3-acetaldoxime(IAOx),a precursor to indole-3-acetic acid,are intermediate oxidation products in NO *** detected the production of NO from IAOx and other oximes catalyzed by peroxidase(POD)enzyme using both 4-amino-5-methylamino-2′,7′-difluorescein fluorescence and *** stimulated the reaction,while superoxide dismutase inhibited ***,mouse NO synthase can also use IAOx to produce NO at a lower rate than *** provided a full mechanism for POD-dependent NO production from IAOx consistent with the experimental data and supported by density functional theory *** showed that the addition of IAOx to extracts from Medicago truncatula increased the in vitro production of NO,while in vivo supplementation of IAOx and other oximes increased the number of lateral roots,as shown for NO donors,and a more than 10-fold increase in IAOx dehydratase ***,we found that in vivo supplementation of IAOx increased NO production in Arabidopsis thaliana wild-type plants,while prx33-34 mutant plants,defective in POD33-34,had reduced *** data show that the release of NO by IAOx,as well as its auxinic effect,explain the superroot ***,our study reveals that plants produce NO utilizing diverse molecules such as oximes,POD,and flavins,which are widely distributed in the plant kingdom,thus introducing a long-awaited oxidative pathway to NO production in plants.T

关键词： ammonium oxidation auxin nitric oxide oxime peroxidase root phenotype

Artificial intelligence-driven radiomics study in cancer:the role of feature engineering and modeling

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Military Medical research 2024年第1期11卷 115-147页

作者： Yuan-Peng Zhang Xin-Yun Zhang Yu-Ting Cheng Bing Li Xin-Zhi Teng Jiang Zhang Saikit Lam Ta Zhou Zong-Rui Ma Jia-Bao Sheng victor CWTam Shara WYLee Hong Ge Jing Cai Department of Medical Informatics Nantong UniversityNantong 226001JiangsuChina Department of Health Technology and Informatics the Hong Kong Polytechnic UniversityHong Kong 999077China The Hong Kong Polytechnic University Shenzhen research institute Shenzhen 518000GuangdongChina Department of Radiation Oncology the Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhou 450008China

Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’***,the interpretation of medical images can be highly subjective and dependent on the expertise of ***,some potentially useful quantitative information in medical images,especially that which is not visible to the naked eye,is often ignored during clinical *** contrast,radiomics performs high-throughput feature extraction from medical images,which enables quantitative analysis of medical images and prediction of various clinical *** have reported that radiomics exhibits promising performance in diagnosis and predicting treatment responses and prognosis,demonstrating its potential to be a non-invasive auxiliary tool for personalized ***,radiomics remains in a developmental phase as numerous technical challenges have yet to be solved,especially in feature engineering and statistical *** this review,we introduce the current utility of radiomics by summarizing research on its application in the diagnosis,prognosis,and prediction of treatment responses in patients with *** focus on machine learning approaches,for feature extraction and selection during feature engineering and for imbalanced datasets and multi-modality fusion during statistical ***,we introduce the stability,reproducibility,and interpretability of features,and the generalizability and interpretability of ***,we offer possible solutions to current challenges in radiomics research.

关键词： Artificial intelligence Radiomics Feature extraction Feature selection Modeling Interpretability Multimodalities Head and neck cancer

Substitution of Aggregates in Concrete and Mortar with Coltan Mining Waste: Mechanical, Environmental, and Economic Impact Case Study

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Journal of Minerals and Materials Characterization and Engineering 2024年第2期12卷 139-163页

作者： Alinabiwe Nyamuhanga Ally Élodie Ruffine Zang Masika Muhiwa Grâce Manjia Marcelline Blanche Ursula Joyce Merveilles Pettang Nana Ngapgue François Bella Nabil Chrispin Pettang Laboratory Engineering Civil and Mechanics Doctoral Research Unit for Engineering and Applications University of Yaound&#233 I Yaound&#233 Cameroon Department of Civil Engineering Faculty of Applied Sciences and Technologies Free University of Great Lakes Countries (ULPGL) Goma DRC Department of Civil Engineering National Advanced School of Engineering of Yaoundé University of Yaoundé I Yaoundé Cameroon Department of Civil Engineering Fotso Victor University Institute of Technology University of Dschang Bandjoun Cameroon FIMAS Laboratory Faculty of Technologies Tahri Mohamed University Bechar Algeria

The mining process involves drilling and excavation, resulting in the production of waste rock and tailings. The waste materials are then removed and stored in designated areas. This study aims to evaluate the mechanical strength and the environmental and economic impact of using Coltan Mining Waste (CMW) as a substitute for aggregates in concrete and mortar production. To achieve this, the CMW needs to be characterised. The Dreux Gorisse method was primarily used to produce concrete with a strength of 20 MPa at 28 days. The mortars, on the other hand, were formulated according to the NF P 18-452 standard. The environmental impact of using CMW as substitutes for natural aggregates in the production of concrete and mortar was analysed using SimaPro software. The results showed that mortars and concrete made with CMW have comparable compressive strengths to the reference mortar and concrete;reduce the negative impact on ecosystem quality, human health, resources, and climate change. It has also been shown that the substitution of aggregates by CMW reduces the cost of concrete and mortar as a function of the distance from the aggregate footprint.

关键词： Aggregate Coltan Mining Waste Concrete Mortar Mechanical Strength Life Cycle Analysis

Prospective study of hepatitis B and D epidemiology and risk factors in Romania:A 10-year update

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World Journal of Hepatology 2024年第4期16卷 640-649页

作者： Speranta Iacob Liana Gheorghe Mirela Onica Laura Huiban Corina Silvia Pop Ciprian Brisc Roxana Sirli Carmen Ester Cristina Mihaela Brisc Sorina Diaconu Ion Rogoveanu Larisa Sandulescu Deiana Vuletici Anca Trifan Department of Gastroenterology Carol Davila University of Medicine and PharmacyBucharest 050474Romania Department of Gastroenterology and Hepatology Fundeni Clinical InstituteBucharest 022328Romania Department of Gastroenterology Grigore T Popa University of Medicine and PharmacyIasi 700115Romania institute of Gastroenterology and Hepatology Saint Spiridon County HospitalIasi 700111Romania Department of Gastroenterology and Medical Oncology University Emergency Clinical HospitalBucharest 050098Romania Faculty of Medicine and Pharmacy University of OradeaOradea 410087Romania Department of Gastroenterology Emergency County HospitalOradea 410169Romania Center for Advanced research in Gastroenterology and Hepatology Department of Gastroenterology and Hepatology“Victor Babeş”University of Medicine and PharmacyTimisoara 300041Romania Department of Gastroenterology and Hepatology TimişCounty Emergency Clinical Hospital"Pius Branzeu"Timisoara 300723Romania Department of Internal Medicine II and Gastroenterology University Emergency Clinical HospitalBucharest 050098Romania Department of Gastroenterology University of Medicine and PharmacyCraiova 200349Romania Department of Cardiology Emergency County HospitalCraiova 200642Romania Department of Gastroenterology Research Center of Gastroenterology and HepatologyUniversity of Medicine and PharmacyCraiova 200349Romania Department of Gastroenterology Emergency County HospitalCraiova 200642Romania Department of Gastroenterology Faculty of MedicineGrigore T Popa University of Medicine and PharmacyIasi 700115Romania

BACKGROUND The global burden of hepatitis D virus(HDV)infection represents a major medical challenge and a public health crisis ***,there is a lack of accurate data on the epidemiology and risk factors for *** B virus(HBV)and HDV coinfection causes the most severe form of viral hepatitis,leading to a higher cumulative incidence of liver-related events compared with HBV monoinfection,including the need for liver transplantation and *** To investigate the epidemiology,natural history,risk factors and clinical management of HBV and HDV coinfection in Romanian *** This prospective study was conducted between January and July 2022 in six tertiary gastroenterology and hepatology referral centres in *** consecutive adults admitted for any gastroenterology diagnosis who were HBV-positive were *** with acute hepatitis or incomplete data were *** the 25390 individuals who presented with any type of gastroenterology diagnosis during the study period,963 met the inclusion *** for anti-HDV antibodies and HDV RNA was performed for all *** and risk factor data were collected by investigators using medical charts and patient *** data were stored in an anonymized online database during the *** The prevalence of HBV was 3.8%;among these patients,the prevalence of HBV/HDV coinfection was 33.1%.The median age of the study population was 54.0 years,and it consisted of 55.1%men.A higher prevalence of HBV/HDV coinfection was observed in patients 50–69 years *** with HBV/HDV coinfection were significantly older than those with HBV monoinfection(P=0.03).Multivariate multiple regression analysis identified female gender(P=0.0006),imprisonment(P<0.0001),older age at diagnosis(P=0.01)and sexual contact with persons with known viral hepatitis(P=0.0003)as significant risk factors for *** This study shows that HDV infection among those with HBV re

关键词： Epidemiology Hepatitis B Hepatitis D Natural history Risk factors Romania

From target discovery to clinical drug development with human genetics

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四川生理科学杂志 2023年第9期45卷 1756-1756页

作者： Katerina Trajanoska Canada Excellence research Chair in Genomic Medicine Department of Human Genetics Faculty of Medicine and Health Sciences Victor Phillip Dahdaleh Institute of Genomic Medicine McGill University Montreal Quebec Canada. Lady Davis institute for Medical research Jewish General Hospital McGill University Montreal Quebec Canada. Department of Epidemiology and Biostatistics and Occupational Health McGill University Montreal Quebec Canada. Canada Excellence research Chair in Genomic Medicine Department of Human Genetics Faculty of Medicine and Health Sciences Victor Phillip Dahdaleh Institute of Genomic Medicine McGill University Montreal Quebec Canada. vincent.mooser@mcgill.ca.

The substantial investments in human genetics and genomics made over the past three decades were anticipated to result in many innovative *** we investigate the extent to which these expectations have been met,excluding cancer *** our search,we identified 40 germline genetic observations that led directly to new targets and subsequently to novel approvedtherapies for 36 rare and 4 common *** median time between genetic target discovery and drug approval was 25 years.

关键词： drug clinical approval

ENSO impacts on litter stocks and water holding capacity in secondary forests in eastern Amazonia

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Journal of Forestry research 2024年第1期35卷 83-89页

作者： Julia Isabella de Matos Rodrigues Walmer Bruno Rocha Martins victor Pereira de Oliveira Myriam Suelen da Silva Wanzerley Hélio Brito dos Santos Júnior Francisco de Assis Oliveira Graduate Program in Forestry Sciences Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural University of Amazonia Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural University of Amazonia Tv.Pau-AmareloCapitão PoçoPará68650-000Brazil National institute of Amazonia research Av.Constelação Cruzeiro do SulManausAmazonas 69060-062Brazil

Among the impacts of climate change,there is the intensification of phenomena such as the El Niño South-ern Oscillation(ENSO)responsible for El Niño and La Niñ***,understanding their effects on the functional pro-cesses of forests is ***,this study evaluated the effects of ENSO on litter stock and water holding capac-ity(WHC)in a successional forest in eastern *** occurred in periods with the most rainfall in El Niño(2019)and least in La Niña(2021)*** permanent plots were used to sample *** effects were evident for WHC,higher during El Niñ***,this influence was not clear for litter,as only in the rainy season effects were *** was a positive correlation of WHC with precipitation and humidity,while litter stocks were negatively correlated with temperature and wind *** the subject of this study requires long-term assessments,preliminary results suggests that,depending on the intensity of ENSO,forest functional processes can be strongly impacted and *** conclusion reinforces warnings by the scientific community about the impacts of climate change on the maintenance of litter stocks,decomposition and,consequently,the biogeochemical cycle and essential ecosystem services for the maintenance of Amazonia *** need to develop long-term research to understand the effects of climatic change on litter stocks and water holding capacity is highlighted,especially in Amazonia.

关键词： Seasonality Climate change Succession ecosystem Biogeochemical cycle Amazonia biodiversity