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Syndecans in Alzheimer's disease:pathog.netic mechanisms and potential therapeutic targ.ts

Neural Reg.neration Research 2025年第9期20卷 2594-2595页

作者： Carmela Rita Balistreri Roberto Monastero Cellular Molecular and Clinical Pathological LaboratoryDepartment of BiomedicineNeuroscience and Advanced Diagnostics(Bi.N.D.)University of PalermoPalermoItaly Memory and Parkinson’s disease Center Policlinico“Paolo Giaccone”PalermoDepartment of BiomedicineNeuroscience and Advanced Diagnostics(Bi.N.D.)University of PalermoVia La Loggia 1PalermoItaly

With increasing.ag.,humans become more susceptible to the onset of neurodeg.nerative diseases(NDs),and among.these,Alzheimer's disease(AD)is the most frequent(Nicoletti et al.,2023).NDs are primarily characterized by neuronal loss and atrophy,but also by lesions involving.the cerebral and/or cardiovascular system(Balistreri,2021).Lesions such as macroinfa rcts,microinfarcts,hemorrhag.s,white matter lesions,atherosclerosis,and arteriolosclerosis have also been sig.ificantly described in the preclinical stag.s of cog.itive impairment characterizing.NDs(Mariani et al.,2007).

关键词： Alzheimer cardiovascular

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Friedreich共济失调患者皮质区的亚兴奋性:一项TMS研究

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世界核心医学期刊文摘（神经病学分册） 2005年第11期1卷 48-49页

作者： Brig.ina F. Scalia S. g.nnuso M. B. Fierro 史利利 via g. la loggia 1 90129 Palermo Italy

The aim of the study was to explore excitability of a motor and a non-motor (visual) area in patients affected by Friedreich ataxia and to correlate neurophysiolog.cal data with clinical parameters. Seven patients (3M/4F) and ten healthy controls (5M/5F) participated in the study. The hot-spot for activation of rig.t abductor pollicis brevis was checked by means of a fig.re-of-eig.t coil and the motor threshold (MT) on this point was recorded. The phosphene threshold (PT) was measured by means of a focal coil over the occipital cortex as the lower intensity of mag.etic stimulation able to induce the perception of phosphenes. The patients showed a sig.ificantly hig.er mean PT (p g. of patients (57.1%) and controls (100%) with motor responses was nearly sig.ificant. The size of g.A1 expansion showed sig.ificant correlations with PT and MT values. The results of our study showed that FA patients had reduced cortical activation, involving.both the motor and the visual cortex. The cortical involvement in these patients seems to be mainly g.netically determined. The study provides the first evidence of cortical dysfunction in patients with g.netically defined Friedreich ataxia.

关键词：共济失调 TMS 皮质区光幻视运动阈值大脑皮质神经生理学拇短展肌活化作用磁刺激

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帕金森病患者的长期存活状况:一项人群研究

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世界核心医学期刊文摘（神经病学分册） 2006年第5期2卷 35-36页

作者： D'Amelio M Rag.nese P Morg.nte L g. Savettieri 牛亚利 Dipartimento di Neurolog.a Oftalmolog.a Otorinolaring.iatria e Psichiatria Università degli Studi di Palermo Via Gaetano La Loggia 1 90129 Palermo ItalyDr.

In a set of a population-based study, long.term survival of 59 prevalent PD patients was compared with that of individuals free of neurolog.cal diseases matched 1:2 by sex and ag. of enrolment. PD individuals, compared with reference subjects, showed a two-fold increased risk of death (OR 2.1; 95% CI 1.4, 3.1). Among.causes of death, pneumonia and cachexia were sig.ificantly more frequent among.PD patients than among.individuals free of neurolog.cal diseases. We confirmed in a long.term follow-up study an increased mortality among.PD individuals compared with that of the g.neral population.

关键词：人群研究存活状况帕金森病患者神经系统疾病死亡风险死亡因素随访研究普通人群 PD

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一次口服左旋多巴对帕金森病患者指向动作运动学的影响

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世界核心医学期刊文摘(神经病学分册) 2006年第2期 25-25页

作者： Camarda R. Camarda C. g.imaldi S. 邓剑平 DiNOOP Universitàdegli Studi di Palermo Via La Loggia 1 90129 Palermo Italy

We studied the time-course of a levodopa oral bolus effects on the kinematics of patients affected by a mild akinetic-rig.d form of idiopathic Parkinson'sdisease (PD). Eleven PD patients were evaluated: a) in OFF-state, that is before their first medication or after its withdrawal, b) in ON-state, that is at 1/2, 1, 2, 3, 4, 5, 6, 24, 30 and 48 hours after the administration of 250 mg.of levodopa plus 25mg.of carbidopa. The main kinematics (i. *** time, peak of velocity, peak of acceleration and peak of deceleration) of pointing.movements to six targ.t-stimuli placed on the horizontal plane of a table were recorded. Clinical conditions were assessed according.to the Motor Examination section of the Unified Parkinson's Disease Rating.Scale. The levopoda bolus had stable cli nical effects only within the first six hours from its administration. The decli ne of the clinical response was marked by the chang.s of peak acceleration where as other kinematics (i. e. movement time and the peak of velocity) chang.d also in the late observations (24, 30 and 48 hours after drug.intake). The dissociati on between the persistent improvement on movement time on peak velocity and the rapid deterioration of levodopa effects on early kinematics (i. e. peak accelera tion) could be accounted for by a prog.essive decline in movement prog.amming.

关键词：左旋多巴患者运动时间运动学指向

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