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Risk factors for impaired glucose tolerance in obese children and adolescents

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World Journal of Diabetes 2010年第4期1卷 129-134页

作者： Michaela Kleber Gideon de Sousa Sophie Papcke Thomas Reinehr vestische Hospital for Children and Adolescents University of Witten/Herdecke Hospital for Children and Adolescents

AIM:To investigate which obese children have an increased risk for impaired glucose tolerance(IGT),a risk factor for later ***:We studied 169 European untreated obese children and adolescents with normal glucose tolerance at *** circumference,fasting glucose,lipids,blood pressure,pubertal stage,2 h glucose in oral glucose tolerance test(oGTT),and HbA1c were deter mined at baseline and 1 year ***:One year after baseline,19(11.2) children demonstrated IGT,4(2.4) children had impaired fas ting glucose,no(0) child suffered from diabetes,and 146(86) children still showed normal glucose *** baseline,the children with IGT and with normal glucose tolerance in a one-year follow-up did not differ significantly in respect of any analyzed parameter,apart from pubertal *** children developing IGT entered puberty significantly more frequently(37 vs 3,P < 0.001).One year after baseline,the childr en with IGT demonstrated significantly increased waist circumference,blood pressure values,insulin and triglyceride concentrations,and insulin resistance index *** children remaining in the normal glucose tolerance status 1 year after baseline did not demonstrate any significant ***:During the study period of 1 year,more than 10 of the obese children with normal glucose tolerance converted to *** screening with oGTT seems meaningful in obese children entering puberty or demonstrating increased insulin resistance,waist circumference,blood pressure,or triglyceride concen trations.

关键词： Impaired glucose tolerance Risk factors Lipids Blood pressure Pubertal stage Waist circumference

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出血性休克脑病综合征

德国医学 1994年第2期11卷 108-110页

作者： B.Schlüter W.Andler 李林 vestische kinderklinik DattelnGermany 同济医科大学附属同济医院

1983年开始报道出血性休克脑病综合征,主要见于健康婴儿在轻微前驱症状后,骤然发生严重的循环休克、意识障碍和惊厥。实验室检查有凝血功能障碍。死亡率高,存活患儿常伴脑损害。尽管这种疾病在临床中较常见,德国迄今仅报道4例。因此,HE... 详细信息

1983年开始报道出血性休克脑病综合征,主要见于健康婴儿在轻微前驱症状后,骤然发生严重的循环休克、意识障碍和惊厥。实验室检查有凝血功能障碍。死亡率高,存活患儿常伴脑损害。尽管这种疾病在临床中较常见,德国迄今仅报道4例。因此,HESE 患儿可能常被误诊。通过完善的实验室检查和其他特检可作出诊断。

关键词：出血性休克脑病综合征婴儿

儿童及青少年期的甲状腺机能亢进——16例患者的临床、治疗及病程

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德国医学 1999年第2期16卷 88-89页

作者： B.Doeker W.Andler 彭小楚 vestische kinderklinik Universitt Witten-HerdeckeLloydstr.5D-45711 DattelnGermany 襄樊市护士学校

甲状腺机能亢进(以下简称“甲亢”)为儿童及青少年罕见疾病,其发病率随年龄增长而增高。其最常见的原因为自体免疫性甲状腺病,包括Basedow病及自体免疫性甲状腺炎。在Basedow病及自体免疫性甲状腺炎均可证实有不同的HLA-单型发生率增高... 详细信息

甲状腺机能亢进(以下简称“甲亢”)为儿童及青少年罕见疾病,其发病率随年龄增长而增高。其最常见的原因为自体免疫性甲状腺病,包括Basedow病及自体免疫性甲状腺炎。在Basedow病及自体免疫性甲状腺炎均可证实有不同的HLA-单型发生率增高,但其免疫机制各不相同,而缺乏抑制抗甲状腺组织抗体产生的能力则是共同的。精神、社会因素及环境影响对疾病的发生亦有重要作用。

关键词：甲状腺机能亢进儿童青少年治疗病程

Prevalence of autoantibodies and the risk of autoimmune thyroid disease in children with chronic hepatitis C virus infection treated with interferon-α

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World Journal of Gastroenterology 2006年第36期12卷 5787-5792页

作者： Stephan Gehring Ulrike Kullmer Sabine Koeppelmann Patrick Gerner Philip Wintermeyer Stefan Wirth The Liver Research Center Department of Medicine Rhode Island Hospital and Brown Medical School Providence Rhode Island USA and Kinderklinik der Johannes-Gutenberg-Universitt Mainz Germany kinderklinik der Johannes-Gutenberg-Universitt Mainz Germany Zentrum für Kinder-und Jugendmedizin HELIOS Klinikum Wuppertal Witten-Herdecke-University Germany

AIM： To evaluate the prevalence of autoantibodies in chronic hepatitis C virus （HCV）-infected children focusing on thyroid ***： We investigated the prevalence of autoantibodies in 123 chronic HCV-infected children before, during and after monotherapy with interferon-alpha （IFN-α） or combined treatment with interferon-α or peginterferon-α and ribavirin. Besides antibodies against smooth muscle （SMA）, nuclei （ANA）, and liver/kidney microsomes （1KM）, the incidence of antithyroid peroxidase antibodies as well as thyroid function parameters （TSH, FT3 and FT4） were ***： We found that 8% of children had autoantibodies before treatment. During treatment, 18% of children were found positive for at least one autoantibody; 15.5% of children developed pathologic thyroid values during IFN-α treatment compared to only one child before therapy. Six children had to be substituted while developing laboratory signs of ***： Our data indicate a strong correlation between interferon-α treatment and autoimmune phenomena, notably the emergence of thyroid antibodies. The fact that some children required hormone replacement underlines the need of close monitoring in particularly those who respond to therapy and have to be treated for more than 6 mo.

关键词： Hepatitis C treatment Children Thyroiddysfunction Autoantibodies

Atlas of Oocytes, Zygotes and Embryos in Reproductive Medicine 1

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2012年

作者： Marc Van den Bergh Thomas Ebner Kay Elder

ISBN: (数字)9781139512183

ISBN: (纸本)9781139512183

The assessment and selection of oocytes and embryos is fundamental to the live birth rate data of all IVF units, the parameter that is used to gauge a clinic's success and credibility. This new atlas contains over 1000 high-quality images of oocytes, zygotes and embryos, presented with accompanying data on indications for treatment, stimulation type and duration, as well as short medical histories of each couple and final outcome of treatment. All images in the book can be downloaded from the accompanying CD-ROM. Structured on a patient-by-patient basis, the atlas describes 100 clinically documented case studies that follow the evolution of oocytes and zygotes between day two and day five. Pronuclear morphology and synchrony as well as embryo morphology are reported and described for each case. Written and produced by experienced embryologists, this practical atlas is an important resource for clinical embryologists and physicians in reproductive medicine.

关键词：妇产科学

来源：畅想之星图书光盘版（南... 评论

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新生儿输尿管囊肿的超声显像

放射学实践 1993年第4期8卷 167-172页

作者： K.Rager 李林 Chefarzt der kinderklinik Caritaskrankenhaus 6990 Bad Mergentheim. 同济医科大学附属同济医院

小儿输尿管囊肿一般在肾盂积水出现时才能作出诊断。随着应用超声技术诊断产前和产后的排尿障碍,在新生儿期就可以作出输尿管囊肿的诊断。异位输尿管囊肿以合并重肾结构者最为常见,重肾的头部引流入异位的输尿管囊肿。迄今为止,输尿管... 详细信息

小儿输尿管囊肿一般在肾盂积水出现时才能作出诊断。随着应用超声技术诊断产前和产后的排尿障碍,在新生儿期就可以作出输尿管囊肿的诊断。异位输尿管囊肿以合并重肾结构者最为常见,重肾的头部引流入异位的输尿管囊肿。迄今为止,输尿管囊肿的诊断通常是在出现尿路感染、发展到尿潴留状态。文献报道新生儿输尿管囊肿的病例很少。在这些病例中,尿潴留状态已在产前经超声波检查证实。本文报道超声检查显示新生儿输尿管囊肿的可能性。

关键词：输尿管囊肿新生儿超声波诊断

Percutaneous endoscopic gastrostomy and gastrooesophageal reflux in neurologically impaired children

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World Journal of Gastroenterology 2011年第2期17卷 191-196页

作者： Mike Thomson Prithviraj Rao David Rawat Tobias G Wenzl Centre for Paediatric Gastroenterology Royal Free and University College Medical School Centre for Paediatric Gastroenterology Sheffield Childrens NHS TrustWestern BankSheffieldS10 2TH United Kingdom kinderklinik Universittsklinikum Aachen

AIM:To investigate the effects of percutaneous endoscopic gastrostomy(PEG) feeding on gastro-oesophageal reflux(GOR) in a group of these children using combined intraluminal pH and multiple intraluminal impedance(pH/MII) . METHODS:Ten neurologically impaired children underwent 12 h combined pH/MII procedures at least 1 d before and at least 12 d after PEG placement. METHODS:Prior to PEG placement(pre-PEG) a total of 183 GOR episodes were detected,156(85.2%) were *** PEG placement(post-PEG) a total of 355 episodes were detected,182(51.3%) were *** total number of distal acid reflux events statistically significantly increased post-PEG placement(prePEG total 27,post-PEG total 173,P=0.028) and themean distal pH decreased by 1.1 *** distal reflux index therefore also significantly increased post-PEG [pre-PEG 0.25(0-2) ,post-PEG 2.95(0-40) ].Average proximal pH was lower post-PEG but the within subject difference was not statistically significant(P=0.058) . Median number of non-acid GOR,average reflux height,total acid clearance time and total bolus clearance time were all lower pre-PEG,but not statistically significant. CONCLUSION:PEG placement increases GOR episodes in neurologically impaired children.

关键词： Percutaneous endoscopic gastrostomy Gastro-oesophageal reflux Multiple intraluminal impedance

早产儿脑萎缩的超声诊断结果与神经发育结果相关

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世界核心医学期刊文摘（儿科学分册） 2006年第6期2卷 8-9页

作者： Horsch S. Muentjes C. Franz A. Roll C. 朱新菊 Universit ts-kinderklinik Hufelandstr. 55 D-45122 Essen Germany

Abstract Abstract Background: Intraventricular haemorrhage and periventricular leukomalacia are associated with poor outcome of very preterm infants, while the role of more subtle cerebral alterations, as detected by cranial ultrasound, is less clear. Aim: In this study, we related periventricular echodensities and signs of brain atrophy to neurodevelopmental outcome at 3 y of age. Patients and methods: All preterm infants born in 1997 in our institution with a gestational age 7 d. At discharge, 18 infants (22%) had signs of brain atrophy. Neurodevelopmental outcome was assessed in 64 infants. Infants with signs of brain atrophy scored significantly lower on MDI (atrophy 91.8, no atrophy 101.9; P = 0.02), PDI (atrophy 91.4, no atrophy 106.5; P = 0.001) and Behaviour Rating Scale (atrophy 41.1, no atrophy 66.4; P = 0.01) than infants without atrophy. Periventricular echodensities were not related to outcome. Conclusion: Our data show that infants with sonographic signs of brain atrophy at discharge achieve lower scores in neurodevelopmental testing at 3 y.

关键词：超声检查神经发育脑萎缩早产儿诊断结果脑室周围白质软化行为评定量表脑室内出血预后不良微小病变

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新生儿成熟度和产后日龄对血清钾水平的影响

中国当代儿科杂志 2000年第1期2卷 4-7页

作者：肖昕 Karl Bauer Hans Versmold 暨南大学医学院附属第一医院儿科广州510632 kinderklinik und Poliklinik Universitatsklinikum Benjamin Franklin kinderklinik und Poliklinik Universitatsklinikum Benjamin Franklin

目的　探讨新生儿成熟度和产后日龄对血清钾浓度的影响。方法　回顾性分析了胎龄为 2 4～ 2 8周 (A组 ) ,2 9～ 3 2周 (B组 ) ,3 3～ 3 6周 (C组 )和 3 7～ 4 2周 (D组 )新生儿生后 1～ 72h内的血清钾水平及其变化。结果　①新生儿的胎... 详细信息

目的　探讨新生儿成熟度和产后日龄对血清钾浓度的影响。方法　回顾性分析了胎龄为 2 4～ 2 8周 (A组 ) ,2 9～ 3 2周 (B组 ) ,3 3～ 3 6周 (C组 )和 3 7～ 4 2周 (D组 )新生儿生后 1～ 72h内的血清钾水平及其变化。结果　①新生儿的胎龄、体重和尿量与血清钾水平存在着线性关系。②生后 1～ 2 4h ,A组新生儿的血清钾水平最高 ,B组次之 ,C和D组相当 ,为最低。生后 4 8h内 ,A和B组的血清钾水平开始下降 ,并于 72h内下降至C和D组新生儿水平。C和D组新生儿生后 72h内的血清钾水平无明显变化。③A ,B和C组早产儿生后 2 4h内高钾血症 (≥7.0mmol/L)发生率分别为 2 0 .0 % ,12 .5%和 4 .0 % ;2 4例高钾血症患儿经常规治疗后 ,14例 (58.3 % )于 72h内血钾降至 7.0mmol/L以下并存活 ;10例 (4 1.7% )高钾血症状态持续存在 ,其中 7例死亡。D组足月儿于生后 72h内未出现高钾血症。结论　新生儿的成熟度和产后胎龄影响血清钾水平 ;极不成熟新生儿 (2 4～ 3 2周 )在生后 2 4h内具有较高的血清钾水平 ,继之随生后日龄的增加而降低 ;早产儿可有致命性高钾血症存在 ,常规治疗仅部分有效。

关键词：新生儿高钾血症成熟度产后日龄