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Convertibility in Multi-Goal and Multi-Objective Optimization

American Journal of Operations Research 2022年第1期12卷 11-17页

作者： Sukriti Gangwar Chandra Sen verily life sciences San Francisco USA Department of Agricultural Economics Institute of Agricultural Sciences Banaras Hindu University Varanasi India

Multi-goal and multi-objective optimizations are similar techniques to achieve multiple conflicting goals/objectives simultaneously. There are several techniques for solving multi-goal and multi-objective optimization problems. The present study proposed the possibility of convertibility in solving multi-goal and multi-objective optimization problems.

关键词： Multi-Goal Optimization Multi-Objective Optimization Individual Optimization

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MiR-27a Promotes Hepatocellular Carcinoma Cell Proliferation Through Suppression of its Target Gene Peroxisome Proliferator-activated Receptor γ

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Chinese Medical Journal 2015年第7期128卷 941-947页

作者： Shuo Li Jing Li Bing-Yuan Fei Dan Shao Yue Pan Zhan-Hao MO Bao-Zhen Sun Dan Zhang Xiao Zheng Ming Zhang Xue-Wen Zhang Li Chen Department of Hepatobiliary and Pancreatic Surgery China-Japan Union Hospital Jilin University Changchun Jilin 130021 China Department of Pharmacology Nanomedicine Engineering Laboratory of Jilin Province College of Basic Medical Sciences Jilin University Changchun Jilin 130021 China Department of General Surgery China-Japan Union Hospital Jilin University Changchun Jilin 130021 China Endoscopy Center China-Japan Union Hospital Jilin University Changchun Jilin 130021 China

Background： MicroRNAs （miRNAs） function as essential posttranscriptional modulators ofgene expression, and are involved in a wide range of physiologic and pathologic states, including cancer. Numerous miRNAs are deregulated in hepatocellular carcinoma （HCC）. This study aimed to investigate the role of miR-27a in the development of HCC. Methods： The expression of MiR-27a was measured by quantitative real-time polymerase chain reaction （qRT-PCR）. 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide was used to examine changes in the viability of HepG2, Bel-7402, Bel-7404 hepatoma cell lines associated with up-regulation or down-regulation of miR-27a. A dual-luciferase activity assay was used to verily a target gene ofmiR-27a, lmmunohistochemistry, qRT-PCR, Western blotting analysis, and cell cycle and apoptosis flow cytometric assays were used to elucidate the mechanism by which miR-27a modulates liver cancer cell proliferation. Results： The expression of miR-27a was significantly increased in HCC tissues and HepG2, Bel-7402, Bel-7404 hepatoma cell lines （P 〈 0.05）. We also found that the down-regulation of miR-27a in HepG2 cells dramatically inhibited proliferation, blocked the G1 to S cell cycle transition and induced apoptosis （P 〈 0.05）. In addition, miR-27a directly targeted the 3＇-untranslated region of peroxisonae proliferator-activated receptor y （PPAR-γ）, and ectopic miR-27a expression suppressed PPAR-γ expression on the mRNA and protein levels. The rosiglitazone-induced overexpression of PPAR-γ attenuated the effect of miR-27a in HCC cells. Conclusions： Our findings suggested that miRNA-27a promoted HCC cell proliferation by regulating PPAR-γ expression. MiR-27a may provide a potential therapeutic strategy for HCC treatment.

关键词： Cell Proliferation Hepatocellular Carcinoma: MiR-27a: Peroxisonle Proliferator-activated Receptor γ

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