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The change of anterior segment parameters after cataract surgery in normal-tension glaucoma

International Journal of Ophthalmology(English edition) 2017年第8期10卷 1239-1245页

作者： Wonseok Lee Hyoung Won Bae Chart Yun Kim Gong Je Seong Institute of vision Research Department of OphthalmologYonsei University College of Medicine Seou103722 Korea

AIM： To investigate the change of anterior chamber angle morphology and intraocular pressure （lOP） reduction after cataract surgery in patients with normal-tension glaucoma （NTG） using swept-source optical coherence tomography （SS-OCT）. METHODS： This prospective, comparative, observational study recruited patients into two groups. Group 1 was the control group including normal subjects except those with cataracts （cataract group, n=67 eyes of 67 patients）, and group 2 was NTG group including patients who were diagnosed with NTG and cataracts （n=43 eyes of 43 patients）, which were treated with phacoemulsification and intraocular lens implantation. Before surgery, and at postoperative 1 and 6too, anterior chamber angles were evaluated by SS-OCT under dark conditions using three- dimensional angle analysis scan protocol. Angle opening distance （AOD）, angle recess area （ARA）, and trabecular- iris surface area （TISA） at four quadrants （temporal, nasal, superior, and inferior） were calculated automatically by SS-OGT, after the observer marked scleral spurs. RESULTS： A total of 106 patients （54 males and 52 females） were enrolled in the study. Angle parameters, AOD, ARA, and TISA were increased after surgery in both groups. However, changes of angle parameters were only significant in group 2. In group 2, preoperative lOP was 13.2＋2.9 mm Hg, and postoperative lOP at 1 and 6mo were 10.5＋3.0 and 10.7＋2.8 mm Hg, respectively. In group 1, preoperative lOP was 12.42.8 mm Hg, and postoperative lOP at 1 and 6mo were 11.6＋2.5 and 12.0＋2.8 mm Hg, respectively. After cataract surgery, angle parameters changed significantly while IOP significantly reduced and was maintained in group 2 （P〈0.001）. The changes in angle parameters （＆AOD500, ATISAS00 at temporal; ＆AOD500, S, RA500 at nasal） were linearly correlated with postoperative IOP changes. CONCLUSION： Cataract surgery may have improved antedor chamber angle parameters and decreased lOP in NTG patients.

关键词： normal-tension glaucoma cataract surgery intraocular pressure reduction swept-source optical coherence tomography angle parameters

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Cell replacement with stem cell-derived retinal ganglion cells from different protocols

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Neural Regeneration Research 2024年第4期19卷 807-810页

作者： Ziming Luo Kun-Che Chang Spencer Center for vision Research Byers Eye InstituteStanford University School of Medicine Department of Ophthalmology Louis J.Fox Center for Vision RestorationUniversity of Pittsburgh School of Medicine Department of Neurobiology Center of NeuroscienceUniversity of Pittsburgh School of Medicine

Glaucoma,characterized by a degenerative loss of retinal ganglion cells,is the second leading cause of blindness *** is currently no cure for vision loss in glaucoma because retinal ganglion cells do not regenerate and are not replaced after *** stem cell-derived retinal ganglion cell transplant is a potential therapeutic strategy for retinal ganglion cell degenerative *** this review,we first discuss a 2D protocol for retinal ganglion cell differentiation from human stem cell culture,including a rapid protocol that can generate retinal ganglion cells in less than two weeks and focus on their transplantation ***,we discuss using 3D retinal organoids for retinal ganglion cell transplantation,comparing cell suspensions and *** review provides insight into current knowledge on human stem cell-derived retinal ganglion cell differentiation and transplantation,with an impact on the field of regenerative medicine and especially retinal ganglion cell degenerative diseases such as glaucoma and other optic neuropathies.

关键词： cell clumps cell suspension cell transplantation differentiation direct-induced protocol glaucoma optic neuropathy regenerative medicine retinal ganglion cell retinal organoids stem cells

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Rethinking random Hough Forests for video database indexing and pattern search

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Computational Visual Media 2016年第2期2卷 143-152页

作者： Craig Henderson Ebroul Izquierdo Multimedia and vision Research Group School of Electronic Engineering and Computer ScienceQueen Mary University of London

Hough Forests have demonstrated effective performance in object detection tasks, which has potential to translate to exciting opportunities in pattern search. However, current systems are incompatible with the scalability and performance requirements of an interactive visual search. In this paper, we pursue this potential by rethinking the method of Hough Forests training to devise a system that is synonymous with a database search index that can yield pattern search results in near real time. The system performs well on simple pattern detection, demonstrating the concept is ***, detection of patterns in complex and crowded street-scenes is more challenging. Some success is demonstrated in such videos, and we describe future work that will address some of the key questions arising from our work to date.

关键词： Hough Forests pattern detection pattern search machine learning

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Movie therapy for children with amblyopia:restoring binocular vision with brain plasticity

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Science China(Life Sciences) 2022年第3期65卷 654-656页

作者： Bernhard A.Sabel Dennis M.Levi Institute of Medical Psychology Medical FacultyOtto-v.-Guericke University of MagdeburgMagdeburg 39120Germany Herbert Wertheim School of Optometry&vision Science and Helen Wills Neuroscience Institute University of CaliforniaBerkeley CA 94720USA

Amblyopia is a common neurodevelopmental disorder that occurs when the two eyes do not send well matched visual signals to the brain early in *** mismatch of the information coming from both eyes can have different causes:it may be due to differences in image clarity or contrast(called"anisometropia")because the two eyes require different corrective lens powers.

关键词： Movie matched visual

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Unseen head pose prediction using dense multivariate label distribution

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Frontiers of Information Technology & Electronic Engineering 2016年第6期17卷 516-526页

作者： Gao-li SANG Hu CHEN Ge HUANG Qi-jun ZHAO State Key Laboratory of Fundamental Science on Synthetic vision College of Computer ScienceSichuan University College of Mathematics and Information Engineering Jiaxing University

Accurate head poses are useful for many face-related tasks such as face recognition, gaze estimation,and emotion analysis. Most existing methods estimate head poses that are included in the training data(i.e.,previously seen head poses). To predict head poses that are not seen in the training data, some regression-based methods have been proposed. However, they focus on estimating continuous head pose angles, and thus do not systematically evaluate the performance on predicting unseen head poses. In this paper, we use a dense multivariate label distribution(MLD) to represent the pose angle of a face image. By incorporating both seen and unseen pose angles into MLD, the head pose predictor can estimate unseen head poses with an accuracy comparable to that of estimating seen head poses. On the Pointing'04 database, the mean absolute errors of results for yaw and pitch are 4.01?and 2.13?, respectively. In addition, experiments on the CAS-PEAL and CMU Multi-PIE databases show that the proposed dense MLD-based head pose estimation method can obtain the state-of-the-art performance when compared to some existing methods.

关键词： Head pose estimation Dense multivariate label distribution Sampling intervals Inconsistent labels

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Development of color density concept with color difference formulas in respect to human vision system

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Frontiers of Electrical and Electronic Engineering in China 2011年第2期6卷 381-387页

作者： Arto KAARNA Wei LIU Heikki KALVIAINEN Machine vision and Pattern Recognition Laboratory Department of Information TechnologyFaculty of Technology ManagementLappeenranta University of TechnologyP.O.Box 20FI-53851 LappeenrantaFinland

The aims of this study are to develop the color density concept and to propose the color density based color difference *** color density is defined using the metric coefficients that are based on the discrimination ellipses and the locations of the colors in the color *** ellipse sets are the MacAdam ellipses in the CIE 1931 xy-chromaticity diagram and the chromaticity-discrimination ellipses in the CIELAB *** latter set was originally used to develop the CIEDE2000 color difference *** color difference can be calculated from the color density for the two colors under *** a result,the color density represents the perceived color difference more accurately,and it could be used to characterize a color by a quantity attribute matching better to the perceived color difference from this *** from this,the color density concept provides simply a correction term for the estimation of the color *** the experiments,the line element formula and the CIEDE2000 color difference formula performed better than the color density based difference *** reason behind this is in the current modeling of the color density *** discrimination ellipses are typically described with three-dimensional data consisting of two axes,the major and the minor,and the inclination *** proposed color density is only a one-dimensional corrector for color differences;thus,it cannot capture all the details of the ellipse ***,the color density gives clearly more correct estimations to perceived color differences than Euclidean distances using directly the coordinates of the color space.

关键词： color density discrimination ellipses color difference formulas color vision

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Binocular treatment of amblyopia:from the laboratory to clinical trials

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Annals of Eye Science 2019年第1期4卷 57-59页

作者： Benjamin thompson School of Optometry and vision Science University of WaterlooWaterlooCanada

Over the last 10 years,numerous psychophysical studies have indicated that binocular mechanisms are structurally intact but functionally suppressed in amblyopia(1-8).Many of these studies have used a contrast balancing approach,whereby the contribution of each eye to binocular vision is equated or“balanced”by presenting higher contrast stimulus elements to the amblyopic eye than the fellow eye(6).Using this approach,the strength of suppression can be quantified by measuring the magnitude of interocular contrast difference required for normal binocular *** suppression strength has been correlated with other clinical measures,stronger suppression has been associated with worse stereoacuity and worse amblyopic eye visual acuity indicting a link between the monocular and binocular deficits in amblyopia(5,7).

关键词： strength suppression clinical

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Simulation of thermal field induced by concave spherical transducer in multi-layer media

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Journal of Central South University 2013年第11期20卷 3166-3170页

作者：丁亚军钱盛友廖志远 Institute of Image Recognition and Computer vision Hunan Normal University College of Physics and Information Science Hunan Normal University

High intensity focused ultrasound(HIFU)therapy is an effective method in clinical treatment of tumors,in order to explore the bio-heat conduction mechanism of in multi-layer media by concave spherical transducer,temperature field induced by this kind of transducer in multi-layer media will be simulated through solving Pennes equation with finite difference method,and the influence of initial sound pressure,absorption coefficient,and thickness of different layers of biological tissue as well as thermal conductivity parameter on sound focus and temperature distribution will be analyzed,*** results show that the temperature in focus area increases faster while the initial sound pressure and thermal conductivity *** absorption coefficient is smaller,the ultrasound intensity in the focus area is bigger,and the size of the focus area is *** the thicknesses of different layers of tissue change,the focus position changes slightly,but the sound intensity of the focus area will change *** temperature in focus area will rise quickly before reaching a threshold,and then the temperature will keep in the threshold range.

关键词： multi-layer media concave spherical transducer high intensity focused ultrasound thermal field

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Reversibility of visual field defects through induction of brain plasticity: vision restoration, recovery and rehabilitation using alternating current stimulation

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Neural Regeneration Research 2020年第10期15卷 1799-1806页

作者： Bernhard A.Sabel Ying Gao Andrea Antal Institute of Medical Psychology Medical FacultyOtto-von-Guericke University of MagdeburgMagdeburgGermany Center for Behavioral and Brain Sciences(CBBS) MagdeburgGermany Sabel vision Restoration Center MagdeburgGermany Department of Clinical Neurophysiology University Medical Center GottingenGottingenGermany

For decades visual field defects were considered irreversible because it was thought that in the visual system the regeneration potential of the neuronal tissues is ***,there is always some potential for partial recovery of the visual field defect that can be achieved through induction of *** refers to the ability of the brain to change its own functional architecture by modulating synaptic *** is maintained throughout life and just as neurological rehabilitation can improve motor coordination,visual field defects in glaucoma,diabetic retinopathy or optic neuropathy can be improved by inducing *** ophthalmology many new treatment paradigms have been tested that can induce neuroplastic changes,including non-invasive alternating current *** with alternating current stimulation(e.g.,30 minutes,daily for 10 days using transorbital electrodes and^10 Hz)activates the entire retina and parts of the *** and functional magnetic resonance imaging studies revealed local activation of the visual cortex,global reorganization of functional brain networks,and enhanced blood flow,which together activate neurons and their *** future of low vision is optimistic because vision loss is indeed,partially reversible.

关键词： alternating current stimulation glaucoma low vision optic nerve rehabilitation recovery stress vision vision restoration therapy visual field

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Metalloproteinases as mediators of inflammation and the eyes： molecular genetic underpinnings governing ocular pathophysiology

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International Journal of Ophthalmology(English edition) 2017年第8期10卷 1308-1318页

作者： Mahavir Singh Suresh C Tyagi Eye and vision Science Laboratory Department of Physiology University of Louisville School of Medicine Louisville KY 40202 USA

There are many vision threatening diseases of the eye affecting millions of people worldwide. In this article, we are summarizing potential role of various matrix metalloproteinases （MMPs）; the Zn （2＋）-dependent endoproteases in eye health along with pathogenesis of prominent ocular diseases such as macular degeneration, diabetic retinopathy, and glaucoma via understanding MMPs regulation in affected patients, interactions of MMPs with their substrate molecules, and key regulatory functions of tissue inhibitor of metalloproteinases （TIMPs） towards maintaining overall homeostasis.

关键词： age-related macular degeneration choroidal neovascularization diabetes glaucoma metalloproteinases tissue inhibitors of metalloproteinases

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