检索结果-南通市图书馆

The prolactin receptor(PRLR)gene is linked to and associated with the comorbidity of depression and type 2 diabetes in Italian families

引用

Genes & Diseases 2024年第3期11卷 15-17页

作者： Mutaz Amin Rongling Wu Teodor T.Postolache Claudia Gragnoli INSERM US14-OrphanetParis 75014France University of Paris Paris 75013France Department of Biochemistryand Molecular Biology Faculty of MedicineAl-Neelain UniversityKhartoum 11121Sudan Department of Public Health Sciences Penn State College of MedicineHersheyPA 17033USA Department of Statistics Penn State College of MedicineHersheyPA 17033USA Mood and Anxiety Program Department of PsychiatryUniversity of Maryland School of MedicineBaltimoreMD 21201USA rocky mountain mental illness research education and clinical center(MIRECC) Veterans Integrated Service Network(VISN)19Military and Veteran Microbiome:Consortium for Research and Education(MVM-CoRE)DenverCO80246USA mental illness research education and clinical center(MIRECC) Veterans Integrated Service Network(VISN)5VA Capitol Health Care NetworkBaltimoreMD 21090USA Division of Endocrinology Department of MedicineCreighton University School of MedicineOmahaNE 68124USA Molecular Biology Laboratory Bios Biotech Multi-Diagnostic Health CenterRome 00197Italy

Major depressive disorder(MDD)and type 2 diabetes(T2D)are two common complex multifactorial disorders that share several genetic and environmental risk factors such as hypercortisolism and related genes'riskvariants within the stress response and the neuroendocrine hypothalamicpituitary *** stress,the pituitary gland releases prolactin(PRL),whose effects are pleiotropic and include mood control and insulin secretion from the beta cells.1 Variations in the prolactin receptor(PRLR)gene are associated in rodent models with stress level,depressionlike behavior,2 and hepatic insulin sensitivity3 and in humans with maternal glucose homeostasis and gestational diabetes.

关键词： diabetes prolactin pituitary

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The role of melatonin receptor 1B gene(MTNR1B)in the susceptibility to depression and type 2 diabetes comorbidity

引用

Genes & Diseases 2024年第3期11卷 113-115页

作者： Mutaz Amin Benjamin Rafla Rongling Wu Teodor T.Postolache Cclaudia Gragnoli INSERM US14-OrphanetParis 75014France Department of Biochemistry and Molecular Biology Faculty of MedicineAl-Neelain UniversityKhartoum 11121Sudan Division of Endocrinology Department of MedicineCreighton University School of MedicineOmahaNE 68124USA Department of Public Health Sciences Penn State College of MedicineHersheyPA 17033USA Department of Statistics Penn State College of MedicineHersheyPA 17033USA Mood and Anxiety Program Department of PsychiatryUniversity of Maryland School of MedicineBaltimoreMD 21201USA rocky mountain mental llness research education and clinical center(MIRECC) Veterans Integrated Service Network(VISN)19Military and Veteran Microbiome:Consortium for Research and Education(MVM-CoRE)DenverCO 80246USA mental Ilness research education and clinical center(MIRECC) Veterans Integrated Service Network(VISN)5VA Capitol Health Care NetworkBaltimoreMD 21090USA Molecular Biology Laboratory Bios Biotech Multi-Diagnostic Health CenterRome00197Italy

Melatonin is an endogenous monoamine hormone secreted by the pineal *** signaling has been shown to play a role in circadian rhythm regulation,lipid and glucose metabolism,and obesity,and it has anti-inflammatory and antioxidant *** melatonin receptor 1B gene(MTNR1B)is expressed in,among other tissues,the brain and pancreatic beta cells,and risk variants for T2D have been reported as impairing early insulin secretion and increasing fasting glucose levels.^(1) Variants in the MTNR1B gene also have been reported in patients with depression(MDD).

关键词： MTNR1B metabolism properties.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light treatment for seasonal Winter depression in African-American vs Caucasian outpatients

引用

World Journal of Psychiatry 2015年第1期5卷 138-146页

作者： Hyacinth N Uzoma Gloria M Reeves Patricia Langenberg Baharak Khabazghazvini Theodora G Balis Mary A Johnson Aamar Sleemi Debra A Scrandis Sarah A Zimmerman Dipika Vaswani Gagan Virk Nijjar Johanna Cabassa Manana Lapidus Kelly J Rohan Teodor T Postolache Department of Psychiatry University of Maryland School of MedicineBaltimoreMD 21201-1549United States Psychiatry Residency Training Program St.Elizabeth’s HospitalWashingtonDC 20032United States Department of Epidemiology and Preventive Medicine University of Maryland School of MedicineBaltimoreMD 21201-1549United States Department of Ophthalmology and Visual Science University of Maryland School of MedicineBaltimoreMD 21201-1549United States Family and Community Health University of Maryland School of NursingBaltimoreMD 21201-1549United States Department of Psychological Science University of VermontBurlingtonVT 05405-0134United States visn 5 Capitol Health Care Network mental illness research education and clinical center BaltimoreMD 21201United States visn 19 rocky mountain mental illness research education and clinical center DenverCO 80220United States 不详

AIM: To compare adherence, response, and remission with light treatment in African-American and Caucasian patients with Seasonal Affective ***: Seventy-eight study participants, agerange 18-64(51 African-Americans and 27 Caucasians)recruited from the Greater Baltimore Metropolitan area, with diagnoses of recurrent mood disorder with seasonal pattern, and confirmed by a Structured clinical Interview for the Diagnostic and Statistical Manual of mental Disorders-Ⅳ, were enrolled in an open label study of daily bright light treatment. The trial lasted6 wk with flexible dosing of light starting with 10000 lux bright light for 60 min daily in the morning. At the end of six weeks there were 65 completers. Three patients had Bipolar Ⅱ disorder and the remainder had Major depressive disorder. Outcome measures were remission(score ≤ 8) and response(50% reduction)in symptoms on the Structured Interview Guide for the Hamilton Rating Scale for Depression(SIGH-SAD)as well as symptomatic improvement on SIGH-SAD and Beck Depression Inventory-Ⅱ. Adherence was measured using participant daily log. Participant groups were compared using t-tests, chi square, linear and logistic regressions. RESULTS: The study did not find any significant group difference between African-Americans and their Caucasian counterparts in adherence with light treatment as well as in symptomatic *** symptomatic improvement and rate of treatment response were not different between the two groups,African-Americans, after adjustment for age, gender and adherence, achieved a significantly lower remission rate(African-Americans 46.3%; Caucasians 75%; P =0.02).CONCLUSION: This is the first study of light treatment in African-Americans, continuing our previous work reporting a similar frequency but a lower awareness of SAD and its treatment in African-Americans. Similar rates of adherence, symptomatic improvement and treatment response suggest that light treatment is a feasible, acceptable,

关键词： Seasonal affective disorder Depression Light treatment African-American Black Remission gap Ethnicity Race

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：