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Viral vector platforms within the gene therapy landscape

Signal Transduction and Targeted Therapy 2021年第3期6卷 664-687页

作者： Jote T.Bulcha Yi Wang Hong Ma Phillip W.L.Tai Guangping Gao Horae Gene Therapy Center University of Massachusetts Medical SchoolWorcesterMAUSA Department of Microbiology and Physiological Systems University of Massachusetts Medical SchoolWorcesterMAUSA Department of Pathophysiology West China College of Basic medical sciences&Forensic MedicineSichuan UniversityChengduChina vide program University of Massachusetts Medical SchoolWorcesterMAUSA Li Weibo Institute for Rare Diseases Research University of Massachusetts Medical SchoolWorcesterMAUSA

Throughout its 40-year history,the field of gene therapy has been marked by many *** has seen great strides in combating human disease,has given hope to patients and families with limited treatment options,but has also been subject to many *** of patients with this class of investigational drugs has resulted in severe adverse effects and,even in rare cases,*** the heart of this dichotomous field are the viral-based vectors,the delivery vehicles that have allowed researchers and clinicians to develop powerful drug platforms,and have radically changed the face of *** the past 5 years,the gene therapy field has seen a wave of drugs based on viral vectors that have gained regulatory approval that come in a variety of designs and purposes,these modalities range from vector-based cancer therapies,to treating monogenic diseases with life-altering *** present,the three key vector strategies are based on adenoviruses,adeno-associated viruses,and *** have led the way in preclinical and clinical successes in the past two ***,despite these successes,many challenges still limit these approaches from attaining their full *** review the viral vector-based gene therapy landscape,we focus on these three highly regarded vector platforms and describe mechanisms of action and their roles in treating human disease.

关键词： drugs landscape approval

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Aging gracefully: social engagement joins exercise and enrichment as a key lifestyle factor in resistance to age-related cognitive decline

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Neural Regeneration Research 2019年第1期14卷 39-42页

作者： Tyler J.Dause Elizabeth D.Kirby Department of Psychology The Ohio State University Department of Neuroscience The Ohio State University Chronic Brain Injury program The Ohio State University

Cognitive impairment is a consequence of the normal aging process that effects many species, including humans and rodent models. Decline in hippocampal memory function is especially prominent with age and often reduces quality of life. As the aging population expands, the need for interventional strategies to prevent cognitive decline has become more pressing. Fortunately, several major lifestyle factors have proven effective at combating hippocampal aging, the most well-known of which are environmental enrichment and exercise. While the evidence supporting the beneficial nature of these factors is substantial, a less well-understood factor may also contribute to healthy cognitive aging: social engagement. We review the evidence supporting the role of social engagement in preserving hippocampal function in old age. In elderly humans, high levels of social engagement correlate with better hippocampal function, yet there is a dearth of work to indicate a causative role. Existing rodent literature is also limited but has begun to provide causative evidence and establish candidate mechanisms. Summed together, while many unanswered questions remain, it is clear that social engagement is a viable lifestyle factor for preserving cognitive function in old age. Social integration across the lifespan warrants more investigation and more appreciation when designing living circumstances for the elderly.

关键词： aging age-related cognitive decline social engagement hippocampus cognitive enrichment exercise memory neurogenesis

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Spatial relationship of tertiary lymphoid structures and tumor-associated neutrophils in bladder cancer and prognostic potential for anti-PD-L1 immunotherapy

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Cancer Communications 2024年第4期44卷 499-503页

作者： Xuechun Wang Anna Juncker-Jensen Gang Huang Mate Levente Nagy Xuemin Lu Liang Cheng Xin Lu Department of Biological Sciences Boler-Parseghian Center for Rare and Neglected DiseasesHarper Cancer Research InstituteUniversity of Notre DameNotre DameINUSA NeoGenomics Laboratories Inc.Aliso ViejoCAUSA Department of Pathology and Laboratory Medicine Brown University Warren Alpert Medical SchoolLifespan Academic Medical CenterLegorreta Cancer Center at Brown UniversityProvidenceRIUSA Tumor Microenvironment and Metastasis program Indiana University Melvin and Bren Simon Comprehensive Cancer CenterIndianapolisINUSA

Dear Editor,Tertiary lymphoid structures(TLSs)are organized clus-ters of immune cells found in non-lymphoid tissues of chronic inflammation,including solid tumors[1].High endothelial venules(HEVs)positive for peripheral node addressin(PNAd)are present in TLSs and may pro-vide highway entry for ***-residing TLSs may be formed by the concerted actions of cytokines and chemokines,a finding supported by the relation between a 12-chemokine signature and TLSs[2].

关键词： bladder lymphoid inflammation

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