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Neuroscience Bulletin 2023年第1期39卷 163-166页

作者： William A.Mills III Ukpong B.Eyo Brain Immunology and Glia Center University of VirginiaCharlottesvilleVA22903USA Department of Neuroscience University of VirginiaCharlottesvilleVA22903USA Robert M.Berne Cardiovascular Research Center University of VirginiaCharlottesvilleVA22903USA

Microglia were long hailed as solely infammatory cells,and though they are responsible for the brain's immuneresponse,they perform a variety of neuroprotective func-tions including the clearance of cellular and toxic debris^([1]).One toxic molecule known to be cleared by microglia isthe protein aggregate found in Alzheimer's Disease(AD),amyloid-B.

关键词： protective degeneration Alzheimer

Luminescent metal-halide perovskites:fundamentals,synthesis,and light-emitting devices

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Science China Chemistry 2024年第6期67卷 1776-1838页

作者： Kang Wang Jeong Hui Kim Jie Yang Xiaoke Liu Yixuan Dou Yuxuan Li Weijian Tao Haiyun Dong Haiming Zhu Kaifeng Wu Li Na Quan Feng Gao Jianpu Wang Letian Dou Yong Sheng Zhao Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of PhotochemistryInstitute of ChemistryChinese Academy of SciencesBeijing100190China Davidson School of Chemical Engineering Purdue UniversityWest LafayetteIN47907USA School of Chemical Sciences University of Chinese Academy of SciencesBeijing100049China Key Laboratory of Flexible Electronics(KLOFE) Institute of Advanced Materials(IAM)&School of Flexible Electronics(Future Technologies)Nanjing Tech University(NanjingTech)Nanjing211816China Department of Physics Linköping UniversityLinköping58183Sweden Department of Chemistry Virginia TechBlacksburgVA24060USA State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China Department of Chemistry Zhejiang UniversityHangzhou310058China Changzhou University Changzhou213164China Department of Chemistry Purdue UniversityWest LafayetteIN47907USA

Metal-halide perovskites have garnered considerable research attention as highly efficient light emitters in recent years due to their outstanding optoelectronic properties with remarkable tunability and excellent solution *** advancements have been achieved in the development of novel halide perovskites,and the exploitations of these materials in lightemitting *** review comprehensively outlines recent breakthroughs in metal-halide perovskites,encompassing the rational design of perovskite materials with tunable light emission properties,the controllable growth of single crystal for a deeper understanding of their structure-property relationships,as well as the fundamental insights into the photophysics and carrier dynamics in perovskite ***,it provides an overview of recent applications of perovskite materials in high-performance light-emitting diodes(LEDs)and lasers.

关键词： metal-halide perovskites perovskite luminescent materials perovskite synthesis excited-state processes perovskite light-emitting diodes perovskite lasers

Long-term effect of intrathecal baclofen treatment on bone health and body composition after spinal cord injury:A case matched report

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World Journal of Orthopedics 2020年第10期11卷 453-464页

作者： Dora E Ifon Mina P Ghatas John C Davis Refka E Khalil Robert A Adler Ashraf S Gorgey Spinal Cord Injury and Disorders Center Central Virginia VA Health Care SystemRichmondVA 23249United States Medical Service Central Virginia VA Health Care SystemRichmondVA 23249United States Department of Internal Medicine Division of EndocrinologyDiabetes and MetabolismVirginia Commonwealth UniversityRichmondVA 23298United States Department of Physical Medicine and Rehabilitation Virginia Commonwealth UniversityRichmondVA 23298United States

BACKGROUND Severe spasticity may negatively impact functionality and quality of life after spinal cord injury(SCI).Intrathecal baclofen treatment(IBT)is effectively used to manage severe spasticity and reduce ***,long-term IBT may have a negative effect on bone mineral content(BMC),bone mineral density(BMD)and body composition(such as percentage fat mass and lean body mass).We demonstrated the negative effects of long-term IBT use in a single case compared with two non-IBT *** SUMMARY A 46-year old Caucasian male Veteran(case)with a 21 year history of complete tetraplegia(complete C6 SCI)was implanted with IBT for 20 *** case was matched to two participants with different time since injuries[2(match 1)and 13(match 2)years]without *** BMC and BMD at the epiphysis and metaphysis of the distal femur and proximal tibia were evaluated using dual knee and the dual femur modules of GE Lunar iDXA *** and leg body composition assessments were also conducted for the three *** effect of long-term IBT was demonstrated by changes in BMD,consistent with bone demineralization,at the distal femur and proximal tibia and changes in percentage fat mass and lean mass of *** case showed 113%lower BMD at the distal femur,and 78.1%lower at the proximal tibia compared to match 1,moreover the case showed 45%lower BMD at the distal femur,and no observed changes at the proximal tibia compared to match *** case had 27.1%and 16.5%greater leg%fat mass compared to match 1 and match 2,***,the case had 17.4%and 11.8%lower%leg lean mass compared to match 1 and match 2,*** Long-term IBT may impact bone health and body composition parameters in persons with complete *** may be prudent to encourage regular screening of individuals on long-term IBT considering the prevalence of osteoporosis related fractures,cardiovascular diseases,and metabolic disorders in this population.

关键词： Intrathecal baclofen Spasticity Bone mineral density Epiphysis Metaphysis Spinal cord injury Case report

Enhancing Communication Accessibility:UrSL-CNN Approach to Urdu Sign Language Translation for Hearing-Impaired Individuals

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 689-711页

作者： Khushal Das Fazeel Abid Jawad Rasheed Kamlish Tunc Asuroglu Shtwai Alsubai Safeeullah Soomro Department of Computer Engineering Modeling Electronics and Systems EngineeringUniversity of CalabriaRende Cosenza87036Italy Department of Information Systems University of Management and TechnologyLahore54770Pakistan Department of Computer Engineering Istanbul Sabahattin Zaim UniversityIstanbul34303Turkey Department of Software Engineering Istanbul Nisantasi UniversityIstanbul34398Turkey Department of Computer Science COMSATS University IslamabadLahore CampusLahore54700Pakistan Faculty of Medicine and Health Technology Tampere UniversityTampere33720Finland Department of Computer Science College of Computer Engineering and Sciences in Al-KharjPrince Sattam Bin Abdulaziz UniversityP.O.Box 151Al-Kharj11942Saudi Arabia Second Department of Computer Science College of Engineering and ComputingGeorge Mason UniversityFairfaxVA 4418USA

Deaf people or people facing hearing issues can communicate using sign language(SL),a visual *** works based on rich source language have been proposed;however,the work using poor resource language is still *** other SLs,the visuals of the Urdu Language are *** study presents a novel approach to translating Urdu sign language(UrSL)using the UrSL-CNN model,a convolutional neural network(CNN)architecture specifically designed for this *** existingworks that primarily focus on languageswith rich resources,this study addresses the challenge of translating a sign language with limited *** conducted experiments using two datasets containing 1500 and 78,000 images,employing a methodology comprising four modules:data collection,pre-processing,categorization,and *** enhance prediction accuracy,each sign image was transformed into a greyscale image and underwent noise *** analysis with machine learning baseline methods(support vectormachine,GaussianNaive Bayes,randomforest,and k-nearest neighbors’algorithm)on the UrSL alphabets dataset demonstrated the superiority of UrSL-CNN,achieving an accuracy of ***,our model exhibited superior performance in Precision,Recall,and F1-score *** work not only contributes to advancing sign language translation but also holds promise for improving communication accessibility for individuals with hearing impairments.

关键词： Convolutional neural networks Pakistan sign language visual language

Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis

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Cellular & Molecular Immunology 2024年第1期21卷 33-46页

作者： Anja Meyer Stephanie R.Zack Wes Nijim Adel Burgos Vishwa Patel Brian Zanotti Michael V.Volin M.Asif Amin Myles J.Lewis Costantino Pitzalis Shiva Arami Joseph A.Karam Nadera J.Sweiss Shiva Shahrara Jesse Brown va Medical Center ChicagoILUSA Department of Medicine Division of RheumatologyThe University of Illinois at ChicagoChicagoILUSA Department of Microbiology and Immunology Midwestern UniversityDowners GroveILUSA Division of Rheumatology and Clinical Autoimmunity Center of Excellence University of MichiganAnn ArborMIUSA Centre for Experimental Medicine and Rheumatology William Harvey Research InstituteBarts and The London School of Medicine and DentistryQueen Mary University of LondonLondonUnited Kingdom Centre for Experimental Medicine&Rheumatology William Harvey Research InstituteQueen Mary University of London and Barts NIHR BRC&NHS TrustLondonUK Department of Biomedical Sciences Humanitas Universityand Humanitas Research HospitalMilanItaly Department of Orthopedic Surgery the University of Illinois at ChicagoChicagoILUSA

A novel rheumatoid arthritis(RA)synovial fluid protein,Syntenin-1,and its receptor,Syndecan-1(SDC-1),are colocalized on RA synovial tissue endothelial cells and fibroblast-like synoviocytes(FLS).Syntenin-1 exacerbates the inflammatory landscape of endothelial cells and RA FLS by upregulating transcription of IRF1/5/7/9,IL-1β,IL-6,and CCL2 through SDC-1 ligation and HIF1α,or mTOR ***,Syntenin-1 orchestrates RA FLS and endothelial cell invasion via SDC-1 and/or mTOR *** Syntenin-1 reprogrammed endothelial cells,the dynamic expression of metabolic intermediates coincides with escalated glycolysis along with unchanged oxidative factors,AMPK,PGC-1α,citrate,and inactive oxidative ***,RA FLS rewired by Syntenin-1 displayed a modest glycolytic-ATP accompanied by a robust mitochondrial-ATP *** enriched mitochondrial-ATP detected in Syntenin-1 reprogrammed RA FLS was coupled with mitochondrial fusion and fission recapitulated by escalated Mitofusin-2 and DRP1 *** found that VEGFR1/2 and Notch1 networks are responsible for the crosstalk between Syntenin-1 rewired endothelial cells and RA FLS,which are also represented in RA *** to RA explants,morphological and transcriptome studies authenticated the importance of VEGFR1/2,Notch1,RAPTOR,and HIF1αpathways in Syntenin-1 arthritic mice and their obstruction in SDC-1 deficient ***,dysregulation of SDC-1,mTOR,and HIF1αnegated Syntenin-1 inflammatory phenotype in RA explants,while inhibition of HIF1αimpaired synovial angiogenic imprint amplified by *** conclusion,since the current therapies are ineffective on Syntenin-1 and SDC-1 expression in RA synovial tissue and blood,targeting this pathway and its interconnected metabolic intermediates may provide a novel therapeutic strategy.

关键词： Syntenin-1 Syndecan-1 RA FLS RA explants immunometabolism

Anti-inflammatory mechanism of electroacupuncture involves the modulation of multiple systems,levels and targets and is not limited to“driving the vagus-adrenal axis”

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Journal of Integrative Medicine 2023年第4期21卷 320-323页

作者： Arthur Yin Fan American TCM Association ViennaVA 22182USA McLean Center for Complementary and Alternative Medicine PLCViennaVA 22182USA

In October 2021,an international collaborative study on the use of electroacupuncture(EA)to treat inflammation was published in the journal Nature by *** Ma’s *** on the results of EA on inflammation in the mouse model of lipopolysaccharide inflammatory storm,the study showed that the distal effect of acupuncture can be achieved by“driving the vagus-adrenal axis(through the adrenal medulla,by releasing catecholamines).”PROKR2Cre-marked sensory neurons,which innervate the deep hindlimb fascia but not the abdominal fascia,are crucial for driving this *** study suggests the existence of specificity distribution of acupoints,that different EA stimulation intensities or different needle penetration depths have different therapeutic effects,that photosensitive stimulation may be a substitute for needle acupuncture,and that massage,stretching and body movements may also activate PROKR2Cremarkable dorsal root ganglion sensory neurons and elicit anti-inflammatory ***,results of some other studies are contrary to the conclusions of Ma’s *** examples:low-intensity EA at GB30 point significantly reduced the inflammation in the rat model of persistent inflammation,which is more relevant to the real daily acupuncture practice,and this effect was partly related to the adrenal cortex and associated with the stimulation of corticosterone and adrenocorticotropic hormone;manual acupuncture(similar to the low-intensity EA)at KI3,Zhichuan point(an extra point),*** effective in a severe COVID-19 patient with sepsis;stimulating ST25 with low-intensity EA or manual acupuncture was effective against gastrointestinal inflammations;the above mentioned points are not in an area enriched with PROKR2Cre-marked sensory nerve *** shows that the mechanism of EA against inflammation includes modulating multi-systems,multi-levels and multi-targets,which does not limit to“driving the vagus-adrenal axis.”

关键词： Electric acupuncture Acupuncture Anti-inflammation Mechanism Adrenal Autonomic nerves

The diffuse ionized gas in the Milky Way galaxy

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Science China(Physics,Mechanics & Astronomy) 2022年第12期65卷 70-71页

作者： Dana S.Balser National Radio Astronomy Observatory Charlottesville VA 22903USA

Existence of a warm(104K),diffuse(0.1 cm^(-3)),ionized gas component in the Galactic disk in our Milky Way was first suggested by Hoyle and Ellis[1]based on low frequency radio continuum *** studies,primarily using H... 详细信息

关键词： primarily Existence galaxy

Using modeling and simulation and artificial intelligence to improve complex adaptive systems engineering

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International Journal of Modeling, Simulation, and Scientific Computing 2022年第2期13卷 70-90页

作者： Andreas Tolk Philip Barry Steven C.Doskey The MITRE Corporation 1001 Research Park Blvd#220 CharlottesvilleVA 22911USA George Mason University 4400 University DrFairfax VA 22030USA The MITRE Corporation 7525 Colshire DrMcLean VA 22102USA

Systems engineering practices are evolving to address fast-changing needs in fielding complex *** needs create an environment in which system needs evolve or change too quickly to be tracked or managed by humans’natural *** propose that systems engineering must aid systems engineering managers by providing architectural alternatives and design ***,as systems become more complex and dynamic,there is an increased need to identify hidden risks,model emergent behav-ior,and expose hidden patterns in the behavior of *** engineering needs to evolve to build fast-fielded,resilient,and adaptive systems that leverage posi-tive reinforcement feedback loops with multiple experimental and real-world information *** very basis of systems engineering must evolve from today’s development paradigms to a future that leverages modeling,simulation,and artificial intelligence to drastically improve the capability and agility for developing new *** paper proposes a common way forward to enable this new form of complex adaptive systems engineering.

关键词： Complex systems digital twin systems engineering

Targeting the m6A mRNA demethylase FTO suppresses vascular endothelial growth factor release and choroidal neovascularization

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Signal Transduction and Targeted Therapy 2023年第3期8卷 905-907页

作者： Shao-bin Wang Yosuke Nagasaka Dionne Argyle Ayami Nagasaka Praveen Yerramothu Bradley DGelfand Jayakrishna Ambati Center for Advanced Vision Science University of Virginia School of MedicineCharlottesvilleVAUSA Department of Ophthalmology University of Virginia School of MedicineCharlottesvilleVAUSA Department of Biomedical Engineering University of Virginia School of MedicineCharlottesvilleVAUSA Department of Pathology University of Virginia School of MedicineCharlottesvilleVAUSA Department of Microbiology Immunologyand Cancer BiologyUniversity of Virginia School of MedicineCharlottesvilleVAUSA

Dear Editor,vascular endothelial growth factor-A(VEGFA,also known as VEGF)is a critical angiogenic factor that regulates the physiological and pathological blood vessel growth.1 Increased abundance of VEGF in the eye underlies many forms of aberrant ocular angiogenesis and resultant vision loss,including in neovascular age-related macular degeneration(nvaMD),proliferative diabetic retinopathy(PDR).

关键词： degeneration ocular release

Persistent diarrhea with petechial rash-unusual pattern of light chain amyloidosis deposition on skin and gastrointestinal biopsies:A case report

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World Journal of Clinical Cases 2022年第28期10卷 10252-10259页

作者： Shawna E Bilton Nikhil Shah Diana Dougherty Sarah Simpson Alex Holliday Farhad Sahebjam Douglas J Grider Department of Basic Science Education Virginia Tech Carilion School of MedicineRoanokeVA 24016United States Department of Internal Medicine Carilion ClinicRoanokeVA 24016United States Gastroenterology and Hepatology Section Department of Internal MedicineCarilion ClinicRoanokeVA 24016United States Dermatology Section Department of Internal MedicineCarilion ClinicRoanokeVA 24016United States Dominion Pathology Associates RoanokeVA 24018United States

BACKGROUND Amyloidosis is a rare disease characterized by extracellular deposition of misfolded protein aggregated into insoluble *** involvement in systemic amyloidosis is common,but is often subclinical or presents as vague and nonspecific *** is rare for gastrointestinal symptoms to be the main presenting symptom in patients with systemic amyloidosis,causing it to be undiagnosed until late-stage *** SUMMARY A 53 year-old man with diarrhea,hematochezia,and weight loss presented to a community *** with biopsy at that time was suspicious for Crohn *** to worsening symptoms including nausea,vomiting,and a new petechial rash,an abdominal fat pad biopsy was *** biopsy showed papillary and adnexal dermal amyloid deposition,in a pattern usually seen with cutaneous ***,Cytokeratin 5/6 was negative,excluding cutaneous *** patterns of nodular amyloidosis,subcutaneous amyloid deposits and perivascular amyloid were not *** Acid-Schiff stain was negative for lipoid proteinosis,Congo red was positive for apple green birefringence on polarization and amyloid typing confirmed amyloid light chain *** endoscopic biopsies of the gastrointestinal tract showed amyloid deposition from the esophagus to the rectum,in a pattern usually seen in serum amyloid A in the setting of chronic inflammatory diseases,including severe inflammatory bowel *** marrow biopsy showed kappa-restricted plasma cell *** Described is an unusual presentation of primary systemic amyloidosis,highlighting the risk of misdiagnosis with subsequent significant organ dysfunction and high mortality.

关键词： Light chain amyloidosis Diarrhea Endoscopy Petechial rash Plasma cell dyscrasia Case report