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Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis

Cellular & Molecular immunology 2024年第1期21卷 33-46页

作者： Anja Meyer Stephanie R.Zack Wes Nijim Adel Burgos vishwa Patel Brian Zanotti Michael v.volin M.Asif Amin Myles J.Lewis Costantino Pitzalis Shiva Arami Joseph A.Karam Nadera J.Sweiss Shiva Shahrara Jesse Brown vA Medical Center ChicagoILUSA Department of Medicine Division of RheumatologyThe University of Illinois at ChicagoChicagoILUSA Department of Microbiology and immunology Midwestern UniversityDowners GroveILUSA Division of Rheumatology and Clinical Autoimmunity Center of Excellence University of MichiganAnn ArborMIUSA Centre for Experimental Medicine and Rheumatology William Harvey Research InstituteBarts and The London School of Medicine and DentistryQueen Mary University of LondonLondonUnited Kingdom Centre for Experimental Medicine&Rheumatology William Harvey Research InstituteQueen Mary University of London and Barts NIHR BRC&NHS TrustLondonUK Department of Biomedical Sciences Humanitas Universityand Humanitas Research HospitalMilanItaly Department of Orthopedic Surgery the University of Illinois at ChicagoChicagoILUSA

A novel rheumatoid arthritis(RA)synovial fluid protein,Syntenin-1,and its receptor,Syndecan-1(SDC-1),are colocalized on RA synovial tissue endothelial cells and fibroblast-like synoviocytes(FLS).Syntenin-1 exacerbates the inflammatory landscape of endothelial cells and RA FLS by upregulating transcription of iRF1/5/7/9,il-1β,il-6,and CCL2 through SDC-1 ligation and HiF1α,or mTOR ***,Syntenin-1 orchestrates RA FLS and endothelial cell invasion via SDC-1 and/or mTOR *** Syntenin-1 reprogrammed endothelial cells,the dynamic expression of metabolic intermediates coincides with escalated glycolysis along with unchanged oxidative factors,AMPK,PGC-1α,citrate,and inactive oxidative ***,RA FLS rewired by Syntenin-1 displayed a modest glycolytic-ATP accompanied by a robust mitochondrial-ATP *** enriched mitochondrial-ATP detected in Syntenin-1 reprogrammed RA FLS was coupled with mitochondrial fusion and fission recapitulated by escalated Mitofusin-2 and DRP1 *** found that vEGFR1/2 and Notch1 networks are responsible for the crosstalk between Syntenin-1 rewired endothelial cells and RA FLS,which are also represented in RA *** to RA explants,morphological and transcriptome studies authenticated the importance of vEGFR1/2,Notch1,RAPTOR,and HiF1αpathways in Syntenin-1 arthritic mice and their obstruction in SDC-1 deficient ***,dysregulation of SDC-1,mTOR,and HiF1αnegated Syntenin-1 inflammatory phenotype in RA explants,while inhibition of HiF1αimpaired synovial angiogenic imprint amplified by *** conclusion,since the current therapies are ineffective on Syntenin-1 and SDC-1 expression in RA synovial tissue and blood,targeting this pathway and its interconnected metabolic intermediates may provide a novel therapeutic strategy.

关键词： Syntenin-1 Syndecan-1 RA FLS RA explants immunometabolism

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Sources of particulate organic matter in the Chukchi and Siberian shelves: clues from carbon and nitrogen isotopes

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Acta Oceanologica Sinica 2020年第9期39卷 96-108页

作者： Renming Jia Xinyue Mu Min Chen Jing Zhu Bo Wang Xiaopeng Li A S Astakhov Minfang Zheng Yusheng Qiu College of Ocean and Earth Sciences Xiamen UniversityXiamen 361005China v.i.il’ichev pacific oceanological institute Far Eastern BranchRussian Academy of SciencesVladivostok 690041Russia

The stable isotopic composition(δ13C andδ15N)and carbon/nitrogen ratio(C/N)of particulate organic matter(POM)in the Chukchi and East Siberian shelves from July to September,2016 were measured to evaluate the spatial variability and origin of ***δ13CPOC values were in the range of−29.5‰to−17.5‰with an average of−25.9‰±2.0‰,and theδ15NPN values ranged from 3.9‰to 13.1‰with an average of 8.0‰±1.6‰.The C/N ratios in the East Siberian shelf were generally higher than those in the Chukchi shelf,while theδ13C andδ15N values were just the *** low C/N ratios(ighδ15NPN(>10‰)values were observed in the Wrangel island polynya,which was attributed to the early bloom of small *** contributions of terrestrial POM,bloom-produced POM and non-bloom marine POM were estimated using a three end-member mixing *** spatial distribution of terrestrial POM showed a high fraction in the East Siberian shelf and decreased eastward,indicating the influence of Russian *** distribution of non-bloom marine POM showed a high fraction in the Chukchi shelf with the highest fraction occurring in the Bering Strait and decreased westward,suggesting the stimulation of biological production by the pacific inflow in the Chukchi *** fractions of bloom-produced POM were highest in the winter polynya and gradually decreased toward the periphery.A negative relationship between the bloom-produced POM and the sea ice meltwater inventory was observed,indicating that the net sea ice loss promotes early bloom in the *** the high fraction of bloom-produced POM,the early bloom of phytoplankton in the polynyas may play an important role on marine production and POM export in the Arctic shelves.

关键词： particulate organic matter carbon isotope nitrogen isotope Chukchi Shelf East Siberian Shelf polynya

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The dynamics of low-frequency signal acoustic intensity vector vortex structure in shallow sea

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Chinese Journal of Acoustics 2019年第2期38卷 113-131页

作者： v.A.Shchurov Federal State Budgetary Scientific institution v.i.il' ichev pacific oceanological institute Far East Branch of the Russian Academy of Sciences

Spatiotemporal vector and phase properties of interference field of low-frequency signalling tone between three local vortices in a real shallow sea wave-guide have been *** has been demonstrated that in the field of constructive interference,components of particle velocity field and acoustic pressure are *** a consequence the transfer of signal energy alog the axis of a shallow sea wave-guide is accomplished with plane *** objects are detected in the field of destructive interference,which,according to known deterministic signs,can be defined as local vortices of the intensity vector.A large-scale vorticity with acoustic intensity vector curl,components different from zero originates in the vicinity of local *** particle displacements of local vortices have been detected against combined receiving device phase centre along the axis of a *** has been demonstrated that the structure of vortices depends on signal/noise *** vortices and vorticity form vortex structure of vector acoustic *** tone with frequency of 88 ± 1 Hz from near-surface moving sound source was taken into *** results of full-scale experiment expand our concepts of real fundamental properties of shallow sea acoustic field and are to be considered in theoretical models.

关键词： Re The dynamics of low-frequency signal acoustic intensity vector vortex structure in shallow sea

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Studying of Deformation Processes by Two-Coordinate Laser Strainmeter

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international Journal of Clean Coal and Energy 2013年第2期2卷 21-23页

作者： Grigory i. Dolgikh v.i. il'ichev pacific oceanological institute Far Eastern Branch of Russian Academy of Sciences Vladivostok Russia

The results of experimental data processing of a two-coordinate laser strainmeter are discussed. The two-coordinate laser strainmeter consists of two laser strainmeters which measuring shoulders are oriented along the lines “North- South” and “West-East”. Measurement accuracy of the earth's crust microdisplacements of these devices makes 0 to1 nm. Working frequency range is from 0 to 1000 Hz. Processing experimental data the main attention is paid to high tides, natural oscillations of the Earth, natural oscillations of geoblocks, superficial sea waves. it is established that after separate earthquakes the natural oscillations of regional geoblocks are strongly excited. Besides, it is revealed that quasiperiodic fluctuations of crust in the range of periods from 1 to 12 min. are caused by atmospheric processes. Besides, it is revealed that quasiperiodic oscillations of the earth's crust in the range of periods from 1 to 12 minutes are caused by atmospheric processes.

关键词： Two-coordinate Laser Strainmeter High Tides Earthquakes Natural Oscillations of the Earth Natural Os-cillations of Geoblocks Natural Oscillations of Bays Superficial and internal Sea Waves Quasiperiodic Oscillations

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Low-Frequency Hydroacoustic Experiments on the Shelf Using the Data of Geoacoustic Sediment Model

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Chinese Physics Letters 2014年第12期31卷 66-69页

作者： SAMCHENKO A. N. KOSHELEvA A.v. SHvYREv A. N. PivOvAROv A. A. il'icheve's pacific oceanological institute (POi) FEB RAS Vladivostok 690041 Russia

Acoustic and seismoacoustic methods have become the most perspective and intensely developed meth- ods in the research of dynamic processes and inho- mogeneities in shallow water. Seismoacoustic moni- toring allows one to draw conclusions about the pres- ence of different inhomogeneities in the water environ- ment and to identify various dynamic processes in the oceanic shelf zone. Studies of the propagation of hy- droacoustic signals of different frequencies and config- urations are widely discussed in scientific publications in Russia, China and the United States Solutions to inversion problems in acoustics, the con- struction of geoacoustic models and research of low- frequency acoustic signals with respect to the absorb- ing bottom are without any doubt at the forefront of underwater acoustics.

关键词： Low-Frequency Hydroacoustic Shelf Using Geoacoustic Sediment Model

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The Confirmed validity of the Thermohydrogravidynamic Theory Concerning the Forthcoming intensification of the Global Natural Processes from December 7, 2019 to April 18, 2020 AD

The Confirmed Validity of the Thermohydrogravidynamic Theory...

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作者： Sergey v.Simonenko v.i. il’ichev pacific oceanological institute Far Eastern Branch of Russian Academy of Sciences

We present the confirmed validity of the prediction（made in unpublished article（Simonenko, 2019 b） presented on December 9, 2019 to the journal Energy Research） of the thermohydrogravidynamic theory（Simonenko, 2014） concerning the evaluated probabilities of the forthcoming intensification of the global seismotectonic, volcanic, climatic and magnetic processes of the Earth during the evaluated beginning（from December 7, 2019 to April 18, 2020） of the established in 2012 AD（Simonenko, 2012 a） and finally confirmed in 2019 AD（Simonenko, 2019 a） "first forthcoming subrange 2020 ÷ 2026 AD of the increased intensification of the Earth" determined by the combined non-stationary cosmic energy gravitational influences on the Earth of the planets（Mercury, venus, Mars and Jupiter） and the Sun（owing to the gravitational interaction of the Sun with Jupiter, Saturn, Uranus and Neptune）.

关键词： Thermohydrogravidynamic Theory Non-Stationary Cosmic Gravitation Cosmic Geophysics Cosmic Seismology Cosmic Geology Generalized First Law of Thermodynamics Global Seismotectonic volcanic Climatic and Magnetic Processes

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Lead induces Different Responses of Two Subpopulations of Phagocytes in the Holothurian Eupentacta fraudatrix

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Journal of Ocean University of China 2018年第6期17卷 1391-1403页

作者： DOLMATOvA Lyudmila S. DOLMATOv.i.or Yu. Laboratory of Biochemistry V.I.Il'ichev Pacific Oceanological Institute Far Eastern Branch Russian Academy of Sciences Laboratory of Comparative Cytology National Scientific Center of Marine Biology Far Eastern Branch Russian Academy of Sciences Department of Cell Biology and Genetics Far Eastern Federal University

in view of increasing lead pollution(Pb^(2+)) of coastal waters, the compensatory abilities of holothurians need to be assessed. The goal of the work is to clarify the functional and phenotypical differences between two types of phagocytes(P1 and P2) in Eupentacta fraudatrix exposed to Pb(NO_3)_2. it has been shown that 2 mg L^(-1) lead exposure for 48 h increases the number of P2 phagocytes as compared to P1 cells, does not significantly affect cell viability in both P1 and P2 phagocyte fractions, and significantly enhances chromatin condensation in P2 but not in P1 phagocytes. A lead concentration of 4 mg L^(-1) increases the number of P1 phagocytes compared to that of P2 type, and does not change cell viability and chromatin condensation in P1 phagocytes. in the P2 type, it decreases cell viability and does not influence the level of apoptosis. The protection against lead-induced apoptosis is apparently mediated by the activities of antioxidant enzymes, especially glutathione S-transferase. The differences in labeling cell surface receptors of P1 and P2 phagocytes by plant lectins also indicate the specific phenotypic properties of these cells. The results clarify the potential and GSH-dependent mechanisms of immune adaptation in holothurians that have been shortly exposed to lead at concentrations close to the maximum environmentally relevant level in coastal waters. Additionally, P1 and P2 phagocytes are first shown to have different functions and phenotypes during the response to lead, which indicates the complexity of the phagocytic system in holothurians and contributes to understanding the immunity evolution.

关键词： amoebocytes antioxidant capacity apoptosis cell adaptation lead plant lectin con A DBA PNA SBA

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Ocean dynamic noise energy flux directivity in the 400 Hz to 700 Hz frequency band

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Chinese Journal of Acoustics 2007年第2期26卷 102-110页

作者： vladimir A. Shchurov Galina F. ivanova Marianna v. Kuyanova Helen S. Tkachenko v.i. il'ichev pacific oceanological institute Far Eastern Branch Russian Academy of Sciences 43 Baltiyskaya St. VladivostokRussia 690041

Results of field studies of underwater dynamic noise energy flux directivity at two wind speeds, 6 m/s and 12 m/s, in the 400 Hz to 700 Hz frequency band in the deep open ocean are presented. The measurements were made by a freely drifting telemetric combined system at 500 m depth. Statistical characteristics of the horizontal and vertical dynamic noise energy flux directivity are considered as functions of wind speed and direction. Correlation between the horizontal dynamic noise energy flux direction and that of the wind was determined; a mechanism of the horizontal dynamic noise energy flux generation is related to the initial noise field scattering on ocean surface waves.

关键词： Ocean dynamic noise energy flux directivity in the 400 Hz to 700 Hz frequency band

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Electric Field of the Ocean induced by Diffusion

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Journal of Electromagnetic Analysis and Applications 2015年第1期7卷 10-18页

作者： Pavel Tishchenko Laboratory of Hydrochemistry V.Il’ichev Pacific Oceanological Institute Vladivostok Russia

The equations for gradient of electric field in seawater induced by gradients of salinity, temperature and pressure were developed by means of non-equilibrium thermodynamics. Extrathermodynamic assumptions and accepted chemical model of seawater permit to carry out numerical calculations of electric field caused by diffusion, thermodiffusion and barodiffusion for realistic hydrophysical structure of the ocean. it is shown that contribution of barodiffusion into electric field of the ocean is almost constant (about -3 × 10-7 v/M). This magnitude can be ignored in many cases because it is too small. However natural salinity and temperature gradients significantly impact into electric field of the ocean.

关键词： Electric Field Seawater Diffusion Thermodiffusion Barodiffusion Pitzer Method

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Methane fluxes and gas hydrates as well as seismic activity in the Okhotsk Sea

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Global Geology 2006年第2期9卷 161-163页

作者： Anatoly Obzhirov v.i.il'ichev pacific oceanological institute FEB RAS Vladivostok 690041Russia

The research works of methane concentration in water column of the Okhotsk Sea from 1984 to 2005 were *** some regularities of methane distribution in water column in the North-East Sakhalin slope of the Okhotsk Sea w... 详细信息

关键词：甲烷流量气体水合物鄂霍次克海地震

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