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Polyethylene glycol fusion repair of severed rat sciatic nerves reestablishes axonal continuity and reorganizes sensory terminal fields in the spinal cord

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Neural Regeneration Research 2025年第7期20卷 2095-2107页

作者： Emily A.Hibbard Liwen Zhou Cathy Z.Yang Karthik Venkudusamy Yessenia Montoya Alexa Olivarez George D.Bittner Dale R.Sengelaub program in Neuroscience Indiana UniversityBloomingtonINUSA Department of Neuroscience University of Texas at AustinAustinTXUSA

Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions;behavioral recovery is typically *** used a plasmalemmal fusogen,polyethylene glycol(PEG),to immediately fuse closely apposed open ends of severed proximal and distal axons in rat sciatic *** have previously reported that sciatic nerve axons repaired by PEG-fusion do not undergo Wallerian degeneration,and PEG-fused animals exhibit rapid(within 2–6 weeks)and extensive locomotor ***,our previous report showed that PEG-fusion of severed sciatic motor axons was non-specific,i.e.,spinal motoneurons in PEG-fused animals were found to project to appropriate as well as inappropriate target *** this study,we examined the consequences of PEG-fusion for sensory axons of the sciatic *** adult male and female rats(Sprague–Dawley)received either a unilateral single cut or ablation injury to the sciatic nerve and subsequent repair with or without(Negative Control)the application of *** action potentials recorded immediately after PEG-fusion repair confirmed conduction across the injury *** success of PEG-fusion was confirmed through Sciatic Functional Index testing with PEG-fused animals showing improvement in locomotor function beginning at 35 days *** 2–42 days postoperatively,we anterogradely labeled sensory afferents from the dorsal aspect of the hindpaw following bilateral intradermal injection of wheat germ agglutinin conjugated horseradish ***-fusion repair reestablished axonal *** to unoperated animals,labeled sensory afferents ipsilateral to the injury in PEG-fused animals were found in the appropriate area of the dorsal horn,as well as inappropriate mediolateral and rostrocaudal ***,despite having intact peripheral nerves,similar reorganizations of labeled sensory afferents were also observed contralateral to the injury and repa

关键词： axotomy dorsal horn peripheral nerve injury plasticity polyethylene glycol(PEG) sciatic nerve sensory terminals wheat germ agglutinin horseradish peroxidase

Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

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Neural Regeneration Research 2025年第2期20卷 343-353页

作者： Ana Milena Silva Olaya Fernanda Martins Almeida Ana Maria Blanco Martinez Suelen Adriani Marques PhD program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomedical Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate program in Pathological Anatomy(PPGAP/UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical ***,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord *** of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional *** the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in *** article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were ***,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

关键词： bioengineering biomaterials cell therapy humans non-human primates spinal cord injury stem cell therapy

Exit selection strategy in pedestrian evacuation simulation with multi-exits

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Chinese Physics B 2014年第5期23卷 195-207页

作者：岳昊张滨雅邵春福邢燕 MOE Key Laboratory for urban Transportation Complex systems Theory and Technology Beijing Jiaotong University Tianjin Bohai urban Planning & Design Institute

A mixed strategy of the exit selection in a pedestrian evacuation simulation with multi-exits is constructed by fusing the distance-based and time-based strategies through a cognitive coefficient, in order to reduce the evacuation imbalance caused by the asymmetry of exits or pedestrian layout, to find a critical density to distinguish whether the strategy of exit selection takes effect or not, and to analyze the exit selection results with different cognitive coefficients. The strategy of exit selection is embedded in the computation of the shortest estimated distance in a dynamic parameter model, in which the concept of a jam area layer and the procedure of step-by-step expending are introduced. Simulation results indicate the characteristics of evacuation time gradually varying against cognitive coefficient and the effectiveness of reducing evacuation imbalance caused by the asymmetry of pedestrian or exit layout. It is found that there is a critical density to distinguish whether a pedestrian jam occurs in the evacuation and whether an exit selection strategy is in effect. It is also shown that the strategy of exit selection has no effect on the evacuation process in the no-effect phase with a low density, and that evacuation time and exit selection are dependent on the cognitive coefficient and pedestrian initial density in the in-effect phase with a high density.

关键词： pedestrian evacuation exit selection strategy critical density dynamic parameters

Functions of nuclear factor Y in nervous system development,function and health

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Neural Regeneration Research 2025年第10期20卷 2887-2894页

作者： Pedro Moreira Roger Pocock Development and Stem Cells program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVICAustralia

Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and *** the last 30 years,research has revealed that the nuclear factor Y complex controls many aspects of brain development,including differentiation,axon guidance,homeostasis,disease,and most recently ***,a complete understanding of transcriptional regulatory networks,including how the nuclear factor Y complex binds to specific CCAAT boxes to perform its function remains *** this review,we explore the nuclear factor Y complex’s role and mode of action during brain development,as well as how genomic technologies may expand understanding of this key regulator of gene expression.

关键词： axon guidance CCAAT boxes neuronal degeneration neuronal differentiation neuronal regeneration nuclear factor Y complex transcription factor transcriptional regulation

Flow difference effect in the lattice hydrodynamic model

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Chinese Physics B 2010年第4期19卷 31-36页

作者：田钧方贾斌李新刚高自友 MOE Key Laboratory for urban Transportation Complex systems Theory and Technology Beijing Jiaotong University

In this paper, a new lattice hydrodynamic model based on Nagatani＇s model INagatani T 1998 Physica A 261 5991 is presented by introducing the flow difference effect. The stability condition for the new model is obtained by using the linear stability theory. The result shows that considering the flow difference effect leads to stabilization of the system compared with the original lattice hydrodynamic model. The jamming transitions among the freely moving phase, the coexisting phase, and the uniform congested phase are studied by nonlinear analysis. The modified KdV equation near the critical point is derived to describe the traffic jam, and kink -antikink soliton solutions related to the traffic density waves are obtained. The simulation results are consistent with the theoretical analysis for the new model.

关键词： lattice hydrodynamic model traffic flow flow difference

A new car-following model considering velocity anticipation

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Chinese Physics B 2010年第1期19卷 197-203页

作者：田钧方贾斌李新刚高自友 MOE Key Laboratory for urban Transportation Complex systems Theory and Technology Beijing Jiaotong University

The full velocity difference model proposed by Jiang et al. [2001 Phys. Rev. E 64 017101] has been improved by introducing velocity anticipation. Velocity anticipation means the follower estimates the future velocity of the leader. The stability condition of the new model is obtained by using the linear stability theory. Theoretical results show that the stability region increases when we increase the anticipation time interval. The mKdV equation is derived to describe the kink-antikink soliton wave and obtain the coexisting stability line. The delay time of car motion and kinematic wave speed at jam density are obtained in this modeh Numerical simulations exhibit that when we increase the anticipation time interval enough, the new model could avoid accidents under urgent braking cases. Also, the traffic jam could be suppressed by considering the anticipation velocity. All results demonstrate that this model is an improvement on the full velocity difference model.

关键词： car-following traffic flow velocity anticipation

Structured trajectory planning of collision-free lane change using the vehicle-driver integration data

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Science China(Technological Sciences) 2016年第5期59卷 825-831页

作者： WANG Jiang Feng ZHANG Qian ZHANG Zhi Qi YAN Xue Dong MOE Key Laboratory for urban Transportation Complex systems Theory and Technology Beijing Jiaotong University

In this paper, the structured trajectory planning of lane change in collision-free road environment is studied and validated using the vehicle-driver integration data, and a new trajectory planning model for lane change is proposed based on linear offset and sine function to balance driver comfort and vehicle dynamics. The trajectory curvature of the proposed model is continuous without mutation, and the zero-based curvature at the starting and end points during lane change assures the motion direction of end points in parallel with the lane line. The field experiment are designed to collect the vehicle-driver integration data, such as steering angle, brake pedal angel and accelerator pedal angel. The correction Correlation analysis of lane-changing maneuver and influencing variables is conducted to obtain the significant variables that can be used to calibrate and test the proposed model. The results demonstrate that vehicle velocity and Y-axis acceleration have significant effects on the lane-changing maneuver, so that the model recalibrated by the samples of different velocity ranges and Y-axis accelerations has better fitted performance compared with the model calibrated by the sample trajectory. In addition, the proposed model presents a decreasing tendency of the lane change trajectory fitted MAE with the increase of time span of calibrating samples at the starting stage.

关键词： intelligent vehicle lane change trajectory planning vehicle-driver integration

Individual departure time decision considering departure scheduling utility

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Journal of Central South University 2015年第2期22卷 787-792页

作者：张文义关伟孙会君毛保华 Key Laboratory for urban Transportation Complex systems Theory and Technology of Ministry of Education (Beijing Jiaotong University)

The scheduling utility plays a fundamental role in addressing the commuting travel behaviours. A new scheduling utility,termed as DMRD-SU, was suggested based on some recent research findings in behavioural economics. DMRD-SU admitted the existence of positive arrival-caused utility. In addition, besides the travel-time-caused utility and arrival-caused utility, DMRD-SU firstly took the departure utility into account. The necessity of the departure utility in trip scheduling was analyzed comprehensively,and the corresponding individual trip scheduling model was presented. Based on a simple network, an analytical example was executed to characterize DMRD-SU. It can be found from the analytical example that: 1) DMRD-SU can predict the accumulation departure behaviors at NDT, which explains the formation of daily serious short-peak-hours in reality, while MRD-SU cannot; 2)Compared with MRD-SU, DMRD-SU predicts that people tend to depart later and its gross utility also decreases faster. Therefore,the departure utility should be considered to describe the traveler's scheduling behaviors better.

关键词： trip scheduling scheduling utility reference-dependence departure utility

A two-stage short-term traffic flow prediction method based on AVL and AKNN techniques

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Journal of Central South University 2015年第2期22卷 779-786页

作者：孟梦邵春福黃育兆王博彬李慧轩 Key Laboratory for urban Transportation Complex systems Theory and Technology of Ministry of Education (Beijing Jiaotong University) Centre for Infrastructure systems Nanyang Technological University

Short-term traffic flow prediction is one of the essential issues in intelligent transportation systems(ITS). A new two-stage traffic flow prediction method named AKNN-AVL method is presented, which combines an advanced k-nearest neighbor(AKNN)method and balanced binary tree(AVL) data structure to improve the prediction accuracy. The AKNN method uses pattern recognition two times in the searching process, which considers the previous sequences of traffic flow to forecast the future traffic state. Clustering method and balanced binary tree technique are introduced to build case database to reduce the searching time. To illustrate the effects of these developments, the accuracies performance of AKNN-AVL method, k-nearest neighbor(KNN) method and the auto-regressive and moving average(ARMA) method are compared. These methods are calibrated and evaluated by the real-time data from a freeway traffic detector near North 3rd Ring Road in Beijing under both normal and incident traffic *** comparisons show that the AKNN-AVL method with the optimal neighbor and pattern size outperforms both KNN method and ARMA method under both normal and incident traffic conditions. In addition, the combinations of clustering method and balanced binary tree technique to the prediction method can increase the searching speed and respond rapidly to case database fluctuations.

关键词： engineering of communication and transportation system short-term traffic flow prediction advanced k-nearest neighbor method pattern recognition balanced binary tree technique