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Neural Regeneration Research 2022年第2期17卷 409-417页

作者： Yi-Tong Lin Qing-Qing Shi Lei Zhang Cai-Ping Yue Zhi-Jun He Xue-Xia Li Qian-Jun He Qiong Liu Xiu-Bo Du College of Life Sciences and Oceanography Guangdong Provincial Key Laboratory for Plant EpigeneticsShenzhen UniversityShenzhenGuangdong ProvinceChina guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging National-Regional Key Technology Engineering Laboratory for Medical UltrasoundSchool of Biomedical EngineeringHealth Science CenterShenzhen UniversityShenzhenGuangdong ProvinceChina Shenzhen Bay Laboratory ShenzhenGuangdong ProvinceChina

Hydrogen exhibits the potential to treat Alzheimer's disease. Stereotactic injection has been previously used as an invasive method of administering active hydrogen, but this method has limitations in clinical practice. In this study, triple transgenic(3×Tg) Alzheimer's disease mice were treated with hydrogen-rich water for 7 months. The results showed that hydrogen-rich water prevented synaptic loss and neuronal death, inhibited senile plaques, and reduced hyperphosphorylated tau and neurofibrillary tangles in 3×Tg Alzheimer's disease mice. In addition, hydrogen-rich water improved brain energy metabolism disorders and intestinal flora imbalances and reduced inflammatory reactions. These findings suggest that hydrogen-rich water is an effective hydrogen donor that can treat Alzheimer's disease. This study was approved by the Animal Ethics and Welfare Committee of Shenzhen University, China(approval No. AEWC-20140615-002) on June 15, 2014.

关键词： Alzheimer's disease amyloid-β anti-inflammation bioenergetics gut microbiota hydrogen therapy neurodegenerative disease neurofibrillary tangles

Slope analysis based on local strength reduction method and variable-modulus elasto-plastic model

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Journal of Central South University 2014年第5期21卷 2041-2050页

作者：杨光华钟志辉傅旭东张玉成温勇张明飞 School of Civil and Architectural engineering Wuhan University guangdong Research Institute of Water Resources and Hydropower Geotechnical engineering Technology center of guangdong province School of Civil engineering and Transportation South China University of Technology

Employing an ideal elasto-plastic model,the typically used strength reduction method reduced the strength of all soil elements of a ***,this method was called the global strength reduction method(GSRM).However,the deformation field obtained by GSRM could not reflect the real deformation of a slope when the slope became *** most slopes,failure occurs once the strength of some regional soil is sufficiently weakened; thus,the local strength reduction method(LSRM)was proposed to analyze slope *** contrast with GSRM,LSRM only reduces the strength of local soil,while the strength of other soil remains ***,deformation by LSRM is more reasonable than that by *** addition,the accuracy of the slope's deformation depends on the constitutive model to a large degree,and the variable-modulus elasto-plastic model was thus *** constitutive model was an improvement of the Duncan–Chang model,which modified soil's deformation modulus according to stress level,and it thus better reflected the plastic feature of *** importantly,the parameters of the variable-modulus elasto-plastic model could be determined through in-situ tests,and parameters determination by plate loading test and pressuremeter test were ***,it is easy to put this model into ***,LSRM and the variable-modulus elasto-plastic model were used to analyze Egongdai ancient *** factor,deformation field,and optimal reinforcement measures for Egongdai ancient landslide were obtained based on the proposed method.

关键词： slope stability local strength reduction method variable-modulus elasto-plastic model in-situ test

Revealing the critical effect of solid electrolyte interphase on the deposition and detriment of Co(Ⅱ) ions to graphite anode

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Journal of Energy Chemistry 2022年第6期31卷 389-396,I0011页

作者： Qiming Xie Jiawei Chen Lidan Xing Xianggui Zhou Zekai Ma Binhong Wu Yilong Lin Hebing Zhou Weishan Li China National and Local Joint engineering Research center of MPTES in High Energy andSafety LIBs Engineering Research Center of MTEES(Ministry of Education)Research Center of BMET(Guangdong Province).Schoolof Chemistry.South China Normal University.Guangzhou 510006.Guangdong.China

"Dissolution,migration,and deposition"of transition metal ions (TMIs) result in capacity degradation of lithium-ion batteries (LIBs).Understanding such detrimental mechanism of TMIs is critical to the development of LIBs with long cycle *** most previous works,TMIs were directly introduced into the electrolyte to investigate such a detrimental *** these cases,the TMIs are deposited directly on the fresh anode ***,in the practical battery system,the TMIs are deposited on the anode covered with solid electrolyte interphase (SEI) *** the pre-presence of SEI film on anode surface influences the deposition and detriment of TMIs is *** this work,the deposition of Co element on graphite anode with and without SEI film were systematically *** results clearly show that,in comparison with that of fresh graphite (SEI-free),the presence of SEI film aggravates the deposition of Co ions due to the Li^(+)–Co^(2+) ion exchange between the SEI and Co^(2+)-containing electrolyte without the driving of the electric field,leading to faster capacity fading of graphite ***,how to regulate electrolytes and film-forming additives to design the components of SEI and prevent its exchange with TMIs,is a crucial way to inhibit the deposition and detriment of TMIs on graphite anode.

关键词： Lithium-ion batteries Transition metal ions Ion exchange Graphite anode SEI film

Near-infrared organic photosensitizers with aggregation-induced emission and switchable fluorescence for fungal infection therapy

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Science China Chemistry 2025年

作者： Xinzhe Yang Zixuan Huang Keke Ding Huili Yang Lirong Wang Qing Xia Rong Hu Guang Shi Bingjia Xu Anjun Qin School of Chemistry South China Normal University State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates Center for Aggregation-Induced Emission AIE Institute South China University of Technology Department of Urology The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College) School of Chemistry and Chemical engineering University of South China

The development of near-infrared (NIR) photosensitizers with aggregation-induced emission (AIE) properties,switchable luminescence colors,and satisfactory photodynamic therapy (PDT) effects on the treatment of fungal infection is of great importance but very ***,two ionic organic luminogens are constructed by employing diphenylamine,diphenylacrylonitrile/1,2-diphenylethene,and methylated quinoline cation as building *** is found that the resulting compounds TCQF and TQF show apparent AIE properties and produce intense fluorescence with high photoluminescence quantum yields of up to 31.2%in the solid *** the meantime,their emission colors can be switched between red and NIR and in the NIR region by mechanical force and solvent vapor,respectively,thereby enabling remarkable and reversible mechanochromism with emission variations of up to 104 *** excitingly,TCQF and TQF can efficiently generate ROS under the illumination of white light and show excellent antimicrobial activities and satisfactory PDT *** by the unique anti-fungus properties,TCQF is employed as a biocompatible NIR photosensitizer for treating wound infection with ***,and apparent PDT effects are *** work provides a new direction for the development of multifunctional NIR materials with AIE properties.

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LiF and LiNO_(3) as synergistic additives for PEO-PVDF/LLZTO-based composite electrolyte towards high-voltage lithium batteries with dualinterfaces stability

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Journal of Energy Chemistry 2022年第2期31卷 319-328页

作者： Liansheng Li Yuanfu Deng Huanhuan Duan Yunxian Qian Guohua Chen The Key Laboratory of Fuel Cell for guangdong province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640GuangdongChina Electrochemical Energy engineering Research center of guangdong province South China University of TechnologyGuangzhou 510640GuangdongChina Shenzhen CAPCHEM Technol Co Ltd. Shenzhen 518118GuangdongChina Department of Mechanical engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Solid electrolytes with desirable properties such as high ionic conductivity,wide electrochemical stable window,and suitable mechanical strength,and stable electrode-electrolyte interfaces on both cathode and anode side are essential for high-voltage all-solid-state lithium batteries(ASSLBs)to achieve excellent cycle *** this work,a novel strategy of using LiF and LiNO_(3) as synergistic additives to boost the performance of PEO-PVDF/LLZTO-based composite solid electrolytes(CSEs)is developed,which also promotes the assembled high-voltage ASSLBs with dual-interfaces stability ***,LiF as an inactive additive can increase the electrochemical stability of the CSE under high cut-off voltage,and improve the high-voltage compatibility between cathode and CSE,thus leading to a stable cathode/CSE ***_(3) as an active additive can lead to an enhanced ionic conductivity of CSE due to the increased free-mobile Li+and ensure a stable CSE/Li interface by forming stable solid electrolyte interphase(SEI)on Li anode *** from the improved performance of CSE and stable dualinterfaces,the assembled NCM622/9[PEO_(15)-LiTFSI]-PVDF-15 LLZTO-2 LiF-3 LiNO_(3)/Li cell delivers a high rate capacity of 102.1 mAh g^(-1) at 1.0 C and a high capacity retention of 77.4%after 200 cycles at 0.5 C,which are much higher than those of the ASSLB assembled with additive-free CSE,with only 60.0 mAh g^(-1) and 52.0%,***,novel cycle test modes of resting for 5 h at different charge states after every 5 cycles are designed to investigate the high-voltage compatibility between cathode and CSE,and the results suggest that LiF additive can actually improve the high-voltage compatibility of cathode and *** the obtained results confirm that the strategy of using synergistic additives in CSE is an effective way to achieve high-voltage ASSLBs with dual-interfaces stability.

关键词： Synergistic additives Composite solid electrolyte Dual-interfaces stability High-voltage cathode Lithium metal battery

Comparison Between Different Finite Element Analyses of Unbonded Flexible Pipe via Different Modeling Patterns

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Journal of Shanghai Jiaotong university(Science) 2019年第3期24卷 357-363页

作者： PANG Guoliang CHEN Chaohe SHEN Yijun LIU Fuyong Naval Architecture and Ocean engineering R&D center of guangdong province South China University of Technology

Three kinds of models based on the same flexible pipe with 8 layers have been separately created to investigate the effects of different modeling approaches on numerical simulation results of finite element(FE)models for unbonded flexible *** the mechanical property of the unbonded flexible pipe under tension,torsion and bending load has been analyzed and compared via ABAQUS software on the basis of three created *** research shows that different modeling methods of flexible pipes make a great difference in the ***,modeling simplifications of the carcass and pressure armor have a great impact on the accuracy of the *** 3,in which the carcass is simulated by spiral isot ropic shell and other layers are Simula ted by solid element,possesses good adaptability,which has been proved by comparing the experiment data and other *** paper can offer a reference for the FE modeling methods,selection and mechanical property analysis of unbonded flexible pipe.

关键词： unbonded flexible pipe numerical simulation methods finite element(FE) analysis

Study on a new chaotic bitwise dynamical system and its FPGA implementation

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Chinese Physics B 2015年第6期24卷 184-191页

作者：王倩雪禹思敏 C.Guyeux J.Bahi 方晓乐 College of Automation Guangdong University of Technology Femto-st Institute University of Franche-Comte Land and Resources Technology center of guangdong province

In this paper, the structure of a new chaotic bitwise dynamical system （CBDS） is described. Compared to our previous research work, it uses various random bitwise operations instead of only one. The chaotic behavior of CBDS is mathemat- ically proven according to the Devaney＇s definition, and its statistical properties are verified both for uniformity and by a comprehensive, reputed and stringent battery of tests called TestU01. Furthermore, a systematic methodology developing the parallel computations is proposed for FPGA platform-based realization of this CBDS. Experiments finally validate the proposed systematic methodology.

关键词： chaos chaotic bitwise dynamical systems FPGA implementation

Advances and applications in single-cell and spatial genomics

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Science China Life Sciences 2025年

作者： Jingjing Wang Fang Ye Haoxi Chai Yujia Jiang Teng Wang Xia Ran Qimin Xia Ziye Xu Yuting Fu Guodong Zhang Hanyu Wu Guoji Guo Hongshan Guo Yijun Ruan Yongcheng Wang Dong Xing Xun Xu Zemin Zhang Beijing Advanced Innovation center for Genomics (ICG) Peking University guangdong Provincial Key Laboratory of Genome Read and Write BGI Research Bone Marrow Transplantation center of the First Affiliated Hospital & Liangzhu Laboratory Zhejiang University School of Medicine Life Sciences Institute and The Second Affiliated Hospital Zhejiang University BGI Research Biomedical Pioneering Innovation center (BIOPIC) and School of Life Sciences Peking University Academy for Advanced Interdisciplinary Studies Peking University Institute of Hematology Zhejiang University Department of Laboratory Medicine of The First Affiliated Hospital & Liangzhu Laboratory Zhejiang University School of Medicine center for Stem Cell and Regenerative Medicine Zhejiang University School of Medicine Zhejiang Provincial Key Lab for Tissue engineering and Regenerative Medicine Dr.Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine

The applications of single-cell and spatial technologies in recent times have revolutionized the present understanding of cellular states and the cellular heterogeneity inherent in complex biological systems. These advancements offer unprecedented resolution in the examination of the functional genomics of individual cells and their spatial context within tissues. In this review, we have comprehensively discussed the historical development and recent progress in the field of single-cell and spatial genomics. We have reviewed the breakthroughs in single-cell multi-omics technologies, spatial genomics methods, and the computational strategies employed toward the analyses of singlecell atlas data. Furthermore, we have highlighted the advances made in constructing cellular atlases and their clinical applications,particularly in the context of disease. Finally, we have discussed the emerging trends, challenges, and opportunities in this rapidly evolving field.

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Preparation of FeCoNi medium entropy alloy from Fe^(3+)-Co^(2+)-Ni^(2+)solution system

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 92-101页

作者： Zongyou Cheng Qing Zhao Mengjie Tao Jijun Du Xingxi Huang Chengjun Liu Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China engineering Research center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education) Shenyang 110819China

In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical *** controlling reasonable elemental composition and processing parameters,the medium entropy alloys can exhibit similar properties to high entropy alloys and have lower *** this paper,a FeCoNi medium entropy alloy precursor was prepared via sol-gel and coprecipitation methods,respectively,and FeCoNi medium entropy alloys were prepared by carbothermal and hydrogen *** phases and magnetic properties of FeCoNi medium entropy alloy were *** showed that FeCoNi medium entropy alloy was produced by carbothermal and hydrogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy alloy prepared by carbothermal *** alloy prepared by hydrogen reduction was uniform and showed a relatively high ***,the hydrogen reduction product exhibited better saturation magnetization and lower coercivity.

关键词： medium entropy alloy sol-gel co-precipitation carbothermal hydrogen reduction

A Topological Evolution Model Based on the Attraction of the Motif Vertex

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China Communications 2021年第4期18卷 27-39页

作者： Xing Li Shuxin Liu Yuhang Zhu Yingle Li PLA Strategic Support Force Information engineering University Zhengzhou 450001Henan ProvinceChina National Digital Switching system engineering and Technological R&D center Zhengzhou 450002Henan ProvinceChina

As a fundamental problem in the field of the network science,the study of topological evolution model is of great significance for revealing the inherent dynamics and mechanisms of complex network *** order to study the influence of different scales of preferential attachment on topological evolution,a topological evolution model based on the attraction of the motif vertex is *** the perspective of network motif,this model proposes the concept of attraction of the motif vertex based on the degree of the motif,quantifies the influence of local structure on the node preferential attachment,and performs the preferential selection of the new link based on the Local World *** simulation experiments show that the model has the small world characteristic apparently,and the clustering coefficient varies with the scale of the local *** degree distribution of the model changes from power-law distribution to exponential distribution with the change of *** some cases,the piecewise power-law distribution is *** addition,the proposed model can present a network with different matching patterns as the parameters change.

关键词： complex network topological evolution model network motif