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Polyethylene glycol fusion repair of severed sciatic nerves accelerates recovery of nociceptive sensory perceptions in male and female rats of different strains

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Neural Regeneration Research 2025年第9期20卷 2667-2681页

作者： Liwen Zhou Karthik Venkudusamy Emily A.Hibbard Yessenia Montoya Alexa Olivarez Cathy Z.Yang Adelaide Leung Varun Gokhale Guhan Periyasamy Zeal Pathak Dale R.Sengelaub George D.Bittner Department of Neuroscience University of TexasAustinTXUSA Program in Neuroscience Indiana UniversityBloomingtonINUSA Department of Molecular Biosciences University of TexasAustinTXUSA

Successful polyethylene glycol fusion(PEG-fusion)of severed axons following peripheral nerve injuries for PEG-fused axons has been reported to:(1)rapidly restore electrophysiological continuity;(2)prevent distal Wallerian Degeneration and maintain their myelin sheaths;(3)promote primarily motor,voluntary behavioral recoveries as assessed by the Sciatic Functional Index;and,(4)rapidly produce correct and incorrect connections in many possible combinations that produce rapid and extensive recovery of functional peripheral nervous system/central nervous system connections and reflex(e.g.,toe twitch)or voluntary *** preceding companion paper describes sensory terminal field reo rganization following PEG-fusion repair of sciatic nerve transections or ablations;howeve r,sensory behavioral recovery has not been explicitly explored following PEG-fusion *** the current study,we confirmed the success of PEG-fusion surgeries according to criteria(1-3)above and more extensively investigated whether PEG-fusion enhanced mechanical nociceptive recovery following sciatic transection in male and female outbred Sprague-Dawley and inbred Lewis *** nociceptive responses were assessed by measuring withdrawal thresholds using von Frey filaments on the dorsal and midplantar regions of the *** von Frey filament tests were a more reliable method than plantar von Frey filament tests to assess mechanical nociceptive sensitivity following sciatic nerve *** withdrawal thresholds of the sciatic-mediated lateral dorsal region differed significantly across strain but not *** thresholds did not change significantly from baseline in chronic Unoperated and Sham-operated *** sciatic transection,all rats exhibited severe hyposensitivity to stimuli at the lateral dorsal region of the hindpaw ipsilateral to the ***,PEG-fused rats exhibited significantly earlier return to baseline withdrawal thresholds than Negative

关键词： autophagia axotomy collateral sprouting neuropathic pain peripheral nerve repair polyethylene glycol fusion(PEG-fusion) saphenous nerve sensory neurons sex and strain Wallerian degeneration

Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi Pradeepkiran Priyanka Rawat Arubala P.Reddy Erika Orlov PHemachandra Reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of Pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of Public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAP-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.Smith Liwen Zhou Cameron L.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood Jared S.Bushman George D.Bittner Department of Molecular Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred Sprague–Dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

Polyethylene glycol fusion repair of severed rat sciatic nerves reestablishes axonal continuity and reorganizes sensory terminal fields in the spinal cord

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Neural Regeneration Research 2025年第7期20卷 2095-2107页

作者： Emily A.Hibbard Liwen Zhou Cathy Z.Yang Karthik Venkudusamy Yessenia Montoya Alexa Olivarez George D.Bittner Dale R.Sengelaub Program in Neuroscience Indiana UniversityBloomingtonINUSA Department of Neuroscience University of Texas at AustinAustinTXUSA

Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions;behavioral recovery is typically *** used a plasmalemmal fusogen,polyethylene glycol(PEG),to immediately fuse closely apposed open ends of severed proximal and distal axons in rat sciatic *** have previously reported that sciatic nerve axons repaired by PEG-fusion do not undergo Wallerian degeneration,and PEG-fused animals exhibit rapid(within 2–6 weeks)and extensive locomotor ***,our previous report showed that PEG-fusion of severed sciatic motor axons was non-specific,i.e.,spinal motoneurons in PEG-fused animals were found to project to appropriate as well as inappropriate target *** this study,we examined the consequences of PEG-fusion for sensory axons of the sciatic *** adult male and female rats(Sprague–Dawley)received either a unilateral single cut or ablation injury to the sciatic nerve and subsequent repair with or without(Negative Control)the application of *** action potentials recorded immediately after PEG-fusion repair confirmed conduction across the injury *** success of PEG-fusion was confirmed through Sciatic Functional Index testing with PEG-fused animals showing improvement in locomotor function beginning at 35 days *** 2–42 days postoperatively,we anterogradely labeled sensory afferents from the dorsal aspect of the hindpaw following bilateral intradermal injection of wheat germ agglutinin conjugated horseradish ***-fusion repair reestablished axonal *** to unoperated animals,labeled sensory afferents ipsilateral to the injury in PEG-fused animals were found in the appropriate area of the dorsal horn,as well as inappropriate mediolateral and rostrocaudal ***,despite having intact peripheral nerves,similar reorganizations of labeled sensory afferents were also observed contralateral to the injury and repa

关键词： axotomy dorsal horn peripheral nerve injury plasticity polyethylene glycol(PEG) sciatic nerve sensory terminals wheat germ agglutinin horseradish peroxidase

Targeting sepsis through inflammation and oxidative metabolism

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World Journal of Critical Care Medicine 2025年第1期14卷 69-81页

作者： Salena Jacob Sanjana Ann Jacob Joby Thoppil Halmos College of Arts and Sciences Nova Southeastern UniversityFort LauderdaleFL 33328United States Dell School of Medicine University of Texas at Austin Medical SchoolAustinTX 78712United States Emergency Medicine UT Southwestern Medical CenterDallasTX 75390United States

Infection is a public health problem and represents a spectrum of disease that can result in sepsis and septic *** is characterized by a dysregulated immune response to *** shock is the most severe form of sepsis which leads to distributive shock and high mortality *** have been significant advances in sepsis management mainly focusing on early identification and ***,complicating matters is the lack of reliable diagnostic tools and the poor specificity and sensitivity of existing scoring tools i.e.,systemic inflammatory response syndrome criteria,sequential organ failure assessment(SOFA),or quick *** limitations have underscored the modest progress in reducing sepsis-related *** review will focus on novel therapeutics such as oxidative stress targets,cytokine modulation,endothelial cell modulation,etc.,that are being conceptualized for the management of sepsis and septic shock.

关键词： Sepsis Inflammation Oxidative Metabolism Infection Reactive oxygen species

Feature-based RGB-D camera pose optimization for real-time 3D reconstruction

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Computational Visual Media 2017年第2期3卷 95-106页

作者： Chao Wang Xiaohu Guo university of texas at dallas RichardsonTexasUSA

In this paper we present a novel featurebased RGB-D camera pose optimization algorithm for real-time 3D reconstruction systems. During camera pose estimation, current methods in online systems suffer from fast-scanned RGB-D data, or generate inaccurate relative transformations between consecutive frames. Our approach improves current methods by utilizing matched features across all frames and is robust for RGB-D data with large shifts in consecutive frames. We directly estimate camera pose for each frame by efficiently solving a quadratic minimization problem to maximize the consistency of3 D points in global space across frames corresponding to matched feature points. We have implemented our method within two state-of-the-art online 3D reconstruction platforms. Experimental results testify that our method is efficient and reliable in estimating camera poses for RGB-D data with large shifts.

关键词： camera pose optimization feature matching real-time 3D reconstruction feature correspondence

Is plate tectonics needed to evolve technological species on exoplanets?

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Geoscience Frontiers 2016年第4期7卷 573-580页

作者： Robert J.Stern Geoscience Department University of Texas at Dallas

As we continue searching for exoplanets, we wonder if life and technological species capable of communicating with us exists on any of them. As geoscientists, we can also wonder how important is the presence or absence of plate tectonics for the evolution of technological species. This essay considers this question, focusing on tectonically active roclw （silicate） planets, like Earth, Venus, and Mars. The development of technological species on Earth provides key insights for understanding evolution on exoplanets, including the likely role that plate tectonics may play. An Earth-sized silicate planet is likely to experience several tectonic styles over its lifetime, as it cools and its lithosphere thickens, strengthens, and becomes denser. These include magma ocean, various styles of stagnant lid, and perhaps plate tectonics. Abundant liquid water favors both life and plate tectonics. Ocean is required for early evolution of diverse single-celled organisms, then colonies of cells which specialized further to form guts, ap- pendages, and sensory organisms up to the complexity of fish （central nervous system, appendages, eyes）. Large expanses of dry land also begin in the ocean, today produced above subduction zones in juvenile arcs and by their coalescence to form continents, although it is not clear that plate tectonics was required to create continental crust on Earth. Dry land of continents is required for further evolution of technological species, where modification of appendages for grasping and manipulating, and improve- ment of eyes and central nervous system could be perfected. These bioassets allowed intelligent crea- tures to examine the night sky and wonder, the beginning of abstract thinking, including religion and science. Technology arises from the exigencies of daily living such as tool-making, agriculture, clothing, and weapons, but the pace of innovation accelerates once it is allied with science. Finally, the importance of plate tectonics for devel

关键词： Plate tectonics Exoplanets Planetary science Intelligent life

SEQUENCING DELIVERIES TO MINIMIZE INVENTORY HOLDING COST WITH DOMINANT UPSTREAM SUPPLY CHAIN PARTNER

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Journal of Systems Science and Systems Engineering 2009年第2期18卷 159-183页

作者： Sushil GUPTA Manoj VANAJAKUMARI Chelliah SRISKANDARAJAH Florida International university USA texas A&M university USA The university of texas at dallas USA

This paper studies a two stage supply chain with a dominant upstream partner. Manufacturer is the dominant partner and operates in a Just-in-Time environment. Production is done in a single manufacturing line capable of producing two products without stopping the production for switching from one product to the other. The manufacturer imposes constraints on the distributor by adhering to his favorable production schedule which minimizes his manufacturing cost. Distributor on the other hand caters to retailers＇ orders without incurring any shortages and is responsible for managing the inventory of finished goods. Adhering to manufacturer＇s schedule may lead to high inventory carrying costs for the distributor. Distributor＇s problem, which is to find an optimal distribution sequence which minimizes the distributor＇s inventory cost under the constraint imposed by the manufacturer is proved NP-Hard by Manoj et al. （2008）. Therefore, solving large size problems require efficient heuristics. We develop algorithms for the distribution problem by exploiting its structural properties. We propose two heuristics and use their solutions in the initial population of a genetic algorithm to arrive at solutions with an average deviation of less than 3.5% from the optimal solution for practical size problems.

关键词： Supply chain scheduling production and distribution system logistics genetic algorithm optimized cross over

Stable haptic interaction based on adaptive hierarchical shape matching

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Computational Visual Media 2015年第3期1卷 253-265页

作者： Yuan Tian Yin Yang Xiaohu Guo Balakrishnan Prabhakaran university of texas at dallas university of New Mexico

In this paper, we present a framework allowing users to interact with geometrically complex3 D deformable objects using(multiple) haptic devices based on an extended shape matching approach. There are two major challenges for haptic-enabled interaction using the shape matching method. The first is how to obtain a rapid deformation propagation when a large number of shape matching clusters exist. The second is how to robustly handle the collision response when the haptic interaction point hits the particlesampled deformable volume. Our framework extends existing multi-resolution shape matching methods,providing an improved energy convergence rate. This is achieved by using adaptive integration strategies to avoid insignificant shape matching iterations during the simulation. Furthermore, we present a new mechanism called stable constraint particle coupling which ensures consistent deformable behavior during haptic interaction. As demonstrated in our experimental results, the proposed method provides natural and smooth haptic rendering as well as efficient yet stable deformable simulation of complex models in real time.

关键词： deformation haptic rendering shape matching multi-resolution