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皮脂腺细胞癌维A酸受体的表达

世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 54-54页

作者： Chakravarti N. El-Naggar A.K. Lotan R. B. Esmaeli 王琼 Section of Ophthalmology University of Texas M. D. AndersonCancerCenter 1515HolcombeB-oulevardHouston TX 77030 United States

Purpose: The aim of this study is to investigate whether there are any abnormalities in the in vivo expression of retinoid acid receptors (RAR-α , RAR-β and RAR-γ ) and retinoid X receptors (RXR-α , RXR-β and RXR-γ ) in sebaceous cell carcinoma. Methods: Expression of retinoid receptors in paired specimens of cancerous tissues (n = 10) and adjacent normal tissues (n = 10) from 10 patients with sebaceous cell carcinoma was studied immunohistochemically by using anti-retinoid receptor antibodies. Results: In eight of the 10 normal tissue samples, all six receptors were expressed. In the other two samples, all receptors were expressed except RAR-γ (one sample) or RXR-γ (two samples). Five tumours (50% ) lacked RAR-α ; RAR-α expression was lower in tumours than in normal tissues in eight of 10 cases. RAR-β was expressed in the cytoplasm of nine of 10 tumours; RAR-β expression was at least as high in tumours as in normal tissue in eight of 10 cases. Two tumours lacked RAR-γ ; three tumours had lower RAR-γ expression than paired normal epithelium; four had the same RAR-γ expression, and one had higher RAR-γ expression. RXR-α expression was strong in all normal tissues and tumour samples. Ten tumours lacked RXR-β and all 10 tumours lacked RXR-γ expression. Conclusions: Diminished RXR-β and RXR-γ expression might be related to the development of sebaceous cell carcinoma. Additional studies are required to establish whether the defects in RAR expression in sebaceous cell carcinoma might affect the potential response of this tumour to treatment with retinoids.

关键词：皮脂腺细胞肿瘤样免疫组化研究活体内正常上皮份样配对样本低表达达维

腰椎不可逆电穿孔的猪模型:是否有神经毒性的临床病理证据?

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国际医学放射学杂志 2014年第6期 574-574页

作者： A.L.Tam M.E.Abdelsalam M.Gagea J.E.Ensor M.Moussa M.Ahmed 李依蔓 Departments of Interventional Radiology the University of Texas M.D.Anderson Cancer CenterPO Box 301402HoustonTX 77230-1402

摘要目的评价不可逆性电穿孔(IRE)在猪脊椎中的作用。材料与方法本研究经实验动物使用与管理委员会批准。由同一操作者对10头猪腰椎在CT引导下经椎弓根或直接

关键词：腰椎病理神经毒性电穿孔电转染

The Era of Immune Checkpoint Therapy: From Cancer to Viral Infection——A Mini Comment on the 2018 Medicine Nobel Prize

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Virologica Sinica 2018年第6期33卷 467-471页

作者： Jia Liu Wen Pan Dongliang Yang Department of Infectious Diseases Union Hospital TongjiMedical College Huazhong University of Science and Technology

The 2018 Medicine Nobel Prize was awarded jointly to two immunologists, James P. Allison at the university of texas MD Anderson Cancer Center in houston and Tasuku Honjo at Kyoto university in Japan, who pioneered a n... 详细信息

关键词： PD In The Era of Immune Checkpoint Therapy A Mini Comment on the 2018 Medicine Nobel Prize

皮肤T细胞淋巴瘤中CD25的表达与组织学分级及患者对地尼白介素的治疗反应相关

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世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 17-17页

作者： Talpur R. Jones D.M. Alencar A.J. M. Duvic 吴佳纹 Department of Dermatology University of Texas MD Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030-4095 United States Dr.

Denileukin diftitox (Ontak ), a recombinant fusion protein of diphtheria toxin and ligand, IL-2, binds to the IL-2 receptor, is internalized, and causes cell death. Denileukin diftitox was approved for the treatment of cutaneous T-cell lymphomas (CTCLs) with CD25+ expression. We prospectively stained lesional skin biopsy specimens from 113 mycosis fungoides and S′ ezary Syndrome patients for activation markers CD25 and CD30 to correlate expression with clinical tumor-node metastasis (TNM) stage, histologic grade, and response to denileukin diftitox. High expression was defined as positivity of ≥ 20% of lesional T-cells using immunohistochemistry (IHC). CD25 and CD30 expression was more common in lesions from advanced patients (P = 0.04 and 0.002, respectively). Advanced TNM(T3 or T4) was significantly associated with intermediate grade (P = 0.002) and large-cell transformation histology (P = 0.04). Of interest, clinical responses were observed in 78.5% of patients with high CD25 expression versus 20% with low to undetectable CD25 expression (P = 0.01) among 24 patients receiving standard 5-day infusions of denileukin diftitox at 18 μ g/kg/day. These data suggest that high CD25 expression by IHC is associated with advanced CTCL and with clinical response to denileukin diftitox therapy.

关键词： CD25 细胞生长蕈样肉芽肿淋巴瘤免疫组化法细胞阳性率临床反应活检标本淋巴结转移白喉

肝脏肿瘤和正常肝组织CT灌注参数的可重复性研究

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国际医学放射学杂志 2011年第6期 580-580页

作者： C.S.Ng A.G.Chandler D.H.Herron E.F.Anderson R.Kurzrock 杨栋 Department of Diagnostic Radiology University of Texas M.D.Anderson Cancer Center1400 Pressler StUnit 1473HoustonTX 77030-4009

目的评估肝脏肿瘤和正常肝组织CT灌注的可重复性,以及呼吸运动和数据采集时间对参数可重复性的影响。材料与方法本前瞻性研究获得伦理委员会批准和受试者知情同意。本研究符合HIPAA要求。7例有肝脏肿瘤的病人间隔2～7d分别进行两次CT灌... 详细信息

目的评估肝脏肿瘤和正常肝组织CT灌注的可重复性,以及呼吸运动和数据采集时间对参数可重复性的影响。材料与方法本前瞻性研究获得伦理委员会批准和受试者知情同意。本研究符合HIPAA要求。7例有肝脏肿瘤的病人间隔2～7d分别进行两次CT灌注扫描,每次检查有2个

关键词：肝脏肿瘤正常肝组织消化系肿瘤可重复性灌注参数 CT

21-Gene Assay to Inform Chemotherapy Benefit in Node-Positive Breast Cancer

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四川生理科学杂志 2021年第10期43卷 1756-1756页

作者： Kevin Kalinsky From the Winship Cancer Institute at Emory university Atlanta (K.K.) Southwest Oncology Group Statistics and Data Management Center (W.E.B. D.L.L. J.M.) and the University of Washington School of Medicine–Seattle Cancer Care Alliance (J.R.G.) — both in Seattle the university of texas M.D. Anderson Cancer Center Houston (F.M.-B. D.T. G.N.H.) Loyola university Chicago Maywood IL (K.S.A.) the university of Michigan Ann Arbor (D.F.H. A.F.S.) Dana–Farber Cancer Institute Boston (N.U.L.) Mayo Clinic Jacksonville FL (E.A.P.) Fox Chase Cancer Center Philadelphia (L.J.G.) and the University of Pittsburgh Pittsburgh (P.R.) — both in Pennsylvania BC Cancer–Vancouver Cancer Centre Vancouver (S.K.L.C.) and Juravinski Cancer Centre at Hamilton Health Sciences Hamilton ON (S.D.-T.) — both in Canada UGCI medical Oncology Hospital Virgen de la Victoria Instituto de Investigación Biomédica de Málaga Malaga (E.A.) Instituto de Investigación Sanitaria Gregorio Marañón Centro de Investigación Biomédica en Red Cáncer–Instituto de Salud Carlos III Universidad Complutense Madrid (M.M.) Hospital Universitario Virgen del Rocío Seville (M.R.-B.) Institut Català d’Oncologia Barcelona (M.G.-G.) Hospital Clínico Universitario de Valencia Biomedical Research Institute Investigación del Hospital Clínico de la Comunidad Valenciana Valencia (B.B.) and Centro Oncológico de Galicia A Coruña (M.R.-V.) — all in Spain Institut Gustave Roussy (S.D.) and Institut Curie (J.-Y.P.) Paris Institut Curie–Centre Réné Huguenin Saint-Cloud (E.G.C.B.) and Centre Antoine Lacassagne Nice (J.-M.F.) — all in France Mater Misericordiae university Hospital Dublin (C.M.K.) Instituto Nacional de Cancerología de México Mexico City (C.H.A.-S.) the National Cancer Center Korea Goyang-si (E.-S.L.) and Asa Medical Center University of Ulsan College of Medicine Seoul (K.-H.J.) — both in South Korea Exact Sciences Redwood City CA (S.S.) the university of Kansas medical Center Kansas City (P.S.) and Yale university New Haven CT

Background:The recurrence score based on the 21-gene breast-cancer assay has been clinically useful in predicting a chemotherapy benefit in hormone-receptor-positive,human epidermal growth factor receptor 2(HER2)-negative,axillary lymphnode-negative breast *** women with positive lymph-node disease,the role of the recurrence score with respect to predicting a benefit of adjuvant chemotherapy is ***:In a prospective trial,we randomly assigned women with hormone-receptor-positive,HER2-negative breast cancer,one to three positive axillary lymph nodes,and a recurrence score of 25 or lower(scores range from 0 to 100,with higher scores indicating a worse prognosis)to endocrine therapy only or to chemotherapy plus endocrine(chemoendocrine)*** primary objective was to determine the effect of chemotherapy on invasive disease-free survival and whether the effect was influenced by the recurrence *** end points included distant relapse-free survival.

关键词： chemotherapy Breast Cancer

联合应用活体功能与解剖成像对体内基因转染进行评估

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国际医学放射学杂志 2009年第6期 576-576页

作者： S.P.Singh M.Ravoori V.Kundra 范惠双 Department of Experimental Diagnostic Imaging The University of Texas M.D.Anderson Cancer Center1515 Holcombe BlvdUnit 368HoustonTX 77030USA

目的评价联合应用活体解剖与功能成像是否有助于对体内基因转染后指针——2型生长抑素受体(SSTR2)的表达进行定量分析。材料与方法所有动物实验获得实验动物管理与使用委员会同意。6只裸鼠均皮下接种2个L3.6pl(人类胰腺癌)肿瘤,向瘤内... 详细信息

目的评价联合应用活体解剖与功能成像是否有助于对体内基因转染后指针——2型生长抑素受体(SSTR2)的表达进行定量分析。材料与方法所有动物实验获得实验动物管理与使用委员会同意。6只裸鼠均皮下接种2个L3.6pl(人类胰腺癌)肿瘤,向瘤内注射嵌载

关键词：基因转染联合应用活体生物分布功能

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孕酮治疗后子宫内膜增生进展为子宫内膜腺癌

世界核心医学期刊文摘（妇产科学分册） 2006年第3期2卷 43-43页

作者： Rubatt J.M. Slomovitz B.M. Burke T.W. Broaddus R.R. 张旸 Department of Pathology Box 85 University of Texas M.D. Anderson Cancer Center 1515 Holcombe Blvd. Houston TX 77030 United States

Background. Conservative treatment with progestins is a reasonable treatment option for endometrial complex atypical hyperplasia and, in the experimental setting, for some women with grade 1 endometrial endometrioid adenocarcinoma. The risk of progression to a high-stage endometrial cancer is quite low, with only two previously reported cases in the English literature. Case. A 40-year-old woman with endometrial complex atypical hyperplasia diagnosed by dilatation and curettage was managed conservatively with progestin therapy (initially, megesterol acetate; then, a combination oral contraceptive). More than 2 years after her original diagnosis, she developed endometrial endometrioid adenocarcinoma,FIGO grade 2, with lymph node metastasis. The tumor was microsatellite instability-high due to methylation of MLH1 and loss of MLH1 protein. Conclusion. Currently, there are no good criteria for predicting which patients with complex atypical hyperplasia/grade 1 endometrioid adenocarcinoma will optimally respond to progestin therapy. There is some evidence that endometrial complex hyperplasia demonstrating loss of MLH1 protein by immunohistochemistry is strongly related to subsequent or concurrent endometrial cancer, especially tumors of higher grade and stage. In a woman with a biopsy diagnosis of endometrial hyperplasia, evaluation of MLH1 protein status by immunohistochemistry may provide useful information when medical management is being considered.

关键词：子宫内膜腺癌子宫内膜增生分段诊刮非典型增生复杂型活检诊断口服避孕药淋巴结转移晚期肿瘤

妇科单孔腹腔镜手术的应用现状和未来的发展趋势

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中国临床新医学 2020年第8期13卷 747-751页

作者：张春花范晓东关小明扬州大学附属淮安市妇幼保健院妇科江苏223002 天津市中心妇产科医院妇科天津300100 texas Baylor College of MedicineHouston 77030 广州医科大学附属第三医院妇科广东510150

单孔腹腔镜是近年的手术热点,也是妇科手术发展的必然趋势。单孔腹腔镜手术根据入路不同,分为经脐单孔腹腔镜手术和经阴道单孔腹腔镜手术,还可以根据操作方式的不同,分为常规单孔腹腔镜手术和机器人辅助单孔腹腔镜手术。目前单孔腹腔镜... 详细信息

单孔腹腔镜是近年的手术热点,也是妇科手术发展的必然趋势。单孔腹腔镜手术根据入路不同,分为经脐单孔腹腔镜手术和经阴道单孔腹腔镜手术,还可以根据操作方式的不同,分为常规单孔腹腔镜手术和机器人辅助单孔腹腔镜手术。目前单孔腹腔镜在妇科良性疾病手术中应用广泛,其微创的理念得到一致认可,在妇科恶性肿瘤手术中的应用仍处于探索讨论阶段。我国单孔腹腔镜手术起步稍晚,但在我国广大医务工作者的不懈努力和部分先行者的引领下也迅速发展起来,无论是单孔腹腔镜手术的数量、术式,还是质量和创新方面,都已处于世界的先进水平。该文就妇科单孔腹腔镜手术的应用现状和未来的发展趋势作一阐述。

关键词：单孔腹腔镜手术经脐单孔腹腔镜手术经自然腔道内镜手术机器人辅助单孔腹腔镜手术人工智能