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眼眶与颅内微重力效应的3T mRI表现

国际医学放射学杂志 2012年第4期 387-387页

作者： L.A. Kramer A.E. Sargsyan K.m. Hasan J.d. Polk d.R. Hamilton 郭雪梅 department of diagnostic and Interventional Imaging University of Texas Health Science Center at Houston6431 Fannin St MSB100HoustonTX77030USA

摘要目的采用定量及定性mRI技术,分析曾暴露于微重力环境的宇航员的眶内及颅内异常。方法此项回顾性研究由机构审查委员会批准,无需获取知情同意,符合HIPAA。27名宇航员[平均年龄±标准差,(48±4.5)岁]接受了3T mRI检查,包括眼眶的薄层... 详细信息

摘要目的采用定量及定性mRI技术,分析曾暴露于微重力环境的宇航员的眶内及颅内异常。方法此项回顾性研究由机构审查委员会批准,无需获取知情同意,符合HIPAA。27名宇航员[平均年龄±标准差,(48±4.5)岁]接受了3T mRI检查,包括眼眶的薄层三维横断位T2加权成像和常规颅脑成像序列

关键词：宇航员航天员微重力环境颅内 mRI 视神经脑神经眼眶

急性脊髓损伤患者治疗的临床操作指南:关于mRI基线在临床治疗决策与结果预测中作用的几点建议（英文）

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中华神经外科疾病研究杂志 2017年第6期16卷 529-529页

作者： Fehlings mG martin AR Tetreault LA Aarabi B anderson P Arnold Pm Brodke d Burns AS Chiba K dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter m Kurpad S Kwon BK marino RJ massicotte E merli G m.d.leton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS Toronto Western Hospital University Health Network university of Toronto university College Cork university of maryland university of Wisconsin university of Kansas m.d.cal center The University of Kansas university of Utah Toronto Rehabilitation Institute University Health Network National defense m.d.cal College Spectrum Research Inc university of California at Los Angeles Christopher & dana Reeve Foundation Ontario Neurotrauma Foundation university of Cambridge m.d.cal College of Wisconsin university of British Columbia Thomas Jefferson university Hospital university of Sydney Nagoya university Keio university The university of Kansas Ottawa Hospital Research Institute Thomas Jefferson university Li Ka Shing Knowledge Institute St. Michael's Hospital Sunnybrook Health Sciences Centre

The objective of this guideline is to outline the role of magnetic resonance imaging(mRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).methods A systematic review of the literature was conducted to address key questions related to the use of mRI in patients with traumatic *** review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline development Group(GdG) used this information,their clinical expertise,and patient input to develop recommendations on the use of mRI for SCI *** on GRAdE(Grading of Recommendation,Assessment,development and Evaluation),a strong recommendation is worded as " we recommend," whereas a weaker recommendation is indicated by "we suggest." Results Based on the limited available evidence and the clinical expertise of the GdG,our recommendations were:(1) "We suggest that mRI be perform.d.in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making"(quality of evidence,very low) and(2) "We suggest that mRI should be perform.d.in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome "(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI.

关键词：神经外科疾病医学研究患者

Ten years of achievements in biological and m.d.cal sciences

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Science China(Life Sciences) 2017年第2期60卷 111-115页

作者： mingyao Liu Tieliu Shi Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences East China Normal University Shanghai 200241 China

This special issue commemorates the 10th anniversary of Institute of Biom.d.cal Sciences （IBmS）, East China Nor- mal university （ECNU）. IBmS was established in 2007 by a group of oversea scientists from Harvard m.d.cal School, Yale university, the texas A＆m university, Baylor Col- lege of m.d.cine, the university of texas md anderson cancer center, the university of California and the Scripps Research Institute. These scientists were brought together on the initiative of dr. mingyao Liu, who was then ap- pointed as the director of IBmS and dean of School of Life Sciences, ECNU. The institute is located on the new ECNU campus in minhang district of Shanghai. IBmS has a mis- sion to promote and advance biological and m.d.cal scienc- es in all their forms through research, education, communi- cation and collaboration.

关键词：生物医学生物学华东师范大学加利福尼亚大学科学研究所 IBmS 生命科学学院德克萨斯

美籍墨西哥裔与白人多囊卵巢综合征妇女血胰岛素及硫酸脱氢表雄酮水平的比较

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世界核心医学期刊文摘（妇产科学分册） 2006年第8期2卷 34-34页

作者： Kauffman R.P. Baker V.m. dimarino P. Castracane V.d. 李跃萍 department of Obstetrics and Gynecology Texas Tech. University Health Sciences Center School of Medicine 1400 Coulter Drive Amarillo TX 79106 United States Dr.

Objective: To determine whether mexican American women with polycystic ovary syndrome (PCOS), a population more insulin resistant than white women with PCOS, demonstrate differences in adrenal androgen production. design: Retrospective study. Setting: university gynecology clinic and research laboratory. Patient(s): One hundred eleven white women and 50 mexican American women with PCOS based on the 2003 Rotterdam Consensus Statement. Intervention(s): Blood sampling, oral glucose tolerance testing, and ultrasonography. main Outcome measure(s): Serum total T, free T, dHEAS, and calculation of multiple insulin sensitivity indices after an oral glucose challenge. Result(s): mexican American women with PCOS were significantly more insulin resistant than their white counterparts but had lower circulating levels of dHEAS, a reliable index of adrenal androgen production. Age and body mass index (BmI) were each inversely proportional to serum.d.EAS, but no association was found between circulating insulin and serum.d.EAS levels. Testosterone levels were similar between groups. Conclusion(s): The lower levels of dHEAS observed in the more insulin resistant mexican American group with PCOS (compared to a similar group of white women living in the same locale) further corroborates the extent of phenotypic variability among specific PCOS populations. Hyperinsulinemia does not appear to significantly influence circulating adrenal androgen levels in PCOS.

关键词：多囊卵巢综合征硫酸脱氢表雄酮血胰岛素胰岛素抵抗口服葡萄糖胰岛素血症诊断标准超声检查研

达拉斯心脏中心关于mR成像上腹主动脉粥样硬化与心血管事件关系的研究

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国际医学放射学杂志 2013年第6期 581-581页

作者： C.d.maroules E.Rosero C.Ayers mS R.m.Peshock A.Khera 高炜 departments of Radiology Anesthesiology Clinical Sciences and Internal Medicine Division of Cardiology and the Donald W.Reynolds Cardiovascular Clinical Research Center University of Texas Southwestern Medical Center 5323 Harry Hines BlvdDallas TX 75390-8896

摘要目的在mR成像上确定两个腹主动脉粥样硬化的测量值,以预测未来的心血管事件发生的风险性。材料与方法本研究得到机构审查委员会的批准,并遵守HIPAA法

关键词：心血管粥样硬化腹主动脉主动脉腹部 mR 达拉斯

1999～2006年急性冠脉综合征患者死亡及心力衰竭发生率降低

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美国医学会杂志（中文版） 2007年第6期26卷 323-330页

作者： Keith A. A. Fox Philippe Gabriel Steg Kim A. Eagle Shaun G. Goodman Frederick A. anderson Christopher B. Granger marcus d. Flather Andrzej Budaj Ann Quill Joel m. Gore 康俊萍（译）马长生（校） Cardiovascular Research Division of Medical and Radiological Sciences The University of Edinburgh Edinburgh Scotland Hospital Bichat Paris France university of michigan Health System Ann Arbor Canadian Heart Research Centre and Terrence donnelly Heart Centre Division of Cardiology St Michael＇s Hospital University of Toronto Toronto Ontario university of massachusetts m.d.cal School Worcester Royal Brompton ＆ Harefield NHS Trust London England Postgraduate m.d.cal School Grochowski Hospital Warsaw Poland duke university m.d.cal center Durham NC 不详

背景：有关药物和介入治疗对ST段抬高型和非ST段抬高型急性冠脉综合征（non—ST-segment elevation acute coronary syndrome，NSTE ACS）患者的作用，随机试验已经提供了足够的证据，但是是否已经转化为相应的临床变化还不清楚。目的... 详细信息

背景：有关药物和介入治疗对ST段抬高型和非ST段抬高型急性冠脉综合征（non—ST-segment elevation acute coronary syndrome，NSTE ACS）患者的作用，随机试验已经提供了足够的证据，但是是否已经转化为相应的临床变化还不清楚。目的：确定ST段抬高型心肌梗死（ST-segment elevation myocardial infarction，STEmI）和NSTE ACS患者的院内治疗改变是否伴随临床结果的改善。设计、地点及患者：全球急性冠脉事件注册研究（Global Registry of Acute Coronary Events，GRACE）是一项多国家队列研究。自1999年7月1日至2006年12月31日，该研究共入选并随访了来自14个国家、113家医院的44372例ACS患者。主要观测指标：当前循证药物和介入治疗应用的趋势及患者预后（死亡、充血性心力衰竭、肺水肿、心源性休克、卒中和心肌梗死）。结果：随着研究时间的进展，相关药物的应用增加（β-受体阻滞剂、他汀类药物、血管紧张素转换酶抑制剂、行或未行经皮冠状动脉介入治疗[percutaneous coronary intervention，PCI]患者应用噻氯毗啶、糖蛋白Ⅱb／Ⅲa抑制剂和低分子肝素；P〈0．001）。STEmI患者药物再灌注治疗下降了22个百分点（95％可信区间[confidence interval，CI]，-27～-17），而直接PCI增加了37个百分点（95％CI，33—41）。在NSTEmI患者中，PCI的比例显著升高了18个百分点（95％CI，15～20）。充血性心力衰竭和肺水肿在STEmI患者中降低了9个百分点（95％CI，-12～-6），在NSTEACS患者中降低了6．9个百分点（95％CI，-8．4～-4．7）。STEmI患者的院内死亡率降低了18个百分点（95％CI，-5．3～-1．9），心源性休克降低了24个百分点（95％CI，-4．3～-0．5）。校正了危险评分后，NSTEACS患者的院内死亡率降低了0．7个百分点（95％CI，-1．7～0．3）；STEmI患者6个月随访时卒中发生率降低了0．8个百分点（95％CI，-1．7～0．1），心肌梗死发生率降低了2．8个百分点（95％CI，-6．4～0．9）。NSTEACS患者6个月死亡率降低了1．6个百分点（95％CI，-3．0～-0．1），卒中发生率降低了0．7个百分点（95％CI，-1．4～0．1）。结论：在本项多国家观察性研究中，ACS患者治疗的改善与6个月新发心力衰竭、死亡率、卒中和心肌梗死发生率显著降低相关。

关键词：充血性心力衰竭急性冠脉综合征院内死亡率发生率经皮冠状动脉介入治疗血管紧张素转换酶抑制剂糖蛋白Ⅱb/Ⅲa抑制剂非ST段抬高型

Leukemia stem cells in drug resistance and metastasis

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Chinese m.d.cal Journal 2010年第7期123卷 954-960页

作者： dENG Chao-hua ZHANG Qiu-ping department of Immunology College of Basic Medical Science Wuhan University Wuhan Hubei 430071 China

Objective To review the central role of leukemia stem cells （LSCs） in drug resistance and metastasis, aiming to provide key insights into leukemogenic pathology and developing novel therapeutic strategies against the relapse of *** sources The data used in this review were obtained mainly from the studies reported in Pubm.d.using the key terms ＂tumor-initiating cells＂, ＂leukemia stem cells＂, ＂drug resistance＂ and ＂metastasis＂.Study selection Relevant articles on studies of leukemia stem cells were *** Increasing numbers of studies have suggested the importance of cancer stem cells （CSCs） in the initiation and maintenance of cancer, especially in leukemia. This review has summarized the origin, characteristics, isolation and identification of LSCs. It highlights the crucial role of LSCs in drug resistance and metastasis of leukemia by illustrating possible mechanisms and aims to provide novel therapeutic strategies for LSCs-targeted *** LSCs play a crucial role in drug resistance and metastasis of leukemia and new promising LSCs-targeted therapies warrant investigation in both experimental m.d.ls and clinical practice.

关键词： cancer stem cells leukemia drug resistance metastasis

少突胶质细胞相关microRNA差异性调控大脑和小脑神经前体细胞的增殖

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第三军医大学学报 2011年第16期33卷 1667-1671页

作者：贺雪莲于洋周永杰何立陈祥肖岚鲁青王凡四川大学基础与法医学院解剖教研室成都610041 四川大学华西第二医院发育干细胞研究所成都610041 四川大学华西医院移植工程与移植免疫卫生部重点实验室成都610041 四川大学生命科学学院成都610041 第三军医大学基础医学部组织与胚胎学教研室重庆市神经科学重点实验室重庆400038 department of developmental Biology University of Texas Southwestern Medical CenterDallas75390 TX

目的探讨少突胶质细胞相关microRNA(m iRNA)对中枢神经系统神经前体细胞增殖的作用。方法利用d icer1 loxp/loxp基因型小鼠和Olig1-Cre品系小鼠杂交获得miRNA加工酶dicer基因条件性敲除小鼠,再用免疫荧光染色和B rdU标记等技术检测这种d... 详细信息

目的探讨少突胶质细胞相关microRNA(m iRNA)对中枢神经系统神经前体细胞增殖的作用。方法利用d icer1 loxp/loxp基因型小鼠和Olig1-Cre品系小鼠杂交获得miRNA加工酶dicer基因条件性敲除小鼠,再用免疫荧光染色和B rdU标记等技术检测这种dicer条件性敲除小鼠大脑和小脑中神经前体细胞的增殖,以及脊髓中新生神经元的变化情况。结果 dicer条件性敲除小鼠大脑中神经前体细胞增殖加快,而小脑中增殖细胞数目较正常小鼠减少(12%,Pm iRNA对中枢神经系统的胶质细胞的发生和增殖具有时空特异性或差异性调节作用。

关键词： miRNA 少突胶质细胞细胞增殖基因敲除

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Chinese Physics C

Chinese Physics C 2016年第10期 915-915页

作者： C.Patrignani K.Agashe G.Aielli C.Amsler m.Antonelli d.m.Asner H.Baer Sw.Banerjee R.m.Barnett T.Basaglia C.W.Bauer J.J.Beatty V.I.Belousov J.Beringer S.Bethke H.Bichsel O.Biebel E.Blucher G.Brooijmans O.Buchmueller V.Burkert m.A.Bychkov R.N.Cahn m.Carena A.Ceccucci A.Cerri d.Chakraborty m.-C.Chen R.S.Chivukula K.Copic G.Cowan O.dahl G.d'Ambrosio T.damour d.de Florian A.de Gouvea T.deGrand P.de Jong G.dissertori B.A.dobrescu m.d.Onofrio m.d.ser m.d.ees H.K.dreiner d.A.dwyer P.Eerola S.Eidelman J.Ellis J.Erler V.V.Ezhela W.Fetscher B.d.Fields B.Foster A.Freitas H.Gallagher L.Garren H.-J.Gerber G.Gerbier T.Gershon T.Gherghetta A.A.Godizov m.Goodman C.Grab A.V.Gritsan C.Grojean d.E.Groom m.Grnewald A.Gurtu T.Gutsche H.E.Haber K.Hagiwara C.Hanhart S.Hashimoto Y.Hayato K.G.Hayes A.Hebecker B.Heltsley J.J.Hernandez-Rey K.Hikasa J.Hisano A.Hcker J.Holder A.Holtkamp J.Huston T.Hyodo K.Irwin J.d.Jackson K.F.Johnson m.Kado m.Karliner U.F.Katz S.R.Klein E.Klempt R.V.Kowalewski F.Krauss m.Kreps B.Krusche Yu.V.Kuyanov Y.Kwon O.Lahav J.Laiho P.Langacker A.Liddle Z.Ligeti C.-J.Lin C.Lippmann T.m.Liss L.Littenberg K.S.Lugovsky S.B.Lugovsky A.Lusiani Y.makida F.maltoni T.mannel A.V.manohar W.J.marciano A.d.martin A.masoni J.matthews U.-G.meiβner d.milstead R.E.mitchell P.molaro K.mnig F.moortgat m.J.mortonson H.murayama K.Nakamura m.Narain P.Nason S.Navas m.Neubert P.Nevski Y.Nir K.A.Olive S.Pagan Griso J.Parsons J.A.Peacock m.Pennington S.T.Petcov V.A.Petrov A.Piepke A.Pomarol A.Quadt S.Raby J.Rademacker G.Raffelt B.N.Ratcliff P.Richardson A.Ringwald S.Roesler S.Rolli A.Romaniouk L.J.Rosenberg J.L.Rosner G.Rybka R.A.Ryutin C.T.Sachrajda Y.Sakai G.P.Salam S.Sarkar F.Sauli O.Schneider K.Scholberg A.J.Schwartz d.Scott V.Sharma S.R.Sharpe T.Shutt m.Silari T.Sjstrand P.Skands T.Skwarnicki J.G.Smith G.F.Smoot S.Spanier H.Spieler C.Spiering A.Stahl S.L.Stone Y.Sumino T.Sumiyoshi m.J.Syphers F.Takahashi m.Tanabashi K.Terashi J.Terning R.S.Thorne L.Tiator m.Titov N.P.Tkachenko N.A.Trnqvist d.Tovey G.Valencia R.Van de Water N.Varelas G Particle data Group Universita di Bologna and INFN dip.Scienze per la Qualita della Vita university of maryland department of Physics College Park Universit degli Studi di Roma "Tor Vergata" Albert Einstein center for Fundamental Physics Universitt Bern Stefan meyer Institute for Subatomic Physics Austrian Academy of Sciences Lab.Nazionali di Frascati dell'INFN Pacific Northwest National Laboratory department of Physics and Astronomy university of Oklahoma university of Louisville Physics division Lawrence Berkeley National Laboratory CERN European Organization for Nuclear Research department of Physics The Ohio State university COmPAS Group Institute for High Energy Physics max-Planck-Institute of Physics department of Physics university of Washington Ludwig-maximilians-Universitt Fakultt fr Physik Enrico Fermi Institute and department of Physics university of Chicago department of Physics Columbia university High Energy Physics Group Blackett Laboratory Imperial College Jefferson Lab department of Physics university of Virginia Fermi National Accelerator Laboratory Kavli Institute for Cosmological Physics university of Chicago department of Physics and Astronomy university of Sussex department of Physics Northern Illinois university department of Physics and Astronomy university of California michigan State university dept.of Physics and Astronomy department of Physics Royal Holloway university of London INFN-Sezione di Napoli Complesso Universitario monte Sant'Angelo Institut des Hautes Etudes Scientifiques International center for Advanced Studies(ICAS) UNSAm department of Physics and Astronomy Northwestern university department of Physics university of Colorado at Boulder Nikhef P.O.Box 41882 1009 dB Amsterdam and university of Amsterdam Institute for Particle Physics ETH Zurich university of Liverpool department of Physics Oliver Lodge Lab Physikalisches Institut Universitt Bonn Helsinki Institute of Physics university of Helsinki department of Physics Budker Institute of Nuclear Physics SB RAS Novosib

The Review summarizes much of particle physics and *** data from previous editions,plus 3,062 new measurements from 721 papers,we list,evaluate,and average measured properties of gauge bosons and the recently discovered Higgs boson,leptons,quarks,mesons,and *** summarize searches for hypothetical particles such as supersymmetric particles,heavy bosons,axions,dark photons,*** the particle properties and search limits are listed in Summary *** also give numerous tables,figures,formulae,and reviews of topics such as Higgs Boson Physics,Supersymmetry,Grand Unified Theories,Neutrino mixing,dark Energy,dark matter,Cosmology,Particle detectors,Colliders,Probability and *** the 117 reviews are many that are new or heavily revised,including new reviews on Pentaquarks and Inflation.

关键词： CA Organization Chinese Physics C USA dESY CERN