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Editorial:Low-carbon Materials and Green Construction

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Low-carbon Materials and Green Construction 2023年第1期1卷 1-2页

作者： Xuwen Xiao Surendra P.Shah Jianzhuang Xiao Department of Structural Engineering College of Civil EngineeringTongji UniversitySiping Road 1239Shanghai 200092China university of texas at Arlington ArlingtonTXUSA Northwestern university EvanstonILUSA

Dear colleagues,Welcome to the inaugural issue of Low-carbon Materials and Green Construction(LMGC).This journal is a new international journal concerned with the materials and construction in civil engineering to cope with the challenges raised by climate change,together with resources and energy consumption,which is dedicated to the widest dissemination of high-quality original research and insights.

关键词： journal insight concerned

Molecular Analysis-Based Genetic Characterization of a Cohort of Patients with Duchenne and Becker Muscular Dystrophy in Eastern China

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Chinese Medical Journal 2018年第7期131卷 770-775页

作者： Hui-Hui Zhao Xue-Ping Sun Ming-Chao Shi Yong-Xiang Yi Hong Cheng Xing-Xia Wang Qing-Cheng Xu Hong-Ming Ma Hao-Quan Wu Qing-Wen Jin Qi Niu Oepartment of Neurology The First Affiliated Hospital of Naniing Medical University Nanjing Jiangeu 210029 China Department of Gynecology and Obstetrics The First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 210029 China Department of Neurology The Affiliated Sir Run Run Hospital of Nanjing Medical University Nanjing Jiangsu 211166 China Department of Neurology The Second Hospital of Nanjing Nanjing Jiangsu 210003 China Department of Neurology Nanjing First Hospital Nanjing Jiangsu 210012 China Department of Biomedical Sciences Texas Tech University Health Science Center Texas 79430 USA

Background： Duchenne muscular dystrophy （DMD） and Becker muscular dystrophy （BMD） are common X-linked recessive neuromuscular disorders caused by mutations in dystrophin gene. Multiplex polymerase chain reaction （multiplex PCR） and multiplex ligation-dependent probe amplification （MLPA） are the most common methods for detecting dystrophin gene mutations, This study aimed to contrast the two methods and discern the genetic characterization of patients with DMD/BMD in Eastern China. Methods： We collected 121 probands, 64 mothers ofprobands, and 15 fetuses in our study. The dystrophin gene was detected by multiplex PCR primarily in 28 probands, and MLPA was used in multiplex PCR-negative cases subsequently. The dystrophin gene of the remaining 93 probands and 62 female potential carriers was tested by MLPA directly. In fetuses, multiplex PCR and MLPA were performed on 4 fetuses and 10 fetuses, respectively. In addition, sequencing was also performed in 4 probands with negative MLPA. Results： We found that 61.98% of the subjects had genetic mutations including deletions （50.41%） and duplications （11.57%）. There were 43.75% of mothers as carriers of the mutation. In 15 fetuses, 2 out of 7 male fetuses were found to be unhealthy and 2 out of 8 female fetuses were found to be carriers. Exons 3-26 and 45-52 have the maximum frequency in mutation regions. In the frequency ofexons individually, exon 47 and exon 50 were the most common in deleted regions and exons 5, 6, and 7 were found most frequently in duplicated regions. Conclusions： MLPA has better productivity and sensitivity than multiplex PCR. Prenatal diagnosis should be applied in DM D high-risk fetuses to reduce the disease incidence. Furthermore, it is the responsibility of physicians to inform female carriers the importance of prenatal diagnosis.

关键词： Becker Muscular Dystrophy Duchenne Muscular Dystrophy Dystrophin Multiplex Ligation-dependent Probe Amplification Multiplex Polymerase Chain Reaction Prenatal Diagnosis

Role of octreotide in small bowel bleeding

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World Journal of Clinical Cases 2022年第26期10卷 9192-9206页

作者： Anwar Khedr Esraa Elaraby Mahmoud Noura Attallah Mikael Mir Sydney Boike Ibtisam Rauf Abbas B Jama Hisham Mushtaq Salim Surani Syed A Khan Department of Internal Medicine BronxCare Health SystemBronxNY 10457United States Department of Medicine University of SharjahSharjah 27272United Arab Emirates Critical Care Medicine Mayo Clinic Health SystemMankatoMN 56001United States Department of Medicine University of MinnesotaMinneapolisMN 55455United States Department of Medicine St.George School of MedicineGrenadaWest Indies Department of Medicine Texas A&M University Health Science CenterBryanTX 77807United States

Gastrointestinal bleeding accounts for a drastic negative impact on the quality of the patients’lives as it requires multiple diagnostic and therapeutic interventions to identify the source of the *** bowel bleeding is the least common cause of gastrointestinal ***,it is responsible for the majority of complaints from patients with persisting or recurring bleeding where the primary source of bleeding cannot be identified despite investigation.A somatostatin analog known as octreotide is among the medical treatment modalities currently used to manage small bowel *** medication helps control symptoms of gastrointestinal bleeding by augmenting platelet aggregation,decreasing splanchnic blood flow,and antagonizing *** this review article,we will highlight the clinical efficacy of octreotide in small bowel bleeding and its subsequent effect on morbidity and mortality.

关键词： Octreotide Small bowel Hemorrhage Angiodysplasia Vascular malformations Hereditary hemorrhagic telangiectasia

Immune receptor signaling： from ubiquitination to NF-κB ctivation

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Cellular & Molecular Immunology 2012年第2期9卷 97-98页

作者： Dr S-C Sun Department of Immunology The university of texas MD Anderson Cancer Center Houston TX 77030 USA

The immune system functions as a dynamic and sophisticated network that ensures efficient response to foreign antigens and tolerance to self-tissues） The function of the immune system relies on signal transduction that connects immune cells to the extracellular environment and mediates communication among the different types of immune cells. Among the well-characterized immunoregulatory sienaling pathways is that which leads to the activation of nuclear

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Marchenko imaging based on self-adaptive traveltime updating

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Applied Geophysics 2020年第1期17卷 81-91,168,169页

作者： Chen Xiao-Chun Hu Ye-Zheng Huang Xu-Ri Zhang Hou-Zhu Cao Wei-Ping Xu Yun-Gui Tang Jing State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China School of Geosciences and Technology Southwest Petroleum UniversityChengdu 610500China Aramco Services Company Houston Research CenterHoustonTexasUSA

Marchenko imaging obtains the subsurface reflectors using one-way Green’s functions,which are retrieved by solving the Marchenko *** method generates an image that is free of spurious artifacts due to internal *** Marchenko imaging method is a target-oriented technique;thus,it can image a user specified *** the traditional Marchenko method,an accurate velocity model is critical for estimating direct waves from imaging points to the *** error in the velocity model results in the inaccurate estimation of direct *** turn,this leads to errors in computation of one-way Green’s functions,which then affects the final Marchenko *** solve this problem,in this paper,we propose a self-adaptive traveltime updating technique based on the principle of equal traveltime to improve the Marchenko imaging *** proposed method calculates the time shift of direct waves caused by the error in the velocity model,and corrects the wrong direct wave according to the time shift and reconstructs the correct Green’s *** proposed method improves the results of imaging using an inaccurate velocity *** comparing the results from traditional Marchenko and the new method using synthetic data experiments,we demonstrated that the adaptive traveltime updating Marchenko imaging method could restore the image of geological structures to their true positions.

关键词： Marchenko imaging Marchenko equation Green’s function principle of equal traveltime self-adaptive traveltime updating

Scientific collaboration for a better, more sustainable tomorrow

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National Science Review 2021年第5期8卷 10-10页

作者： H.N.Cheng Angela K.Wilson Luis Echegoyen The American Chemical Society John A.Hannah Distinguished Professor Department of ChemistryMichigan State University Robert A.Welch Chair Professor of Chemistry Department of Chemistry and BiochemistryUniversity of Texas at El Paso

Collaboration among scientists and the chemistry community is as much a feature of the research process as the desire to discover. At the American Chemical Society (ACS), encouraging international scientific collaboration between chemists has long been a key component of our global outreach and an objective for our organization as a whole. Indeed, the stated mission of ACS is ‘Advancing the broader chemistry enterprise and its practitioners for the benefit of Earth and all its people.’

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Periostin promotes EMT via inhibition of RIN1-mediated endocytosis of EGFR in gliomas

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Holistic Integrative Oncology 2022年第1期1卷 255-267页

作者： Fengqi Zhou Tianfu Yu Fan Xiao Binbin Wang Wei Tian Ran Xu Xiaochun Zhao Ailiang Zeng Ning Liu Yingyi Wang Yongping You Junxia Zhang Department of Neurosurgery The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Neurosurgery The Affiliated hospital of Nanjing University Medical SchoolNanjingJiangsu ProvinceChina Department of Neurosurgery Affiliated Hospital of Jiangnan UniversityWuxiJiangsu ProvinceChina Department of Neurosurgery University of Oklahoma Health Science CenterOklahoma CityOKUSA Department of Cancer Biology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA

Purpose:Approximately 1/3 of brain tumors are *** glioma-related studies have reported increased expression of periostin(POSTN)in these cancerous tissues,but the role and mechanism of POSTN in glioma development remain ***:Nanoscale liquid chromatography coupled with tandem mass spectrometry(nano LC-MS/MS)and RNA sequencing were used to identify diferential protein and mRNA expression in clinical glioma *** real-time PCR(qRT-PCR)was used to measure the expression of POSTN in tissues and *** efects of POSTN on glioma cell migration and invasion were examined using wound healing,Transwell,and three-dimensional spheroid assays in vitro and a nude mouse xenograft model in *** efects of POSTN on the stability,endocytosis,and degradation of EGFR were examined by immunoblotting and immunofuorescence *** mutation analysis was performed to investigate direct interactions between POSTN and *** staining was carried out to confrm the clinical signifcance of ***:Overexpression of POSTN induced epithelial-to-mesenchymal transition(EMT)in glioma cells in vivo and in ***,POSTN downregulation inhibited EGFR signaling by promoting EGFR endocytosis and *** addition,POSTN was found to bind to EGFR and RIN1,inhibiting EGFR endocytosis and degradation and thus activating the PI3K-Akt signaling ***:These fndings indicate the mechanism by which the POSTN/EGFR/RIN1 axis inhibits EGFR endocytosis and degradation,resulting in glioma cell EMT through the PI3K-AKT signaling *** POSTN/EGFR/RIN1 interactions may guarantee benefcial outcomes of glioma treatment.

关键词： POSTN EGFR Endocytosis Glioma RIN1

A personal journey on cracking the genomic codes

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Quantitative Biology 2021年第1期9卷 8-22页

作者： Michael Q.Zhang Department of Biological Sciences Center for Systems Biologythe University of Texas at DallasRichardsonTX 75080-3021USA MOE Key Laboratory of Bioinformatics and Bioinformatics Division Center for Synthetic and System BiologyDepartment of AutomationBeijing National Research Center for Information Science and TechnologyTsinghua UniversityBeijing 100084China

In February 2001,the IHGSC(International Human Genome Sequencing Consortium)[1]and Celera Genomics[2]each reported draft sequences providing a first overall view of the human *** the occasion of the 20th anniversary celebration,I would like to provide some of my personal account on how the HGP(Human Genome Project)has impacted my academic research interests and to offer some candid advice for the new comers.1.

关键词： Genome cracking Human

The ins and outs of spermatology

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Asian Journal of Andrology 2015年第4期17卷 521-521页

作者： Dickson D Varner Department of Large Animal Clinical Sciences College of Veterinary Medicine and Biomedical Sciences Texas A and M University College Station TX 77843-4475 USA.

Now Webster himself defines Ins and Outs As discussions with a technical slant, So when you see a title like this Get curious rather than rant.

关键词： ins outs spermatology