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Potential sex differences in activation of pain-related brain regions in nonhuman primates with a unilateral spinal nerve ligation

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Neural Regeneration Research 2023年第11期18卷 2466-2473页

作者： Kanae Murata Kenya Nozawa Mayumi Matsushita Aozora Yamashita Rintaro Fujii Yuji Awaga Aldric Hama Takahiro Natsume Go Yoshida Yukihiro Matsuyama Hiroyuki Takamatsu Hamamatsu Pharma Research Inc.HamamatsuShizuokaJapan Department of Orthopedic Surgery Hamamatsu University School of MedicineHamamatsuShizuokaJapan

The lack of truly robust analgesics for chronic pain is owed,in part,to the lack of an animal model that reflects the clinical pain state and of a mechanismbased,objective neurological indicator of *** present study examined stimulus-evo ked brain activation with functional magnetic resonance imaging in male and female cynomolgus macaques following unilateral L7 spinal nerve ligation and the effects of clinical analgesics pregabalin,duloxetine,and morphine on brain activation in these macaques.A modified straight leg raise test was used to assess pain severity in awake animals and to evo ke regional brain activation in anesthetized *** potential effects of clinical analgesics on both awake pain behavior and regional brain activation were *** spinal nerve ligation,both male and female macaques showed significantly decreased ipsilateral straight leg raise thresholds,suggesting the presence of radicula rlike *** treatment increased straight leg raise thresholds in both males and females whereas duloxetine and pregabalin did *** male macaques,the ipsilateral straight leg raise activated contralateral insular and somatosensory cortex(Ins/SII),and *** female macaques,the ipsilateral leg raise activated cingulate cortex and contralateral insular and somatosensory *** leg raises of the contralateral,unligated leg did not evoke brain *** reduced activation in all brain regions in both male and female *** males,neither pregabalin nor duloxetine decreased brain activation compared with vehicle *** females,however,pregabalin and duloxetine decreased the activation of cingulate cortex compared with vehicle *** current findings suggest a diffe rential activation of brain areas depending on sex following a peripheral nerve *** rential brain activation observed in this study could underlie qualitative sexual dimorphism in clinical chronic pain perception and responses to

关键词： biomarkers functional magnetic resonance imaging lumbar radicular pain Macaca fascicularis neuroimaging neuropathic pain sciatica straight leg raise

Field observations of debris-flow initiation processes on sediment deposits in a previous deep-seated landslide site

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Journal of Mountain Science 2016年第2期13卷 213-222页

作者： Fumitoshi IMAIZUMI Satoshi TSUCHIYA Okihiro OHSAKA Department of Environment and Forest Resources Science Faculty of AgricultureShizuoka University

Although information regarding the initiation processes of debris flows is important for the development of mitigation measures,field data regarding these processes are *** conducted field observations of debris-flow initiation processes in the upper Ichinosawa catchment of the Ohya landslide,central *** 19 June 2012,our videocamera monitoring systems recorded the moment of debris-flow initiation on channel deposits(nine surges) and talus slopes(eight surges).The initiation mechanisms of these surges were classified into three types by analyzing the video images: erosion by the surface flow,movement of deposits as a mass,and upward development of the fluid *** first type was associated with the progress of surface flow from the upper stream on unsaturated channel *** second type was likely caused by an increase in the pore water pressure associated with the rising in the groundwater level in channel deposits;a continuous water supply from the upper stream by the surface flow might have induced this *** third type was associated with changes in the downstream topography caused by *** flow velocity of most surges was less than 3 m s^(-1) and they usually stopped within 100 m from the initiation *** with abundant pore fluid had a higher flow velocity(about 3- 5 m s^(-1)) and could travel for alonger *** observations indicate that the surface flow plays an important role in the initiation of debris flows on channel deposits and talus slopes.

关键词： Debris flow Initiation zone Field monitoring Ohya landslide

Observation of ultra-microtexture of fault rocks in shearing-sliding zones

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Progress in Natural Science:Materials International 2005年第5期15卷 430-434页

作者： SUN Yan1*, LU Xiancai1, SHU Liangshu1, GU Lianxing1, ZHU Wenbin1, GUO Jichun1 and LIN Aiming2(1. State Key Laboratory of Mineral Deposits Research, Department of Earth Sciences, Nanjing university, Nanjing 210093, China 2. Department of Geosciences, shizuoka university, shizuoka 836, Japan) State Key Laboratory of Mineral Deposits Research Department of Earth Sciences Nanjing University Nanjing 210093 China Department of Geosciences Shizuoka University Shizuoka 836 Japan

Based on scanning electronic microscopic observation of three fault rocks in ductile-brittle shearing-sliding zones (including one palimpsest mylonite sampled from deep bore cores of Cajon Pass, California, two flowing-structured carbargillites sampled from Shaancan Well 1 located in north Shaanxi, and Well NH located in Huanghai, respectively), micron- and nanometer-scaled ultra-fine grinding grain texture of fault rocks is discovered in this study. And the geological significance of grinding grain texture is discussed in terms of its particulate organization, rheology of particulate slipping, laminar petrography and micro dynamics including dynamothermal metamorphism, fluid transferring, particulate autorotation, and so on. In addition, the remaining problems to be solved and broad prospects in this new study field are also discussed.

关键词： ductile-brittle shearing zone fault rock texture of grinding grain rheology of particulate slipping.

Protein phase separation of plant nuclear pore complex

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Molecular Plant 2023年第6期16卷 973-974页

作者： Kentaro Tamura Masaya Koide School of Food and Nutritional Sciences Department of Environmental and Life SciencesUniversity of ShizuokaShizuoka 422-8526Japan

The nuclear pore complex(NPC)is an evolutionally conserved channel that controls the exchange of macromolecules between the nucleus and *** pores of the NPC form a permeability barrier that allows free permeability of small molecules(<40 kDa or~5 nm in diameter)(Schmidt and Gorlich,2016).However,larger molecules must interact with nuclear transport receptors(NTRs)to overcome the NPC permeability barrier.

关键词： separation overcome pores

The 2023 Turkey earthquake doublet: Earthquake relocation, seismic tomography, and stress field inversion

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Earth and Planetary Physics 2024年第3期8卷 535-548页

作者： HuiLi Zhan Ling Bai Bagus Adi Wibowo ChaoYa Liu Kazuo Oike Yuzo Ishikawa State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China university of Chinese Academy of Sciences Beijing 100049China Center of Earthquake and Tsunami Agency of MeteorologyClimatology and GeophysicsJakarta 10610Indonesia university of shizuoka Shizuoka 422-8526Japan shizuoka university Shizuoka 422-8529Japan

On February 6,2023,two earthquakes with magnitudes of M_(W) 7.8 and M_(W) 7.5 struck southeastern Turkey,causing significant casualties and economic *** seismic events occurred along the East Anatolian Fault Zone,a convergent boundary between the Arabian Plate and the Anatolian *** this study,we analyze the M_(W) 7.8 and M_(W) 7.5 earthquakes by comparing their aftershock relocations,tomographic images,and stress field *** earthquakes were localized in the upper crust and exhibited steep dip ***,the aftershocks occurred either close to the boundaries of low and high P-wave velocity anomaly zones or within the low P-wave velocity anomaly *** East Anatolia Fault,associated with the M_(W) 7.8 earthquake,and the SürgüFault,related to the M_(W) 7.5 earthquake,predominantly experienced shear ***,their western sections experienced a combination of strike-slip and tensile stresses in addition to shear *** ruptures of the M_(W) 7.8 and M_(W) 7.5 earthquakes appear to have bridged a seismic gap that had seen sparse seismicity over the past 200 years prior to the 2023 Turkey earthquake sequence.

关键词： Turkey earthquake doublet earthquake relocation seismic tomography stress field seismicity

Element geochemical characteristics of a soil profile developed on dolostone in central Guizhou, southern China: implications for parent materials

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Acta Geochimica 2016年第4期35卷 445-462页

作者： Xingxing Cao Pan Wu Zhenxing Cao College of Resource and Environmental Engineering Guizhou University Graduate School of Science and Technology Shizuoka University

This study presents bulk chemical compositions of the Tongmuling soil profile, which developed on dolostone, and the overlying strata covering the bedrock in the central Guizhou province(southern China). The chemical weathering characteristics of the studied profile were investigated and the inheritance relationships between the terra rossa and overlying strata were discussed. The results show that there is no remarkable variation in the major elements and weathering indices from the rock–soil interface to the topsoil, indicating that the studied profile was not typical for in situ crustal chemical weathering. The terra rossa were mainly composed of Si O_2, Al_2O_3 and Fe_2O_3. Compared with the insoluble residues and overlying strata, the terra rossa are characterized by an enrichment of Y and Cs and depletion of Ba and Sr. The subsoil shows a notable Ce negative anomaly, characterized by heavy rare earth element enrichment(L/H = 1.55–3.74), whereas the topsoil shows a positive Ce anomaly with light rare earth element enrichment(L/H = 5.93–9.14). According to Laterite-forming capacity estimates, the terra rossa could not have only been formed from acid-insoluble residues from the bedrock; Al_2O_3 versus Fe_2O_3and Nb plotted against Ta show significant positive correlations between the terra rossa and overlying strata. The Eu/Eu* versusGd_N/Yb_Nand ternary diagrams for Sc, Th, Zr, and Ta suggest that the overlying strata could also provide parent materials for the genesis of terra rossa.

关键词： Terra rossa Dolomite Parent materials Guizhou China

Rate of hexabromocyclododecane decomposition and production of brominated polycyclic aromatic hydrocarbons during combustion in a pilot-scale incinerator

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Journal of Environmental Sciences 2017年第11期29卷 91-96页

作者： Yuichi Miyake Masahiro Tokumura Qi Wang Takashi Amagai Yuichi Horii university of shizuoka 52-1 Yada Suruga-ku Shizuoka 422-8526 Japan Center for Environmental Science in Saitama 914 Kamitanadare Kazo Saitama 34F-0115 Japan

Here, we examined the incineration of extruded polystyrene containing hexabromocyclododecane（HBCD） in a pilot-scale incinerator under various combustion temperatures（800–950℃） and flue gas residence times（2–8 sec）. Rates of HBCD decomposition ranged from 99.996%（800℃, 2 sec） to 99.9999%（950℃, 8 sec）; the decomposition of HBCD, except during the initial stage of combustion（flue gas residence time 〈 2 sec）, followed a pseudo-first-order kinetics model. An Arrhenius plot revealed that the activation energy and frequency factor of the decomposition of HBCD by combustion were 14.2 kJ/mol and 1.69 sec^（-1）,respectively. During combustion, 11 brominated polycyclic aromatic hydrocarbons（BrPAHs）were detected as unintentional by-products. Of the 11 BrPAHs detected, 2-bromoanthracene and 1-bromopyrene were detected at the highest concentrations. The mutagenic and carcinogenic BrPAHs 1,5-dibromoanthracene and 1-bromopyrene were most frequently detected in the flue gases analyzed. The total concentration of BrPAHs exponentially increased（range,87.8–2,040,000 ng/m^3） with increasing flue gas residence time. Results from a qualitative analysis using gas chromatography/high-resolution mass spectrometry suggest that bromofluorene and bromopyrene（or fluoranthene） congeners were also produced during the combustion.

关键词： Brominated polycyclic aromatic hydrocarbons Flame retardant Hexabromocyclododecane(HBCD) Incinerator Persistent organic pollutants(POPs)

Semisupervised Deep State-Space Model for Plant Growth Modeling

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Plant Phenomics 2020年第1期2卷 122-137页

作者： S.Shibata R.Mizuno H.Mineno Graduate School of Integrated Science and Technology Shizuoka University3-5-1 JohokuNaka-kuHamamatsuShizuoka 432-8011Japan College of Informatics Academic InstituteShizuoka University3-5-1 JohokuNaka-kuHamamatsuShizuoka 432-8011Japan JST PRESTO4-1-8 HonchoKawaguchiSaitama 332-0012Japan

The optimal control of sugar content and its associated technology is important for producing high-quality crops more stably and ***-based reinforcement learning(RL)indicates a desirable action depending on the type of situation based on trialand-error calculations conducted by an environmental *** this paper,we address plant growth modeling as an environmental model for the optimal control of sugar *** the growth process,fruiting plants generate sugar depending on their state and evolve via various external stimuli;however,sugar content data are sparse because appropriate remote sensing technology is yet to be developed,and thus,sugar content is measured *** propose a semisupervised deep state-space model(SDSSM)where semisupervised learning is introduced into a sequential deep generative *** achieves a high generalization performance by optimizing the parameters while inferring unobserved data and using training data efficiently,even if some categories of training data are *** designed an appropriate model combined with model-based RL for the optimal control of sugar content using SDSSM for plant growth *** evaluated the performance of SDSSM using tomato greenhouse cultivation data and applied cross-validation to the comparative evaluation *** SDSSM was trained using approximately 500 sugar content data of appropriately inferred plant states and reduced the mean absolute error by approximately 38%compared with other supervised learning *** results demonstrate that SDSSM has good potential to estimate time-series sugar content variation and validate uncertainty for the optimal control of high-quality fruit cultivation using model-based RL.

关键词： Deep sugar optimal

New Early Cretaceous paleomagnetic results from Qilian orogenic belt and its tectonic implications

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Science China Earth Sciences 2002年第6期45卷 565-576页

作者：杨天水林爱明杨振宇孙知明 1. Institute of Geomechanics Chinese Academy of Geological Sciences 100081 Beijing China 2. Department of Earth and Planetary Sciences Shizuoka University Shizuoka Japan

Lower Cretaceous red sedimentary rocks from the depositional basin of East Qilian fold belt have been collected for a paleomagnetic study. Stepwise thermal demagnetization reveals two or three components of magnetization from dark red sandstones. Low-temperature magnetic component is consistent with the present Earth Field direction in geographic coordinates. High-temperature magnetic components are mainly carried by hematite. The mean pole of 19 sites for high-temperature magnetic components after tilt-correction is λ=62.2°N, φ=193.4°E, A95=3.2°, and it passes fold tests at 99% confidence level and reversal tests at 95% confidence level. The paleopole is insignificantly different from that of Halim et al. (1998) from the same sampling area at the 95% confidence level. Compared with paleomagnetic results for North China, South China, and Eurasia, our results suggest that no significant relative latitudinal displacement has taken place between Lanzhou region and these blocks since Cretaceous time. Remarkably, the pole of Lanzhou shows a 20° clockwise rotation with respect to those of North China, South China, and Eurasia. Geological information indicates that the crustal shortening in the western part of Qilian is greater than that in eastern part. In this case, the clockwise rotation of sampling area was related to India/Eurasia collision, and this collision resulted in a left-lateral strike-slip motion of the Altun fault in north Tibetan Plateau after the Cretaceous.

关键词： Qilian Mountain, paleomagnetism, Early Cretaceous, Hekou group.