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Therapeutic Use of Viruses:Newcastle Disease Virus HK84 Oncolytic Treatment for Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2022年第5期10卷 783-785页

作者： Leonardo Baiocchi Heather Francis Gianfranco Alpini Unit of Hepatology Tor Vergata UniversityRomeItaly Division of Gastroenterology and Hepatology Department of MedicineIndiana University School of MedicineIndianapolisINUSA Research Richard L.Roudebush VA Medical CenterIndianapolisINUSA

Hepatocellular carcinoma(HCC)is the most frequent primary liver tumor worldwide and,despite regional therapeutic and diagnostic differences,it stands among the three most lethal cancers found in *** or ablative treatments,together with liver transplant,are the most successful clinical approaches,frequently ensuring complete HCC healing and the best survival ***,curative techniques are applicable only in patients at early stages of the disease(limits:one nodule≤5 cm in diameter or not more than three nodules all less than 3 cm in diameter).1 A significant percentage of HCC patients(≥50%)have a more advanced stage at diagnosis and must rely on less effective treatment or palliative care,thus signifying the need for alternative systemic ***,a tyrosine kinase inhibitor(TKI)was the first effective HCC drug treatment discovered after negative results were obtained with canonical cytotoxic *** 2018 lenvatinib,another TKI,was approved in the USA as a first line treatment for *** immunotherapy combining the checkpoint inhibitor,atezolizumab with the VEGF-antibody bevacizumab,has improved survival rates compared with previous TKI-based monotherapies.2 Despite treatment improvements,1-year survival is attained by only two-thirds of patients,thus prompting investigation of more effective therapies for advanced stage HCC.

关键词： Carcinoma healing diagnosis

What is a reliable CT scan for diagnosing splenosis under emergency conditions?

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World Journal of Gastroenterology 2009年第29期15卷 3684-3686页

作者： Francesco Giuseppe Garaci Michele Grande Massimo Villa Stefano Mancino Daniel Konda Giovanni Simonetti Grazia Maria Attinà Gabriele Galatà Department of Diagnostic Imaging and Interventional Radiology University Hospital of Tor Vergata viale Oxford 81 00133 Rome Italy Department of Surgery University Hospital of Tor Vergata viale Oxford 81 00133 Rome Italy

Splenosis is a condition in which splenic tissue is present in a non-anatomical position. Implants of splenic tissue can mimic neoplasms and only specific examinations can confirm the correct diagnosis. Here we report a case of a 23-year-old male patient with a history of surgical splenectomy during childhood after trauma. He was admitted to the emergency department with acute bowel obstruction. An abdominalpelvic computed tomography (CT) scan revealed small bowel obstruction and the presence of two rounded, solid masses located in the rectal-vescical pouch. Quantitative analyses of the different density values in the arterial phase and early portal venous phase demonstrated that these lesions were highly vascularised (92 and 97 Hounsfield Units, respectively). The hypothesis of an ectopic splenic mass was made after evaluation of the CT images and clinical history. The acute bowel obstruction caused by adhesive intestinal syndrome was resolved by surgical adhesiolysis. The smallest mass adherent to the rectum was removed. Histopathologic examination confirmed the benign nature of the lesion, which consisted of splenic tissue.

关键词： CT扫描脾脏紧急情况诊断计算机断层扫描肠梗阻扫描显示 CT图像

Examining the interplay between artificial intelligence and the agri-food industry

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Artificial Intelligence in Agriculture 2022年第1期6卷 111-128页

作者： Abderahman Rejeb Karim Rejeb Suhaiza Zailani John G.Keogh Andrea Appolloni Department of Management and Law Faculty of EconomicsUniversity of Rome Tor VergataVia Columbia2Rome 00133Italy Faculty of Sciences of Bizerte University of CarthageTunisTunisia Department of Management Faculty of Business and EconomicsUniversity MalayaKuala Lumpur50203Malaysia Henley Business School University of ReadingGreenlandsHenley-on-Thames RG93AUUK

Artificial intelligence(AI)has advanced at an astounding rate and transformed numerous economic ***,a comprehensive understanding of how AI can improve the agri-food industry is *** addition,there is a notable dearth of research on AI that investigates the influence of AI on agri-food resources and educates practitioners on the significance of knowledge-based and smart *** utilised bibliometric analysis to investigate the present state of the art and emerging trends in the relationship between AI and the agri-food *** research identified three distinct growth phases and the most prevalent AI strategies in the *** addition,we analysed key trends and offered researchers and practitioners insightful recommendations for future *** resource-based view(RBV)as the theoretical lens,this study established a framework emphasising the long-term effects of AI on various agri-food resources and proposed several research *** addition,AI-related obstacles have been identified and categorised into four major ***,the originality of the article lies in its numerous research suggestions and recommendations for advancing the AI field in the agri-food industry.

关键词： Artificial intelligence Agriculture Farming Machine learning Deep learning Bibliometric analysis Resource-based view

Minimally invasive surgical therapies(MISTs)for lower urinary tract symptoms(LUTS):promise or panacea?

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Asian Journal of Andrology 2024年第2期26卷 135-143页

作者： Gian Maria Busetto Andrea Checchia Marco Recchia Edoardo Tocci Ugo G Falagario Gennaro Annunziata Pasquale Annese Nicola d'Altilia Vito Mancini Matteo Ferro Felice Crocetto Octavian Sabin Tataru Luca Di Gianfrancesco Angelo Porreca Francesco Del Giudice Ettore De Berardinis Carlo Bettocchi Luigi Cormio Giuseppe Carrieri university of Foggia Foggia 71122Italy Department of Urology and Renal Transplantation Policlinico of FoggiaFoggia 71122Italy Urology Unit "G.Tatarlla"HospitalCerignola 71042Italy Urology Unit European Institute of Oncology(IE0)IRCcSMilan 20141Italy university of Naples Federico Il Naples 80126Italy G.E.Palade university of Medicine PharmacyScienceand Technology of Targu MuresTargu Mures 540142Romania Department of Oncological Urology Veneto Institute of Oncology(IOv)IRccSPadua 35128Italy Department of Maternal-Infant and Urological Sciences Sapienza Rome UniversityRoma 00161Italy Urology Unit "L.Bonomo"HospitalAndria 76123Italy

The increasing importance of treatment of lower urinary tract symptoms(LUTS),while avoiding side effects and maintaining sexual function,has allowed for the development of minimally invasive surgical therapies(MiSTs).Recently,the European Association of Urology guidelines reported a paradigm shift from the management of benign prostatic hyperplasia(BPH)to the management of nonneurogenic male *** aim of the present review was to evaluate the efficacy and safety of the most commonly used MisTs:ablative techniques such as aquablation,prostatic artery embolization,water vapor energy,and transperineal prostate laser ablation,and nonablative techniques such as prostatic urethral lift and temporarily implanted nitinol device(iTIND).MiSTs are becoming a new promise,even if clinical trials with longer follow-up are still *** of them are still under investigation and,to date,only a few options have been given as a recommendation for *** cannot be considered as standard of care and are not suitable for all *** and disadvantages should be underlined,without forgetting our objective:treatment of LUTS and re-treatment avoidance.

关键词： aquablation iTIND prostatic artery embolization prostatic urethral lift transperineal prostate laser ablation water vapor energy

Twin-Wire Networks for Zero Interconnect,High-Density 4-Wire Electrical Characterizations of Materials

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Research 2022年第2期2022卷 225-234页

作者： Nerio Andres Montoya Valeria Criscuolo Andrea Lo Presti Raffaele Vecchione Christian Falconi Department of Electronic Engincering University of Rome Tor VergataVia del Politecnico 1Roma 00133Italy School of Physics Universidad Nacional de ColombiaA.A.3840 MedellinColombia Center for Advanced Biomaterial for Health Care Istituto Italiano di TecnologiaLargo Barsantie Matteucci 53Naples 80125Italy

Four-wire measurements have been introduced by Lord Kelvin in 1861 and have since become the standard technique for characterizing small resistances and ***,high-density 4-wire measurements are generally complex,time-consuming,and inefficient because of constraints on interconnects,pads,external wires,and mechanical contacts,thus reducing reproducibility,statistical significance,and throu ***,we introduce,systematically design,analyze,and experimentally validate zero interconnect networks interfaced to external instrumentation by couples of twin wire.3D-printed holders with magnets,interconnects,nonadhesive layers,and spacers can effortlessly establish excellent electrical connections with tunable or minimum contact forces and enable accurate measurements even for delicate devices,such as thin metals on soft *** an example,we measured all the resistances of a twin-wire 29-resistor network made of silver-nanoparticle ink printed on polyimide,paper,or photo paper,including during sintering or temperature calibration,resulting in anunprecedentedly easy and accurate characterization of both resistivity and its temperature *** theoretical framework and experimental strategies reported here represent a breakthrough toward zero interconnect,simple,and efficient high-density 4-wire characterizations,can be generalized to other 4-wire measurements(impedances,sensors)and can open the way to more statistically meaningful and reproducible analyses of materials,high-throughput measurements,and minimally invasive characterizations of biomaterials.

关键词： impedance characterization breakthrough

Is there a relationship between dopamine and rhegmatogenous retinal detachment?

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Neural Regeneration Research 2020年第2期15卷 311-314页

作者： Alessio Martucci Massimo Cesareo Maria Dolores Pinazo-Durán Michela Di Pierro Matteo Di Marino Carlo Nucci Massimiliano Coletta Raffaele Mancino Ophthalmology Unit Department of Experimental MedicineUniversity of Rome Tor VergataRomeItaly Ophthalmic Research Unit "Santiago Grisolia"/FISABIO and Cellular-Molecular Ophthalmobiology Group/university of Valencia ValenciaSpain Department of Clinical Sciences and Translational Medicine University of Rome Tor VergataRomeItaly

Dopamine and its receptors have been widely studied in the neurological conditions and in the retina. In this study, we evaluated the possible role of dopamine in rhegmatogenous retinal detachment(RRD) by comparing the amount of 3,4-dihydroxyphenylacetic acid(DOPAC), a surrogate index of retinal dopamin levels, in the vitreous sample of patients affected by RRD with those affected by macular pucker and vitre ous hemorrhage. Our results showed that significantly higher levels of DOPAC were found in the vitreou sample of patients affected by RRD compared with those affected by vitreous hemorrhage and macula pucker(P = 0.002). Specifically, no trace of the substance was found in vitreous hemorrhage and macula pucker samples. A slightly significant positive correlation was found among DOPAC and post-operativ best corrected visual acuity(r = 0.470, P = 0.049). No correlation was found between DOPAC and the day elapsed between diagnosis and surgery(P = 0.317). For the first time our findings suggest that DOPAC i released in RRD, but not in other retinal diseases such as vitreous hemorrhage and macular pucker. More over, we showed a correlation between visual acuity outcome and the amount of DOPAC in the vitreous This might have a potential, although still unknown, implication in the pathogenesis of the disease and/o in the associated photoreceptors loss. This study was approved by the Ethics Committee of rome tor Ver gata university Hospital(R.S.92.10) on September 24, 2010.

关键词： 3,4-dihydroxyphenylacetic acid DOPAC dopamine dopaminergic amacrine cells dopaminergic neurotoxicity macular pucker oxidative stress photoreceptor degeneration rhegmatogenous retinal detachment vitreous hemorrhage

Osteomyelitis in diabetic foot:A comprehensive overview

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World Journal of Diabetes 2017年第4期8卷 135-142页

作者： Laura Giurato Marco Meloni Valentina Izzo Luigi Uccioli Department of Systems Medicine University of Tor Vergata00133 RomeItaly

Foot infection is a well recognized risk factor for major amputation in diabetic patients. The osteomyelitis is one of the most common expression of diabetic foot infection, being present approximately in present in 10%-15% of moderate and in 50% of severe infectious process. An early and accurate diagnosis is required to ensure a targeted treatment and reduce the risk of major amputation. The aim of this review is to report a complete overview about the management of diabetic foot osteomyelitis. Epidemiology, clinical aspects, diagnosis and treatment are widely described according to scientific reccomendations and our experience.

关键词：糖尿病的脚溃疡糖尿病的脚感染骨髓炎外科抗菌素治疗

New sepsis biomarkers

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Asian Pacific Journal of Tropical Biomedicine 2016年第6期6卷 516-519页

作者： Dolores Limongi Cartesio D'Agostini Marco Ciotti Telematic university San Raffaele rome Clinical Microbiology and Virology Polyclinic Tor Vergata Foundation Laboratory of Molecular Virology Polyclinic Tor Vergata Foundation

Sepsis remains a leading cause of death in the intensive care units and in all age groups worldwide. Early recognition and diagnosis are key to achieving improved ***, novel biomarkers that might better inform clinicians treating such patients are surely needed. The main attributes of successful biomarkers would be high sensitivity,specificity, possibility of bedside monitoring and financial accessibility. A panel of sepsis biomarkers along with currently used laboratory tests will facilitate earlier diagnosis,timely treatment and improved outcome may be more effective than single biomarkers. In this review, we summarize the most recent advances on sepsis biomarkers evaluated in clinical and experimental studies.

关键词： Biomarker Sepsis Plasma chitotriosidase Presepsin Interleukin-27 Hepcidin Macrophage migration inhibitory factor

Current role of surgery for tuberous sclerosis complex-associated epilepsy

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Pediatric Investigation 2022年第1期6卷 16-22页

作者： Nicola Specchio Giusy Carfi Pavia Luca de Palma Alessandro De Benedictis Chiara Pepi Marta Conti Carlo Efisio Marras Federico Vigevano Paolo Curatolo Rare and Complex Epilepsy Unit Department of NeurosciencesBambino GesùChildren’s HospitalIRCCSRomeItaly Neurosurgery Unit Department of NeurosciencesBambino GesùChildren’s HospitalIRCCSRomeItaly Department of Neurosciences Bambino GesùChildren’s HospitalIRCCSRomeItaly Child Neurology and Psychiatry Unit Systems Medicine DepartmentTor Vergata UniversityRomeItaly

Tuberous sclerosis complex(TSC)is a rare multisystem,autosomal dominant neurocutaneous syndrome in which epilepsy is the most common of several neurological and psychiatric *** two thirds of patients develop drug-resistant epilepsy for whom surgical resection of epileptogenic foci is indicated when seizures remain inadequately controlled following trial of two antiseizure *** challenge with presurgical and surgical approaches with patients with TSC is overcoming the complexity from the number of tubers and the multiplex epileptogenic network forming the epileptogenic *** suggest that seizure freedom is achieved by 55%-60%of patients,but predictive factors for success have remained elusive,which makes for unconfident selection of surgical *** article presents three different cases as illustrations of the potential challenges faced when assessing the suitability of TSC patients for epilepsy surgery.

关键词： Epilepsy Everolimus Imaging Prognostics Surgery Tuberous sclerosis complex(TSC)