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Efficient and sustainable V-catalyzed oxidative desulfurization of fuels assisted by ionic liquids

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燃料化学学报 2018年第9期46卷 1121-1129页

作者： Alessia Coletti Federica Sabuzi Barbara Floris Pierluca Galloni Valeria Conte Department of Chemical Science and Technologies University of Rome Tor Vergatavia della Ricerca Scientifica sncRome 00133Italy BT-InnoVaChem srl Academic Spin-Offc/o University of Rome Tor Vergatavia della Ricerca Scientifica sncRome 00133Ita

Fuel desulfurization is an appealing topic for the chemical industry since severe environmental regulations regarding SO_2 emissions have been legislated in many countries. In order to reduce the amount of sulfur-containing compounds in fuels,responsible for high SO_x emission levels,a green chemistry approach is compulsory. In this paper,vanadium salen and salophen complexes were used in the oxidation of a model aromatic sulfide,such as dibenzothiophene( DBT),in the presence of H_2O_2 as green oxidant. The oxidative process was successfully coupled with the extraction of the oxidized compounds by ionic liquids. The system resulted highly selective for sulfide oxidation,showing poor reactivity toward the oxidation of alkenes and allowing a significant reduction of S content in a model benzine. To note,the use of microwave in place of standard heating allowed to obtain 98% of DBT oxidation and almost complete sulfur extraction in the model fuel in 1000 s. For these reasons,this system was considered an easy,rapid and clean process to achieve fuel desulfurization.

关键词： fuel desulfurization V-catalysis sustainability ionic liquids microwaves

Loss of homeostatic functions in microglia from a murine model of Friedreich's ataxia

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Genes & Diseases 2024年第6期11卷 60-64页

作者： Ilaria Della Valle Martina Milani Simona Rossi Riccardo Turchi Flavia tortolici Valentina Nesci Alberto Ferri Cristiana Valle Daniele Lettieri-Bar-bato Katia Aquilano Mauro Cozzolino Savina Apolloni Nadia D'Ambrosi Department of Biology University of Rome Tor VergataRome 00133Italy PhD Program in Cellular and Molecular Biology University of Rome Tor VergataRome 00133Italy Institute of Translational Pharmacology National Research Council(CNR)Rome 00133Italy Santa Lucia Foundation IRCCS Rome 00179Italy Department of Systems Medicine "Tor Vergata"University of RomeRome 00133Italy

Friedreich's ataxia(FRDA)is a rare genetic disorder characterized by motor discoordination and cerebellar involvement due to mutations in the frataxin(FXN)gene,which encodes a mitochondrial protein involved in ironsulfur cluster biogenesis and iron handling."While progress has been made in understanding FRDA's pathophysiology and cerebellar degeneration caused by frataxin deficiency,the role of central nervous system(CNS)-resident nonneuronal cells,as microglia,necessitates further investigation.

关键词： involvement degeneration Friedreich

Genetic diversity in Ebola virus:Phylogenetic and in silico structural studies of Ebola viral proteins

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Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 329-335页

作者： Alba Grifoni Alessandra Lo Presti Marta Giovanetti Carla Montesano Massimo Amicosante Vittorio Colizzi Alessia Lai Gianguglielmo Zehender Eleonora Cella Silvia Angeletti Massimo Ciccozzi ProxAgen Ltd.Sofia.Bulgaria Department of Infectious Parasitic and Immunomediated Diseases National Institute of Health Department of Biology University of Rome 'Tor Vergata' Department of Biomedicine and Prevention University of Rome Tor Vergata Laboratory of Infectious Diseases and Tropical Medicine University of Milan Department of Public Health and Infectious Diseases.Sapienza university of rome.rome Clinical Pathology and Microbiology Laboratory University Hospital Campus Bio-Medico of Rome university Campus Bio-Medico

Objective:To explore the genetic diversity and the modification of antibody response in the recent outbreak of Ebola ***:Sequences retrieved from public databases,the selective pressure analysis and the homology modelling based on the all protein(***35,*** glycoprotein,small soluble ***30,VP24 and polymerase) were ***:Structural proteins ***35 and VP40 showed relative conserved sequences making them suitable target candidates for antiviral *** the contrary,*** and soluble glycoprotein have high mutation ***:Data from this study point out important aspects of Ebola virus sequence variability that for epitope and vaccine design should be considered for appropriate targeting of conserved protein regions.

关键词： Ebola virus Proteins Evolutionary analysis

Repurposing niclosamide for the treatment of neurological disorders

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Neural Regeneration Research 2023年第12期18卷 2705-2706页

作者： Savina Apolloni Nadia D’Ambrosi Department of Biology University of Rome Tor VergataRomeItaly

Neurological disorders are still one of the major causes of death,and the vast need to find efficacious therapy is nowadays an essential goal of the scientific *** Parkinson's disease(PD),amyotrophic lateral sclerosis... 详细信息

关键词： disorders death neurological

A methodology for assessing the urban supply of on-street delivery bays

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Green Energy and Intelligent Transportation 2022年第3期1卷 63-72页

作者： Antonio Comi JoséLuis Moura Sara Ezquerro university of rome tor vergata RomeItaly university of Cantabria SantanderSpain

The loading and unloading operations carried out by transport and logistics operators have a strong impact on city mobility if they are not performed *** loading/unloading bays,i.e.,delivery bays(DB),are not available for freight vehicle operations,operators may opt to double park or park on the sidewalk where there is no strong enforcement of these laws,with significant impact on *** paper proposes a methodology for verifying and designing the number of delivery bays needed for freight vehicles for not interfere with cars or *** methodology consists of two stages:in the first stage,an initial estimation is made using queueing ***,in the second stage,using such tentative scenario,in order to take into account the system stochasticity involving different entities,a discrete event simulation is performed to more realistically verify and upgrade(if necessary)the number of delivery bays to obtain the expected *** methodology was applied in the inner area of Santander(Spain).The study area was subdivided into 29 zones where the methodology was applied *** results indicated that none of these zones currently have an optimal number of delivery bays to satisfy *** some zones,there is an excess of delivery bays,although in most of them,there is a deficit which can cause significant impacts on *** method proposed can be an effective tool to be used by city planners for improving freight operations in urban areas limiting the negative impacts produced in terms of internal and external costs.

关键词： Urban freight transportation On-street delivery bays Discrete event simulation City logistics Urban goods movements

Prophylactic drains in totally laparoscopic distal gastrectomy:are they always necessary?

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World Journal of Gastroenterology 2022年第3期28卷 399-401页

作者： Tommaso Maria Manzia Alessandro Parente Roberta Angelico HPB and Transplant Unit Department of Surgery ScienceUniversity of Rome Tor VergataRome 00133Italy Queen Elizabeth Hospital Liver UnitUniversity of BirminghamBirmingham UK and HPB and Transplant UnitDepartment of Surgery ScienceUniversity of Rome Tor VergataRome 00133Italy

Prophylactic drains have always been a useful tool to detect early complications and prevent postoperative fluid collections,particularly in gastrointestinal ***,the utilization of such drains has been debated,due to mounting evidence that they could be harmful rather than *** on recent published articles,Liu et al reported that the routine use of prophylactic drains in total laparoscopic distal gastrectomy might not be necessary for all ***,we express our opinion regarding this interesting publication.

关键词： Gastric cancer Prophylactic drainage Totally laparoscopic gastrectomy Enhanced recovery after surgery Minimally invasive surgery Early gastric cancer

Fibrosis as a common trait in amyotrophic lateral sclerosis tissues

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Neural Regeneration Research 2022年第1期17卷 97-98页

作者： Savina Apolloni Nadia D’Ambrosi Department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a highly aggressive adult-onset neurodegenerative disease caused by the progressive loss of upper and lower motor ***,it causes irreversible muscle atrophy and spasticity,leading to death due to respiratory failure,usually within 2–5 years after the first symptom *** 85%of ALS cases are classified as sporadic,while the remaining 15%are of familial origin,but the overall clinical and molecular features of the disease are almost undistinguishable in the two *** majority of familial ALS cases are caused by pathogenic variants of C9orf72,SOD1,TARDBP,FUS,ANG and OPTN genes that are inherited by a Mendelian pattern and display high penetrance(Kiernan et al.,2020).

关键词： respiratory Clinical atrophy

Mepolizumab induced palmoplantar psoriasis:A case report

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World Journal of Clinical Cases 2023年第26期11卷 6154-6158页

作者： Fabio Artosi Laura Diluvio Martina Vultaggio Elena Campione Luca Bianchi Department of Systems Medicine University of Rome“Tor Vergata”Rome 00133Italy Department of Dermatology Dermatology UnitPoliclinico Tor VergataRome 00133Italy Department of Dermatology University Roma Tor VergataRome 00133Italy

BACKGROUND Atopic dermatitis and asthma are two diseases whose pathogenesis is largely attributable to the activation,at least in the initial stages,of T helper(Th)-2 Lymphocytes,the related cytokine axis,and B lymphocytes with antibody *** is conversely a pathology resulting from a recruitment of Th-17 and Th-1 lymphocytes,after an initial role of innate *** is a humanized monoclonal antibody directed against interleukin(IL)-5,a central cytokine in the Th-2 axis,therefore involved in the pathogenesis of *** authors have described the appearance of psoriatic lesions in patients with asthma or atopic dermatitis following the therapy with dupilumab,a monoclonal antibody that blocks the interleukin(IL)-4,another Th-2 *** SUMMARY We present the case of a 59-year-old patient who developed psoriasiform lesions on the palms after mepolizumab therapy for asthma,for the activation of the parallel cytokine cascade after the blockade of *** successfully treated the patient with a topical calcipotriol and betamethasone *** We should investigate with further attention the possible impact on the human immunological ecosystem put in place by the inhibition of the activity of individual inflammatory mediators,so as to be able to recognize the initial adverse effects early.

关键词： Psoriasis Interleukin-5 Mepolizumab Asthma Immunology Case report

Lipid catabolism and mitochondrial uncoupling are stimulated in brown adipose tissue of amyotrophic lateral sclerosis mouse models

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Genes & Diseases 2023年第2期10卷 321-324页

作者： Fabio Ciccarone Serena Castelli Giacomo Lazzarino Silvia Scaricamazza Renata Mangione Sergio Bernardini Savina Apolloni Nadia D'Ambrosi Alberto Ferri Maria Rosa Ciriolo Department of Biology University of Rome “Tor Vergata”00133 RomeItaly IRCCS San Raffaele Roma 00166 RomeItaly UniCamillus-Saint Camillus International university of Health Sciences 00131 RomeItaly IRCCS Fondazione Santa Lucia 00179 RomeItaly Department of Basic Biotechnological Sciences Intensive and Perioperative ClinicsCatholic University of Rome00168 RomeItaly Fondazione Policlinico Universitario A. Gemelli IRCCS 00168 RomeItaly Institute of Translational Pharmacology IFT-CNR 00133 RomeItaly

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease typically leading to death within 5 years from symptom onset. ALS familial forms are associated with mutations in several genes, including Superoxide Dismutase 1 (SOD1) and Fused in Sarcoma (FUS). Although genes linked to ALS participate in disparate biological processes, ALS genetic variants largely trigger shared pathogenic events such as oxidative stress, protein aggregation and defects in RNA processing. Moreover, ALS patients show systemic hypermetabolism that leads to increased energy expenditure at rest and thus weight loss during the disease course.1 ALS hypermetabolic phenotype and weight loss have been extensively characterized in mice bearing the G93A substitution in SOD1 protein (SOD1-G93A), which exhibit skeletal-muscle metabolic reprogramming before disease onset.

关键词： Lipid metabolism aggregation