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Neural Regeneration Research 2025年第9期20卷 2581-2582页

作者： Marianne Bardy-Lagarde Narimène Asbelaoui Abdel Mouman Ghoumari UMR1195 “Diseases and Hormones of the Nervous System”Inserm and University Paris-SaclayKremlin-BicêtreFrance

Multiple sclerosis(MS)is the most common chronic disease of the central nervous system(CNS)in young adults and represents the first cause of severe handicap,originally non-traumatic(Oh et al.,2018).MS is chara cterized by the infiltration of auto reactive lymphocytes specific to myelin through the blood-brain barrier,which results in the appearance of inflammatory demyelinating lesions caused by the death of the central nervous system myelinating cells,oligodendrocytes(Oh et al.,2018).There is a prevalence sexual with a ratio of three times more affected women than men.

关键词： myelin CXCR4

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Tale of mitochondria and mitochondria-associated ER membrane in patient-derived neuronal models of Wolfram syndrome

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Neural Regeneration Research 2025年第9期20卷 2587-2588页

作者： Laetitia Aubry Timothy Barrett Sovan Sarkar I-STEM CECSCorbeil-EssonnesFrance Universitéparis-saclay Universitéd’EvryINSERMI-STEMUMR861Corbeil-EssonnesFrance Institute of Cancer and Genomic Sciences Institute of Biomedical ResearchCollege of Medical and Dental SciencesUniversity of BirminghamEdgbastonBirminghamUK Department of Endocrinology Birmingham Women’s and Children’s HospitalSteelhouse LaneBirminghamUK

Mitochondria and mitochondria-associated endoplasmic reticulum membrane in neurodegenerative diseases:Mitochondria generate most of the chemical energy needed to power the biochemical reactions of cells,and thus are often referred to as the"powerhouse"of the ***,this organelle is also involved in a pleth,ora of different cellular functions such as calcium(Ca^(2+))homeostasis,apoptosis,oxidative stress,and several metabolic pathways including oxidative phosphorylation,tricarboxylic acid cycle,andβ-oxidation of fatty acids.

关键词： oxidative cycle carboxylic

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Preface to special topic on information and intelligent metasurfaces

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National Science Review 2023年第8期10卷 7-8页

作者： Tie Jun Cui Marco Di Renzo Southeast university Université paris-saclay

In the past decades, information science and technology has developed rapidly, but has also encountered some *** further development requires some original driving force of underlying physics(such as quantum mechanics...

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Einstein Probe discovery of EP240408a: A peculiar X-ray transient with an intermediate timescale

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 222-240页

作者： Wenda Zhang Weimin Yuan Zhixing Ling Yong Chen Nanda Rea Arne Rau Zhiming Cai Huaqing Cheng Francesco Coti Zelati Lixin Dai Jingwei Hu Shumei Jia Chichuan Jin Dongyue Li Paul O’Brien Rongfeng Shen Xinwen Shu Shengli Sun Xiaojin Sun Xiaofeng Wang Lei Yang Bing Zhang Chen Zhang Shuang-Nan Zhang Yonghe Zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier Liming Dou Rob Eyles-Ferris Zhou Fan Hua Feng Shaoyu Fu Johan P.U.Fynbo Lluis Galbany Saurabh W.Jha Shuaiqing Jiang Albert Kong Erik Kuulkers Weihua Lei Wenxiong Li Bifang Liu Mingjun Liu Xing Liu Yuan Liu Zhu Liu Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal Nandra Jeremy Sanders Roberto Soria Lian Tao Junfeng Wang Song Wang Tinggui Wang Zhongxiang Wang Qingwen Wu Xuefeng Wu Dong Xu Yanjun Xu Suijian Xue Yongquan Xue Zijian Zhang Zipei Zhu Hu Zou Congying Bao Fansheng Chen Houlei Chen Tianxiang Chen Wei Chen Yehai Chen Yifan Chen Chenzhou Cui Weiwei Cui Yanfeng Dai Dongwei Fan Ju Guan Dawei Han Dongjie Hou Haibo Hu Maohai Huang Jia Huo Zhenqing Jia Bowen Jiang Ge Jin Chengkui Li Junfei Li Longhui Li Maoshun Li Wei Li Zhengda Li Tianying Lian Congzhan Liu Heyang Liu Huaqiu Liu Fangjun Lu Laidan Luo Jia Ma Xuan Mao Haiwu Pan Xin Pan Liming Song Hui Sun Yunyin Tan Qingjun Tang Yihan Tao Hao Wang Juan Wang Lei Wang Wenxin Wang Yilong Wang Yusa Wang Qinyu Wu Haitao Xu Jingjing Xu Xinpeng Xu Yunfei Xu Zhao Xu Changbin Xue Yulong Xue Ailiang Yan Haonan Yang Xiongtao Yang Yanji Yang Juan Zhang Mo Zhang Wenjie Zhang Zhen Zhang Zhen Zhang Ziliang Zhang Donghua Zhao Haisheng Zhao Xiaofan Zhao Zijian Zhao Hongyan Zhou Yilin Zhou Yuxuan Zhu Zhencai Zhu National Astronomical Observatories Chinese Academy of Sciences School of Astronomy and Space Sciences university of Chinese Academy of Sciences Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Institute of Space Sciences (ICE) CSIC Institut d’Estudis Espacials de Catalunya (IEEC) Max Planck Institute for Extraterrestrial Physics Innovation Academy for Microsatellites Chinese Academy of Sciences Department of Physics university of Hong Kong School of Physics and Astronomy university of Leicester School of Physics and Astronomy Sun Yat-sen university Department of Physics Anhui Normal university Shanghai Institute of Technical Physics Chinese Academy of Sciences Physics Department Tsinghua university Nevada Center for Astrophysics university of Nevada Las Vegas Department of Physics and Astronomy university of Nevada Las Vegas South African Astronomical Observatory Department of Astronomy university of Cape Town Department of Physics university of the Free State Université paris Cité CNRS Astroparticule et Cosmologie Université paris Cité CEA paris-saclay IRFU/DAp-AIM Department of Astronomy Guangzhou university Cosmic Dawn Center (DAWN) Niels Bohr Institute university of Copenhagen Department of Physics and Astronomy Rutgers the State university of New Jersey Institute for Cosmic Ray Research The university of Tokyo ESA/ESTEC Department of Astronomy School of Physics Huazhong university of Science and Technology INAF-Osservatorio Astrofisico di Torino Sydney Institute for Astronomy School of Physics The university of Sydney Department of Astronomy Xiamen university Institute for Frontiers in Astronomy and Astrophysics Beijing Normal university Department of Astronomy university of Science and Technology School of Astronomy and Space Sciences university of Science and Technology of China Institute of Deep Space Sciences Deep Space Exploration Laboratory Department of Astronomy School of Physics and Astronomy Yunnan university Shanghai Astronomical Observatory Chi

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe （EP） and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope （WXT） on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for *** flare reached a peak flux of 3.9×10-9erg cm-2s-1in 0.5-4 ke V,～300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 ke V,with a power-law photon index varying *** X-ray light curve shows a plateau lasting for ～4 d,followed by a steep decay till becoming undetectable ～10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of～10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

关键词： X-ray transients ${\bm~{Einstein~~Probe}}$

Sampling via the aggregation value for data-driven manufacturing

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National Science Review 2022年第11期9卷 161-171页

作者： Xu Liu Gengxiang Chen Yingguang Li Lu Chen Qinglu Meng Charyar Mehdi-Souzani School of Mechanical and Power Engineering Nanjing Tech University College of Mechanical &Electrical Engineering Nanjing University of Aeronautics and Astronautics university Research Laboratory in Automated Production Ecole normale superieure Paris-SaclayUniversite Paris-SaclayUniversite Sorbonne Paris Nord

Data-driven modelling has shown promising potential in many industrial applications, while the expensive and time-consuming labelling of experimental and simulation data restricts its further *** a more informative but smaller dataset to reduce labelling efforts has been a vital research problem. Although existing techniques can assess the value of individual data samples, how to represent the value of a sample set remains an open problem. In this research, the aggregation value is defined using a novel representation for the value of a sample set by modelling the invisible redundant information as the overlaps of neighbouring values. The sampling problem is hence converted to the maximisation of the submodular function over the aggregation value. The comprehensive analysis of several manufacturing datasets demonstrates that the proposed method can provide sample sets with superior and stable performance compared with state-of-the-art methods. The research outcome also indicates its appealing potential to reduce labelling efforts for more data-scarcity scenarios.

关键词： data-driven modelling intelligent manufacturing data sampling data value

Reevaluating health metrics:Unraveling the limitations of disabilityadjusted life years as an indicator in disease burden assessment

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World Journal of Methodology 2025年第1期15卷 14-19页

作者： Ariel Beresniak Dominique Bremond-Gignac Danielle Dupont Gerard Duru Data Mining International Geneva 1216Switzerland Department of Ophtalmology Necker-Enfants Malades University HospitalAP-HPParis-CitéUniversityINSERMUMRS1138Team 17From Physiopathology of Ocular Diseases to Clinical DevelopmentSorbonne Paris CitéUniversityCentre de Recherche des CordeliersParis 75015France Data Mining America Montreal H2YCanada

In 1993,the World Bank released a global report on the efficacy of health promotion,introducing the disability-adjusted life years(DALY)as a novel *** DALY,a composite metric incorporating temporal and qualitative data,is grounded in preferences regarding disability *** review delineates the algorithm used to calculate the value of the proposed DALY synthetic indicator and elucidates key methodological challenges associated with its *** contrast to the quality-adjusted life years approach,derived from multi-attribute utility theory,the DALY stands as an independent synthetic indicator that adopts the assumptions of the Time Trade Off utility technique to define Disability *** to rely on no mathematical or economic theory,DALY users appear to have exempted themselves from verifying whether this indicator meets the classical properties required of all indicators,notably content validity,reliability,specificity,and *** DALY concept emerged primarily to facilitate comparisons of the health impacts of various diseases globally within the framework of the Global Burden of Disease initiative,leading to numerous publications in international *** widespread adoption,the DALY synthetic indicator has prompted significant methodological concerns since its inception,manifesting in inconsistent and non-reproducible *** the substantial diffusion of the DALY indicator and its critical role in health impact assessments,a reassessment is *** reconsideration is imperative for enhancing the robustness and reliability of public health decisionmaking processes.

关键词： Disability adjusted life years Cost-utility analyses Outcome research Public health Burden of disease

Thermoelectric properties of high-entropy rare-earth cobaltates

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Journal of Materiomics 2023年第1期9卷 191-196页

作者： Ashutosh Kumar Diana Dragoe David Berardan Nita Dragoe ICMMO(UMR CNRS 8182) University of Paris-SaclayOrsay91405France

High-entropy concept introduced with a promising paradigm to obtain exotic physical properties has motivated us to explore the thermoelectric properties of Sr-substituted high-entropy rare-earth cobaltates i.e.,(LaNdPrSmEu)_(1-x)Sr_(x)CoO_(3)(0≤x≤0.10).The structural analysis of the samples,synthesized using the standard solid-state route,confirms the orthorhombic structure with the Pbnm space *** Seebeck coefficient and electrical resistivity decrease with rising Sr concentration as well as with an increase in *** multiple A-site ions in high-entropy rare-earth cobaltates result in an improved Seebeck coefficient(α)compared to La_(0.95)Sr_(0.05)CoO_(3),associated with a decrease in the Cosingle bondOsingle bondCo bond angle,which further enhances the power *** random distribution of cations at the rare-earth site results in a significant lowering of phonon thermal *** a result,a maximum figure of merit(zT)of 0.23 is obtained at 350K for(LaNdPrSmEu)_(0.95)Sr_(0.05)CoO_(3),which is one of the highest values of zT reported at this temperature for oxide *** study shows promise to decouple thermoelectric parameters using the high-entropy concept in several materials.

关键词： materials. temperature. entropy

DNA demethylases remodel DNA methylation in rice gametes and zygote and are required for reproduction

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Molecular Plant 2021年第9期14卷 1569-1583页

作者： Shaoli Zhou Xue Li Qian Liu Yu Zhao Wei Jiang Anqi Wu Dao-Xiu Zhou National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University430070 WuhanChina Institute of Plant Science paris–saclay(IPS2) CNRSINRAEUniversity Paris–Saclay91405 OrsayFrance

Fertilization constitutes a critical step in the plant life cycle during which the gamete genomes undergo chromatin dynamics in preparation for embryogenesis. In mammals, parental chromatin is extensively reprogrammed through the global erasure of DNA methylation. However, in flowering plants it remains unclear whether and how DNA methylation is remodeled in gametes and after fertilization in the zygote. In this study, we characterize DNA methylation patterns and investigate the function of DNA glycosylases in rice eggs, sperm, and unicellular zygotes and during embryogenesis. We found that DNA methylation is locally reconfigured after fertilization and is intensified during embryogenesis. Genetic, epigenomic, and transcriptomic analysis revealed that three rice DNA glycosylases, DNG702, DNG701, and DNG704, demethylate DNA at distinct genomic regions in the gametes and the zygote, and are required for zygotic gene expression and development. Collectively, these results indicate that active DNA demethylation takes place in the gametes and the zygote to locally remodel DNA methylation, which is critical for egg and zygote gene expression and reproduction in rice.

关键词： DNA methylation DNA glycosylase fertilization

Histone deacetylase HDA710 controls salt tolerance by regulating ABA signaling in rice

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Journal of Integrative Plant Biology 2021年第3期63卷 451-467页

作者： Farhan Ullah Qiutao Xu Yu Zhao Dao-Xiu Zhou National Key Laboratory of Crop Genetic Improvement Huazhong Agriculture UniversityWuhan 430030China Institute of Plant Science of paris-saclay(IPS2) University Paris-SaclayCNRSINRAEOrsay 91405France

Plants have evolved numerous mechanisms that assist them in withstanding environmental *** deacetylases(HDACs)play crucial roles in plant stress responses;however,their regulatory mechanisms remain poorly ***,we explored the function of HDA710/OsHDAC2,a member of the HDAC RPD3/HDA1 family,in stress tolerance in rice(Oryza sativa).We established that HDA710 localizes to both the nucleus and cytoplasm and is involved in regulating the acetylation of histone H3 and H4,specifically targeting H4 K5 and H4 K16 under normal ***710 transcript accumulation levels were strongly induced by abiotic stresses including drought and salinity,as well as by the phytohormones jasmonic acid(JA)and abscisic acid(ABA).hda710 knockout mutant plants showed enhanced salinity tolerance and reduced ABA sensitivity,whereas transgenic plants overexpressing HDA710 displayed the opposite ***,ABAand salt-stress-responsive genes,such as OsLEA3,OsABI5,OsbZIP72,and OsNHX1,were upregulated in hda710 compared with wild-type *** expression differences corresponded with higher levels of histone H4 acetylation in gene promoter regions in hda710 compared with the wild type under ABA and salt-stress ***,these results suggest that HDA710 is involved in regulating ABA-and salt-stress-responsive genes by altering H4 acetylation levels in their promoters.

关键词： abscisic acid HDA710 histone acetylation rice salinity

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Simulation of the Hygrothermal Behavior of a Building Envelope Based on Phase Change Materials and a Bio-Based Concrete

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Fluid Dynamics & Materials Processing 2022年第5期18卷 1483-1494页

作者： Dongxia Wu Mourad Rahim Wendong Li Mohammed El Ganaoui Rachid Bennacer university of Lorraine LERMABIUT H Poincaréde LongwyLongwy54400France university of paris-saclay ENS Paris-SaclayCNRSLMTGif-sur-Yvette91190France

Phase Change Materials(PCMs)have high thermal inertia,and hemp concrete(HC),a bio-based concrete,has strong hygroscopic *** previous studies,PCM has been extensively combined with many materials,however,most of these studies focused on thermal properties while neglecting hygroscopic *** this study,the two materials have been combined into a building envelope and the related hygrothermal properties have been *** particular,numerical studies have been performed to investigate the temperature and relative humidity behavior inside the HC,and the effect of adding PCM on the hygrothermal behavior of the *** results show that there is a high coupling between temperature and relative humidity inside the HC,since the relative humidity changes on the second and third days are different,with values of 8%and 4%,***,the variation of relative humidity with temperature indicates the dominant influence of temperature on relative humidity *** the presence of PCM,the temperature variation inside the HC is damped due to the high thermal inertia of the PCM,which also leads to suppression of moisture evaporation and thus damping of relative humidity *** the second and third days,the temperature changes at the central position are reduced by 4.6%and 5.1%,compared to the quarter *** the relative humidity change,the reductions are 5.3%and 5.4%on the second and third days,***,PCM,with high thermal inertia,acts as a temperature damper and has the potential to increase the moisture buffering capacity inside the *** makes it possible for such a combined envelope to have both thermal and hygric inertia.

关键词： Phase change material(PCM) bio-based concrete passive building envelope heat and moisture transfer hygrothermal performance