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Reevaluating health metrics:Unraveling the limitations of disabilityadjusted life years as an indicator in disease burden assessment

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World Journal of Methodology 2025年第1期15卷 14-19页

作者： Ariel Beresniak Dominique Bremond-Gignac Danielle Dupont Gerard Duru Data Mining International Geneva 1216Switzerland Department of Ophtalmology Necker-Enfants Malades University HospitalAP-HPParis-CitéUniversityINSERMUMRS1138Team 17From Physiopathology of Ocular Diseases to Clinical DevelopmentSorbonne Paris CitéUniversityCentre de Recherche des CordeliersParis 75015France Data Mining America Montreal H2YCanada

In 1993,the World Bank released a global report on the efficacy of health promotion,introducing the disability-adjusted life years(DALY)as a novel *** DALY,a composite metric incorporating temporal and qualitative data,is grounded in preferences regarding disability *** review delineates the algorithm used to calculate the value of the proposed DALY synthetic indicator and elucidates key methodological challenges associated with its *** contrast to the quality-adjusted life years approach,derived from multi-attribute utility theory,the DALY stands as an independent synthetic indicator that adopts the assumptions of the Time Trade Off utility technique to define Disability *** to rely on no mathematical or economic theory,DALY users appear to have exempted themselves from verifying whether this indicator meets the classical properties required of all indicators,notably content validity,reliability,specificity,and *** DALY concept emerged primarily to facilitate comparisons of the health impacts of various diseases globally within the framework of the Global Burden of Disease initiative,leading to numerous publications in international *** widespread adoption,the DALY synthetic indicator has prompted significant methodological concerns since its inception,manifesting in inconsistent and non-reproducible *** the substantial diffusion of the DALY indicator and its critical role in health impact assessments,a reassessment is *** reconsideration is imperative for enhancing the robustness and reliability of public health decisionmaking processes.

关键词： Disability adjusted life years Cost-utility analyses Outcome research Public health Burden of disease

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Crosstalk between androgen signaling and the chemokine receptor CXCR4:a novel strategy to promote myelin regeneration

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Neural Regeneration Research 2025年第9期20卷 2581-2582页

作者： Marianne Bardy-Lagarde Narimène Asbelaoui Abdel Mouman Ghoumari UMR1195 “Diseases and Hormones of the Nervous System”Inserm and University Paris-SaclayKremlin-BicêtreFrance

Multiple sclerosis(MS)is the most common chronic disease of the central nervous system(CNS)in young adults and represents the first cause of severe handicap,originally non-traumatic(Oh et al.,2018).MS is chara cterized by the infiltration of auto reactive lymphocytes specific to myelin through the blood-brain barrier,which results in the appearance of inflammatory demyelinating lesions caused by the death of the central nervous system myelinating cells,oligodendrocytes(Oh et al.,2018).There is a prevalence sexual with a ratio of three times more affected women than men.

关键词： myelin CXCR4

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Transjugular intrahepatic portosystemic shunt as bridge-to-surgery in refractory gastric antral vascular ectasia

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World Journal of Gastroenterology 2015年第18期21卷 5749-5750页

作者： Aymeric Becq Violaine Ozenne Aurélie Plessier Patrice Valleur Xavier Dray Department of Gastroenterology and Hepatology Sorbonne Paris Cité Paris 7 University & APHP Lariboisière Hospital Department of Hepatology Sorbonne Paris Cité Paris 7 University & APHP Beaujon Hospital Department of Surgery Sorbonne Paris Cité Paris 7 University & APHP Lariboisière Hospital

Gastric antral vascular ectasia(GAVE) may cause gastrointestinal bleeding(GIB). The treatment of GAVE relies on endoscopic approaches such as electrocoagulation(argon plasma coagulation, laser therapy, heater probe therapy, radiofrequency ablation), cryotherapy, and band ligation. In refractory cases, antrectomy may be considered. In the event of an associated cirrhosis and portal hypertension, it has been suggested that antrectomy could be an option, provided the mortality risk isn't considered too great. We report the case of a 67-year-old cirrhotic patient who presented with GAVE related GIB, unresponsive to multiple endoscopic treatments. The patient had a good liver function(model for end-stage disease 10). After a multidisciplinary meeting, a transjugular intrahepatic portosystemic shunt(TIPS) procedure was performed, in order to treat the cirrhosis associated ascites. The outcome was successful. An antrectomy was then performed, with no recurrence of GIB and no transfusion need during three months of follow up. In this case, the TIPS procedure achieved a complete ascites regression, allowing a safer surgical treatment of the GAVE-related GIB.

关键词： Gastric antral vascular ectasia Gastro-intestinal bleeding Cirrhosis Ascites Transjugular intrahepatic portosystemic shunt Antrectomy

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Active explorers show low learning performance in a social insect

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Current Zoology 2017年第5期63卷 555-560页

作者： Eve UDINO Margot PEREZ Claudio CARERE Patrizia d'ETTORRE Laboratory of Experimental and Comparative Ethology University Paris 13 Sorbonne Paris Cit6 93430 Villetaneuse France

An intriguing question in behavioral biology is whether consistent individual differences （calledanimal personalities） relate to variation in cognitive performance because commonly measuredpersonality traits may be associated with risk-reward trade-offs. Social insects, whose learningabilities have been extensively characterized, show consistent behavioral variability, both at colonyand at individual level. We investigated the possible link between personality traits and learningperformance in the carpenter ant Camponotus aethiops. Exploratory activity, sociability, and ag-gression were assessed twice in ant foragers. Behaviors differed among individuals, they werepartly repeatable across time and exploratory activity correlated positively with *** abilities were quantified by differential conditioning of the maxilla-labium extension re-sponse, a task that requires cue perception and information storage. We found that exploratory ac-tivity of individual ants significantly predicted learning performance：＂active-explorers＂ wereslower in learning the task than ＂inactive-explorers＂. The results suggest for the first time a link be-tween a personality trait and cognitive performance in eusocial insects, and that the underlying in-dividual variability could affect colony performance and success.

关键词： ants, associative learning, cognition, exploratory activity, personality.

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Recovering Navier–Stokes Equations from Asymptotic Limits of the Boltzmann Gas Mixture Equation

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Communications in Theoretical Physics 2016年第5期65卷 553-562页

作者： Carlo Bianca Christian Dogbe Laboratoire de Physique Statistique Ecole Normale Superieure PSL Research University University Paris Diderot Sorbonne Paris-Cite Sorbonne Universites UPMC Univ Paris 06 CNRS Department of Mathematics Universite de Caen Normandie LMNOCNRS

This paper is devoted to the derivation of macroscopic fluid dynamics from the Boltzmann mesoscopic dynamics of a binary mixture of hard-sphere gas *** the hydrodynamics limit is performed by employing different time and space *** paper shows that,depending on the magnitude of the parameters which define the scaling,the macroscopic quantities(number density,mean velocity and local temperature)are solutions of the acoustic equation,the linear incompressible Euler equation and the incompressible Navier–Stokes *** derivation is formally tackled by the recent moment method proposed by[***,et al.,***.63(1991)323]and the results generalize the analysis performed in[***,et al.,*** ***.29(2015)240].

关键词： gas mixtures hydrodynamic limit asymptotic limit fluid equation conservation law

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Simulation study on cosmic ray background at large zenith angle based on GRANDProto35 coincidence array experiment

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Nuclear Science and Techniques 2021年第1期32卷 35-45页

作者： Xiang-Li Qian Xu Wang Hui-Ying Sun Zhen Wang Olivier Martineau-Huynh School of Intelligent Engineering Shandong Management UniversityJinan 250357China Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China sorbonne paris Cite CNRS/IN2P3LPNHESorbonne UniversiteUniversite Paris DiderotParisFrance

Neutrino detection in the 100 PeV energy region is the ultimate means of studying the origin of ultra-highenergy cosmic rays,in which the large radio detection array giant radio array for neutrino detection(GRAND)project aims to use to decipher this century-old *** GRANDProto35 compact array is a microform of 35 radio prototype detectors for the GRAND experiment,which verifies the reliability of GRAND performance through operation,and data analysis of the prototype *** radio detectors are a novel development in recent years,and their indexes need to be verified by traditional detectors,the GRAND Cooperation Group designed and constructed the GRANDProto35 coincidence array composed of radio detectors and scintillation *** study simulated the changes in detection efficiency,effective area,and event rate of cosmic rays with zenith angle based on this coincidence *** study found that the 1017 eV energy region is sensitive to GRANDProto35 *** the energy exceeded 1017 eV,the array detection efficiency could reach more than 95%and the effective area was up to*29106 m2.A simulation study on cosmic ray events with large zenith angles showed that the event rate detected by the array decreased significantly with increasing zenith angle,and the event rate of cosmic rays was approximately 0.1 per day for a zenith angle of 75.This serves as the background pollution rate for neutrino observation caused by largeangle cosmic-ray events,providing an important reference for further *** study results will be verified after the joint operation of the coincidence array.

关键词： GRANDProto35 GEANT4 Scintillation detector Cosmic ray

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Laboratory radiative accretion shocks on GEKKO XⅡlaser facility for POLAR project

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High Power Laser Science and Engineering 2018年第2期6卷 181-188页

作者： L.Van Box Som E.Falize M.Koenig Y.Sakawa B.Albertazzi E Barroso J.-***-Bidaud C.Busschaert A.Ciardi Y.Hara N.Katsuki R.Kumar E Lefevre C.Michaut Th.Michel T.Miura T.Morita M.Mouchet G.Rigon T.Sano S.Shiiba H.Shimogawara S.Tomiya CEA-DAM-DIF F-91297 ArpajonFrance LERMA Sorbonne UniversiteObservatoire de ParisUniversite PSLCNRSF-75005 ParisFrance CEA Saclay DSM/Irfu/Service d'AstrophysiqueF-91191 Gif-sur-YvetteFrance LULI-CNRS Ecole PolytechniqueCEA:Universite Paris-Saclay UPMC Univ paris 06:sorbonne Universite-F-91128 Palaiseau Cedex France Graduate School of Engineering Osaka UniversitySuitaOsaka 565-0871Japan Institute of Laser Engineering Osaka UniversitySuitaOsaka 565-0871Japan Faculty of Engineering Sciences Kyushu University6-1 Kasuga-KoenKasugaFukuoka 816-8580Japan Aoyama Gakuin university Japan GEPI Observatoire de ParisPSL Research UniversityCNRSUniversite Paris DiderotSorbonne Paris CiteF-75014 ParisFrance LUTH Observatoire de ParisPSL Research UniversityCNRSUniversite Paris DiderotSorbonne Paris CiteF-92195 MeudonFrance

A new target design is presented to model high-energy radiative accretion shocks in polars. In this paper, we present the experimental results obtained on the GEKKO XII laser facility for the POLAR project. The experimental results are compared with 2 D FCI2 simulations to characterize the dynamics and the structure of plasma flow before and after the collision. The good agreement between simulations and experimental data confirms the formation of a reverse shock where cooling losses start modifying the post-shock region. With the multi-material structure of the target,a hydrodynamic collimation is exhibited and a radiative structure coupled with the reverse shock is highlighted in both experimental data and simulations. The flexibility of the laser energy produced on GEKKO XII allowed us to produce high-velocity flows and study new and interesting radiation hydrodynamic regimes between those obtained on the LULI2000 and Orion laser facilities.

关键词： accretion processes high power laser hydrodynamics laboratory astrophysics

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Einstein Probe discovery of EP240408a: A peculiar X-ray transient with an intermediate timescale

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 222-240页

作者： Wenda Zhang Weimin Yuan Zhixing Ling Yong Chen Nanda Rea Arne Rau Zhiming Cai Huaqing Cheng Francesco Coti Zelati Lixin Dai Jingwei Hu Shumei Jia Chichuan Jin Dongyue Li Paul O’Brien Rongfeng Shen Xinwen Shu Shengli Sun Xiaojin Sun Xiaofeng Wang Lei Yang Bing Zhang Chen Zhang Shuang-Nan Zhang Yonghe Zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier Liming Dou Rob Eyles-Ferris Zhou Fan Hua Feng Shaoyu Fu Johan P.U.Fynbo Lluis Galbany Saurabh W.Jha Shuaiqing Jiang Albert Kong Erik Kuulkers Weihua Lei Wenxiong Li Bifang Liu Mingjun Liu Xing Liu Yuan Liu Zhu Liu Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal Nandra Jeremy Sanders Roberto Soria Lian Tao Junfeng Wang Song Wang Tinggui Wang Zhongxiang Wang Qingwen Wu Xuefeng Wu Dong Xu Yanjun Xu Suijian Xue Yongquan Xue Zijian Zhang Zipei Zhu Hu Zou Congying Bao Fansheng Chen Houlei Chen Tianxiang Chen Wei Chen Yehai Chen Yifan Chen Chenzhou Cui Weiwei Cui Yanfeng Dai Dongwei Fan Ju Guan Dawei Han Dongjie Hou Haibo Hu Maohai Huang Jia Huo Zhenqing Jia Bowen Jiang Ge Jin Chengkui Li Junfei Li Longhui Li Maoshun Li Wei Li Zhengda Li Tianying Lian Congzhan Liu Heyang Liu Huaqiu Liu Fangjun Lu Laidan Luo Jia Ma Xuan Mao Haiwu Pan Xin Pan Liming Song Hui Sun Yunyin Tan Qingjun Tang Yihan Tao Hao Wang Juan Wang Lei Wang Wenxin Wang Yilong Wang Yusa Wang Qinyu Wu Haitao Xu Jingjing Xu Xinpeng Xu Yunfei Xu Zhao Xu Changbin Xue Yulong Xue Ailiang Yan Haonan Yang Xiongtao Yang Yanji Yang Juan Zhang Mo Zhang Wenjie Zhang Zhen Zhang Zhen Zhang Ziliang Zhang Donghua Zhao Haisheng Zhao Xiaofan Zhao Zijian Zhao Hongyan Zhou Yilin Zhou Yuxuan Zhu Zhencai Zhu National Astronomical Observatories Chinese Academy of Sciences School of Astronomy and Space Sciences university of Chinese Academy of Sciences Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Institute of Space Sciences (ICE) CSIC Institut d’Estudis Espacials de Catalunya (IEEC) Max Planck Institute for Extraterrestrial Physics Innovation Academy for Microsatellites Chinese Academy of Sciences Department of Physics university of Hong Kong School of Physics and Astronomy university of Leicester School of Physics and Astronomy Sun Yat-sen university Department of Physics Anhui Normal university Shanghai Institute of Technical Physics Chinese Academy of Sciences Physics Department Tsinghua university Nevada Center for Astrophysics university of Nevada Las Vegas Department of Physics and Astronomy university of Nevada Las Vegas South African Astronomical Observatory Department of Astronomy university of Cape Town Department of Physics university of the Free State Université paris Cité CNRS Astroparticule et Cosmologie Université paris Cité CEA paris-Saclay IRFU/DAp-AIM Department of Astronomy Guangzhou university Cosmic Dawn Center (DAWN) Niels Bohr Institute university of Copenhagen Department of Physics and Astronomy Rutgers the State university of New Jersey Institute for Cosmic Ray Research The university of Tokyo ESA/ESTEC Department of Astronomy School of Physics Huazhong university of Science and Technology INAF-Osservatorio Astrofisico di Torino Sydney Institute for Astronomy School of Physics The university of Sydney Department of Astronomy Xiamen university Institute for Frontiers in Astronomy and Astrophysics Beijing Normal university Department of Astronomy university of Science and Technology School of Astronomy and Space Sciences university of Science and Technology of China Institute of Deep Space Sciences Deep Space Exploration Laboratory Department of Astronomy School of Physics and Astronomy Yunnan university Shanghai Astronomical Observatory Chi

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe （EP） and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope （WXT） on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for *** flare reached a peak flux of 3.9×10-9erg cm-2s-1in 0.5-4 ke V,～300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 ke V,with a power-law photon index varying *** X-ray light curve shows a plateau lasting for ～4 d,followed by a steep decay till becoming undetectable ～10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of～10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

关键词： X-ray transients ${\bm~{Einstein~~Probe}}$

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Interplay of RNA-binding proteins controls germ cell development in zebrafish

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Journal of Genetics and Genomics 2024年第9期51卷 889-899页

作者： De-Li Shi Laboratory of Developmental Biology CNRS-UMR7622Institut de Biologie Paris-Seine(IBPS)Sorbonne University75005 ParisFrance

The specification of germ cells in zebrafish mostly relies on an inherited mechanism by which localized maternal determinants,called germ plasm,confer germline fate in the early *** studies have partially allowed the identification of key regulators governing germ plasm formation and subsequent germ cell ***-binding proteins,acting in concert with other germ plasm components,play essential roles in the organization of the germ plasm and the specification,migration,maintenance,and differentiation of primordial germ *** loss of their functions impairs germ cell formation and causes sterility or sexual *** is emerging that they instruct germline development through differential regulation of mRNA fates in somatic and germ ***,the challenge remains to decipher the complex interplay of maternal germ plasm components in germ plasm compartmentalization and germ cell *** failure to control the developmental outcome of germ cells disrupts the formation of gametes,it is important to gain a complete picture of regulatory mechanisms operating in the germ cell *** review sheds light on the contributions of RNA-binding proteins to germ cell development in zebrafish and highlights intriguing questions that remain open for future investigation.

关键词： Germplasm Primordialgerm cell Germlinestem cell Gametogenesis Zebrafish RNA-binding protein Posttranscriptional gene expression Translational activation and repression

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Analytical modelling of the expansion of a solid obstacle interacting with a radiative shock

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High Power Laser Science and Engineering 2018年第2期6卷 123-132页

作者： Th.Michel E.Falize B.Albertazzi G.Rigon Y.Sakawa T.Sano H.Shimogawara R.Kumar T.Morita C.Michaut A.Casner R Barroso P.Mabey Y.Kuramitsu S.Laffite L.Van Box Som G.Gregori R.Kodama N.Ozaki P.Tzeferacos D.Lamb M.Koenig luli-cnrs ecole polytechniquecea:universite paris-saclayupmc univ paris 06:sorbonne universites-f-91128 palaiseau cedexFrance cea damdifF-91297 ArpajonFrance cea saclay dsm/irfu/service d'astrophysiqueF-91191 Gif-sur-YvetteFrance institute of laser engineering osaka universitySuitaOsaka 565-0871Japan faculty of engineering sciences kyushu university6-1 Kasuga-KoenKasugaFukuoka 816-8580Japan luth observatoire de parispsl research universitycnrsuniversite paris diderotSorbonne Paris Cite92190 MeudonFrance universite de bordeaux-cnrs-cea celia UMR 5107F-33405 TalenceFrance gepi observatoire de parispsl research universitycnrsuniversite paris diderotSorbonne Paris Cite75014 ParisFrance graduate school of engineering osaka universitySuitaOsaka 565-0871Japan lerma observatoire de parispsl research universitycnrssorbonne universitesUPMC Univ.Paris 06F-75005 ParisFrance clarendon laboratory university of oxfordParks RoadOxford OX1 3PUUK flash center for computational science university of chicagoIL 60637USA

In this paper, we present a model characterizing the interaction of a radiative shock(RS) with a solid material, as described in a recent paper(Koenig et al., Phys. Plasmas, 24, 082707(2017)), the new model is then related to recent experiments performed on the GEKKO XII laser facility. The RS generated in a xenon gas cell propagates towards a solid obstacle that is ablated by radiation coming from the shock front and the radiative precursor, mimicking processes occurring in astrophysical phenomena. The model presented here calculates the dynamics of the obstacle expansion,which depends on several parameters, notably the geometry and the temperature of the shock. All parameters required for the model have been obtained from experiments. Good agreement between experimental data and the model is found when spherical geometry is taken into account. As a consequence, this model is a useful and easy tool to infer parameters from experimental data(such as the shock temperature), and also to design future experiments.

关键词： high energy density physics laser–plasmas interaction modelling plasmas astrophysics plasma physics radiative hydrodynamics radiative shock

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