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Deubiquitinase USP28 inhibits ubiquitin ligase KLHL2-mediated uridine-cytidine kinase 1 degradation and confers sensitivity to 5'-azacytidine-resistant human leukemia cells

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解剖学杂志 2021年第S1期44卷 168-168页

作者： Zhang Heng Huang He Feng Xing Song Huirven Zhang Zhiyong Shen Aizong Qiu Xingfeng Department of Histology and Embryology Xiang Ya School of MedicineCentral South UniversityChangsha 410083China The Affiliated Hospital of Guilin Medical university Guangxi Key Laboratory of Brain and Cognitive NeuroscienceGuangxi Neurological Diseases Clinical Research Center Department of Cardiology Jiading District Central Hospital Affiliated Shanghai University of Medicine&Health Sciences National Center for International Research of Biological Targeting Diagnosis and Therapy(Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research) Guangxi Medical University Department of Surgery Robert-Wood-Johnson Medical School University HospitalThe State University of New JerseyNew BrunswickNew JerseyUSA Pharmacy Department The First Affiliated Hospital of USTCDirvision of Life Sciences and MedicineUniversity of Science and Technology of China Department of Gastrointestinal Surgery Zhongshan Hospital of Xiamen University

Resistance to the chemotherapeutic drug 5'-azacytidine(5'-AZA)is a major obstacle in the treatment of patients with acute myeloid leukemia(AML).The uridine-cytidine kinase 1(UCK1)has an established role in activating 5'-AZA and its protein level is significantly downregulated in patients resistant to the ***,the underlying molecular mechanism for the reduced UCK1 expression remains to be *** demonstrated that the ubiquitin E3 ligase KLHL2 interacted with UCK1 and mediated its polyubiquitination at the K81 residue and *** showed that deubiquitinase USP28 antagonized KLHL2-mediated polyubiquitylation of *** also provided evidence that ATM-mediated phosphorylation of USP28 resulted in its disassociation from KLHL2 and UCK1 ***,UCK1 phosphorylation by 5'-AZA-activated ATM enhanced the KLHL2-UCK1 complex formation,Importantly,silencing KLHL2 or USP28 overexpression not only inhibited AML cell proliferation but also sensitized AML cells to 5'-AZA-induced apoptosis in vitro and in *** results were no longer observed in USP28-deficient cells.

关键词： ubiquitin KLH mediated

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Filling agricultural waste into coal mine goafs:a potential carbon sequestration in China

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Journal of Bioresources and Bioproducts 2016年第2期1卷 55-57页

作者： Hongbin Liu Xingye An Jing Shen Yonghao Ni Tianjin Key Laboratory of Pulp and Paper Tianjin University of Science and TechnologyTianjin 300457China Key Laboratory of Bio-based Material Science and Technology of Ministry of Education Material Science and Engineering CollegeNortheast Forestry UniversityHarbin 150040China Department of Chemical Engineering&Limerick Pulp and Paper Centre University of New BrunswickFrederictonNBE3B 5A3Canada

China is a significant atmospheric carbon dioxide *** of agricultural waste in China is also a problematic issue,raising environmental and carbon-emission-related ***,the coal-dependent economy is accompanied by the formation of large coal mine goaf areas,particularly in Shanxi *** this context,the idea of filling crop residues into the coal mine goafs is *** concept addresses multi-functions:(1)carbon sequestration,(2)an alternative disposal method of crop residue in rural areas,and(3)coal mine goaf remedy.

关键词： Agricultural crop residues Coal mine goaf safety Climate change Carbon emission

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Complementarity of Sentinel-1 and Sentinel-2 Data for Mapping Agricultural Areas in Senegal

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Advances in Remote Sensing 2020年第3期9卷 101-115页

作者： Gayane Faye Fama Mbengue Lacina Coulibaly Mamadou Adama Sarr Modou Mbaye Amath Tall Dome Tine Omar Marigo Mouhamadou Moustapha Mbacke Ndour Laboratoire de Télédétection Appliquée Institut des Sciences de la Terre Cheikh Anta DIOP University of Dakar (LTA/IST/UCAD) Dakar Senegal Laboratoire de Géomatique Environnementale école de Foresterie Université de Moncton Nouveau-Brunswick Canada Centre de Suivi Ecologique (CSE) of Dakar Dakar Senegal Laboratoire d’études et de Recherche en Statistique et Développement UFR de Sciences Appliquées et de Technologie Département de Mathématiques Appliquées Université Gaston BERGER of Saint-Louis Dakar Senegal Ecole Nationale Supérieure d’Agriculture (ENSA) Thies University Thies Senegal UFR Science de l’Ingenieur Thies University Thies Senegal

The small size of agricultural plots is the main difficulty for crops mapping with remote sensing data in the Sahelian region of Africa. The study aims to combine Sentinel-1 (radar) and Sentinel-2 (Optic) data to discriminate millet, maize and peanut crops. Training plots were used in order to analyse temporal variation of the three crops’ signals. The NDVI (Normalized Difference Vegetation Index) was able to differentiate crops only at the end of the rainy season (October). The optical data as well as the radar ones could not easily discriminate the three crops during the growing season, because in that period vegetation cover is low, and soil contribution to the signals (due to roughness and moisture) was more important than that of real vegetation. However, the ratio of VH/VV (VH: incident signal in vertical polarization and reflected signal in horizontal polarization;VV: incident signal in vertical polarization and reflected signal in horizontal polarization) gave a difference between millet and the two other crops at the beginning cultural season (July 11). Difference appears from the second third of September when the harvest of cereals crops (millet and maize) began. From middle of October, the peanut signal dropped sharply thus facilitating the differentiation of peanut from the two other crops. This analysis led to the identification of data that have could be used to discriminate these crops (useful data). Classification of the combined useful data gave an overall high accuracy of 82%, with 96%, 61% and 65% for peanut, maize and millet, respectively. The non-agricultural areas (water, natural vegetation, habit, bare soil) were well classified with an accuracy greater than 90%.

关键词： Agricultural Areas Remote Sensing Sentinel-1 Sentinel-2 Senegal

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Microfungi associated with Clematis(Ranunculaceae)with an integrated approach to delimiting species boundaries

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Fungal Diversity 2020年第3期102卷 1-203页

作者： Chayanard Phukhamsakda Eric H.C.McKenzie Alan J.L.Phillips E.B.Gareth Jones D.Jayarama Bhat Stadler Marc Chitrabhanu S.Bhunjun Dhanushka N.Wanasinghe Benjarong Thongbai Erio Camporesi Damien Ertz Ruvishika S.Jayawardena Rekhani Hansika Perera Anusha H.Ekanayake Saowaluck Tibpromma Mingkwan Doilom Jianchu Xu Kevin D.Hyde Institute of Plant Health Zhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225People’s Republic of China Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Landcare Research Manaaki Whenua Private Bag 92170AucklandNew Zealand university of Lisbon Faculty of SciencesBiosystems and Integrative Sciences Institute(BioISI)Campo Grande1749‑016 LisbonPortugal Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand State Key Laboratory for Conservation and Utilization of East and Central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanPeople’s Republic of China 33B St.Edwards Road Southsea Hants Hampshire PO53DHUK Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O Box 2455Riyadh 11451Kingdom of Saudi Arabia A.M.B.Gruppo Micologico Forlivese“Antonio Cicognani”Viale Roma 1847121 ForliItaly A.M.B Circolo Micologico“Giovanni Carini”C.P.10125121 BresciaItaly Societáper gli Studi Naturalistici della Romagna C.P.14348012 BagnacavalloRAItaly No.128/1-J Azad Housing SocietyCurcaP.O.Goa Velha403108India Center for Yunnan Plateau Biological Resources Protection and Utilization College of Biological Resource and Food EngineeringQujing Normal UniversityQujingYunnan 655011People’s Republic of China Department of Microbial Drugs Helmholtz Centre for Infection Research and German Centre for Infection Research(DZIF)partner site Hannover/BraunschweigInhoffenstrasse 738124 BrunswickGermany Department of Research Meise Botanic Garden1860 MeiseBelgium Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyangGuizhou Province 550006People’s Repu

The cosmopolitan plant genus Clematis contains many climbing species that can be found *** genus occurs in the wild and is grown commercially for *** on Clematis were collected from Belgium,China,Italy,Thailand and the *** are characterized by morphology and analyses of gene sequence data using an integrated species concept to validate *** study revealed two new families,12 new genera,50 new species,26 new host records with one dimorphic character report,and ten species are transferred to other *** new families revealed by multigene phylogeny are Longiostiolaceae and Pseudomassarinaceae in Pleosporales(Dothideomycetes).new genera are Anthodidymella(Didymellaceae),Anthosulcatispora and Parasulcatispora(Sulcatisporaceae),Fusiformispora(Amniculicolaceae),Longispora(Phaeosphaeriaceae),Neobyssosphaeria(Melanommataceae),Neoleptosporella(Chaetosphaeriales,genera incertae sedis),Neostictis(Stictidaceae),Pseudohelminthosporium(Neomassarinaceae),Pseudomassarina(Pseudomassarinaceae),Sclerenchymomyces(Leptosphaeriaceae)and Xenoplectosphaerella(Plectosphaerellaceae).The newly described species are Alloleptosphaeria clematidis,Anthodidymella ranunculacearum,Anthosulcatispora subglobosa,Aquadictyospora clematidis,Brunneofusispora clematidis,Chaetosphaeronema clematidicola,***,Chromolaenicola clematidis,Diaporthe clematidina,Dictyocheirospora clematidis,Distoseptispora clematidis,Floricola clematidis,Fusiformispora clematidis,Hermatomyces clematidis,Leptospora clematidis,Longispora clematidis,Massariosphaeria clematidis,Melomastia clematidis,***,Neobyssosphaeria clematidis,Neoleptosporella clematidis,Neoroussoella clematidis,***,Neostictis nigricans,Neovaginatispora clematidis,Parasulcatispora clematidis,Parathyridaria clematidis,***,***,Periconia verrucose,Phomatospora uniseriata,Pleopunctum clematidis,Pseudocapulatispora clematidis,Pseudocoleophoma clematidis,Pseudohelminthos

关键词： 73 new taxa Ascomycota Belgium China Dothideomycetes Incertae sedis Italy Lecanoromycetes Phylogeny Sordariomycetes Taxonomy Thailand UK

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遥感云平台系统设计——以西安航投一号卫星平台为例

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三峡生态环境监测 2023年第4期8卷 82-92页

作者：苏杰王栋秦小宝何晓彤 Wang Dingyi 上海导远智能系统有限公司上海200131 陕西铁路工程职业技术学院陕西渭南714099 西安中科天塔科技股份有限公司西安710100 Physics Department University of New BrunswickCanadaE3B 5A3

遥感云平台基于云计算技术,整合各种信息和技术资源,将遥感数据、信息产品、应用软件、计算及存储资源作为公共服务设施,通过网络为用户提供一站式的空间信息云服务。西安航投一号遥感云平台基于卫星数据产品,采用“GIS+遥感+大数据”... 详细信息

遥感云平台基于云计算技术,整合各种信息和技术资源,将遥感数据、信息产品、应用软件、计算及存储资源作为公共服务设施,通过网络为用户提供一站式的空间信息云服务。西安航投一号遥感云平台基于卫星数据产品,采用“GIS+遥感+大数据”等技术深度融合的方式,为省市、区县各级政府职能部门,大型省市属企业及相关行业用户提供针对环保、林业、农业、水利、应急救灾、地质、矿产、国土、交通、城市管理、金融等多领域基于遥感监测的数字化综合解决方案;助力陕西省在环境保护、秦岭生态保护、水利工程、自然灾害等领域以数字化手段进行风险预判和应急决策,进一步强化了相关领域的现代化管理能力。本文以西安航投一号卫星遥感云平台为例,介绍系统建设的目标、原则和内容,以期推动遥感云服务的产业化,满足公众用户实际业务的需求。

关键词：云平台 GIS 遥感大数据

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Fabrication of highly water-repelling paper by surface coating with stearic acid modified calcium carbonate particles and reactive biopolymers

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Journal of Bioresources and Bioproducts 2017年第2期2卷 89-92页

作者： Zhiwei Wang Min Yi Zheyun Zhang Mengya Guo Peng Lu Zheng Chen Shuangfei Wang Institute of Light Industry and Food Engineering&Guangxi Key Laboratory of Clean Pulp and Papermaking and Pollution Control Guangxi UniversityNanning530004China Department of Chemical Engineering and Limerick Pulp&Paper Centre University of New BrunswickFrederictonNB E3B 5A3Canada State Key Laboratory of Pulp and Paper Engineering South China University of TechnologyGuangzhou510640China.

Cellulose paper is the most attractive green packaging material due to its recyclability, renewability, sustainability and biodegradability. In some applications, paper with a high level of water resistance is desirable to meet specific requirements in modern packaging fields. This research aimed to develop a water-repelling paper with cost-effective and nontoxic materials. Commercial precipitated calcium carbonate (PCC) particles were modified by stearic acid (SA) and incorporated with soybean oil-based binder as a water repelling coating agent. The water-repelling efficiency of the coated paper was highly dependent on the ratio of SA / PCC as well as the binder content in the coating formula. PCC particles modified with 12wt% SA were efficient in increasing the water contact angle (WCA) of the coated paper to 146° at a coating weight of 5 g/m2. The binder for the coating was synthesized with acrylated epoxidized soybean oil (AESO) through Michael addition reaction. The triglyceride structure in the polymer chain imparted good bio-degradability to the binder polymer. It was found that surface modification of PCC with stearic acid played an important role in improving the WCA of paper. A super hydrophobic paper with a WCA of 162° was fabricated with a coating formula of 60% SA-modified PCC and 40 wt% AESO-binder.

关键词： Paper Biopolymer binder Modified calcium carbonate particles Coating Water-repelling Water contact angle

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Analysis of Offshore Wind Power： Application to Southern Thailand

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Journal of Energy and Power Engineering 2011年第11期5卷 1096-1101页

作者： J. Waewsak C. Kongruang M. Landry Y. Gagnon Solar and Wind Energy Research Laboratory （SWERL） Phatthalung 93110 Thailand Renewable Energy System Research and Demonstration Center （RERD） Phatthalung 93110 Thailand Department of Physics Faculty of Science Thaksin University Phatthalung 93110 Thailand School of Management Walailak University Nakhon Si Thammarat 80160 Thailand K. C. Irving Chair in Sustainable Development Universite de Moncton New Brunswick Canada

This paper presents an analysis of a pre-feasibility study of a 10 MW offshore wind power project in Nakhon Si Thammarat province, southern Thailand. The wind speeds at the hub heights of large scale wind turbine generators (WTG), i. e. 80-100 m, were extrapolated using monthly mean wind shear coefficients and the 1/7th exponent. Using WAsP 9.0, the annual energy production from several models of offshore wind farms using different WTG was analyzed. The capacity factor and the cost of energy were then computed. Using best available estimates, the analysis shows that the estimated annual mean offshore wind speeds at 80-100 m were in the range of 6.4 and 8.3 m/s. The annual energy production by the wind farm from nine models of wind turbine generators were in the range of 20-39 GWh/year, corresponding to a capacity factor in the range of 26-46%, while the cost of energy was 12-15 US cent/kWh.

关键词：海上风力发电泰国大型风力发电机风力涡轮发电机应用风力发电项目风力发电机组年发电量

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Tailoring starch-engineered mineral particles towards enhanced interaction with cellulosic fibers

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Journal of Bioresources and Bioproducts 2017年第1期2卷 36-44页

作者： Ting Li Jun Fan Jie Qi Lina Liu Limei Li Xueren Qian Qingwen Wang Yonghao Ni Jing Shen Key Laboratory of Bio-based Material Science and Technology of Ministry of Education Northeast Forestry UniversityHarbin 150040China College of Materials and Energy South China Agricultural UniversityGuangzhou 510642China Department of Chemical Engineering&Limerick Pulp and Paper Centre University of New BrunswickFredericton E3B 5A3Canada Hangzhou Research Institute of Chemical Technology Co. Ltd.Hangzhou 310014China

Interaction of unmodified starch with guest molecules or ligands(e.g.,fatty acids)as a basis for the formation of starch-encapsulated mineral filler particles is an effective process for mitigating the negative impact of filler addition on the strength properties of cellulosic *** unmodified starch is essentially nonionic,the interaction of starch-engineered fillers with negatively charged cellulosic fibers is somehow ***,the concept of substituting unmodified starch with a minor amount of cationic starch in filler engineering with starch inclusion complexes was *** was hypothesized that filler-fiber interaction would be enhanced by cationic-anionic ***,the effectiveness of this concept was demonstrated to be very *** instance,at a cationic starch percentage of 3%(relevant to the weight of total starch),filler retention and filler bondability with cellulosic fibers were significantly improved,leading to further mitigated negative impact of filler addition on tensile ***,this easily scalable concept may shed light on greener,more efficient use of filler technologies on the basis of starch inclusion complex formation,opening up new possibilities for real commercial applications.

关键词： Unmodified starch Cationic starch Starch inclusion complex Cellulosic networks Mineral fillers

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Geomechanical effects of stress shadow created by large-scale destress blasting

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第6期9卷 1085-1093页

作者： Isaac Vennes Hani Mitri Department of Mining and Materials Engineering McGill UniversityMontrealH3A 0E8Canada

This study aims to determine if large-scale choked panel destress blasting can provide sufficient beneficial stress reduction in highly-stressed remnant ore pillar that is planned for production. The orebody is divided into 20 stopes over 2 levels, and 2 panels are choke-blasted in the hanging wall to shield the ore pillar by creating a stress shadow around it. A linear-elastic model of the mining system is constructed with finite difference code FLAC3 D. The effect of destress blasting in the panels is simulated by applying a fragmentation factor(α) to the rock mass stiffness and a stress reduction factor(β) to the current state of stress in the region occupied by the destress panels. As an extreme case, the destress panel is also modeled as a void to obtain the maximum possible beneficial effects of destressing and stress *** stopes are mined in the stress shadow of the panels in 6 lifts and then backfilled. The effect of destress blasting on the remnant ore pillar is quantified based on stress change and brittle shear ratio(BSR) in the stress shadow zone compared to the base case without destress blasting. To establish realistic rock fragmentation and stress reduction factors, model results are compared to measured stress changes reported for case studies at Fraser and brunswick mines. A 1.5 MPa immediate stress decrease was observed 20 m away from the panel at Fraser Mine, and a 4 MPa immediate stress decrease was observed 25 m away at brunswick Mine. Comparable results are obtained from the current model with a rock fragmentation factor α of 0.2 and a stress reduction factor α of 0.8. It is shown that a destress blasting with these parameters reduces the major principal stress in the nearest stopes by 10-25 *** yields an immediate reduction of BSR, which is deemed sufficient to reduce volume of ore at risk in the pillar.

关键词： Destress blasting Preconditioning Rockbursts Strainbursts Numerical modeling Rock failure

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THE ACCELERATED CONCRETE PRISM TEST （60℃）:VARIABILITY OF THE TEST METHOD AND PROPOSED EXPANSION LIMITS

THE ACCELERATED CONCRETE PRISM TEST （60℃）:VARIABILITY OF ...

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第十二届国际混凝土碱集料反应会议

作者： Benoit Fournier Ray Chevrier Marie de Grosbois Rino Lisella Kevin Folliard Jason Ideker Medhat Shehatad Mike Thomas Steve Baxter ICON/CANMET Natural Resources Canada405 Rochester StreetOttawaONCanadaK1A 0G1 ICON/CANMET Natural Resources Canada405 Rochester StreetOttawaONCanadaK1A 0G1 Lafarge North America 6150 Royalmount Av.MontrealQcCanadaH4P 2R3 Lafarge North America 6150 Royalmount Av.MontrealQcCanadaH4P 2R3 Department of Civil Engineering University of Texas in AustinAustinTexasUSA78712-1076 Department of Civil Engineering University of Texas in AustinAustinTexasUSA78712-1076 Department of Civil Engineering Ryerson University350 Victoria StreetTorontoONCanadaM5B 2K3 Department of Civil Engineering University of New BrunswickFrederictonNBCanadaE3B 5A3 Steve Baxter Research Inc. 313 E.Virginia Ave.Bessemer CityNC 28016

＜正＞ This paper discusses the results of an interlaboratory study on the Accelerated Concrete Prism Test （i.e. 60℃, R.H. ＞ 95%） for ASR. Concrete mixtures were made in one laboratory with moderately- and highly-reactive Canadian aggregates. Test prisms were prepared and further tested for weight changes and expansion in the participant’s laboratories both in the standard （38℃） and the accelerated （60℃） test conditions. The results obtained in this study and in the literature indicate that the variability in the expansion results obtained in the accelerated concrete prism test is quite comparable to that of the standard CPT performed at 38℃. A review of available test results shows that a limit of 0.04% at three months generally give the same diagnostic as that obtained after one year in the standard CPT. Increased leaching of alkalis from the test prisms and an increased sulfate content in the pore solution （with consequent reduction of pH） with increasing testing temperature, likely explain why, in most cases, the main expansion phase of the test prisms at 60℃is often completed after 3 months of testing.

关键词： Alkali-silica reaction accelerated concrete prism test concrete prism test multi-laboratory variability.

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