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Roles of serum uric acid on the association between arsenic exposure and incident metabolic syndrome in an older Chinese population

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Journal of Environmental Sciences 2025年第1期147卷 332-341页

作者： Haiyan Jiang Simei Zhang Yaoyao Lin Lin Meng Jiayi Li Wenqing Wang Kaixuan Yang Mingjuan Jin Jianbing Wang Mengling Tang Kun Chen Department of public health Fourth Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China Department of public health Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China Department of public health National Clinical Research Center for Child Health of Children’s HospitalZhejiang University School of MedicineHangzhou 310058China

Growing evidences showed that heavy metals exposure may be associated with metabolic ***,themechanism underlying arsenic(As)exposure and metabolic syndrome(MetS)risk has not been fully *** we aimed to prospectively investigate the role of serum uric acid(SUA)on the association between blood As exposure and incident MetS.A sample of 1045 older participants in a community in China was *** determined As at baseline and SUA concentration at follow-up in the Yiwu Elderly *** events were defined according to the criteria of the International Diabetes Federation(IDF).Generalized linear model with log-binominal regression model was applied to estimate the association of As with incident *** investigate the role of SUA in the association between As andMetS,amediation analysiswas *** the fully adjusted log-binominal model,per interquartile range increment of As,the risk of MetS increased *** with the lowest quartile of As,the adjusted relative risk(RR)of MetS in the highest quartile was 1.42(95%confidence interval,CI:1.03,2.00).Additionally,blood As was positively associated with SUA,while SUA had significant association with MetS *** mediation analysis demonstrated that the association of As and MetS risk was mediated by SUA,with the proportion of 15.7%.Our study found higher As was remarkably associated with the elevated risk of MetS in the Chinese older adults *** analysis indicated that SUA might be a mediator in the association between As exposure and MetS.

关键词： Arsenic(As)exposure Metabolic syndrome(MetS) Serum uric acid(SUA) Cohort study Mediation effect Older adults

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The association of isocarbophos and isofenphos with different types of glucose metabolism:The role of inflammatory cells

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Journal of Environmental Sciences 2025年第1期147卷 322-331页

作者： Jintian Geng Dandan Wei Lulu Wang Qingqing Xu Juan Wang Jiayu Shi Cuicui Ma Mengzhen Zhao Wenqian Huo Tao Jing Chongjian Wang Zhenxing Mao Department of Epidemiology and Biostatistics College of Public HealthZhengzhou UniversityZhengzhou 450001China Department of Occupational and Environmental health Sciences College of Public HealthZhengzhou UniversityZhengzhou 450001China school of public health Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China

To investigate the associations between isocarbophos and isofenphos with impaired fasting glucose(IFG)and type 2 diabetes mellitus(T2DM),and to assess the mediation roles of inflammation *** were 2701 participants in the case-control study,including 896 patients with T2DM,900 patients with IFG,905 subjects with *** isocarbophos and isofenphos concentrationsweremeasured using gas chromatography and triple quadrupole tandem mass *** linear models were used to calculate the relationships between plasma isofenphos and isocarbophos levels with inflammatory factor levels and *** cell was used as mediators to estimate the mediating effects on the above *** and isofenphos were positively related with T2DM after adjusting for other *** odds ratio(95%confidence interval)(OR(95%CI))for T2DM was 1.041(1.015,1.068)and for IFG was 1.066(1.009,1.127)per unit rise in *** prevalence of T2DM increased by 6.4%for every 1 unit more of ln-isofenphos(OR(95%CI):1.064(1.041,1.087)).Additionally,a 100%rise in ln-isocarbophos was linked to 3.3%higher ln-HOMA2IR and a 0.029 mmol/L higher glycosylated hemoglobin(HbA1c)(95%CI:0.007,0.051).While a 100%rise in ln-isofenphos was linked to increase in ln-HOMA2 and ln-HOMA2IR of 5.8%and 3.4%,***,white blood cell(WBC)and neutrophilic(NE)were found to be mediators in the relationship between isocarbophos and T2DM,and the corresponding proportions were 17.12%and 17.67%,*** and isocarbophos are associated with IFG and T2DM in the rural Chinese population,WBC and NE have a significant role in this relationship.

关键词： Isocarbophos Isofenphos Type 2 diabetes mellitus Inflammatory cells Mediation effect

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Oxidation-reduction process of Arabidopsis thaliana roots induced by bisphenol compounds based on RNA-seq analysis

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Journal of Environmental Sciences 2025年第2期148卷 188-197页

作者： Xiaotong Ji Weiwei Wang Jiande Li Liangpo Liu Huifeng Yue Department of Environmental health School of Public HealthShanxi Medical UniversityTaiyuan 030001China MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical UniversityTaiyuan 030001China Center for Ecological public health Security of Yellow River Basin Shanxi Medical UniversityTaiyuan 030001China Department of public health Laboratory Sciences School of Public HealthShanxi Medical UniversityTaiyuan 030001China College of Environment and Resource Research Center of Environment and HealthShanxi UniversityTaiyuan 030006China

Bisphenol compounds(BPs)have various industrial uses and can enter the environment through various *** evaluate the ecotoxicity of BPs and identify potential gene candidates involved in the plant toxicity,Arabidopsis thaliana was exposed to bisphenol A(BPA),BPB,BPE,BPF,and BPS at 1,3,10 mg/L for a duration of 14 days,and their growth status were *** day 14,roots and leaves were collected for internal BPs exposure concentration detection,RNA-seq(only roots),and morphological *** shown in the results,exposure to BPs significantly disturbed root elongation,exhibiting a trend of stimulation at low concentration and inhibition at high ***,BPs exhibited pronounced generation of reactive oxygen species,while none of the pollutants caused significant changes in root *** exposure concentration analysis indicated that BPs tended to accumulate in the roots,with BPS exhibiting the highest level of *** results of RNA-seq indicated that the shared 211 differently expressed genes(DEGs)of these 5 exposure groups were enriched in defense response,generation of precursormetabolites,response to organic substance,response to oxygen-containing,response to hormone,oxidation-reduction process and so *** unique DEGs in each group,BPS wasmainly associated with the redox pathway,BPB primarily influenced seed germination,and BPA,BPE and BPF were primarily involved in metabolic signaling *** results provide newinsights for BPs induced adverse effects on Arabidopsis thaliana and suggest that the ecological risks associated with BPA alternatives cannot be ignored.

关键词： Bisphenol compounds Arabidopsis thaliana Root elongation RNA-seq ROS

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Consumer products are important reservoirs and sources of organophosphate tri-esters and di-esters:Characteristics,mass inventory,and implication for waste management

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Journal of Environmental Sciences 2025年第5期151卷 550-559页

作者： Jie Zhou Chan Liang Jinyun Li Jiayi Gu Amina Salamova Liangying Liu Guangdong Key Laboratory of Environmental Pollution and health School of EnvironmentJinan UniversityGuangzhou 511443China Gangarosa Department of Environmental health Rollins School of Public HealthEmory UniversityGeorgia 30322USA

Numerous studies documented the occurrence of organophosphate tri-esters(tri-OPEs)and di-esters(di-OPEs)in the *** information is available on their occurrence in waste consumer products,reservoirs and sources of these *** study collected and analyzed 92 waste consumer products manufactured from diverse polymers,including polyurethane foam(PUF),polystyrene(PS),acrylonitrile butadiene styrene(ABS),polypropylene(PP),and polyethylene(PE)to obtain information on the occurrence and profiles of 16 tri-OPEs and 10 *** concentrations of di-OPEs(18−370,000 ng/g,median 1,700 ng/g)were one order of magnitude lower than those of tri-OPEs(94−4,500,000 ng/g,median 5,400 ng/g).The concentrations of both tri-and di-OPEs in products made of PUF,PS,and ABS were orders of magnitude higher than those made of PP and *** compositional patterns of OPEs varied among different polymer types but were generally dominated by bisphenol A bis(diphenyl phosphate),triphenyl phosphate,tris(1-chloro-2-propyl)phosphate,di-phenyl phosphate(DPHP),and bis(2-ethylhexyl)*** industrially applied di-OPEs(di-n-butyl phosphate and DPHP)exhibited higher levels than their respective tri-OPEs,contrary to their production *** non-industrially applied chlorinated di-OPEs were also detected,with concentrations up to 97,000 ng/*** findings suggest that degradation of tri-OPEs during the manufacturing and use of products is an important source of *** mass inventories of tri-OPEs and di-OPEs in consumer products were estimated at 3,100 and 750 tons/year,*** study highlights the importance of consumer products as emission sources of a broad suite of OPEs.

关键词： Organophosphate tri-esters Organophosphate di-esters Waste consumer products Source assessment Mass inventory

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Arsenic exposure and oxidative damage to lipid,DNA,and protein among general Chinese adults:A repeated-measures cross-sectional and longitudinal study

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Journal of Environmental Sciences 2025年第1期147卷 382-391页

作者： Yongfang Zhang Min Zhou Dongming Wang Ruyi Liang Wei Liu Bin Wang Weihong Chen Department of Occupational and Environmental health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Key Laboratory of Environment and health Ministry of Education and Ministry of Environmental Protectionand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Arsenic-related oxidative stress and resultant diseases have attracted global concern,while longitudinal studies are *** assess the relationship between arsenic exposure and systemic oxidative damage,we performed two repeatedmeasures among 5236 observations(4067 participants)in theWuhan-Zhuhai cohort at the baseline and follow-up after 3 *** total arsenic,biomarkers of DNA oxidative damage(8-hydroxy-2-deoxyguanosine(8-OHdG)),lipid peroxidation(8-isoprostaglandin F2alpha(8-isoPGF2α)),and protein oxidative damage(protein carbonyls(PCO))were detected for all *** we used linearmixed models to estimate the cross-sectional and longitudinal associations between arsenic exposure and oxidative ***-response curves were constructed by utilizing the generalized additive mixed models with thin plate *** adjusting for potential confounders,arsenic level was significantly and positively related to the levels of global oxidative damage and their annual increased rates in dose-response *** cross-sectional analyses,each 1%increase in arsenic levelwas associated with a 0.406%(95%confidence interval(CI):0.379%to 0.433%),0.360%(0.301%to 0.420%),and 0.079%(0.055%to 0.103%)increase in 8-isoPGF2α,8-OHdG,and PCO,*** importantly,arsenic was further found to be associated with increased annual change rates of 8-isoPGF2α(β:0.147;95%CI:0.130 to 0.164),8-OHdG(0.155;0.118 to 0.192),and PCO(0.050;0.035 to 0.064)in the longitudinal *** study suggested that arsenic exposurewas not only positively related with global oxidative damage to lipid,DNA,and protein in cross-sectional analyses,but also associated with annual increased rates of these biomarkers in dose-dependent manners.

关键词： Arsenic Oxidative stress Oxidative damage 8-isoPGF2α 8-OHdG Protein carbonyls(PCO)

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health risks of rare earth elements exposure:Impact on mitochondrial DNA copy number and micronucleus frequency

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Journal of Environmental Sciences 2025年第5期151卷 150-160页

作者： Shiyi Hong Yali Zhang Qiaojian Zhang Zekang Su Guiping Hu Li Wang Shanfa Yu Xiaojun Zhu Guang Jia Department of Occupational and Environmental health Sciences School of Public HealthPeking UniversityBeijing 100083China school of Engineering Medicine and Beijing Advanced Innovation Center for Big Data-Based Precision Medicine Beihang UniversityBeijing 100083China Department of Toxicology School of Public HealthBaotou Medical CollegeBaotouInner Mongolia 014040China Henan Institute for Occupational Medicine Zhengzhou 450052China National Center for Occupational Safety and health Beijing 102308China Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety School of Public HealthPeking UniversityBeijing 100083China

Toxic effects in terms of mitochondria and hereditary substances have been characterized in vitro for individual rare earth elements,while,the joint effects of mixed elements exposure in the population remain *** on the Occupational Chromate Exposure Dynamic Cohort of China,this study investigated the relationship between 15 blood rare earth elements(cerium,dysprosium,erbium,europium,gadolinium,holmium,lanthanum,lutetium,neodymium,praseodymium,samarium,terbium,thulium,yttrium,and ytterbium)and mitochondrial DNA copy number(MtDNACN)as well as peripheral blood lymphocyte micronucleus frequency(MNF).The elastic net was used to select elements highly correlated with effect indicators,whose dose-response relationships were further illustrated by restricted cubic *** kernel regressionwas employed to explore the combined effects of elements and the contributions of single *** results showed that most rare earth elementswere positively correlatedwith effect indicators,with yttrium showing the strongest association(β(95%CI):0.139(0.1089–0.189)for MtDNACN,0.937(0.345–1.684)for MNF).In the mixed exposure model,with the exposure level fixed at the 50th percentile as the reference,the effect estimates on MtDNACN and MNF increased by 0.228 and 0.598 units,respectively,at the 75th *** single effect analysis implied that yttrium,lanthanum and terbium contributed the most to the elevation of MtDNACN,while yttrium posed the highest risk for genetic damage,accordingly,we provided recommendations to prioritize these elements of *** addition,we observed a chief mediating effect of MtDNACN on the elevation of MNF caused by lanthanum,whereas further mechanistic exploration is required to confirm this finding.

关键词： Rare earth elements Mitochondrial DNA copy number Micronucleus frequency Mixed effect

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Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

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Science China Chemistry 2025年第1期68卷 377-384页

作者： Shiwen Liu Xuerui Wan Meng Zhao Jiaqi Wang Weilan Wu Linlin You Yonggui Yuan Qian Xu Rong Gao Key Laboratory of Environmental Medicine Engineering Ministry of EducationSchool of Public HealthSoutheast UniversityNanjing 210009China Key Laboratory of Modern Toxicology of Ministry of Education Department of Hygienic Analysis and DetectionSchool of Public HealthNanjing Medical UniversityNanjing 211166China Department of Psychosomatics and Psychiatry Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009China

The measurement of amino acid and monoamine neurotransmitters(NTs)in serum plays a central role in the identification and monitoring of clinical panic disorder(PD).However,the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely ***,we developed a strategy that integrated solid phase extraction based on magnetic Fe_(3)O_(4)coated with polydopamine(Fe_(3)O_(4)@PDA)and direct analysis of mass spectrometry in real time(DART-MS)for quantification of 10 *** systematically investigated the optimal conditions of this strategy to achieve good accuracy and *** with existing magnetic solid phase extraction methods for NTs detection in biological samples,this strategy could adsorb more targets while having similar adsorption efficiencies,and the total process time was reduced by an average of 69.42%.We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic *** addition,an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this *** results highlighted the potential ability of Fe_(3)O_(4)@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

关键词： neurotransmitters panic disorder magnetic solid phase extraction direct analysis of mass spectrometry in real time

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DNA methylation in the association between pesticide exposures and type 2 diabetes

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World Journal of Diabetes 2025年第2期16卷 237-245页

作者： Guang-Jun Zheng Zheng-Er Fang Bi-Ying Zhou Lei Zuo Xia Chen Ming-Liang Liu Lei Yu Chun-Xia Jing Guang Hao Department of public health and Preventive Medicine School of MedicineJinan UniversityGuangzhou 510632Guangdong ProvinceChina Department of Pathophysiology School of MedicineJinan UniversityGuangzhou 510632Guangdong ProvinceChina Guangdong Key Laboratory of Environmental Exposure and health Jinan UniversityGuangzhou 510632Guangdong ProvinceChina Guangdong Provincial Engineering Research Center of public health Detection and Assessment School of Public HealthGuangdong Pharmaceutical UniversityGuangzhou 510632Guangdong ProvinceChina

BACKGROUND Numerous epidemiological studies have found that pesticide exposure is associated with the incidence of type 2 diabetes(T2D);however,the underlying mechanisms remain *** methylation may play a role in this *** To identify the genes associated with pesticide exposure and T2D by reviewing the current *** We systematically searched PubMed and Embase for relevant studies that examined the association between pesticide exposure and DNA methylation,and studies on DNA methylation and T2D through January 15,*** We identified six genes(Alu,CABLES1,CDH1,PDX1,PTEN,PTPRN2)related to pesticide exposure and *** also suggested future research directions to better define the role of DNA methylation in the association between pesticide exposure and *** DNA methylation of specific genes may play a vital role in the association between pesticide exposure and T2D.

关键词： DNA methylation Pesticide exposure Type 2 diabetes Gene Mechanisms

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Leveraging Artificial Intelligence to Achieve Sustainable public healthcare Services in Saudi Arabia: A Systematic Literature Review of Critical Success Factors

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Computer Modeling in Engineering & Sciences 2025年第2期142卷 1289-1349页

作者： Rakesh Kumar Ajay Singh Ahmed Subahi Ahmed Kassar Mohammed Ismail Humaida Sudhanshu Joshi Manu Sharma Department of health Management College of Public Health and Health InformaticsUniversity of Ha’ilHa’il81451Saudi Arabia Department of Management&Information Systems College of Business AdministrationUniversity of Ha’ilHa’il81451Saudi Arabia Department of public health College of Public Health and Health InformaticsUniversity of Ha’ilHa’il81451Saudi Arabia school of Management Doon UniversityDehradunUttarakhand248001India Department of Management Studies Graphic Era UniversityDehradunUttarakhand248002India

This review aims to analyze the development and impact of Artificial Intelligence(AI)in the context of Saudi Arabia’s public healthcare system to fulfill Vision 2030 *** is extensively devoted to AI technology deployment relevant to disease management,healthcare delivery,epidemiology,and ***,its AI is culturally sensitive and ethically grounded in *** on the PRISMA framework,an SLR evaluated primary academic literature,cases,and practices of Saudi Arabia’s AI implementation in the public healthcare ***,it categorizes prior research based on how AI can work,the issues it poses,and its implications for the Kingdom’s healthcare *** Saudi Arabian context analyses show that AI has increased the discreet prediction of diseases,resource management,and monitoring outbreaks during mass congregations such as ***,the study outlines critical areas for defining the potential for artificial intelligence and areas for enhancing digital development to support global healthcare *** key themes emerging from the review include Saudi Arabia:(i)the effectiveness of AI with human interaction for sustainable health services;(ii)conditions and quality control to enhance the quality of health care services using AI;(iii)environmental factors as influencing factors for public health care;(iv)Artificial Intelligence,and advanced decision-making technology for Middle Eastern health care *** policymakers,healthcare managers,and researchers who will engage with AI innovation,the review proclaims that AI applications should respect the country’s socio-cultural and ethical practices and pave the way for sustainable healthcare *** empirical research is needed on the implementation issues with AI,creating culturally appropriate models of AI,and finding new applications of AI to address the increasing demand for healthcare services in Saudi Arabia.

关键词： Artificial intelligence public health services sustainability healthcare Saudi Arabia PRISMA

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Association between Per and Polyfluoroalkyl Substance and Abdominal Fat Distribution:A Trait Spectrum Exposure Pattern and Structure-Based Investigation

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Biomedical and Environmental Sciences 2025年第1期38卷 3-14页

作者： Zhi Li Shilin Shan Chenyang Song Chengzhe Tao Hong Qian Qin Yuan Yan Zhang Qiaoqiao Xu Yufeng Qin Yun Fan Chuncheng Lu State Key Laboratory of Reproductive Medicine Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina Key Laboratory of Modern Toxicology of Ministry of Education School of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina Department of public health Kangda College of Nanjing Medical UniversityLianyungang 222000JiangsuChina Department of Microbes and Infection School of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina

Objective To investigate the associations between eight serum per-and polyfluoroalkyl substances(PFASs)and regional fat depots,we analyzed the data from the National health and Nutrition Examination Survey(NHANES)2011-2018 *** Multiple linear regression models were developed to explore the associations between serum PFAS concentrations and six fat compositions along with a fat distribution score created by summing the concentrations of the six fat *** associations between structurally grouped PFASs and fat distribution were assessed,and a prediction model was developed to estimate the ability of PFAS exposure to predict obesity *** Among females aged 39-59 years,trunk fat mass was positively associated with perfluorooctane sulfonate(PFOS).Higher concentrations of PFOS,perfluorohexane sulfonate(PFHxS),perfluorodecanoate(PFDeA),perfluorononanoate(PFNA),and n-perfluorooctanoate(n-PFOA)were linked to greater visceral adipose tissue in this *** men,exposure to total perfluoroalkane sulfonates(PFSAs)and long-chain PFSAs was associated with reductions in abdominal fat,while higher abdominal fat in women aged 39-59 years was associated with short-chain *** prediction model demonstrated high accuracy,with an area under the curve(AUC)of 0.9925 for predicting obesity *** PFAS exposure is associated with regional fat distribution,with varying effects based on age,sex,and PFAS *** findings highlight the potential role of PFAS exposure in influencing fat depots and obesity risk,with significant implications for public *** prediction model provides a highly accurate tool for assessing obesity risk related to PFAS exposure.

关键词： Per-and polyfluoroalkyl substances Regional fat depots Obesity Structure-based NHANES

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