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Liver or kidney:Who has the oar in the gluconeogenesis boat and when?

World Journal of Diabetes 2023年第7期14卷 1049-1056页

作者： Biswajit Sahoo Medha Srivastava Arpit Katiyar Carolyn Ecelbarger Swasti Tiwari Department of Molecular Medicine and Biotechnology Sanjay Gandhi Postgraduate Institute of Medical SciencesLucknow 226014India Department of Medicine Georgetown UniversityWashingtonDC 20057United States

Gluconeogenesis is an endogenous process of glucose production from noncarbohydrate carbon *** the liver and kidneys express the key enzymes necessary for endogenous glucose production and its export into *** would be remiss to add that more recently gluconeogenesis has been described in the small intestine,especially under high-protein,lowcarbohydrate *** contribution of the liver glucose release,the net glucose flux,towards systemic glucose is already well *** liver is,in most instances,the primary bulk contributor due to the sheer size of the organ(on average,over 1 kg).The contribution of the kidney(at just over 100 g each)to endogenous glucose production is often under-appreciated,especially on a weight *** is released from the liver through the process of glycogenolysis and *** glucose release is almost exclusively due to gluconeogenesis,which occurs in only a fraction of the cells in that organ(proximal tubule cells).Thus,the efficiency of glucose production from other carbon sources may be superior in the kidney relative to the liver or at least on the *** both these tissues,gluconeogenesis regulation is under tight hormonal control and depends on the availability of *** and renal gluconeogenesis are differentially regulated under various pathological *** impact of one source vs the other changes,based on post-prandial state,acid-base balance,hormonal status,and other less understood *** organ has the oar(is more influential)in driving systemic glucose homeostasis is still inconclusive and likely changes with the daily rhythms of *** reviewed the literature on the differences in gluconeogenesis regulation between the kidneys and the liver to gain an insight into who drives the systemic glucose levels under various physiological and pathological conditions.

关键词： Gluconeogenesis in the kidney and liver Diabetes Hormonal regulation Metabolic acidosis Insulin resistance Net glucose metabolism

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Rhyolites in continental mafic Large Igneous Provinces: Petrology,geochemistry and petrogenesis

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Geoscience Frontiers 2021年第1期12卷 53-80页

作者： Mahesh Halder Debajyoti Paul Sarajit Sensarma Department of Earth Sciences Indian Institute of Technology KanpurKanpur 208016India Centre of Advanced Study in Geology University of LucknowLucknow 226007India

We present a detailed review of the petrological and geochemical aspects of rhyolite and associated silicic volcanic rocks(up to 20 vol%of all rocks)reported to date from twelve well known Phanerozoic continental mafic Large Igneous Provinces(LIPs).These typically spread over900℃.Rhyolites formed by significant crustal contribution are characterized by strong negative Nb-Ta anomalies,absence of clinopyroxene phenocrysts,and are likely to have a magma temperature<900℃.Geochemical signatures suggest rhyolite melt generation in the plagioclase stability field with a minor fraction originating from lower crustal depths.A large part of the compositional variability in rhyolites,particularly the SrNd-Pb-O isotope ratios,suggests a significant role of continental crust(upper crustal melting or AFC)in the evolution of these silicic rocks in the continental mafic LIPs.

关键词： Large Igneous Province Silicic rock Rhyolite Geochemistry Petrogenesis AFC

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A NUMERICAL APPROACH STUDYING THE EFFECTS OF PRECIPITATION SCAVENGING ON STEADY-STATE DISPERSION OF AIR POLLUTANTS

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International Journal of Modeling, Simulation, and Scientific Computing 2012年第1期3卷 51-67页

作者： MANJU AGARWAL ABHINAV TANDON Department of Mathematics and Astronomy university of lucknow LucknowUttar PradeshIndia Department of Mathematics Shri Ramswaroop Memorial Group of Professional Colleges Tiwariganj Faizabad RoadLucknowUttar PradeshIndia

The present paper demonstrates the applicability of finite element method of weighted residuals to study the effects of precipitation scavenging through raindrops on the steady-state dispersion of air pollutants in the atmosphere under realistic variable wind and diffusivity ***,the washout of pollutants by rain droplets is considered and the whole analysis for the pollutant concentration is carried out in two phases *** phase and droplet *** model solutions are obtained by using local basis and asymmetric quadratic weighting functions which can provide a promising alternative to the standard Galerkin formulation for problems with advective and diffusive *** results of the model reveal that the precipitation scavenging by rain is quite effective in cleaning the polluted *** the need of pollutant concentration in rain drops regarding acid precipitation(or acid rain),the concentration of the absorbed pollutant in the droplet phase are also ***,the present study provides an understanding on the concentration distribution of pollutant in gaseous and droplet phases,under the effects of variable wind and diffusivity profiles.

关键词： Precipitation scavenging pollutant gaseous phase droplet phase finite element asymmetric weighting functions

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A New Approach on Mixed-Type Nondifferentiable Higher-Order Symmetric Duality

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Journal of the Operations Research Society of China 2019年第2期7卷 321-335页

作者： Khushboo Verma Pankaj Mathur Tilak Raj Gulati Department of Mathematics and Astronomy University of LucknowLucknow 226001India Department of Mathematics Indian Institute of Technology RoorkeeRoorkee 247667India

In this paper,a new mixed-type higher-order symmetric duality in scalar-objective programming is *** the literature we have results either Wolfe or Mond–Weir-type dual or separately,while in this we have combined those results over one *** weak,strong and converse duality theorems are proved for these programs underη-invexity/η-pseudoinvexity ***-duality is also *** results generalize some existing dual formulations which were discussed by Agarwal et al.(Generalized second-order mixed symmetric duality in nondifferentiable mathematical ***://***/10.1155/2011/103597),Chen(Higher-order symmetric duality in nonlinear nondifferentiable programs),Gulati and Gupta(Wolfe type second order symmetric duality in nondifferentiable ***.310,247–253,2005,Higher order nondifferentiable symmetric duality with generalized ***.329,229–237,2007),Gulati and Verma(Nondifferentiable higher order symmetric duality under invexity/generalized *** 28(8),1661–1674,2014),Hou andYang(On second-order symmetric duality in nondifferentiable programming.J Math Anal Appl.255,488–491,2001),Verma and Gulati(Higher order symmetric duality using generalized ***:Proceeding of 3rd International Conference on Operations Research and Statistics(ORS).***://***/10.5176/2251-1938_ORS13.16,Wolfe type higher order symmetric duality under invexity.J Appl Math Inform.32,153–159,2014).

关键词： Higher-order dual model Symmetric duality Duality theorems Higher-order invexity/generalized invexity Self duality

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A RESOURCE-DEPENDENT COMPETITION MODEL:EFFECTS OF POPULATION PRESSURE AUGMENTED INDUSTRIALIZATION

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International Journal of Modeling, Simulation, and Scientific Computing 2012年第2期3卷 109-130页

作者： MANJU AGARWAL SAPNA DEVI Department of Mathematics&Astronomy lucknow university Lucknow-226007India DST Centre for Interdisciplinary Mathematical Sciences Banaras Hindu university Varanasi-221005India

In this paper,a nonlinear mathematical model is proposed and analyzed to study the effects of population pressure augmented industrialization on the survival of competing species dependent on *** is assumed that the growths of competing species are logistic and carrying capacities increase with increase in the density of resource ***,it is assumed that the resource biomass too is growing logistically in the envi-ronment and its carrying capacity decreases with the increase in densities of competing species and *** growth rate of population pressure is assumed to be proportional to the densities of competing *** of all equilibria and con-ditions which influence the permanence of the system are carried out using theory of differential *** simulations are performed to accomplish our analytical *** is shown that the equilibrium density of resource biomass decreases as(i)the growth rate coefficient of population pressure increases(ii)the growth rate coeffi-cient of industrialization due to population pressure increases and(iii)the growth rate coefficient of industrialization due to resource biomass *** is found that the competitive outcome alters with increase in the growth rate coefficient of population *** in the equilibrium densities of competing species is also noted with increase in the growth rate coefficient of industrialization due to resource biomass.

关键词： Resource biomass competing species population pressure industrialization stability persistence.

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WNT/β-catenin signaling in urothelial carcinoma of bladder

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World Journal of Nephrology 2019年第5期8卷 83-94页

作者： Minal Garg Niharika Maurya Department of Biochemistry University of Lucknow

Urothelial carcinoma of bladder is the second most prevalent genitourinary *** is a highly heterogeneous disease as it represents a spectrum of neoplasms,including non-muscle invasive bladder cancer(NMIBC),muscle invasive bladder cancer(MIBC)and metastatic ***-wide approaches and candidate gene analysis suggest that malignant transformation of the bladder is multifactorial and a multitude of genes are involved in the development of MIBC or NMIBC *** signaling is being examined to control and maintain balance between stemness and differentiation in adult stem cell *** to its participation in urothelial development and maintenance of adult urothelial tissue homeostasis,the components of Wnt signaling are reported as an important diagnostic and prognostic markers as well as novel therapeutic ***/epigenetic alterations in the key molecules of Wnt/β-catenin canonical pathway have been linked with tumorigenesis,development of drug resistance and enhanced *** review extends our understanding on the functions of key regulatory molecules of canonical Wnt/β-catenin pathway in urothelial tumorigenesis by inducing cancer stem cell phenotype(UCSCs).UCSCs may be responsible for tumor heterogeneity,high recurrence rates and complex biological behavior of bladder ***,understanding the role of UCSCs and the regulatory mechanisms that are responsible for high relapse rates and metastasis could help to develop pathway inhibitors and augment current *** implications in the treatment of urothelial carcinoma of bladder by targeting this pathway primarily in UCSCs as well as in bulk tumor population that are responsible for high relapse rates and metastasis may facilitate potential therapeutic avenues and better prognosis.

关键词： Chemoresistance Therapeutic approaches Urothelial carcinoma of bladder Urothelial cancer stem cells Wnt/β-catenin

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Evaluating the Impact of Software Security Tactics: A Design Perspective

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Computers, Materials & Continua 2021年第3期66卷 2283-2299页

作者： Mamdouh Alenezi Abhishek Kumar Pandey Richa Verma Mohd Faizan Shalini Chandra Alka Agrawal Rajeev Kumar Raees Ahmad Khan College of Computer and Information Sciences Prince Sultan UniversitySaudi Arabia Department of Information Technology Babasaheb Bhimrao Ambedkar UniversityLucknowUttar PradeshIndia Department of Computer Science Babasaheb Bhimrao Ambedkar UniversityLucknowUttar PradeshIndia Department of Computer Application Shri Ramswaroop Memorial UniversityLucknowUttar PradeshIndia

Design architecture is the edifice that strengthens the functionalities as well as the security of web *** order to facilitate architectural security from the web application’s design phase itself,practitioners are now adopting the novel mechanism of security *** the intent to conduct a research from the perspective of security tactics,the present study employs a hybrid multi-criteria decision-making approach named fuzzy analytic hierarchy process-technique for order preference by similarity ideal solution(AHP-TOPSIS)method for selecting and assessing multi-criteria *** adopted methodology is a blend of fuzzy analytic hierarchy process(fuzzy AHP)and fuzzy technique for order preference by similarity ideal solution(fuzzy TOPSIS).To establish the efficacy of this methodology,the results are obtained after the evaluation have been tested on fifteen different web application projects(Online Quiz competition,Entrance Test,and others)of the Babasaheb Bhimrao Ambedkar university,lucknow,*** tabulated outcomes demonstrate that the methodology of the Multi-Level Fuzzy Hybrid system is highly effective in providing accurate estimation for strengthening the security of web *** proposed study will help experts and developers in developing and managing security from any web application design phase for better accuracy and higher security.

关键词： Web application software security security tactics fuzzy AHP fuzzy TOPSIS

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Seroprevalence of cysticercosis in North Indian population

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Asian Pacific Journal of Tropical Medicine 2010年第8期3卷 589-593页

作者： Nitin Shukla Nuzhat Husain Vimala Venkatesh Jamal Masood Mazhar Husain Department of Pathology CSM Medical UniversityLucknow-3Uttar Pradesh.India Department of Microbiology CSM Medical UniversityLucknow-3Uttar PradeshIndia Department of Community Medicine CSM Medical UniversityLucknow-3Uttar PradeshIndia Department of Neurosurgery CSM Medical UniversityLucknow-3Uttar PradeshIndia

Objective:To estimate the seroprevalence,morbidity of Taenia solium(***) cysticercosis and its relationship to socio-economic,sanitary ***:Using multistage stratified random sampling.2 500 subjects from urban(n=1 250) and rural population(n =1 250) of lucknow. India were ***,stool samples,socioeconomic and demographic data were collected. Serum enzyme-linked-immunosorbent-assay(ELISA) was used to detect anticysticercus IgG and IgM *** examination of stool samples after processing by concentration method was done to observe taeniasis and other intestinal *** scan of seropositive cases presenting with seizures was done for confirmation of ***:The overall,urban and rural seroprevalence of *** cysticercosis was 3.48%,4.64%and 2.32%, *** risk factors significantly associated with the disease were pig rearing in both study populations,unsanitary waste disposal in urban,vegetarian diet and open defecation in rural *** case of intestinal taeniasis was ***-six of 30 cases undergoing CT scan were diagnosed as ***:Seroprevalence of cysticercosis is high in the study *** of cysticercosis is related to roaming pigs and behavioral and environmental practices in local *** education and identification of tapeworm carriers seems promising control strategy.

关键词： Cysticercosis Community Seroprevalence North India Taenia solium ELISA

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Palynofloral changes in the Upper Paleozoic and Mesozoic of the Deocha-Pachami area, Birbhum Coalfield, West Bengal, India

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Science China Earth Sciences 2009年第12期52卷 1932-1952页

作者： VIJAYA Birbal Sahni Institute of Palaeobotany 53 University Road Lucknow 226007 India

The study of Upper Paleozoic and Mesozoic palynomorphs in three boreholes from the Deocha-Pachami area, Birbhum Coalfield, West Bengal, India, has allowed dating of the Talchir, Barakar, Dubrajpur, and Rajmahal formations, and revealed many hiatuses. The lowermost unit, the Talchir Formation, yielded earliest Permian palynomorphs. The Barakar Formation, which includes coal-bearing strata, was previously dated as Early Permian. However, data presented herein indicate an Early Permian to earliest Triassic age for this unit,containing actually the Karharbari, Barakar s.s., Kulti, and Ranigang formations as well as the basal part of the Panchet Formation. The overlying Dubrajpur Formation is Jurassic (Callovian to Tithonian), with an unconformity at its base. The uppermost Dubrajpur Formation is Tithonian-Berriasian. The palynomorphs from the intertrappeans within the Rajmahal Formation suggest an Early Cretaceous age. The revised ages of the Barakar and Dubrajpur formations are of major regional significance. The distribution patterns of spore-pollen may provide a broad spectrum of paleoclimate during Permian, Late Jurassic, and Early Cretaceous times, as there is no record of marine signatures in the study area.

关键词： Talchir to Rajmahal formations Upper Paleozoic Mesozoic spores and pollen biostratigraphy India

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Analyzing the Implications of COVID-19 Pandemic through an Intelligent-Computing Technique

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Computer Systems Science & Engineering 2022年第6期41卷 959-974页

作者： Abhishek Kumar Pandey Jehad F.Al-Amri Ahmad F.Subahi Rajeev Kumar Raees Ahmad Khan Department of Information Technology Babasaheb Bhimrao Ambedkar UniversityLucknow226025India Department of Information Technology College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia Department of Computer Science University College of Al JamoumUmm Al Qura UniversityMakkah21421Saudi Arabia Department of Computer Applications Shri Ramswaroop Memorial UniversityBarabanki225003India

The outbreak of Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2 virus or COVID-19) disease was declared pandemic by the WorldHealth Organization (WHO) on March 11, 2020. COVID-19 has already affectedmore than 211 nations. In such a bleak scenario, it becomes imperative to analyzeand identify those regions in Saudi Arabia that are at high risk. A preemptivestudy done in the context of predicting the possible COVID-19 hotspots wouldfacilitate in the implementation of prompt and targeted countermeasures againstSARS-CoV-2, thus saving many lives. Working towards this intent, the presentstudy adopts a decision making based methodology of simulation named Analytical Hierarchy Process (AHP), a multi criteria decision making approach, forassessing the risk of COVID-19 in different regions of Saudi Arabia. AHP givesthe ability to measure the risks numerically. Moreover, numerical assessments arealways effective and easy to understand. Hence, this research endeavour employsFuzzy based computational method of decision making for its empirical *** in the proposed paper suggest that Riyadh and Makkah are the mostsusceptible regions, implying that if sustained and focused preventive measuresare not introduced at the right juncture, the two cities could be the worst afflictedwith the infection. The results obtained through Fuzzy based computationalmethod of decision making are highly corroborative and would be very usefulfor categorizing and assessing the current COVID-19 situation in the Kingdomof Saudi Arabia. More specifically, identifying the cities that are likely to beCOVID-19 hotspots would help the country’s health and medical fraternity toreinforce intensive containment strategies to counter the ills of the pandemic insuch regions.

关键词： COVID-19 Saudi Arabian regions risk assessment dynamics of infection fuzzy AHP

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