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Therapeutic Application,Phytoactives and Pharmacology of Tinospora cordifolia:An Evocative Review

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Chinese Journal of Integrative Medicine 2023年第6期29卷 549-555页

作者： Rabiya Ahsan Anuradha Mishra Badruddeen Badar Mohammad Owais Vijayshwari Mishra Research Scholar Faculty of PharmacyIntegral UniversityLucknowUP226022India Department of Pharmacology Amity Institute of PharmacyLucknowAmity University Uttar PradeshSector 125Noida201313India Research Scholar Rameshwaram Institute of TechnologyLucknowIndia

Tinospora cordifolia(Guduchi or Gurjo),a herbaceous vine or climbing deciduous shrub,is consider as an important medicine in the Ayurvedic system of medication,which is available in India,China,Myanmar,Bangladesh and *** is the family of this *** have a variety of properties to treat various ailments such as fevers,jaundice,diabetes,dysentery,urinary infections,and skin *** compound has been subjected to many chemicals,pharmacological,pre-clinical,or clinical investigations and some new therapeutic potential effects have been *** review aims to summarize the critical information concerning in areas of chemical constituents,chemical structure,and pharmacokinetic activities such as anti-diabetic,anticancer,immune-modulatory,antivirus(especially in silico study about COVID-19),antioxidant,antimicrobial,hepatoprotective and its effect on cardiovascular and neurological disorders as well as rheumatoid *** traditional herb needs more experimental study on the clinical,pre-clinical study,and clinical efficacy of these compounds for the prevention and treatment of COVID-19 and needs large-scale clinical studies to prove the clinical efficacy of this compound,especially in stress-related diseases and other neuronal disorders.

关键词： Tinospora cordifolia Guduchi menispermaceae pharmacology

Rhyolites in continental mafic Large Igneous Provinces: Petrology,geochemistry and petrogenesis

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Geoscience Frontiers 2021年第1期12卷 53-80页

作者： Mahesh Halder Debajyoti Paul Sarajit Sensarma Department of Earth Sciences Indian Institute of Technology KanpurKanpur 208016India Centre of Advanced Study in Geology University of LucknowLucknow 226007India

We present a detailed review of the petrological and geochemical aspects of rhyolite and associated silicic volcanic rocks(up to 20 vol%of all rocks)reported to date from twelve well known Phanerozoic continental mafic Large Igneous Provinces(LIPs).These typically spread over900℃.Rhyolites formed by significant crustal contribution are characterized by strong negative Nb-Ta anomalies,absence of clinopyroxene phenocrysts,and are likely to have a magma temperature<900℃.Geochemical signatures suggest rhyolite melt generation in the plagioclase stability field with a minor fraction originating from lower crustal depths.A large part of the compositional variability in rhyolites,particularly the SrNd-Pb-O isotope ratios,suggests a significant role of continental crust(upper crustal melting or AFC)in the evolution of these silicic rocks in the continental mafic LIPs.

关键词： Large Igneous Province Silicic rock Rhyolite Geochemistry Petrogenesis AFC

Emerging trends in self-healable nanomaterials for triboelectric nanogenerators:A comprehensive review and roadmap

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Frontiers in Energy 2023年第6期17卷 727-750页

作者： Prabhakar YADAV Kuldeep SAHAY Malvika SRIVASTAVA Arpit VERMA Bal Chandra YADAV Department of Electrical Engineering Institute of Engineering and TechnologyA P J Kalam Technical UniversityLucknow 226031India Nanomaterials and Sensors Research Laboratory Department of PhysicsBabasaheb Bhimrao Ambedkar UniversityLucknow 226025India

A thorough analysis of triboelectric nanogenerators (TENGs) that make use of self-healable nanomaterials is presented in this review. These TENGs have shown promise as independent energy sources that do not require an external power source to function. TENGs are developing into a viable choice for powering numerous applications as low-power electronics technology advances. Despite having less power than conventional energy sources, TENGs do not directly compete with these. TENGs, on the other hand, provide unique opportunities for future self-powered systems and might encourage advancements in energy and sensor technologies. Examining the many approaches used to improve nanogenerators by employing materials with shape memory and self-healable characteristics is the main goal of this review. The findings of this comprehensive review provide valuable information on the advancements and possibilities of TENGs, which opens the way for further research and advancement in this field. The discussion of life cycle evaluations of TENGs provides details on how well they perform in terms of the environment and identifies potential improvement areas. Additionally, the cost-effectiveness, social acceptability, and regulatory implications of self-healing TENGs are examined, as well as their economic and societal ramifications.

关键词： triboelectric nanogenerator(TENG) self-healable nanomaterials self-powered devices energy

A NUMERICAL APPROACH STUDYING THE EFFECTS OF PRECIPITATION SCAVENGING ON STEADY-STATE DISPERSION OF AIR POLLUTANTS

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International Journal of Modeling, Simulation, and Scientific Computing 2012年第1期3卷 51-67页

作者： MANJU AGARWAL ABHINAV TANDON Department of Mathematics and Astronomy university of lucknow LucknowUttar PradeshIndia Department of Mathematics Shri Ramswaroop Memorial Group of Professional Colleges Tiwariganj Faizabad RoadLucknowUttar PradeshIndia

The present paper demonstrates the applicability of finite element method of weighted residuals to study the effects of precipitation scavenging through raindrops on the steady-state dispersion of air pollutants in the atmosphere under realistic variable wind and diffusivity ***,the washout of pollutants by rain droplets is considered and the whole analysis for the pollutant concentration is carried out in two phases *** phase and droplet *** model solutions are obtained by using local basis and asymmetric quadratic weighting functions which can provide a promising alternative to the standard Galerkin formulation for problems with advective and diffusive *** results of the model reveal that the precipitation scavenging by rain is quite effective in cleaning the polluted *** the need of pollutant concentration in rain drops regarding acid precipitation(or acid rain),the concentration of the absorbed pollutant in the droplet phase are also ***,the present study provides an understanding on the concentration distribution of pollutant in gaseous and droplet phases,under the effects of variable wind and diffusivity profiles.

关键词： Precipitation scavenging pollutant gaseous phase droplet phase finite element asymmetric weighting functions

A RESOURCE-DEPENDENT COMPETITION MODEL:EFFECTS OF POPULATION PRESSURE AUGMENTED INDUSTRIALIZATION

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International Journal of Modeling, Simulation, and Scientific Computing 2012年第2期3卷 109-130页

作者： MANJU AGARWAL SAPNA DEVI Department of Mathematics&Astronomy lucknow university Lucknow-226007India DST Centre for Interdisciplinary Mathematical Sciences Banaras Hindu university Varanasi-221005India

In this paper,a nonlinear mathematical model is proposed and analyzed to study the effects of population pressure augmented industrialization on the survival of competing species dependent on *** is assumed that the growths of competing species are logistic and carrying capacities increase with increase in the density of resource ***,it is assumed that the resource biomass too is growing logistically in the envi-ronment and its carrying capacity decreases with the increase in densities of competing species and *** growth rate of population pressure is assumed to be proportional to the densities of competing *** of all equilibria and con-ditions which influence the permanence of the system are carried out using theory of differential *** simulations are performed to accomplish our analytical *** is shown that the equilibrium density of resource biomass decreases as(i)the growth rate coefficient of population pressure increases(ii)the growth rate coeffi-cient of industrialization due to population pressure increases and(iii)the growth rate coefficient of industrialization due to resource biomass *** is found that the competitive outcome alters with increase in the growth rate coefficient of population *** in the equilibrium densities of competing species is also noted with increase in the growth rate coefficient of industrialization due to resource biomass.

关键词： Resource biomass competing species population pressure industrialization stability persistence.

WNT/β-catenin signaling in urothelial carcinoma of bladder

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World Journal of Nephrology 2019年第5期8卷 83-94页

作者： Minal Garg Niharika Maurya Department of Biochemistry University of Lucknow

Urothelial carcinoma of bladder is the second most prevalent genitourinary *** is a highly heterogeneous disease as it represents a spectrum of neoplasms,including non-muscle invasive bladder cancer(NMIBC),muscle invasive bladder cancer(MIBC)and metastatic ***-wide approaches and candidate gene analysis suggest that malignant transformation of the bladder is multifactorial and a multitude of genes are involved in the development of MIBC or NMIBC *** signaling is being examined to control and maintain balance between stemness and differentiation in adult stem cell *** to its participation in urothelial development and maintenance of adult urothelial tissue homeostasis,the components of Wnt signaling are reported as an important diagnostic and prognostic markers as well as novel therapeutic ***/epigenetic alterations in the key molecules of Wnt/β-catenin canonical pathway have been linked with tumorigenesis,development of drug resistance and enhanced *** review extends our understanding on the functions of key regulatory molecules of canonical Wnt/β-catenin pathway in urothelial tumorigenesis by inducing cancer stem cell phenotype(UCSCs).UCSCs may be responsible for tumor heterogeneity,high recurrence rates and complex biological behavior of bladder ***,understanding the role of UCSCs and the regulatory mechanisms that are responsible for high relapse rates and metastasis could help to develop pathway inhibitors and augment current *** implications in the treatment of urothelial carcinoma of bladder by targeting this pathway primarily in UCSCs as well as in bulk tumor population that are responsible for high relapse rates and metastasis may facilitate potential therapeutic avenues and better prognosis.

关键词： Chemoresistance Therapeutic approaches Urothelial carcinoma of bladder Urothelial cancer stem cells Wnt/β-catenin

A New Approach on Mixed-Type Nondifferentiable Higher-Order Symmetric Duality

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Journal of the Operations Research Society of China 2019年第2期7卷 321-335页

作者： Khushboo Verma Pankaj Mathur Tilak Raj Gulati Department of Mathematics and Astronomy University of LucknowLucknow 226001India Department of Mathematics Indian Institute of Technology RoorkeeRoorkee 247667India

In this paper,a new mixed-type higher-order symmetric duality in scalar-objective programming is *** the literature we have results either Wolfe or Mond–Weir-type dual or separately,while in this we have combined those results over one *** weak,strong and converse duality theorems are proved for these programs underη-invexity/η-pseudoinvexity ***-duality is also *** results generalize some existing dual formulations which were discussed by Agarwal et al.(Generalized second-order mixed symmetric duality in nondifferentiable mathematical ***://***/10.1155/2011/103597),Chen(Higher-order symmetric duality in nonlinear nondifferentiable programs),Gulati and Gupta(Wolfe type second order symmetric duality in nondifferentiable ***.310,247–253,2005,Higher order nondifferentiable symmetric duality with generalized ***.329,229–237,2007),Gulati and Verma(Nondifferentiable higher order symmetric duality under invexity/generalized *** 28(8),1661–1674,2014),Hou andYang(On second-order symmetric duality in nondifferentiable programming.J Math Anal Appl.255,488–491,2001),Verma and Gulati(Higher order symmetric duality using generalized ***:Proceeding of 3rd International Conference on Operations Research and Statistics(ORS).***://***/10.5176/2251-1938_ORS13.16,Wolfe type higher order symmetric duality under invexity.J Appl Math Inform.32,153–159,2014).

关键词： Higher-order dual model Symmetric duality Duality theorems Higher-order invexity/generalized invexity Self duality

Oxidative chemical pretreatment by piranha solution for enhanced methane yield of wheat straw:mechanism and kinetic study

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Waste Disposal and Sustainable Energy 2023年第3期5卷 351-366页

作者： Nikita Kanaujia Shalu Rawat Jiwan Singh Department of Environmental Science Babasaheb Bhimrao Ambedkar UniversityLucknow226025India

The present research work aims to explore the potency of piranha solutions at the best-optimized concentrations,i.e.,40%and 30%to reduce the recalcitrant and heterogeneous structure of wheat straw,and the treated wheat straw was denoted as WS40 and *** effect of pretreatment on wheat straw was determined by anaerobic digestion(AD)in a batch mode,followed by the analysis of soluble chemical oxygen demand(sCOD)and volatile fatty acids(VFAs).After pretreatment,the surface fibers shattered and detached,showing a distorted surface of wheat *** increase in the crystallinity of wheat straw after pretreatment was also observed due to the removal of amorphous cellulose and *** in methane yield was obtained on the 9th day,which was 103±6.92 and 99.33±0.57 mL/d for WS40 and WS30,*** water measurement revealed that the pretreatment of wheat straw minimized the hydrolysis period by 14 *** also improved the methane yield by 2.65(WS40)and 2.45(WS30)fold in comparison with the control which yielded 35.66 mL/d methane on the 23rd *** modified Gompertz model(MGM),logistic function model(LFM)and transference function model(TFM)adequately described the degradation process and explained the kinetic behavior of the cumulative methane *** the three models,MGM was found to fit best for the methane yield of WS40 and WS30.

关键词： Anaerobic digestion Wheat straw Oxidative pretreatment Piranha solution Methane

Network biology:A promising approach for drug target identification against neurodevelopmental disorders

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BIOCELL 2023年第8期47卷 1675-1687页

作者： WAYEZ NAQVI ANANYA SINGH PREKSHI GARG PRACHI SRIVASTAVA Amity Institute of Biotechnology Amity UniversityLucknow226028India

Biological entities are involved in complicated and complex connections;hence,discovering biological information using network biology ideas is *** the past few years,network biology has emerged as an integrative and systems-level approach for understanding and interpreting these complex *** network analysis is one method for reducing enormous data sets to clinically useful knowledge for disease diagnosis,prognosis,and *** network of biological entities can help us predict drug targets for several *** drug targets identified through the systems biology approach help in targeting the essential biological pathways that contribute to the progression and development of the *** novel strategical approach of system biologyassisted pharmacology coupled with computer-aided drug discovery(CADD)can help drugs fight multifactorial diseases *** the present review,we have summarized the role and application of network biology for not only unfolding the mechanism of complex neurodevelopmental disorders but also identifying important drug targets for diseases like ADHD,Autism,Epilepsy,and Intellectual *** biology has emerged as a promising approach to identifying drug targets and aiming for targeted drug discovery for the precise treatment of neurodevelopmental disorders.

关键词： Network biology Neurodevelopmental disorders Drug target Pharmacology System biology assisted CADD