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Hepatic TRPC3 loss contributes to chronic alcohol consumption-induced hepatic steatosis and liver injury in mice

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Life Metabolism 2024年第1期3卷 51-66页

作者： Qinchao Ding Rui Guo Liuyi Hao Qing Song Ai Fu Shanglei Lai Tiantian Xu Hui Zhuge Kaixin Chang Yanli Chen Haibin Wei Daxi Ren Zhaoli Sun Zhenyuan Song Xiaobing Dou Songtao Li School of Public Health Zhejiang Chinese Medical UniversityHangzhouZhejiang 310053China College of Animal Science Zhejiang UniversityHangzhouZhejiang 310058China Department of Kinesiology and Nutrition University of Illinois at ChicagoChicagoIL 60612United States School of Life Science Zhejiang Chinese Medical UniversityHangzhouZhejiang 310053China Department of Surgery Johns Hopkins University School of MedicineBaltimoreMD 21205United States

Emerging evidence discloses the involvement of calcium channel protein in the pathological process of liver *** receptor potential cation channel subfamily C member 3(TRPC3),a ubiquitously expressed non-selective cation channel protein,controls proliferation,inflammation,and immune response via operating calcium influx in various ***,our understanding on the biofunction of hepatic TRPC3 is still *** present study aims to clarify the role and potential mechanism(s)of TRPC3 in alcohol-associated liver disease(ALD).We recently found that TRPC3 expression plays an important role in the disease process of *** exposure led to a significant reduction of hepatic TRPC3 in patients with alcohol-related hepatitis(AH)and ALD ***(N-acetylcysteine and mitoquinone)intervention improved alcohol-induced suppression of TRPC3 via a miR-339-5p-involved ***3 loss robustly aggravated the alcohol-induced hepatic steatosis and liver injury in mouse liver;this was associated with the suppression of Ca^(2+)/calmodulin-dependent protein kinase kinase 2(CAMKK2)/AMP-activated protein kinase(AMPK)and dysregulation of genes related to lipid ***3 loss also enhanced hepatic inflammation and early fibrosis-like change in *** hepatic TRPC3 effectively reversed chronic alcohol-induced detrimental alterations in ALD ***,chronic alcohol exposure-induced TRPC3 reduction contributes to the pathological development of ALD via suppression of the CAMKK2/AMPK *** stress-stimulated miR-339-5p upregulation contributes to alcohol-reduced ***3 is the requisite and a potential target to defend alcohol consumption-caused ALD.

关键词： TRPC3 alcohol-associated liver disease miR-339-5p hepatic steatosis liver injury CAMKK2/AMPK

Recurrent cyclops lesion after primary resection of fibroreactive nodule following anterior cruciate ligament reconstruction

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World Journal of Orthopedics 2024年第6期15卷 495-497页

作者： Cadence Lee Farid Amirouche Department of Orthopedic Surgery University of Illinois College of MedicineChicagoIL 60612United States

In this case report featured in World Journal of Orthopedics,Kelmer et al describe a rare finding of a 28-year-old female patient who presented with a recurrent fibroreactive nodule 7 months following the resection of a primary cyclops lesion,suggesting recurrent cyclops *** patient had undergone an initial anterior cruciate ligament reconstruction for a non-contact right knee injury and reported successful *** years later,the patient sustained a repeat right knee injury followed by a positive McMurray test and acute pain with terminal *** synovectomy confirmed magnetic resonance imaging(MRI)finding of a cyclops lesion,which was surgically *** months postoperatively,the patient reported stiffness and difficulty with terminal *** MRI indicated a recurrent cyclops lesion,which was surgically *** resection of the second lesion,the patient underwent physical therapy and achieved full range of motion,maintaining complete recovery 19 months *** cyclops lesions have rarely been reported in the literature,and this article is novel in its report of recurrent cyclops syndrome following a bone-patellar tendon-bone *** presentation of this unusual finding exposes a need for further investigation of cyclops lesion pathology,which will aid its prevention and treatment.

关键词： Cyclops lesion Anterior cruciate ligament reconstruction Fibrous nodule Bone-patellar-tendon-bone allograft Cyclops syndrome

Secure and Reliable Routing in the Internet of Vehicles Network:AODV-RL with BHA Attack Defense

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 633-659页

作者： Nadeem Ahmed Khalid Mohammadani Ali Kashif Bashir Marwan Omar Angel Jones Fayaz Hassan School of Electronic Science Beijing University of Post and TelecommunicationBeijing100086China Department of Computer Science Huanggang Normal UniversityHuanggangChina Department of Computing and Mathematics Manchester Metropolitan UniversityManchesterUK Woxsen School of Business Woxsen UniversityHyderabad502345India Department of Computer Science and Mathematics Lebanese American UniversityBeirutLebanon Information Technology and Management Illinois Institute of TechnologyChicagoUSA College of Computing Capital Technology UniversityLaurelUSA

Wireless technology is transforming the future of transportation through the development of the Internet of Vehicles(IoV).However,intricate security challenges are intertwinedwith technological progress:Vehicular ad hoc Networks(VANETs),a core component of IoV,face security issues,particularly the Black Hole Attack(BHA).This malicious attack disrupts the seamless flow of data and threatens the network’s overall reliability;also,BHA strategically disrupts communication pathways by dropping data packets from legitimate nodes *** the importance of this challenge,we have introduced a new solution called ad hoc On-Demand Distance Vector-Reputation-based mechanism Local Outlier Factor(AODV-RL).The significance of AODVRL lies in its unique approach:it verifies and confirms the trustworthiness of network components,providing robust protection against *** additional safety layer is established by implementing the Local Outlier Factor(LOF),which detects and addresses abnormal network *** testing of our solution has revealed its remarkable ability to enhance communication in ***,Our experimental results achieve message delivery ratios of up to 94.25%andminimal packet loss ratios of just 0.297%.Based on our experimental results,the proposedmechanismsignificantly improves VANET communication reliability and *** results promise a more secure and dependable future for IoV,capable of transforming transportation safety and efficiency.

关键词： Black hole attack IoV vehicular ad hoc network AODV routing protocol

Algorithms for Multicriteria Scheduling Problems to Minimize Maximum Late Work, Tardy, and Early

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Journal of Applied Mathematics and Physics 2024年第2期12卷 661-682页

作者： Karrar Alshaikhli Aws Alshaikhli Department of Engineering and Mathematics St. Philip’s College San Antonio USA Department of Biology Northeastern Illinois University Chicago USA

This study examines the multicriteria scheduling problem on a single machine to minimize three criteria: the maximum cost function, denoted by maximum late work (Vmax), maximum tardy job, denoted by (Tmax), and maximum earliness (Emax). We propose several algorithms based on types of objectives function to be optimized when dealing with simultaneous minimization problems with and without weight and hierarchical minimization problems. The proposed Algorithm (3) is to find the set of efficient solutions for 1//F (Vmax, Tmax, Emax) and 1//(Vmax + Tmax + Emax). The Local Search Heuristic Methods (Descent Method (DM), Simulated Annealing (SA), Genetic Algorithm (GA), and the Tree Type Heuristics Method (TTHM) are applied to solve all suggested problems. Finally, the experimental results of Algorithm (3) are compared with the results of the Branch and Bound (BAB) method for optimal and Pareto optimal solutions for smaller instance sizes and compared to the Local Search Heuristic Methods for large instance sizes. These results ensure the efficiency of Algorithm (3) in a reasonable time.

关键词： Scheduling Single Machine Hierarchical Simultaneous Minimization Algorithms Branch and Bound Local Search Heuristic Methods

Glucose measurement via Raman spectroscopy of graphene:Principles and operation

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Nano Research 2022年第10期15卷 8697-8704页

作者： Alireza Ahmadianyazdi Ngoc Hoang Lan Nguyen Jie Xu Vikas Berry Department of Mechanical and Industrial Engineering University of Illinois at ChicagoChicagoIllinois 60607USA Department of Chemical Engineering University of Illinois at ChicagoChicagoIllinois 60607USA

The sensitivity of graphene’s Raman characteristics to external perturbations can be exploited for sensing *** apply this principle,Raman spectroscopy of graphene in contact with a chemical/biological analyte is recorded to unravel a correlation between analyte’s physical/chemical/biological properties and electronic properties(Fermi energy and dopants level)of *** an example,we demonstrate the principle and operation of glucose measurement using graphene’s Raman spectroscopy,utilizing both affinity and enzymatic detection *** the affinity detection,we monitor Raman spectrum of graphene in contact with a glucose containing sample to quantify the attachment of glucose onto 1-pyrene boronic acid(PBA)functionalized *** is revealed that glucose covalent bond to PBA induces n-type doping in graphene and increases its Fermi level following the Hill–Langmuir *** the enzymatic detection,we show that graphene’s Fermi energy shifts due to the biocatalytic oxidation of glucose by immobilized glucose oxidase(GOx)*** a result,graphene becomes p-doped with increasing glucose *** attribute this sensitivity to a re-distribution of ionic charges within the electric double layer(EDL)of graphene upon introducing the glucose *** model explains both our affinity and enzymatic glucose detection *** glucose detection,our graphene Raman spectroscopy-based sensor(GRS)may extend its applications to a broader range of remote and non-invasive detection without the need to employ electronics such as field-effect transistors.

关键词： graphene Raman spectroscopy glucose affinity detection glucose oxidase

Nanocomposite materials in orthopedic applications

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Frontiers of Chemical Science and Engineering 2019年第1期13卷 1-13页

作者： Mostafa R.Shirdar Nasim Farajpour Reza Shahbazian-Yassar Tolou Shokuhfar Department of Bioengineering University of Illinois at Chicago Chicago IL 60607 USA Department of Electrical Engineering University of Illinois at Chicago Chicago IL 60607 USA Department of Mechanical & Industrial Engineering University of Illinois at Chicago Chicago IL 60607 USA Department of Dentistry University of Illinois at Chicago Chicago IL 60607 USA

This chapter is an introduction to nanocomposite materials and its classifications with emphasis on orthopedic application. It covers different types of matrix n anocomposites in eluding ceramics, metal, polymer and natural-based nanocomposites with the main features and applications in the orthopedic. In addition, it presents structure, composition, and biomechanical features ofbone as a natural nanocomposite. Finally, it deliberately presents developing methods for nanocomposites bone grafting.

关键词： nanocomposite materials orthopedic applications bone grafting nanocomposites nanocomposites classification

Improving Prediction of Chronic Kidney Disease Using KNN Imputed SMOTE Features and TrioNet Model

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3513-3534页

作者： Nazik Alturki Abdulaziz Altamimi Muhammad Umer Oumaima Saidani Amal Alshardan Shtwai Alsubai Marwan Omar Imran Ashraf Department of Information Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department College of Computer Science and Engineering University of Hafr Al-BatinHafarAl-Batin39524Saudi Arabia Department of Computer Science&Information Technology The Islamia University of BahawalpurP.O.Box 63100BahawalpurPakistan Department of Computer Science College of Computer Engineering and SciencesPrince Sattam bin Abdulaziz UniversityP.O.Box 151Al-Kharj11942Saudi Arabia Information Technology and Management Illinois Institute of TechnologyChicagoIL 60616-3793USA Information and Communication Engineering Yeungnam UniversityGyeongsan38541Korea

Chronic kidney disease(CKD)is a major health concern today,requiring early and accurate *** learning has emerged as a powerful tool for disease detection,and medical professionals are increasingly using ML classifier algorithms to identify CKD *** study explores the application of advanced machine learning techniques on a CKD dataset obtained from the university of California,UC Irvine Machine Learning *** research introduces TrioNet,an ensemble model combining extreme gradient boosting,random forest,and extra tree classifier,which excels in providing highly accurate predictions for ***,K nearest neighbor(KNN)imputer is utilized to deal withmissing values while synthetic minority oversampling(SMOTE)is used for class-imbalance *** ascertain the efficacy of the proposed model,a comprehensive comparative analysis is conducted with various machine learning *** proposed TrioNet using KNN imputer and SMOTE outperformed other models with 98.97%accuracy for *** in-depth analysis demonstrates the model’s capabilities and underscores its potential as a valuable tool in the diagnosis of CKD.

关键词： Precisionmedicine chronic kidney disease detection SMOTE missing values healthcare KNNimputer ensemble learning

Endoscopic ultrasound-guided portal pressure gradient identifies patients with previously undiagnosed clinically significant portal hypertension

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Portal Hypertension & Cirrhosis 2024年第2期3卷 67-74页

作者： Jerome C.Edelson Scott F.D.Edelson John G.Quiles Cyrus V.Edelson Eric M.Montminy Christian L.Horn John P.Magulick Don C.Rockey Department of Gastroenterology and Hepatology Brooke Army Medical CenterFort Sam HoustonTexasUSA Department of Medicine Uniformed Services University of the Health SciencesBethesdaMarylandUSA Department of Medicine Brooke Army Medical CenterFort Sam HoustonTexasUSA John H.Stroger Jr.Hospital of Cook County ChicagoIllinoisUSA Digestive Disease Research Center Medical University of South CarolinaCharlestonSouth CarolinaUSA

Aims:Portal hypertension(PH)is a complication of cirrhosis that leads to hepatic *** the portal pressure gradient(PPG)provides valuable information for disease assessment,staging,and *** this study,we aimed to report the utilization of endoscopic ultrasound(EUS)-guided PPG(EUS-PPG)measurements in a real-world ***:This retrospective analysis included patients at a tertiary care center who underwent EUS-PPG between February 2021 and May *** most common indication was to establish or exclude the diagnosis of cirrhosis,followed by an assessment of surgical risk in the setting of suspected *** demographic and clinical data were collected,and statistical analysis was performed using the Student's t ***:Eighteen patients underwent *** success was achieved in 17 of the 18 *** complications were *** mean scores of Child-Pugh,Model for End-Stage Liver Disease-Sodium,and Fibrosis-4 scores were 5.1±0.5,9.0±3.0,and 3.7±4.5,*** the 18 patients,two presented with esophageal varices and six with portal hypertensive *** mean PPG was 5.8±4.5 mmHg,and five patients exhibited clinically significant PH(CSPH).Of the 18 patients,15 underwent concurrent EUS-liver biopsy,which was 100%successful and provided diagnostic histology for all *** PPG data led to changes in the clinical management of 17 ***:EUS-PPG is safe and technically *** Child-Pugh score did not correlate well with the presence of CSPH;however,PPG measurements resulted in changes in the management of almost all *** studies correlating EUS-PPG with other assessments of liver diseases are required.

关键词： EUS portal hypertension portal pressure gradient

Impact of bacterial infection and intestinal microbiome on colorectal cancer development

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Chinese Medical Journal 2022年第4期135卷 400-408页

作者： Jun Sun Department of Medicine College of MedicineUniversity of Illinois at ChicagoChicagoILUSA Department of Microbiology/Immunology College of MedicineUniversity of Illinois at ChicagoChicagoILUSA UIC Cancer Center University of Illinois at ChicagoChicagoILUSA

Accumulating evidence suggests that intestinal bacteria play an important role in the pathogenesis of colorectal cancer(CRC).Due to the complexity of the intestinal microbiome,identification of the specific causative microbial agents in CRC remains challenging,and the search for the causative microbial agents is ***,whether bacteria or their products can induce inflammation that results in tumorigenesis or directly causes CRC in humans is still not *** review will mainly focus on the progress of bacterial infection and CRC,and introduce the microbial contribution to the hallmarks of *** article usesSalmonella and its chronic infection as an example to investigate a single pathogen and its role in the development of CRC,based on laboratory and epidemiological *** bacterial infection leads to an altered intestinal *** review also discusses the dysfunction of the microbiome and the mechanism of host-microbial interactions,for example,bacterial virulence factors,key signaling pathways in the host,and microbial post-translational modifications in the *** carcinogenesis involves a progressive accumulation of mutations in a genetically susceptible host leading to cellular *** forward,more human data are needed to confirm the direct roles of bacterial infection in CRC *** into the inhibiting infection will help to prevent cancer and develop strategies to restore the balance between host and microorganisms.

关键词： Adenomatous polyposis coil Beta-catenin Colorectal cancer Microbiome Post-translational modifications Salmonella