检索结果-南通市图书馆

Chemical Approaches to Emerging Advancements in Deformable Bioelectronics:Synthesis,Device Concepts,Performance,and Applications

引用

CCS Chemistry 2024年第1期6卷 11-26页

作者： Jj Abu-Halimah Aman Majmudar Bozhi Tian Department of Chemistry University of ChicagoChicagoIllinois 60637 The James Franck Institute University of ChicagoChicagoIllinois 60637 The Institute for Biophysical Dynamics University of ChicagoChicagoIllinois 60637

This mini review examines the current advances and future prospects of chemical approaches in deformable bioelectronics,emphasizing their transformative potential in healthcare and other *** mini review outlines novel fabrication strategies that rely on chemical principles to create adaptable,comfortable,and durable bioelectronic devices that are capable of seamlessly integrating into the dynamic biological *** discussion also extends to the integration of innovative device concepts that enhance the outcomes in both sensing and modulation ***-enhancing strategies that use chemistry to refine the sensitivity and precision of these devices are also ***,the mini review explores the emerging applications of chemically enhanced bioelectronic devices in healthcare,reflecting the potential of this field to revolutionize patient care and improve health *** the outlook section,this mini review investigates the promising future of transient and living bioelectronics,emphasizing the pivotal role of chemical approaches in their *** additionally covers the potential of chemical techniques in powering bioelectronic devices using biological systems and discusses the prospective applications of chemically synthesized bioelectronic devices outside of *** the field has made substantial progress,this mini review also identifies challenges that must be addressed,thus underlining the necessity for continued research and chemical innovation in bioelectronics.

关键词： deformable bioelectronics hydrogels biointerfaces sensing modulation semiconductors cells and tissues

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SARS-CoV-2 spike protein-ACE2 interaction increases carbohydrate sulfotransferases and reduces N-acetylgalactosamine-4-sulfatase by p38 MAPK

引用

Signal Transduction and Targeted Therapy 2024年第3期9卷 1174-1185页

作者： Sumit Bhattacharyya Joanne K.Tobacman Jesse Brown VA Medical Center and university of illinois at chicago ChicagoIL 60612USA

Immunostaining in lungs of patients who died with CovID-19 infection showed increased intensity and distribution of chondroitin sulfate and decline in N-acetylgalactostamine-4-sulfatase(Arylsulfatase B;ARSB).To explain these findings,human small airway epithelial cells were exposed to the SARS-CoV-2 spike protein receptor binding domain(SPRBD)and transcriptional mechanisms were ***-p38 MAPK and phospho-SMAD3 increased following exposure to the SPRBD,and their inhibition suppressed the promoter activation of the carbohydrate sulfotransferases CHST15 and CHST11,which contributed to chondroitin sulfate *** in ARSB was mediated by phospho-38 MAPK-induced N-terminal Rb phosphorylation and an associated increase in Rb-E2F1 binding and decline in E2F1 binding to the ARSB *** increases in chondroitin sulfotransferases were inhibited when treated with phospho-p38-MAPK inhibitors,SMAD3(SIS3)inhibitors,as well as antihistamine desloratadine and antibiotic *** the mouse model of carrageenan-induced systemic inflammation,increases in phosphop38 MAPK and expression of CHST15 and CHST11 and declines in DNA-E2F binding and ARSB expression occurred in the lung,similar to theobserved effects in this SPRBD model of COVID-19 *** accumulation of chondroitin sulfates is associated with fibrotic lung conditions and diffuse alveolar damage,increased attention to p38-MAPK inhibition may be beneficial in amelioratingCovid-19infections.

关键词： ACE2 lung inhibited

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Metabolites and micronutrition in modulating amyotrophic lateral sclerosis

引用

Neural Regeneration Research 2024年第6期19卷 1183-1184页

作者： Katerina Claud Jun Sun Department of Medicine University of Illinois Chicago Jesse Brown VA Medical Center chicago

Amyotrophic lateral sclerosis(ALS) is a progressive neurodegenerative disease. The majority of ALS cases are sporadic with only about 20% of familial forms. Even in families with genetic predisposition, there is significant phenotypic variability, suggesting that ALS onset may be triggered by a combination of genetic factors, environmental factors(e.g., military service,

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Pretreating and normalizing metabolomics data for statistical analysis

引用

Genes & Diseases 2024年第3期11卷 188-205页

作者： Jun Sun Yinglin Xia Division of Gastroenterology and Hepatology Department of MedicineDepartment of Microbiology/ImmunologyUIC Cancer CenterUniversity of Illinois ChicagoJesse Brown VA Medical Center Chicago(537)ChicagoIL 60612USA Division of Gastroenterology and Hepatology Department of MedicineUniversity of Illinois ChicagoChicagoIL 60612USA

Metabolomics as a research field and a set of techniques is to study the entire small molecules in biological *** is emerging as a powerful tool generally for pre-cision ***,integration of microbiome and metabolome has revealed the mechanism and functionality of microbiome in human health and ***,metabo-lomics data are very ***/pretreating and normalizing procedures on metabolomics data are usually required before statistical *** this review article,we comprehensively review various methods that are used to preprocess and pretreat metabolo-mics data,including MS-based data and NMR-based data preprocessing,dealing with zero and/or missing values and detecting outliers,data normalization,data centering and scaling,data *** discuss the advantages and limitations of each *** choice for a suitable preprocessing method is determined by the biological hypothesis,the characteristics of the data set,and the selected statistical data analysis *** then provide the perspective of their applications in the microbiome and metabolome research.

关键词： Data centering and scaling Data normalization Data transformation Missing values MS-Baseddata preprocessing NMRData preprocessing Outliers Preprocessing/pretreatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Boston type I keratoprosthesis

引用

Annals of Eye Science 2024年第2期9卷 12-23页

作者： Karen Hu Imane Tarib Maria Soledad Cortina Department of Ophthalmology and Visual Sciences University of Illinois at ChicagoChicagoILUSA

Successful corneal solid tissue transplantation,beginning with penetrating keratoplasty(PKP),and evolving to include contemporary lamellar and endothelial keratoplasty,has been a tremendous advancement in the struggle to combat corneal ***,there remain patients with high-risk features predictive of transplant failure,for whom donor keratoplasty is not a viable *** corneas have therefore been developed in order to meet the needs of these *** Boston type I keratoprosthesis(BKPro)is the most widely used prosthetic cornea in the treatment of corneal *** the years since the BKPro’s introduction,refinement of surgical technique and clinical management as well as improvements in prosthetic design have contributed to promising patient outcomes,particularly in the short *** such,patients with keratoprosthesis implants continue to grow in number,and the indications for the BKPro have commensurately ***,risks of permanently blinding complications after implantation persist over all stages of *** the foreseeable future,the success of keratoprosthesis(KPro)implantation will continue to depend on refined patient selection,preoperative optimization,and incisive postoperative *** we explore indications,surgical technique and postoperative outcomes as well as several core tenants in the management of BKPro patients:limiting glaucomatous progression,controlling inflammation,and optimizing the ocular *** exquisite sensitivity of the BKPro-implanted eye to perturbations in any one of these areas showcases the intimate relationship between the prosthetic device and its surrounding environment.

关键词： Keratoprosthesis corneal transplant Boston type I keratoprosthesis(BKPro) keratoprosthesis(KPro)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Extracellular vesicles and angiotensin-converting enzyme 2 in COVID-19 disease

引用

BIOCELL 2024年第1期48卷 1-8页

作者： YU LIU ROBERT J.KASPER NATALIE J.S.CHOI Department of Family and Community Medicine Northwestern University Feinberg School of MedicineChicagoIllinois

Extracellular vesicles(EVs)are membranous vesicular structures released from almost all eukaryotic cell types under different physiological or pathological *** evidence demonstrates that EVs can serve as mediators of intercellular communication between donor and recipient cells or microorganism-infected and noninfected *** disease 2019(COVID-19)disease is caused by infection of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)of host cells in the respiratory system and various extra-pulmonary tissue/organs,resulting in complications of multiple organ *** the cell surface receptor,angiotensin-converting enzyme 2(ACE2)mediates cellular entry of SARS-CoV-2 into the host cells in patients with *** studies have found that ACE2 can be released with EVs,which have been shown to interfere with the entry of the virus into host cells and thus may be involved in COVID-19 *** addition,ACE2,neprilysin(NEP),and thimet oligopeptidase(TOP)are the key enzymes that regulate angiotensin metabolism by converting angiotensin II or angiotensin I to angiotensin 1-7,the latter of which has protective effects in counterbalancing the harmful effects of angiotensin II in COVID-19 *** review summarizes the recent research progress regarding EV-associated ACE2,NEP,and TOP and the perspectives of their potential involvement in the pathophysiology of COVID-19 disease.

关键词： Extracellular vesicles COVID-19 Angiotensin converting enzyme 2 Thimet oligopeptidase

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intrinsically Stretchable Electroluminescent Materials and Devices

引用

CCS Chemistry 2024年第6期6卷 1360-1379页

作者： Wei Liu Glingna Wang Sihong Wang Pritzker School of Molecular Engineering The University of ChicagoChicagoIllinois 60637 Nanoscience and Technology Division and Center for Molecular Engineering Argonne National LaboratoryLemontIllinois 60439

Intrinsically stretchable electroluminescent(EL)devices have emerged as pivotal components with transformative potential in various domains,including wearable technology,medical devices,human-machine interfaces,and *** mini-review focuses on the recent progress in the development of intrinsically stretchable EL materials,highlighting milestones and breakthroughs in the *** article discusses the basic principles,advantages,and disadvantages associated with various EL mechanisms and *** material design strategies,particularly focusing on light-emitting layers,are thoroughly examined,detailing their implementation in EL devices and the resultant EL *** also provide perspectives on the active challenges and future research needs for each type of EL material and devices for achieving stretchable designs,together with some insights into the future trajectory of stretchable EL technology.

关键词： stretchable electronics electroluminescent materials electroluminescent devices lightemitting diodes thermally activated delayed fluorescence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Epithelial stem cells and niches in lung alveolar regeneration and diseases

引用

Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第1期2卷 17-26页

作者： Jilei Zhang Yuru Liu Department of Pharmacology and Regenerative Medicine University of Illinois College of MedicineChicagoIL 60612USA university of illinois Cancer Center ChicagoIL 60612USA

Alveoli serve as the functional units of the lungs,responsible for the critical task of blood-gas ***-prising type I(AT1)and type II(AT2)cells,the alveolar epithelium is continuously subject to external aggressors like pathogens and airborne *** such,preserving lung function requires both the homeostatic renewal and reparative regeneration of this epithelial *** in these processes contribute to various lung *** research has pinpointed specific cell subgroups that act as potential stem or progenitor cells for the alveolar epithelium during both homeostasis and ***,endothelial cells,fibroblasts,and immune cells synergistically establish a nurturing microenvironment-or“niche”-that modulates these ep-ithelial stem *** review aims to consolidate the latest findings on the identities of these stem cells and the components of their niche,as well as the molecular mechanisms that govern ***,this article highlights diseases that arise due to perturbations in stem cell-niche *** also discuss recent technical innovations that have catalyzed these ***,this review underscores the heterogeneity,plastic-ity,and dynamic regulation of these stem cell-niche *** is our aspiration that a deeper understanding of the fundamental cellular and molecular mechanisms underlying alveolar homeostasis and regeneration will open avenues for identifying novel therapeutic targets for conditions such as chronic obstructive pulmonary disease(COPD),fibrosis,coronavirus disease 2019(COVID-19),and lung cancer.

关键词： Alveoli Epithelium Type II cell(AT2) Stem cell Niche

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transient Characteristics and Accommodative Current Limiting Strategy for Bidirectional Interlinking Converters in Hybrid AC/DC Microgrids

引用

CSEE Journal of Power and Energy Systems 2024年第4期10卷 1575-1588页

作者： Xia Shen Zhikang Shuai Wen Huang Chao Shen Yang Shen Z.John Shen College of Electrical and Information Engineering Hunan UniversityChangsha 410082China Department of Electrical and Computer Engineering Illinois Institute of TechnologyChicagoIL 60616 USA

Bidirectional interlinking converter(BIC)is the core equipment in a hybrid AC/DC microgrid connected between AC and DC ***,the variety of control modes and flexible bidirectional power flow complicate the influence of AC faults on BIC itself and on DC sub-grid,which potentially threaten both converter safety and system *** study first investigates AC fault influence on the BIC and DC bus voltage under different BIC control modes and different pre-fault operation states,by developing a mathematical model and equivalent sequence ***,based on the analysis results,a general accommodative current limiting strategy is proposed for BIC without limitations to specific mode or operation *** amplitude is predicted and constrained according to the critical requirements to protect the BIC and relieving the AC fault influence on the DC bus *** with conventional methods,potential current limit failure and distortions under asymmetric faults can also be ***,experiments verify feasibility of the proposed method.

关键词： Bidirectional interlinking converter current limiting fault characteristic hybrid AC/DC microgrid variation/oscillation of DC bus voltage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chain Rule for Extracting Resilience Procurement Costs from Locational Marginal Prices

引用

CSEE Journal of Power and Energy Systems 2024年第3期10卷 1342-1355页

作者： Yifei Wang Tong Zhu Tiancong Chen Mohammad Shahidehpour Qingshan Xu College of Electrical Engineering Southeast UniversityNanjing 210096China Henan Mechanical&Electrical Vocational College Xinzheng 451191China illinois Institute of Technology ChicagoIllinois 60616USA IEEE CSEE

Power system resilience procurement costs in N-k contingencies have gained more prominence as number of extreme events continues to increase.A chain rule is presented in this paper for extracting resilience procurement costs from a fully decomposed locational marginal price(LMP)***,power transfer distribution factor(PTDF)matrices with AC power flow(i.e.,AC-PTDF)are ***-PTDF and AC-LODF(line outage distribution factor)equations are derived for N-k contingencies and a fully decomposed LMP model is developed where generation and transmission security components are established for specific ***,resilience procurement costs can be measured at different buses for the proposed security *** of N-k contingencies on resilience procurement costs at specific buses can be determined as proposed security components will gain more insight for resilience procurement in power *** modified IEEE 6-bus and 118-bus systems are adopted to verify effectiveness of the proposed resilience procurement method.

关键词： Line outage distribution factors locational marginal price power system resilience power transfer distribution factor security components

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：