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Photo-responsive functional materials based on light-driven molecular motors

Light(Science & Applications) 2024年第3期13卷 407-420页

作者： Yanping Deng Guiying Long Yang Zhang Wei Zhao Guofu Zhou Ben L.Feringa Jiawen Chen SCNU-UG International Joint Laboratory of Molecular Science and Displays National Center for International Research on Green OptoelectronicsSouth China Normal UniversityGuangzhou 510006China Stratingh Institute for Chemistry University of GroningenNijenborgh 49747AG GroningenThe Netherlands

In the past two decades,the research and development of light-triggered molecular machines have mainly focused on developing molecular devices at the nanoscale.A key scientific issue in the field is how to amplify the controlled motion of molecules at the nanoscale along multiple length scales,such as the mesoscopic or the macroscopic scale,or in a more practical perspective,how to convert molecular motion into changes of properties of a macroscopic material.Light-driven molecular motors are able to perform repetitive unidirectional rotation upon irradiation,which offers unique opportunities for responsive macroscopic systems.With several reviews that focus on the design,synthesis and operation of the motors at the nanoscale,photo-responsive macroscopic materials based on light-driven molecular motors have not been comprehensively summarized.In the present review,we first discuss the strategy of confining absolute molecular rotation into relative rotation by grafting motors on surfaces.Secondly,examples of self-assemble motors in supramolecular polymers with high internal order are illustrated.Moreover,we will focus on building of motors in a covalently linked system such as polymeric gels and polymeric liquid crystals to generate complex responsive functions.Finally,a perspective toward future developments and opportunities is given.This review helps us getting a more and more clear picture and understanding on how complex movement can be programmed in light-responsive systems and how man-made adaptive materials can be invented,which can serve as an important guideline for further design of complex and advanced responsive materials.

关键词： functions materials material

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Transfer learning from T1-weighted to T2-weighted Magnetic resonance sequences for brain image segmentation

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 26-39页

作者： Imene Mecheter Maysam Abbod Habib Zaidi Abbes Amira Brunel university LondonUK Geneva university Hospital GenevaSwitzerland Geneva university GenevaSwitzerland university of groningen GroningenNetherlands university of Southern Denmark OdenseDenmark university of Sharjah SharjahUAE De Montfort university LeicesterUK

Magnetic resonance(MR)imaging is a widely employed medical imaging technique that produces detailed anatomical images of the human body.The segmentation of MR im-ages plays a crucial role in medical image analysis,as it enables accurate diagnosis,treatment planning,and monitoring of various diseases and conditions.Due to the lack of sufficient medical images,it is challenging to achieve an accurate segmentation,especially with the application of deep learning networks.The aim of this work is to study transfer learning from T1-weighted(T1-w)to T2-weighted(T2-w)MR sequences to enhance bone segmentation with minimal required computation resources.With the use of an excitation-based convolutional neural networks,four transfer learning mechanisms are proposed:transfer learning without fine tuning,open fine tuning,conservative fine tuning,and hybrid transfer learning.Moreover,a multi-parametric segmentation model is proposed using T2-w MR as an intensity-based augmentation technique.The novelty of this work emerges in the hybrid transfer learning approach that overcomes the overfitting issue and preserves the features of both modalities with minimal computation time and resources.The segmentation results are evaluated using 14 clinical 3D brain MR and CT images.The results reveal that hybrid transfer learning is superior for bone segmentation in terms of performance and computation time with DSCs of 0.5393±0.0007.Although T2-w-based augmentation has no significant impact on the performance of T1-w MR segmentation,it helps in improving T2-w MR segmentation and developing a multi-sequences segmentation model.

关键词： computer vision convolution image segmentation learning(artificial intelligence)

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A novel multi-channel porous structure facilitating mass transport towards highly efficient alkaline water electrolysis

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Journal of Energy Chemistry 2024年第6期93卷 511-518,I0013页

作者： Xinge Jiang Vasileios Kyriakou Chen Song Xianbin Wang Sophie Costil Chunming Deng Taikai Liu Tao Jiang Hanlin Liao Universitéde technologie de Belfort Montbéliard Centre national de la recherche scientifiqueLaboratoire Interdisciplinaire Carnot de BourgogneBelfort 90010France Department of Chemical Engineering Engineering and Technology Institute Groningen(ENTEG)University of GroningenGroningen 9747 AGThe Netherlands The Institute of New Materials Guangdong Academy of ScienceGuangzhou 510650GuangdongChina

An advantageous porous architecture of electrodes is pivotal in significantly enhancing alkaline water electrolysis(AWE)efficiency by optimizing the mass transport mechanisms.This effect becomes even more pronounced when aiming to achieve elevated current densities.Herein,we employed a rapid and scalable laser texturing process to craft novel multi-channel porous electrodes.Particularly,the obtained electrodes exhibit the lowest Tafel slope of 79 mV dec^(-1)(HER)and 49 mV dec^(-1)(OER).As anticipated,the alkaline electrolyzer(AEL)cell incorporating multi-channel porous electrodes(NP-LT30)exhibited a remarkable improvement in cell efficiency,with voltage drops(from 2.28 to 1.97 V)exceeding 300 mV under 1 A cm^(-1),compared to conventional perforated Ni plate electrodes.This enhancement mainly stemmed from the employed multi-channel porous structure,facilitating mass transport and bubble dynamics through an innovative convection mode,surpassing the traditional convection mode.Furthermore,the NP-LT30-based AEL cell demonstrated exceptional durability for 300 h under 1.0 A cm^(-2).This study underscores the capability of the novel multi-channel porous electrodes to expedite mass transport in practical AWE applications.

关键词： Alkaline water electrolysis Mass transport Bubble dynamics Innovative convection mode Multi-channel porous structure

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Clean air captures attention whereas pollution distracts:evidence from brain activities

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 5-15页

作者： Jianxun Yang Yunqi Liu Berry van den Berg Susie Wang Lele Chen Miaomiao Liu Jun Bi State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology(CICAEET) Nanjing University of Information Science&TechnologyNanjing 210044China Nanjing Foreign Language School Nanjing 210008China Department of Experimental Psychology University of GroningenGrote Kruisstraat 2/19712 TSGroningenThe Netherlands Department of Social Psychology University of GroningenGrote Kruisstraat 2/19712 TSGroningenThe Netherlands School of Education Science Nantong UniversityNantong 226019China

Awareness of the adverse impact of air pollution on attention-related performance such as learning and driving is rapidly growing.However,there is still little known about the underlying neurocognitive mechanisms.Using an adapted dot-probe task paradigm and event-related potential(ERP)technique,we investigated how visual stimuli of air pollution influence the attentional allocation process.Participants were required to make responses to the onset of a target presented at the left or right visual field.The probable location of the target was forewarned by a cue(pollution or clean air images),appearing at either the target location(attention-holding trials)or the opposite location(attention-shifting trials).Behavioral measures showed that when cued by pollution images,subjects had higher response accuracy in attention-shifting trials.ERP analysis results revealed that after the cue onset,pollution images evoked lower N300 amplitudes,indicating less attentioncapturing effects of dirty air.After the target onset,pollution cues were correlated with the higher P300 amplitudes in attention-holding trials but lower amplitudes in attention-shifting trials.It indicates that after visual exposure to air pollution,people need more neurocognitive resources to maintain attention but less effort to shift attention away.The findings provide the first neuroscientific evidence for the distracting effect of air pollution.We conclude with several practical implications and suggest the ERP technique as a promising tool to understand human responses to environmental stressors.

关键词： Air pollution Attention Disengagement Performance Event-related potential

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Investigation of Projectile Impact Behaviors of Graphene Aerogel Using Molecular Dynamics Simulations

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3047-3061页

作者： Xinyu Zhang Wenjie Xia Yang Wang Liang Wang Xiaofeng Liu Department of Engineering Mechanics Shanghai Jiao Tong UniversityShanghai200240China Department of Aerospace Engineering Iowa State UniversityAmesIA50011USA School of Materials Science and Engineering University of Science&Technology BeijingBeijing100083China Zernike Institute for Advanced Materials University of GroningenGroningen9747The Netherlands

Graphene aerogel(GA),as a novel solid material,has shown great potential in engineering applications due to its unique mechanical properties.In this study,the mechanical performance of GA under high-velocity projectile impacts is thoroughly investigated using full-atomic molecular dynamics(MD)simulations.The study results show that the porous structure and density are key factors determining the mechanical response of GA under impact loading.Specifically,the impact-induced penetration of the projectile leads to the collapse of the pore structure,causing stretching and subsequent rupture of covalent bonds in graphene sheets.Moreover,the effects of temperature on the mechanical performance of GA have been proven to be minimal,thereby highlighting the mechanical stability of GA over a wide range of temperatures.Finally,the energy absorption density(EAD)and energy absorption efficiency(EAE)metrics are adopted to assess the energy absorption capacity of GA during projectile penetration.The research findings of this work demonstrate the significant potential of GA for energy absorption applications.

关键词： Graphene aerogel molecular dynamics simulation impact response energy absorption

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SnS2 nanosheets decorated SnO2 hollow multishelled nanostructures for enhanced sensing of triethylamine gas

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Rare Metals 2024年第5期43卷 2339-2348页

作者： Wen-Di Liu Ya Xiong Ao Shen Xin-Zhen Wang Xiao Chang Wen-Bo Lu Jian Tian School of Materials Science and Engineering Shandong University of Science and Technology College of Physics Qingdao University Zernike Institute for Advanced Materials University of Groningen

Highly sensitive,fast and low-temperature detection of triethylamine （TEA） gas based on Sn O2is attractive yet remains challenging.Herein,Sn S2nanosheets （NSs）/Sn O2hollow multishelled structures （Ho MSs）-based sensors are designed by the synthesis of Sn O2Ho MSs,followed by in situ sulfuration with thioacetamide.By varying the thioacetamide levels,Sn S2/Sn O2heterostructures with different Sn S2contents were obtained and their TEA gas sensing performances were investigated.

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Dual ligand-targeted Pluronic P123 polymeric micelles enhance the therapeutic effect of breast cancer with bone metastases

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Oncology Research 2024年第4期32卷 769-784页

作者： HUAN GAO JIE ZHANG TONY GKLEIJN ZHAOYONG WU BING LIU YUJIN MA BAOYUE DING DONGFENG YIN Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics Department of PharmaceuticsCollege of MedicineJiaxing UniversityJiaxing314001China Department of Pharmacy The General Hospital of Xinjiang Military RegionUrumqi830000China Department of Pathology and Medical Biology University Medical Center GroningenUniversity of GroningenGroningen9713 GZThe Netherlands Department of Pathology Laboratory of Experimental OncologyErasmus MCRotterdam3015 GDThe Netherlands Department of Pharmacy Jiaxing Maternal and Child Health Care HospitalAffiliated Hospital of Jiaxing UniversityJiaxing314001China Qinghai Enlu Biotechnology Co. Ltd.Haidong810700China

Bone metastasis secondary to breast cancer negatively impacts patient quality of life and survival.The treatment of bone metastases is challenging since many anticancer drugs are not effectively delivered to the bone to exert a therapeutic effect.To improve the treatment efficacy,we developed Pluronic P123(P123)-based polymeric micelles dually decorated with alendronate(ALN)and cancer-specific phage protein DMPGTVLP(DP-8)for targeted drug delivery to breast cancer bone metastases.Doxorubicin(DOX)was selected as the anticancer drug and was encapsulated into the hydrophobic core of the micelles with a high drug loading capacity(3.44%).The DOX-loaded polymeric micelles were spherical,123 nm in diameter on average,and exhibited a narrow size distribution.The in vitro experiments demonstrated that a pH decrease from 7.4 to 5.0 markedly accelerated DOX release.The micelles were well internalized by cultured breast cancer cells and the cell death rate of micelle-treated breast cancer cells was increased compared to that of free DOX-treated cells.Rapid binding of the micelles to hydroxyapatite(HA)microparticles indicated their high affinity for bone.P123-ALN/DP-8@DOX inhibited tumor growth and reduced bone resorption in a 3D cancer bone metastasis model.In vivo experiments using a breast cancer bone metastasis nude model demonstrated increased accumulation of the micelles in the tumor region and considerable antitumor activity with no organ-specific histological damage and minimal systemic toxicity.In conclusion,our study provided strong evidence that these pH-sensitive dual ligand-targeted polymeric micelles may be a successful treatment strategy for breast cancer bone metastasis.

关键词： Pluronic micelles Targeted nanotherapeutics Nanoparticulate drug delivery system Breast cancer with bone metastasis Therapeutic efficacy

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Mindfulness training in medical education as a means to improve resilience,empathy,and mental health in the medical profession

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World Journal of Psychiatry 2024年第4期14卷 489-493页

作者： Edison Iglesias de Oliveira Vidal Luiz Fernando Alvarenga Ribeiro Marco Antonio de Carvalho-Filho Fernanda Bono Fukushima Internal Medicine Department Botucatu Medical SchoolSao Paulo State University(UNESP)Botucatu 18618-687SPBrazil Wenckebach Institute for Education and Training LEARN-Lifelong LearningEducation and Assessment Research NetworkUniversity Medical Center GroningenGroningen 9713AVGroningenNetherlands Assertiva Mindfulness Botucatu 18603-970SPBrazil Surgical Specialties and Anesthesiology Department Botucatu Medical SchoolSão Paulo State University(UNESP)Botucatu 18618-687SPBrazil

The high rates of depression,burnout,and increased risk of suicide among medical students,residents,and physicians in comparison with other careers signal a mental health crisis within our profession.We contend that this crisis coupled with the inadequate acquisition of interpersonal skills during medical education results from the interaction between a challenging environment and the mental capital of individuals.Additionally,we posit that mindfulness-based practices are instrumental for the development of major components of mental capital,such as resilience,flexibility of mind,and learning skills,while also serving as a pathway to enhance empathy,compassion,self-awareness,conflict resolution,and relational abilities.Importantly,the evidence base supporting the effectiveness of mindfulness-based interventions has been increasing over the years,and a growing number of medical schools have already integrated mindfulness into their curricula.While we acknowledge that mindfulness is not a panacea for all educational and mental health problems in this field,we argue that there is currently an unprecedented opportunity to gather momentum,spread and study mindfulness-based programs in medical schools around the world as a way to address some longstanding shortcomings of the medical profession and the health and educational systems upon which it is rooted.

关键词： Mindfulness Medical education Mental capital Mental health Medical students Resilience

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Aqueous-phase reforming of hydroxyacetone solution to bio-based H_(2)over supported Pt catalysts

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Green Energy & Environment 2024年第4期9卷 777-788页

作者： A.K.K.Vikla K.Koichumanova Songbo He K.Seshan Joint International Research Laboratory of Circular Carbon Nanjing Tech UniversityNanjing211816China Faculty of Science and Technology University of Twente7500 AE EnschedeThe Netherlands CoRe Pro 9723 BL GroningenThe Netherlands

Aqueous-phase reforming(APR)is an attractive process to produce bio-based hydrogen from waste biomass streams,during which the catalyst stability is often challenged due to the harsh reaction conditions.In this work,three Pt-based catalysts supported on C,AlO(OH),and ZrO_(2)were investigated for the APR of hydroxyacetone solution in afixed bed reactor at 225℃and 35 bar.Among them,the Pt/C catalyst showed the highest turnover frequency for H_(2)production(TOF of 8.9 molH_(2)molPt^(-1)min^(-1))and the longest catalyst stability.Over the AlO(OH)and ZrO_(2)supported Pt catalysts,the side reactions consuming H_(2),formation of coke,and Pt sintering result in a low H_(2)production and the fast catalyst deactivation.The proposed reaction pathways suggest that a promising APR catalyst should reform all oxygenates in the aqueous phase,minimize the hydrogenation of the oxygenates,maximize the WGS reaction,and inhibit the condensation and coking reactions for maximizing the hydrogen yield and a stable catalytic performance.

关键词： APR Hydroxyacetone TOF Bio-based H_(2) Support effect

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Dynamic Control of Multiple Optical Patterns of Cholesteric Liquid Crystal Microdroplets by Light-Driven Molecular Motors

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CCS Chemistry 2024年第2期6卷 427-438页

作者： Jiaqin Li Shuting Xie Jiahui Meng Yuying Liu Qi Zhan Yang Zhang Lingling Shui Guofu Zhou Ben L.Feringa Jiawen Chen SCNU-UG International Joint Laboratory of Molecular Science and Displays National Center for International Research on Green OptoelectronicsSouth China Normal UniversityGuangzhou 510006 Joint Laboratory of Optofluidic Technology and Systems Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and DevicesSchool of Information and Optoelectronic Science and EngineeringSouth China Normal UniversityGuangzhou 510006 Stratingh Institute for Chemistry University of Groningen9747AG Groningen

The key to high-level encryption and anti-counterfeiting techniques is the storage of multiple levels of distinct information that can be individually and precisely addressed by certain stimuli.This continues to be a formidable challenge as the concealed images or codes must be read with fast response and high resolution without cross-talk to the first layer of information.Here,we report a non-fluorescencebased strategy to establish responsive encryption labels taking advantage of solely tuning multiple optical patterns of cholesteric liquid crystal(CLC)microdroplets doped with light-driven molecular motors.The photo-triggered unidirectional rotation of the motor induced not only changes in the helical twist power value but the opposite helical orientation of the superstructure in CLCs as well,resulting in changes in both the structural color and the selective reflection of circularly polar light.The designed labels,which featured highly selective addressability of dual-level distinct information,good reversibility,and viewing angle-independence,were applied to build devices for daily practical use,demonstrating great potential in anti-counterfeiting technology and provide a versatile platform for enhanced data protection and encryption of authentic information.

关键词： molecular motor chirality amplification cholesteric liquid crystal anti-counterfeiting label data encryption

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