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An ethically guided preclinical device for phenotyping H_(2)production in laboratory rodents

Animal Models and Experimental Medicine 2024年第4期7卷 553-561页

作者： Victor Pascal-Moussellard Emilie Boucher Stéphane Tanguy Philippe Cinquin Pierre-Alain Barraud ChloéDavin Cordélia Salomez-Ihl Dalil Hannani François Boucher Jean-Pierre Alcaraz university grenoble Alpes CNRSUMR 5525VetAgro SupGrenoble INPTIMCGrenobleFrance

Background:Dihydrogen(H_(2))is produced endogenously by the intestinal microbiota through the fermentation of diet *** the past few years,numer-ous studies have demonstrated the significant therapeutic potential of H_(2)in various pathophysiological contexts,making the characterization of its production in labora-tory species of major preclinical ***:This study proposes an innovative solution to accurately monitor H_(2)pro-duction in free-moving rodents while respecting animal welfare *** devel-oped device consisted of a wire rodent cage placed inside an airtight chamber in which the air quality was maintained,and the H_(2)concentration was continuously *** the airtightness and efficiency of the systems used to control and maintain air quality in the chamber were checked,tests were carried out on rats and mice with different metabolic phenotypes,over 12 min to 1-h experiments and repeatedly.H_(2)production rates(HPR)were obtained using an easy calculation algorithm based on a first-order moving ***:HPR in hyperphagic Zucker rats was found to be twice as high as in control Wistar rats,respectively,2.64 and 1.27 nmol.s^(−1)per *** addition,the ingestion of inulin,a dietary fiber,stimulated H_(2)production in *** were 0.46 nmol.s^(−1)for animals under control diet and 1.99 nmol.s^(−1)for animals under inulin ***:The proposed device coupled with our algorithm enables fine analysis of the metabolic phenotype of laboratory rats or mice with regard to their endogenous H_(2)production.

关键词： hydrogen therapy laboratory rodents microbiota molecular hydrogen noninvasive monitoring device

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Bayesian ensemble methods for predicting ground deformation due to tunnelling with sparse monitoring data

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Underground Space 2024年第3期16卷 79-93页

作者： Zilong Zhang Tingting Zhang Xiaozhou Li Daniel Dias School of Civil Engineering Central South UniversityChangshaHunan 410075China Laboratory 3SR Grenoble Alpes UniversityCNRS UMR 5521Grenoble 38000France

Numerous analytical models have been developed to predict ground deformations induced by tunneling,which is a critical issue in tunnel ***,the accuracy of these predictions is often limited by errors and uncertainties resulting from model selection and parameter fittings,given the paucity of monitoring data in field *** paper proposes a novel approach to estimate tunnelling-induced ground deformations by applying Bayesian model averaging to several representative prediction *** accounting for both model and parameter uncertainties,this approach enables more realistic predictions of ground deformations than individual ***,our results indicate that the Gonzalez-Sagaseta model outperforms other models in predicting ground surface settlements,while the Loganathan-Poulos model is most suitable for predicting subsurface vertical and horizontal ***,our analysis reveals that when monitoring data are sparse,model uncertainties may contribute up to 78.7%of the total ***,obtaining sufficient data for parameter fitting is crucial for accurate *** proposed method in this study offers a more realistic and efficient prediction of tunnelling-induced ground deformations.

关键词： Tunnelling-induced ground deformations Sparse data Model uncertainties Bayesian model averaging

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Rockburst prediction and prevention in underground space excavation

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Underground Space 2024年第1期14卷 70-98页

作者： Jian Zhou Yulin Zhang Chuanqi Li Haini He Xibing Li School of Resources and Safety Engineering Central South UniversityChangsha 410083China Laboratory 3SR CNRS UMR 5521Grenoble Alpes UniversityGrenoble 38000France

The technical challenges associated with deep underground space activities have become increasingly *** these challenges,one major concern is the assessment of rockburst risks and the instability of rock *** research has been conducted by numerous scholars to mitigate the risks and prevent occurrences of rockburst through various assessment *** incidents commonly occur during the excavation of hard rock in underground environments,posing severe threats to personnel safety,equipment integrity,and operational ***,it is crucial to systematically document real cases of rockburst,allowing for a comprehensive understanding of the underlying mechanisms and triggering *** understanding will contribute to the advancement of rockburst prediction and prevention *** selection of an appropriate rockburst assessment method is a fundamental aspect in underground ***,there is a limited number of studies that summarize and compare different prediction and prevention methods of *** paper aims to address this gap by analyzing global trends using CiteSpace software since *** discusses rockburst classification and characteristics,comprehensively reviews research findings related to rockburst prediction,including empirical,simulation,mathematical modeling,and microseismic monitoring ***,the paper presents a compilation of current rockburst prevention ***,the paper emphasizes the significance of control strategies,which provide key insights into the effective utilization of stored energy within ***,the paper concludes by suggesting six directions for implementing intelligent management techniques to mitigate hazards during underground operations and reduce the probability of rockburst incidents.

关键词： Rockburst Underground space Scientometric analysis Characteristic analysis Rockburst prediction Rockburst prevention

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Migration time prediction and assessment of toxic fumes under forced ventilation in underground mines

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Underground Space 2024年第5期18卷 273-294页

作者： Jinrui Zhang Tingting Zhang Chuanqi Li School of Resources&Civil Engineering Northeastern UniversityShenyang 110819China Laboratory 3SR CNRS UMR 5521Grenoble Alpes UniversityGrenoble 38000France

This study aims to predict the migration time of toxic fumes induced by excavation blasting in underground *** reduce numerical simulation time and optimize ventilation design,several back propagation neural network(BPNN)models optimized by honey badger algorithm(HBA)with four chaos mapping(CM)functions(i.e.,Chebyshev(Che)map,Circle(Cir)map,Logistic(Log)map,and Piecewise(Pie)map)are developed to predict the migration time.125 simulations by the computational fluid dynamics(CFD)method are used to train and test the developed *** determination coefficient(R2),the variance accounted for(VAF),the Willmott’s index(WI),the root mean square error(RMSE),the mean absolute percentage error(MAPE),and the sum of squares error(SSE)are utilized to evaluate the model *** evaluation results indicate that the CirHBA-BPNN model has achieved the most satisfactory performance by reaching the highest values of R2(0.9945),WI(0.9986),VAF(99.4811%),and the lowest values of RMSE(15.7600),MAPE(0.0343)and SSE(6209.4),*** wind velocity in roadway(Wv)is the most important feature for predicting the migration time of toxic ***,the intrinsic response characteristic of the optimal model is implemented to enhance the model interpretability and provide reference for the relationship between features and migration time of toxic fumes in ventilation design.

关键词： Migration time Underground mines Honey badger algorithm Chaos mapping Back propagation neural network

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Numerical study on the use of soft material walls to enhance seismic performance of an existing tunnel

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Underground Space 2024年第2期15卷 90-112页

作者： Qiangqiang Sun Menghao Hou Daniel Dias Institute of Geotechnical Engineering College of Civil Engineering and ArchitectureHebei UniversityBaoding 071002China Laboratory 3SR CNRS UMR 5521Grenoble Alpes UniversityGrenoble 38000France

Seismic risk is one of the biggest challenges for tunnel safety,and several mitigation techniques have been proposed to enhance the seismic performance of existing *** paper aims to investigate the effectiveness of an innovative approach for reducing the seismic risk of existing tunnels by using soft material walls(SMW)symmetrically installed in the surrounding *** investigation is performed with a two-dimensional numerical model and the effectiveness of SMW in mitigating the seismic-induced lining forces is quantitatively evaluated by reduction *** influences of nonlinear properties of soil,SMW and tunnel lining on the isolation effectiveness are also *** parametric studies show that the computed reduction ratio is strongly affected by the modulus ratio between the SMW and the soil,the wall geometric parameter,and the flexibility *** is more effective for the thick and soft isolation walls that are inserted near a stiff tunnel in the soft *** tunnel seismic response can be reduced by up to 50%for the scenarios ***,the parametric study identifies an optimum normalized depth of SMW and recommends a relation between the maximum isolation effect and the flexibility ***,simple charts are suggested in this work for estimating the isolation effect in specific conditions of the soil and the *** these lines,the results of this work may be used in the seismic retrofitting of an existing tunnel,aiding the preliminary design of the isolation walls.

关键词： Tunnels Earthquakes Seismic analysis Isolation walls Soft material

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Does photobiomodulation require glucose to work effectively?

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Neural Regeneration Research 2024年第5期19卷 945-946页

作者： Jaimie Hoh Kam John Mitrofanis Universitégrenoble Alpes Fonds de Dotation ClinatecGrenobleFrance university College London Institute of OphthalmologyUK

A main requirement for cells to function normally is the availability of ***,available either direct from circulation or storage,is converted to the essential energy that cells need to drive critical intrinsic *** cells are deprived of glucose,they become dysfunctional and suffer ***,the use of specific wavelengths of light on body tissues,has been shown to promote,through small organelles called mitochondria,the metabolism of glucose to make energy for cells;this energy can be used to improve cell function and *** this perspective,we hypothesize that the availability of glucose is central to the core mechanism of photobiomodulation;that photobiomodulation is at its most efficient in stimulating mitochondrial activity and improving cell function when there is glucose readily available.

关键词： metabolism distress stimulating

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Innovations in measuring and mitigating phytohemagglutinins,a key food safety concern in beans

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Food Quality and Safety 2024年第1期8卷 1-11页

作者：吕晨泽房智慧杨素宁康徐敏 Arnaud Buhot Yanxia Hou 胡培雅徐沛 Key Laboratory of Specialty Agri-products Quality and Hazard Controlling Technology of Zhejiang Province College of Life SciencesChina Jiliang UniversityHangzhouChina university grenoble Alpes CEACNRSINAC-SyMMESGrenobleFrance

Phytohemagglutinin(PHA)is a seed storage protein and a type of lectin originally discovered in the common bean(Phaseolus vulgaris)for its blood-agglutinating *** to its interactions with gut epithelia and digestive enzymes and its potential to trigger allergic reactions,PHA can lead to various symptoms in the human *** a result,it has been regarded as a signifcant antinutritional factor in beans and other *** several published works have summarized its structural,biochemical,and toxicological features,there is a scarcity of literature that reviews the detection,quantifcation,and reduction of PHA in beans,which is fundamental for the development of safer bean *** this review,we present a comprehensive analysis of traditional and innovative bio-sensing methods for measuring PHA,including the recently available ultrapure liquid chromatography–tandem mass spectrometry and emerging aptamer sensor-based techniques,while discussing their respective advantages and *** also revisit existing studies dedicated to creating PHA-depleted common bean varieties and explore the potential for reducing PHA content in beans without compromising their resistance to biotic ***,we offer insights into the potential for controlling PHA content using the latest biotechnologies and breeding ***,this review compiles rare and valuable information from studies that solely focuses on detection and depletion of PHA to shed light on and apply technological advancements in addressing potential food safety risks associated with the consumption of common beans.

关键词： Phytohemagglutinin common bean food safety breeding quantifcation.

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Deterministic and probabilistic analysis of great-depth braced excavations:A 32 m excavation case study in Paris

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1505-1521页

作者： Tingting Zhang Julien Baroth Daniel Dias Khadija Nejjar Université grenoble Alpes CNRSGrenoble INP3SRGrenoble38000France Antea Group Antony92160France School of Automotive and Transportation Engineering Hefei University of TechnologyHefei23009China Terrasol 42-52 Quai de la RapéeParis75012France

The Fort d’Issy-Vanves-Clamart(FIVC)braced excavation in France is analyzed to provide insights into the geotechnical serviceability assessment of excavations at great depth within deterministic and probabilistic *** FIVC excavation is excavated at 32 m below the ground surface in Parisian sedimentary basin and a plane-strain finite element analysis is implemented to examine the wall deflections and ground surface settlements.A stochastic finite element method based on the polynomial chaos Kriging metamodel(MSFEM)is then proposed for the probabilistic *** with field measurements and former studies are carried *** academic cases are then conducted to investigate the great-depth excavation stability regarding the maximum horizontal wall deflection and maximum ground surface *** results indicate that the proposed MSFEM is effective for probabilistic analyses and can provide useful insights for the excavation design and construction.A sensitivity analysis for seven considered random parameters is then *** soil friction angle at the excavation bottom layer is the most significant one for *** soil-wall interaction effects on the excavation stability are also given.

关键词： Braced deep excavation Soil-wall interaction Stochastic finite element method Horizontal wall deflection Settlement Failure probability

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Probabilistic analysis of tunnel face seismic stability in layered rock masses using Polynomial Chaos Kriging metamodel

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2678-2693页

作者： Jianhong Man Tingting Zhang Hongwei Huang Daniel Dias Department of Geotechnical Engineering Key Laboratory of Geotechnical and Underground Engineering of Ministry of EducationCollege of Civil EngineeringTongji UniversityShanghai200092China grenoble Alpes 3SR LabCNRS UMR 5521Grenoble38000France

Face stability is an essential issue in tunnel design and *** rock masses are typical and ubiquitous;uncertainties in rock properties always *** view of this,a comprehensive method,which combines the Upper bound Limit analysis of Tunnel face stability,the Polynomial Chaos Kriging,the Monte-Carlo Simulation and Analysis of Covariance method(ULT-PCK-MA),is proposed to investigate the seismic stability of tunnel faces.A two-dimensional analytical model of ULT is developed to evaluate the virtual support force based on the upper bound limit *** efficient probabilistic analysis method PCK-MA based on the adaptive Polynomial Chaos Kriging metamodel is then implemented to investigate the parameter uncertainty *** input parameters,including geological strength indices,uniaxial compressive strengths and constants for three rock formations,and the horizontal seismic coefficients,are treated as random *** effects of these parameter uncertainties on the failure probability and sensitivity indices are *** addition,the effects of weak layer position,the middle layer thickness and quality,the tunnel diameter,the parameters correlation,and the seismic loadings are investigated,*** results show that the layer distributions significantly influence the tunnel face probabilistic stability,particularly when the weak rock is present in the bottom *** efficiency of the proposed ULT-PCK-MA is validated,which is expected to facilitate the engineering design and construction.

关键词： Tunnel face stability Layered rock masses Polynomial Chaos Kriging(PCK) Sensitivity index Seismic loadings

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Study on the tunnel shape and soil-lining interaction influencing the lining behavior under seismic loading

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Earthquake Engineering and Engineering Vibration 2024年第4期23卷 845-862页

作者： Van Vi Pham Ngoc Anh Do Piotr Osinski Ngoc Thai Do Daniel Dias Sustainable Development in Underground Engineering Research Team Hanoi University of Mining and GeologyHanoiVietnam Department of Underground and Mining Construction Faculty of Civil EngineeringHanoi University of Mining and GeologyHanoiVietnam Department of Geotechnical Engineering Institute of Civil EngineeringWarsaw University of Life Sciences-SGGWWarszawaPoland Laboratory 3SR Grenoble Alpes UniversityGrenoble 38400France

The response of tunnels subjected to seismic loading is a complex mechanism and depends not only on the seismic nature but also on tunnel structure and surrounding soil *** individual behavior of circular,rectangular,and sub-rectangular tunnels subjected to seismic loadings has already been studied in the *** the present research,two case scenarios of circular,rectangular tunnels and four sub-rectangular shaped tunnels,with similar cross-section areas,were adopted to perform a comprehensive numerical *** purpose of the study was to determine the mechanical behavior of tunnels of different shapes,depending upon seismic *** were performed by considering the influence of soil-lining interaction,soil parameters,and lining thickness,as well as lining *** were performed for no-slip and full-slip *** results indicate that the tunnel shape design is of great importance when regarding the mechanical behavior of the surrounding *** concerns no-slip as well as full-slip soil-lining interaction,especially when the lining is subjected to seismic ***,it is shown that changes in incremental bending moments for circular,rectangular and sub-rectangular tunnels that depend upon the soil-lining interaction conditions differ significantly.

关键词： tunnel shape soil-lining interaction seismic loading internal forces numerical analysis

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