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Solid-liquid extraction for yttrium recovery using porous polymeric resin(XAd-7) functionalized with d_(2)EHpA

Journal of Rare Earths 2024年第9期42卷 1764-1773,I0005页

作者： p.A.martínez-montoya R.G.Sanchez-Alvarado d.Y.medina-Velazquez m.L.carrera-Jota p.Garnica-chávez A.de J.morales-Ramirez Higher School of chemical Engineering and Extractive Industries ESIQIEIPNDepartment of Metallurgical EngineeringUPALM S/NCol.LindavistaGustavo A.Madero Cd.de MéxicoC.P07738Mexico metropolitan Autonomous university Department of MaterialsBasic Sciences and EngineeringAv.San Pablo No.180Col.Reynosa TamaulipasCd.de MéxicoC.P02200Mexico center for Research and Technological Innovation CIITECIPNCda.de CECATIs/nSanta CatarinaAzcapotzalcoC.P02250CDMXMexico

The recovery of yttrium is proposed by applying a solid-liquid extraction process using di-2-ethyl hexylphosphoric acid(d2EHpA) as extracting *** extracting agents were supported on a macro porous polymeric resin XAd-7(solid phase).Yttrium ions extraction and discharge tests were performed,firstly from a synthetic aqueous solution of 100 mg/L Y(liquid phase) at 25℃ with *** effects of pH of aqueous solutions bearing yttrium,volume fraction of extracting agents and the solid/liquid(S/L)ratio on the yttrium recovery were *** most favorable conditions for yttrium ions extraction are;20 vol% d_(2)EHpA functionalized resin,pH=1.5 and an S/L ratio of 10 mg/mL The discharge of yttrium ions was done under the same conditions of extraction stage,using a 2 mol/L [H_(2)SO_(4)] as stripping *** to 80% yttrium is extracted,while 75% yttrium is recovered in the striping *** all experiments,the reaction equilibrium is reached after 20 min,and the kinetics for the extraction stage was determined as a second-order ***,experiments were carried out to discharge the yttriumloaded resins,and it has been determined that the best pH value to strip the Y ions is *** tests of extraction and discharge for yttrium ions show that the functionalized resin can work at least five cycles without decreasing its ***,the proposed process was tested in a real solution with Y ions fro m a waste fluorescent la mp powder leached in H_(2)SO_(4),demonstrating the ability to effectively recover yttrium,separating it from various metals from the studied residue.

关键词： Yttrium recovery Rare earth solid-liquid extraction XAd-7 resin Fluorescent lamps recycling Solid-liquid kinetics extraction

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messing with cancer therapy:how the melanoma phenotype predicts checkpoint inhibitor response

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1784-1785页

作者： Svenja meierjohann corine Bertolotto Institute of pathology University of WürzburgWürzburgGermany university côte d’Azur InsermBiology and Pathologies of melanocytesteam1Equipe labellisée Ligue 2020Centre Méditerranéen de Médecine MoléculaireNiceFrance

In a study published in cell,pozniak et *** the spectrum of the phenotypic cell states of human metastatic melanomas in their tumor microenvironment before and early during immune checkpoint inhibitor(IcI)therapy and identified an enrichment of mesenchymal-like(mES)state melanoma cells in non-responders to IcI.1 These findings offer valuable insights into the factors contributing to the refractoriness of certain melanoma patients to IcI,while also unveiling novel molecular targets that hold promise for improving their treatment outcomes.

关键词： melanoma al. therapy

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Exploring one material for dual applications:A red-emitting mg2GeO4:Eu3+ nanophosphor for future generation energy efficient WLEds and dosimetric applications

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Journal of Rare Earths 2024年第10期42卷 1835-1845页

作者： Akshay Arjun G.p.darshan S.c.Sharma H.Nagabhushana d.V.Sunitha H.B.premkumar department of physics Faculty of Mathematical and Physical SciencesM.S.Ramaiah University of Applied Sciences Jain university c.N.R.Rao centre for Advanced materials Tumkur University School of Applied Sciences (physics) REVA University

The envisaged design and developme nt of individual mate rials to excavate a broader spectrum of desired properties and offer multiple applications are highly *** this in mind,a series of forsterite-structured mg2GeO4:Eu3+（1 mol%-9 mol%） nanophosphors was synthesized via a solution combustion method using oxalyl dihydrazide as a *** X-ray diffraction patterns confirm the orthorhombic crystal system with a puma space *** results clearly show irregularly shaped cluster-like structures with aggregation of the *** diffuse reflectance spectra,the optical energy band gap of the mg2GeO4:Eu3+（1 mol%-9 mol%） nanophosphors was estimated and obtained to be～4.12-4.32 *** photoluminescence emission spectra exhibit intense peaks at ～579,589,610,661,and 707 nm,which are due to characteristic5d0→7F0,5d0→7F1,5do→7F2,5d0→7F3and5d0→7F4transitions of Eu3+ions,*** commission International de L'Eclairage color coordinates are gradually tuned from pale red（0.5980,0.4012） to a pure red（0.6385,0.3611） *** glow peaks showcase excellent super-linear response at low doses of γ-irradiations,indicating that the prepared phosphor can be used in thermoluminescent personal dosimetry which is a biological tissue *** aforementioned results demonstrate that the prepared mg2GeO4:Eu3+（1 mol%-9 mol%） nanophosphors are considered an excellent candidate for dual applications,i.e.,red component in future generation white-light-emitting diodes（WLEds） and personal dosimetric applications.

关键词： dosimetry Nanophosphors photoluminescence photometric properties Rare earths Thermoluminescence

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Association between mental disorders and Subsequent medical conditions

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四川生理科学杂志 2024年第4期46卷 217-217页

作者： Natalie c momen From the National center for Register-based Research (N.c.m. O.P.-R. E.A. M.K.C. S.D. J.-C.P.G.D. T.M.L. P.B.M. K.L.M. C.B.P. L.V.P. B.V. N.W. J.J.M.) Center for Integrated Register-based Research (E.A. P.B.M. C.B.P.) the Departments of Biomedicine-Human Genetics (A.D.B.) and Public Health (M.K.C. M.F.-G. K.M.I. M.V. A.P.) the Center for Integrative Sequencing (A.D.B.) and the Big Data Center for Environment and Health (C.B.P.) Aarhus University the Lundbeck Foundation Initiative for Integrative Psychiatric Research (E.A. A.D.B. S.D. O.M. P.B.M. K.L.M. M.N. C.B.P. L.V.P. A.J.S. B.V. T.W.) the Center for Genomics and Personalized Medicine (A.D.B.) the Department of Neurology (J.-C.P.G.D.) and the Research Unit Department of Psychosis (O.M.) Aarhus University Hospital and the Research Unit for General Practice (M.F.-G. A.R.R. M.V. A.P.) Aarhus the Copenhagen Research Center for Mental Health Mental Health Center Copenhagen Copenhagen University Hospital (M.E.B. M.N. H.J.S.) Psychiatric Center Copenhagen (L.V.K.) Faculty of Health and Medical Sciences (L.V.K.) the Department of Clinical Medicine (T.W.) and the Lundbeck Foundation GeoGenetics Center GLOBE Institute (T.W.) University of Copenhagen Copenhagen and the Institute of Biological Psychiatry Mental Health Center Sankt Hans Mental Health Services Capital Region Roskilde (A.J.S. T.W.) - all in Denmark the National Drug and Alcohol Research Centre University of New South Wales Sydney (L.D.) the Department of General Practice Melbourne Medical School University of Melbourne Melbourne VIC (J.M.G.) and the Queensland Brain Institute (C.C.W.L. S.S. J.J.M.) Queensland Centre for Mental Health Research the Park Centre for Mental Health (C.C.W.L. S.S. T.J.S. H.A.W. J.J.M.) and the School of Public Health Faculty of Medicine (H.A.W.) University of Queensland Brisbane - all in Australia the Departments of Psychology (P.J.) and Developmental Psychology (A.M.R.) Heymans Institute and the I

Background:persons with mental disorders are at a higher risk than the general population for the subsequent development of certain medical ***:We used a population-based cohort from danish national registries that included data on more than 5.9 million persons born in denmark from 1900 through 2015 and followed them from 2000 through 2016,for a total of 83.9 million person-years.

关键词： conditions milli population

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dysfunction of the adhesion G protein-coupled receptor latrophilin 1(AdGRL1/LpHN1)increases the risk of obesity

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg AndréNguyen dietzsch Hadi Al-Hasani Joachim Altschmied Katharina Bottermann Jana Brendler Judith Haendeler Susanne Horn Isabell Kaczmarek Antje Körner Kerstin Krause Kathrin Landgraf diana Le duc Laura Lehmann Stefan Lehr Stephanie pick Albert Ricken Rene Schnorr Angela Schulz martina Strnadová Akhil Velluva Heba Zabri Torsten Schöneberg doreen Thor Simone prömel Rudolf Schönheimer Institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for clinical Biochemistry and pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German center for diabetes Research(dZd e.V.) Munich-NeuherbergGermany cardiovascular degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany cardiovascular Research Institute(cARId) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany center for pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholtz Institute for metabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany department of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human Genetics Leipzig University Medical CenterLeipzigGermany Institute of cell Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide *** the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity.G protein-coupled receptors(GpcRs)are among the main modulators of metabolism and energy ***,for instance,regulate appetite and satiety in certain hypothalamic neurons,as well as glucose and lipid metabolism and hormone secretion from *** in some GpcRs,such as the melanocortin receptor type 4(mc4R),have been associated with early-onset ***,we identified the adhesion GpcR latrophilin 1(AdGRL1/LpHN1)as a member of the regulating network governing food intake and the maintenance of energy *** of the highly conserved receptor in mice results in increased food consumption and severe obesity,accompanied by dysregulation of glucose ***,we identified a partially inactivating mutation in human AdGRL1/LpHN1 in a patient suffering from ***,we propose that LpHN1 dysfunction is a risk factor for obesity development.

关键词： obesity metabolism intake

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Alternaria TeA toxin activates a chloroplast retrograde signaling pathway to facilitate JAdependent pathogenicity

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plant communications 2024年第3期5卷 123-140页

作者： Jiale Shi He Wang mengping Li Liru mi Yazhi Gao Sheng Qiang Yu Zhang dan chen Xinbin dai Hongyu ma Huan Lu chanhong Kim Shiguo chen Weed Research Laboratory Nanjing Agricultural UniversityNanjing 210095China Shanghai center for plant Stress Biology Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 200032China Bioinformatics and computational Biology Laboratory Noble Research Institute2510 Sam Noble ParkwayArdmoreOK 73401USA college of plant protection Nanjing Agricultural UniversityNanjing 210095China department of Botany and plant Biology University of GenevaGenevaSwitzerland

The chloroplast is a critical battleground in the arms race between plants and *** microbe-secreted mycotoxins,tenuazonic acid(TeA),produced by the genus Alternaria and other phytopathogenic fungi,inhibits photosynthesis,leading to a burst of photosynthetic singlet oxygen(1O2)that is implicated in damage and chloroplast-to-nucleus retrograde *** the signicant crop damage caused by Alternaria pathogens,our understanding of the molecular mechanism by which TeA promotes pathoge-nicity and cognate plant defense responses remains *** now reveal that *** induces necrotrophic foliar lesions by harnessing EXEcUTER1(EX1)/EX2-mediated chloroplast-to-nucleus retro-grade signaling activated by TeA toxin–derived photosynthetic 1O2 in Arabidopsis *** of the 1O2-sensitive EX1-W643 residue or complete deletion of the EX1 singlet oxygen sensor domain compro-mises expression of 1O2-responsive nuclear genes and foliar *** also found that TeA toxin rapidly induces nuclear genes implicated in jasmonic acid(JA)synthesis and signaling,and EX1-mediated retro-grade signaling appears to be critical for establishing a signaling cascade from 1O2 to *** present study sheds new light on the foliar pathogenicity of ***,during which EX1-dependent 1O2 signaling in-duces JA-dependent foliar cell death.

关键词： TeA mycotoxin Alternaria pathogen chloroplast singlet oxygen retrograde signaling jasmonic acid

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Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

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Bone Research 2024年第1期12卷 180-198页

作者： morten S.Hansen Kaja madsen maria price Kent Søe Yasunori Omata mario m.Zaiss caroline m.Gorvin morten Frost Alexander Rauch molecular Endocrinology Laboratory(KmEB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark department of clinical Research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark clinical cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of metabolism and Systems Research(ImSR)and centre for diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK centre for membrane proteins and Receptors(cOmpARE) Universities of Birmingham and NottinghamBirmingham B152TTUK department of molecular medicine University of Southern DenmarkDK-5000 Odense CDenmark department of Orthopedic Surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan department of Internal medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany deutsches Zentrum Immuntherapie(dZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Steno diabetes center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment *** study aimed to provide an overview of transcriptional reprogramming during human osteoclast *** were differentiated from cd14+monocytes from eight female *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across *** patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on RNA from iliac crest biopsies and bone mineral density *** analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at the monocyte stage,such as filamin B(FLNB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the resorptive activity of mature *** expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density SNps,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(c5AR1),somatostatin receptor 2(SSTR2),and free fatty acid receptor 4(FFAR4/GpR120).Activating c5AR1 enhanced osteoclast formation,while activating SSTR2 decreased the resorptive activity of mature osteoclasts,and activating FFAR4 decreased both the number and resorptive activity of mature *** conclus

关键词： osteoclast programming identif

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Real-world data on ALK rearrangement test in chinese advanced non-small cell lung cancer(RATIcAL):a nationwide multicenter retrospective study

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cancer communications 2024年第9期44卷 992-1004页

作者： Lin Li Wencai Li chunyanWu Yanfeng Xi Lei Guo Yuan Ji Lili Jiang Ji Li Jingping Yun Gang chen Yuan Li Yueping Liu dianbinmu Yuchen Han Leina Sun Qingxin Xia Xiaodong Teng Nanying che WeiWu Xueshan Qiu chao Liu Xiaochu Yan daiqiang Li Zhihong Zhang ZheWang Yujun Li ZhengWang Lingchuan Guo Xiu Nie Jingshu Geng Jianhua Zhou Jianming Ying department of pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking UnionMedical CollegeBeijingP.R.China department of pathology the First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China department of pathology Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiP.R.China department of pathology Cancer Hospital Affiliated to Shanxi Medical UniversityShanxi Province Cancer HospitalShanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical SciencesTaiyuanShanxiP.R.China department of pathology Zhongshan HospitalFudan UniversityShanghaiP.R.China department of pathology West China Hospital of Sichuan UniversityChengduSichuanP.R.China department of pathology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China department of pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China department of pathology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianP.R.China department of pathology Department of OncologyFudan University Cancer CenterShanghaiMedical College of Fudan UniversityShanghaiP.R.China department of pathology The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebeiP.R.China department of pathology Shandong Cancer HospitalJinanShandongP.R.China department of pathology Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiP.R.China department of pathology Tianjin Medical University Cancer Institute and HospitalTianjinP.R.China department of pathology the Affiliated Cancer Hospital of Zhengzhou UniversityHenan Provincial Cancer HospitalZhengzhouHenanP.R.China department of pathology the First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiangP.R.China department of pathology Bei

Background:Anaplastic lymphoma kinase(ALK)test in advanced non-small cell lung cancer(NScLc)can help physicians provide target therapies for patients harboring ALK gene *** study aimed to investigate the real-world test patterns and positive rates of ALK gene rearrangements in advanced ***:In this real-world study(chicTR2000030266),patientswith advanced NScLc who underwent an ALK rearrangement test in 30 medical centers in china between October 1,2018 and december 31,2019 were retrospectively *** training was conducted before the study was *** controls were performed at participating centers using immunohistochemistry(IHc)-*** positive ALK gene rearrangement rate and consistency rate were *** associated clinicopathological characteristics of ALK gene rearrangement were investigated as ***:The overall ALK gene rearrangement rate was 6.7%in 23,689 patients with advanced NScLc and 8.2%in 17,436 patients with advanced lung *** quality control analysis of IHc-VENTANA-d5F3 revealed an intrahospital consistency rate of 98.2%(879/895)and an inter-hospital consistency rate of 99.2%(646/651).IHc-VENTANA-d5F3 was used in 53.6%,real-time polymerase chain reaction(RT-pcR)in 25.4%,next-generation sequencing(NGS)in 18.3%,and fluorescence in-situ hybridization(FISH)in 15.9%in the adenocarcinoma *** specimens tested with multiple methods,the consistency rates confirmed by IHc-VENTANA-d5F3 were 98.0%(822/839)for FISH,98.7%(1,222/1,238)forNGS,and 91.3%(146/160)for *** overall ALK gene rearrangement rateswere higher in females,patients of≤35 years old,never smokers,tumor cellularity of>50,and metastatic specimens used for testing in the total NScLc population and adenocarcinoma subgroup(all pconclusions:This study highlights the real-world variability and challenges of ALK test in advanced NScLc,demonstrating a predominant use of IHcVENTANA-d5F3 with high co

关键词： anaplastic lymphoma kinase diagnosis gene fusion non-small cell lung cancer

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disitamab vedotin,a HER2-directed antibody-drug conjugate,in patients with HER2-overexpression and HER2-low advanced breast cancer:a phase I/Ib study

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cancer communications 2024年第7期44卷 833-851页

作者： Jiayu Wang Yunjiang Liu Qingyuan Zhang Wei Li Jifeng Feng XiaojiaWang Jianmin Fang Yiqun Han Binghe Xu department of medical Oncology Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Breast center The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebeiP.R.China department of Breast medicine Harbin Medical University Cancer HospitalHarbinHeilongjiangP.R.China department of medical Oncology The First Hospital of Jilin UniversityChangchunJilinP.R.China department of medical Oncology Jiangsu Cancer HospitalNanjingJiangsuP.R.China department of Breast medicine Zhejiang Cancer HospitalHangzhouZhejiangP.R.China School of Life Science and Technology Tongji UniversityShanghaiP.R.China

Background:disitamab vedotin(dV;Rc48-Adc)is an antibody-drug conjugate comprising a human epidermal growth factor receptor 2(HER2)-directed antibody,linker and monomethyl auristatin *** studies have shown that dV demonstrated potent antitumor activity in preclinical models of breast,gastric,and ovarian cancers with different levels of HER2 *** this pooled analysis,we report the safety and efficacy of dV in patients with HER2-overexpression and HER2-low advanced breast cancer(ABc).methods:In the phase I dose-escalation study(c001 cANcER),HER2-overexpression ABc patients received dV at doses of 0.5-2.5 mg/kg once every two weeks(Q2W)until unacceptable toxicity or progressive *** dose range,safety,and pharmacokinetics(pK)were *** phase Ib dose-range and expansion study(c003 cANcER)enrolled two cohorts:HER2-overexpression ABc patients receiving dV at doses of 1.5-2.5 mg/kg Q2W,with the recommended phase 2 dose(Rp2d)determined,andHER2-lowABc patients receiving dV at doses of 2.0 mg/kg Q2W to explore the efficacy and safety of dV in HER2-low ***:Twenty-four patients with HER2-overexpression ABc in c001 cANcER,46 patients with HER2-overexpressionABcand 66 patients with HER2-low ABc in c003 cANcER were *** 2.0 mg/kg Rp2d Q2W,the confirmed objective response rates were 42.9%(9/21;95%confidence interval[cI]:21.8%-66.0%)and 33.3%(22/66;95%cI:22.2%-46.0%),with median progression-free survival(pFS)of 5.7 months(95%cI:5.3-8.4 months)and 5.1 months(95%cI:4.1-6.6 months)for HER2-overexpression and HER2-low ABc,***(≥5%)grade 3 or higher treatment-emergent adverse events included neutrophil count decreased(17.6%),gamma-glutamyl transferase increased(13.2%),asthenia(11.0%),white blood cell count decreased(9.6%),peripheral neuropathy such as hypoesthesia(5.9%)and neurotoxicity(0.7%),and pain(5.9%).conclusion:dV demonstrated promising efficacy in HER2-overexpression and HER2-low ABc,with a favorable safety profile at

关键词： antibody-drug conjugate breast cancer clinical trials disitamab vedotin HER2-low HER2-overexpression

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Enhancing milk quality and modulating rectal microbiota of dairy goats in starch‑rich diet:the role of bile acid supplementation

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Journal of Animal Science and Biotechnology 2024年第2期15卷 862-877页

作者： Qingyan Yin Junjian Yu Jiaxiao Li Tianci Zhang Tianyu Wang Yufei Zhu Jun Zhang Junhu Yao college of Animal Science and Technology Northwest A&F UniversityYangling 712100ShaanxiP.R.China Key Laboratory of Livestock Biology Northwest A&F UniversityYangling 712100ShaanxiP.R.China dAYU Bioengineering(Xi’an)Industrial development Research Institute Xi’an 710000ShaanxiP.R.China

Background diets rich in starch have been shown to increase a risk of reducing milk fat content in dairy *** bile acids(BAs)have been used as a lipid emulsifier in monogastric and aquatic animals,their effect on ruminants is not well *** study aimed to investigate the impact of BAs supplementation on various aspects of dairy goat physiology,including milk composition,rumen fermentation,gut microbiota,and BA *** We randomly divided eighteen healthy primiparity lactating dairy goats(days in milk=100±6 d)into two groups and supplemented them with 0 or 4 g/d of BAs undergoing 5 weeks of feeding on a starch-rich *** results showed that BAs supplementation positively influenced milk yield and improved the quality of fatty acids in goat *** supplementation led to a reduction in saturated fatty acids(c16:0)and an increase in monounsaturated fatty acids(cis-9 c18:1),resulting in a healthier milk fatty acid *** observed a significant increase in plasma total bile acid concentration while the proportion of rumen short-chain fatty acids was not ***,BAs supplementation induced significant changes in the composition of the gut microbiota,favoring the enrichment of specific bacterial groups and altering the balance of microbial *** analysis revealed associations between specific bacterial groups(Bacillus and christensenellaceae R-7 group)and BA types,suggesting a role for the gut microbiota in BA *** prediction analysis revealed notable changes in pathways associated with lipid metabolism,suggesting that BAs supplementation has the potential to modulate lipid-related *** These findings highlight the potential benefits of BAs supplementation in enhancing milk production,improving milk quality,and influencing metabolic pathways in dairy *** research is warranted to elucidate the underlying mechanisms and explore the broader implications of these findi

关键词： Bile acids dairy goats Lipid metabolism Gut microbiota

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