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Paleomapping:Creating testable visual hypotheses of ancient worlds

Journal of Palaeogeography 2025年第01期14卷 91-104页

作者： Holger Petermann Annaka M.Clement Patrick M.Sullivan Hannah M.Bonner James W.Hagadorn Department of Earth and Space Sciences Denver Museum of Nature & Science colorado School of Mines Department of Geology and Geologic Engineering Division of Water Quality Utah Department of Environmental Quality

The story of the Earth's changing landscapes is often told through paleogeographic maps. These images are some of the most accessible and widely used illustrations in the Earth sciences. However, no formal procedure for the creation of photorealistic paleomaps(i.e., paleosatellite images) exists. Using an example from the Late Jurassic of the Rocky Mountain region, we present a method for making paleoenvironmental and paleosatellite maps that is scalable, reproducible, testable, and incorporates peer review. The process includes a literature review followed by data-visualization, paleoenvironmental interpretation, peer-review,iterative revisions, and the creation of a false contour map and color gradient used to render a paleosatellite image. Paleosatellite images are photorealistic versions of paleoenvironmental maps that incorporate global climatic and tectonic information as well as principles of actualism; they can be made through comparison to analogous modern landscapes. An important component of this process is that the data maps that ground this paleomapping process allow evaluation of where paleoenvironmental interpretations are wellsupported by outcrop and subsurface data, and where such visualization is highly interpretive-often because of lack of available rocks or studies in a given area. As such, our paleoenvironmental maps and paleosatellite images are testable pictorial hypotheses. By outlining a procedure that produces referenced,data-rich, and visually realistic maps, we hope to demystify the paleoenvironmental map-making process and improve accessibility of paleomaps for the broader geoscience community. Where resources and complementary data are available, such maps also have potential for georeferencing and integration with larger continent-scale paleogeographic maps.

关键词： Ancient landscapes Cartography Paleogeography Paleoenvironments Jurassic

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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services university of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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On-chip light control of semiconductor optoelectronic devices using integrated metasurfaces

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Opto-Electronic Advances 2025年第1期8卷 5-30页

作者： Cheng-Long Zheng Pei-Nan Ni Yi-Yang Xie Patrice Genevet Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Materials PhysicsMinistry of EducationSchool of PhysicsZhengzhou UniversityZhengzhou 450052China Key Laboratory of Optoelectronics Technology Beijing University of TechnologyMinistry of EducationBeijing 100124China colorado School of Mines 1523 Illinois St.GoldenCO 80401USA

Semiconductor optoelectronics devices,capable of converting electrical power into light or conversely light into electrical power in a compact and highly efficient manner represent one of the most advanced technologies ever developed,which has profoundly reshaped the modern life with a wide range of *** recent decades,semiconductor technology has rapidly evolved from first-generation narrow bandgap materials(Si,Ge)to the latest fourth-generation ultra-wide bandgap semiconductor(GaO,diamond,AlN)with enhanced performance to meet growing ***,merging semiconductor devices with other techniques,such as computer assisted design,state-of-the-art micro/nano fabrications,novel epitaxial growth,have significantly accelerated the development of semiconductor optoelectronics *** them,integrating metasurfaces with semiconductor optoelectronic devices have opened new frontiers for on-chip control of their electromagnetic response,providing access to previously inaccessible degrees of *** review the recent advances in on-chip control of a variety of semiconductor optoelectronic devices using integrated metasurfaces,including semiconductor lasers,semiconductor light emitting devices,semiconductor photodetectors,and low dimensional *** integration of metasurfaces with semiconductors offers wafer-level ultracompact solutions for manipulating the functionalities of semiconductor devices,while also providing a practical platform for implementing cuttingedge metasurface technology in real-world applications.

关键词： optoelectronics nanophotonics metasurfaces semiconductor

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Poly(imine-amide)Hybrid Covalent Adaptable Networks via in situ Oxidation Polymerization

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Chinese Journal of Polymer Science 2023年第10期41卷 1577-1583页

作者： Hong-Xuan Chen Ze-Peng Lei Shao-Feng Huang Huan Jiang Kai Yu Ying-Hua Jin Wei Zhang Department of Chemistry University of Colorado BoulderBoulderColorado80309USA RockyTech Ltd. BoulderColorado80309USA Department of Mechanical Engineering University of Colorado DenverDenverColorado80217USA

Polyimine represents a rapidly emerging class of readily accessible and affordable covalent adaptable networks(CANs)that have been extensively studied in the past few *** being highly malleable and recyclable,the pioneering polyimine materials are relatively soft and not suitable for certain applications that require high mechanical *** studies have demonstrated the possibility of significantly improving polyimine properties by varying its monomer building blocks,but such component variations are usually not straightforward and can be potentially challenging and ***,we report an in situ oxidation polymerization strategy for preparation of mechanically strong poly(imine-amide)(PIA)hybrid CANs from simple amine and aldehyde *** converting a portion of reversible imine bonds into high-strength amide linkages in situ,the obtained hybrid materials exhibit gradually improved Young’s modulus and ultimate tensile strength as the oxidation level ***,the PIAs remain reprocessable and can be depolymerized into small molecules and oligomers similar as *** work demonstrates the great potential of the in situ transformation strategy as a new approach for development of various mechanically tunable CANs from the same starting building blocks.

关键词： Covalent adaptable networks Polyimine Polyamide In situ oxidation polymerization

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Direct and in direct effects of light pollution on the performance of an herbivorous insect

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Insect Science 2019年第4期26卷 770-776页

作者： Kylee Grenis Shannon M. Murphy Department of Biological Sciences University of Denver Denver Colorado USA

Light pollution is a global disturbance with resounding impacts on a wide variety of organisms, but our understanding of these impacts is restricted to relatively few higher vertebrate species. We tested the direct effects of light pollution on herbivore performance as well as indirect effects mediated by host plant quality. We found that artificial light from streetlights alters plant toughness. Additionally, we found evidence of both direct and indirect effects of light pollution on the performance of an herbivorous insect, which indicates that streetlights can have cascading impacts on multiple trophic levels. Our novel findings suggest that light pollution can alter plant-insect interactions and thus may have important community-wide consequences.

关键词： anthropogenic disturbance continuous photoperiod light pollution Lepidoptera

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Autocyclic switching processes and architecture of lobes in river-dominated lacustrine deltas

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Journal of Palaeogeography 2025年第1期14卷 126-140页

作者： Zhen-Hua Xu Sheng-He Wu Piret Plink-Bj?rklund Tao Zhang Da-Li Yue Qi-Hao Qian Qing Li Wen-Jie Feng National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum (Beijing) College of Geosciences China University of Petroleum (Beijing) Department of Geology and Geological Engineering Colorado School of Mines Gas Production Plant 2 PetroChina Changqing Oilfield Company PetroChina Research Institute of Petroleum Exploration and Development College of Geosciences Yangtze University

River-dominated lacustrine deltas typically consist of multiple lobes due to autogenic lobe switching that occurs over short time scales. However, the switching patterns of multiple lobes in these deltas remain poorly understood, and the architectural features attributed to lobe switching are also lacking. By integrating Delft3D simulations, flume experiments, and modern deposit analysis, we proposed that autogenic lobe switching follows a cyclic pattern. Autocyclicity begins with the formation of an offshore lobe and concludes after a series of longshore lobe growth events, marked by longshore avulsions occurring along the sides of offshore distributary *** avulsions follow a sequence that usually occurs earlier distally than proximally and subsequently occurs on one longshore side and then on the other side. Each lobe begins with rapid growth, which gradually slows and then stops once a channel avulsion is influenced by the backwater effect that triggers lobe switching. Three signals indicate lobe switching: a decrease in progradation rate, foreset slope steepening coupled with topset slope gentling, and the deposition of mud-dominated sediments. The number of autocyclic events never exceeds *** first two autocyclicities contribute to more than 55% of delta length and 70% of delta area. The lobes are separated by 1-6 stages of mud-dominated accretion beds that exhibit a downstream-inclined shape and convexup or lateral overlapping pattern. This study conducts a coupled growth-geometric assessment to establish an architectural pattern for river-dominated lacustrine deltas. This architectural pattern offers valuable insights into predicting sandy lobe distribution in river-dominated lacustrine delta reservoirs, and the architecture of muddy accretion beds aids in predicting the rule of oil-water movement and distribution of remaining oil.

关键词： Autocyclic lobe switching River-dominated lacustrine delta Architecture Avulsion sequence Backwater effect

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Effect of prolonged cryptorchidism on germ cell apoptosisand testicular sperm count

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Asian Journal of Andrology 2004年第1期6卷 47-51页

作者： Albaha Barqawi Herald Trummer Randall Meacham Division of Urology Department of Surgery University of Colorado School of Medicine Denver Colorado 80262 USADivision of Urology Department of Surgery University of Colorado School of Medicine Denver Colorado 80262 USADivision of Urology Department of Surgery University of Colorado School of Medicine Denver Colorado 80262 USA

Aim: To evaluate the long term effect of experimental cryptorchidism on germ cell apoptotic rate and testicular sperm content in adult rats. Methods: Bilateral cryptorchidism was created in 40 adult male Sprague-Dawley rats by surgically manipulating the testes into the abdominal cavity and closing the internal inguinal ring. The rats were sacrificed and the testes removed 6 hours and 2, 4, 7, 21, 28 and 56 days after cryptorchidism. Germ cell apoptosis was quantified by means of TUNEL assay and apoptosis was confirmed using transmission electron microscopy. Results: The rate of apoptosis peaked at 4 days of cryptorchidism and then progressively declined to a nadir at 14 days of cryptorchidism. At 56 days of cryptorchidism, the germinal epithelium was largely depleted by the apoptotic process and only a few mature sperm were seen within the testis. At this point, a few tubules were seen to be repopulating with primary spermatocytes and the level of germ cell apoptosis began to increase marginally. Testicular sperm count (TSC) began to decline rapidly at day 7 of cryptorchidism. Only a few mature sperm were found in the testes of rats following 56 days of cryptorchidism. Multinucleated giant cells (MGC) were most numerous within the seminiferous tubules at day 4. At day 7, 35 % of MGCs were TUNEL positive. At all subsequent time points, however, MGCs fail to stain positive for apoptosis. This resumption of increased apoptosis coincided with the appearance of a population of primary spermatocytes in some seminiferous tubules. Moreover, there was not a corresponding increase in the number of mature sperm after 56 days of cryptorchidism. Conclusion: The decline in germ cell apoptosis after 4 days of cryptorchidism can be attributed to be the result of an overall depletion of germ cells. It appears that after a prolonged cryptorchidism (56 days), there is a limited resumption of spermatogenesis presumably as a result of a decrease in the maturing germ cells undergoing pr

关键词： cryptorchidism apoptosis germ cell testis

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Diagnosis of ectopic pancreas by endoscopic ultrasound with fine-needle aspiration

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World Journal of Gastroenterology 2015年第8期21卷 2367-2373页

作者： Augustin Attwell Sharon Sams Norio Fukami Division of Gastroenterology Department of Medicine University of Colorado-Denver School of Medicine Department of Pathology University of Colorado-Denver School of Medicine

AIM:To study the clinical,endoscopic,sonographic,and cytologic features of ectopic pancreas(EP).METHODS:This was a retrospective study performedat an academic referral center including two *** review board approval was *** referred to the university Hospital or denver Health Medical Center Gastrointestinal Endoscopy Lab for gastroduodenal subepithelial lesions(SEL)with a final diagnosis of EP between January 2009and December 2013 were *** in this group were selected for the study if they underwent endoscopic ultrasound(EUS)with fine-needle aspiration(FNA)or deep biopsy.A review of the medical record was performed specifically to review the following information:presenting symptoms,endoscopic and EUS findings,computed tomography or magnetic resonance imaging findings,pathology results,procedure-related adverse events,and subsequent treatments after *** with FNA or deep submucosal biopsy was performed in all patients on an outpatient basais by one of two physicians(Attwell A,Fukami N).Review of all subsequent clinic notes and operative reports was performed in order to determine follow-up and final ***:Between July 2009 and December 2013,10patients[3 males,7 females,median age 52(26-64)years]underwent EUS for a gastroduodenal SEL and were diagnosed with *** patient was ***(60%)lesions were in the antrum,3(30%)in the body,and 1(10%)in the duodenum.A mucosal dimple was noted in 6(60%).Mean lesion size was 17(8-25)*** wall involvement:muscularis mucosae,10%;submucosa,70%;muscularis propria,60%;and serosa,10%.Nine(90%)lesions were hypoechoic and 5(50%)were homogenous.A duct was seen in 5(50%).FNA was attempted in 9(90%)and successful in 8(80%)patients after 4(2-6)*** showed acini or ducts in 7 of 8(88%).Superficial biopsies in 7 patients(70%)showed normal gastric *** endoscopic biopsies were taken in 2 patients and diagnostic in *** patient(10%)dev

关键词： Endoscopic ultrasound Pancreatitis Ectopic pancrea

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Temperature distributions in concrete box girders due to heat of concrete hydration

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Journal of Harbin Institute of Technology(New Series) 2011年第1期18卷 47-51页

作者：梅竹贾艳敏李成玉 Northeast Forestry university university of colorado denver

Based on heat transfer theory,a two-dimensional complex exponential function was used to compute heat of concrete hydration.A concrete box girder consisting of a single box with two cells used on Harbin Songpu Bridge was measured on *** two coefficients in the complex exponential function were determined to best fit the field measured *** program was used to simulate the heat transfer and determine the temperature distribution in the concrete box girders during concrete *** calculated temperature distribution in the box girders were compared with the field measured data and good agreement was *** temperature distribution and gradient in the entire box section,webs and bottom slab were analyzed using the measured and calculated results during the course of concrete hydration.

关键词： heat of hydration temperature distribution box girder bridge concrete hydration

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On the development of optical peripheral nerve interfaces

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Neural Regeneration Research 2019年第3期14卷 425-436页

作者： Hans E.Anderson Richard F.ff.Weir Department of Bioengineering University of Colorado Denver|Anschutz Medical Campus

Limb loss and spinal cord injury are two debilitating conditions that continue to grow in prevalence. Prosthetic limbs and limb reanimation present two ways of providing affected individuals with means to interact in the world. These techniques are both dependent on a robust interface with the peripheral nerve. Current methods for interfacing with the peripheral nerve tend to suffer from low specificity, high latency and insufficient robustness for a chronic implant. An optical peripheral nerve interface may solve some of these problems by decreasing invasiveness and providing single axon specificity. In order to implement such an interface three elements are required:(1) a transducer capable of translating light into a neural stimulus or translating neural activity into changes in fluorescence,(2) a means for delivering said transducer and(3) a microscope for providing the stimulus light and detecting the fluorescence change. There are continued improvements in both genetically encoded calcium and voltage indicators as well as new optogenetic actuators for stimulation. Similarly, improvements in specificity of viral vectors continue to improve expression in the axons of the peripheral nerve. Our work has recently shown that it is possible to virally transduce axons of the peripheral nerve for recording from small fibers. The improvements of these components make an optical peripheral nerve interface a rapidly approaching alternative to current methods.

关键词： peripheral nerve interfaces optogenetics optical neural interface optical peripheral nerve interface GCaMP ArcLight adenoassociated viral vector lentiviral vectors viral vectors implantable microscopy

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