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Testicular prostheses-impact on quality of life and sexual function

Asian Journal of Andrology 2024年第2期26卷 160-164页

作者： Ana Sofia Araujo Sara Anacleto Ricardo Rodrigues Catarina Tinoco Andreia Cardoso Carlos Oliveira Ricardo Leao Department of Urology Braga's HospitalBraga 4710Portugal Faculty of Medicine Coimbra UniversityCoimbra 3000Portugal

Orchiectomy is the recommended treatment for many testicular conditions.However,testicular prosthesis placement is not always performed for different reasons.In this study,we aimed to evaluate patients'opinions and the impact on sexual function and quality of life.This retrospective observational single-center study included patients who underwent orchiectomy between January 2014 and December 2020 at the Department of Urology,Braga's Hospital(Braga,Portugal),where testicular implants were always available and the decision to undergo the procedure was made fully independent of cost.Patients completed four questionnaires that assessed demographic data,satisfaction,self-esteem,and sexual function.Of the 96 patients who underwent orchidectomy,59 replied to the questionnaires,and of these patients,86.4%decided to undergo silicone-based testicular prostheses implantation.The remaining 13.6%refused the implant based on concerns about complications(37.5%),because they felt that it was unnecessary(37.5%),or because it was not offered by the doctor(25.0%).Overall,96.1%of these patients were satisfied with the implant;however,25.5%classified it as"too firm".No statistically significant differences were found in sexual function(all P>0.05).However,it can be observed that there are more patients with prostheses presenting normal sexual activity compared to patients without prostheses(74.0%vs 50.0%),and none of them reported severe erectile dysfunction(0 vs 16.7%).Regarding self-esteem,both patients with and without prostheses present very similar average scores with no statistically significant differences.The present study highlights the highest level of satisfaction among patients who received testicular prostheses.Testicular prostheses implantation is a safe procedure that does not hamper sexual function after orchiectomy.

关键词： orchiectomy patient satisfaction quality of life sexual dysfunction sexual health testicular prostheses

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Carbon Monoxide as C1 Building Block in Fine Chemical Synthesis

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Chinese Journal of Chemistry 2024年第2期42卷 199-221页

作者： Rui M.B.Carrilho Mario J.F.Calvete Gabor Mikle Laszlo Kollar Mariette M.Pereira university of coimbra Coimbra Chemistry CentreDepartment of ChemistryRua Larga3004-535 CoimbraPortugal Department of General and Inorganic Chemistry and ELKH-PTE Research Groupfor Selective Chemical Syntheses University of PecsIfjusag utja 6H-7624 PecsHungary

Carbon monoxide(CO)has become one of the most relevant and versatile renewable C1 building blocks for chemical synthesis,especially in the fine chemicals industry,due to the development of efficient and selective catalysts for its activation.In this review,we present a comprehensive critical analysis of the last 10 years literature on the use of CO as a renewable feedstock for fine chemicals production.The review is organized by type of catalytic reaction,namely alkene and alkyne carbonylation,hydroformylation,carbonylation of aryl halides,carbonylative cross-coupling and C-H carbonylation.Notable examples of the synthesis of relevant building blocks and/or known pharmaceuticals are highlighted.Emphasis is placed on examples of utilizing CO as the C1 building block in one or more catalytic steps.The catalyst used and the reaction conditions are consistently presented throughout all of the examples.

关键词： Carbon monoxide Fine chemicals Carbonylation Hydroformylation C-H functionalization

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Design multifunctional Mg–Zr coatings regulating Mg alloy bioabsorption

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Journal of Magnesium and Alloys 2024年第4期12卷 1461-1478页

作者： Zohra Benzarti Sandesh Itani JoséDavid Castro Sandra Carvalho Ana Sofia Ramos university of coimbra CEMMPREARISEDepartment of Mechanical EngineeringRua Luís Reis Santos3030-788CoimbraPortugal Laboratory of Multifunctional Materials and Applications(LaMMA) Department of PhysicsFaculty of Sciences of SfaxUniversity of SfaxSoukra Road km 3.5B.P.1171Sfax3000Tunisia

Magnesium(Mg)alloys are widely used for temporary bone implants due to their favorable biodegradability,cytocompatibility,hemocompatibility,and close mechanical properties to bone.However,rapid degradation and inadequate strength limit their applicability.To overcome this,the direct current magnetron sputtering technique is employed for surface coating in Mg-based alloys using various zirconium(Zr)content.This approach presents a promising strategy for simultaneously improving corrosion resistance,maintaining biocompatibility,and enhancing strength without compromising osseointegration.By leveraging Mg’s inherent biodegradability,it has the potential to minimize the need for secondary surgeries,thereby reducing costs and resources.This paper is a systematic study aimed at understanding the corrosion mechanisms of Mg–Zr coatings,denoted Mg-xZr(x=0–5 at.%).Zr-doped coatings exhibited columnar growth leading to denser and refined structures with increasing Zr content.XRD analysis confirmed the presence of the Mg(00.2)basal plane,shifting towards higher angles(1.15°)with 5 at.%Zr doping due to lattice parameter changes(i.e.,decrease and increase of“c”and“a”lattice parameters,respectively).Mg–Zr coatings exhibited“liquidphilic”behavior,while Young’s modulus retained a steady value around 80 GPa across all samples.However,the hardness has significantly improved across all samples’coating,reaching the highest value of(2.2±0.3)GPa for 5 at.%Zr.Electrochemical testing in simulated body fluid(SBF)at 37℃ revealed a significant enhancement in corrosion resistance for Mg–Zr coatings containing 1.0–3.4 at.%Zr.Compared with the 5 at.%Zr coating which exhibited a corrosion rate of 32 mm/year,these coatings displayed lower corrosion rates,ranging from 1 to 12 mm/year.This synergistic enhancement in mechanical properties and corrosion resistance,achieved with 2.0–3.4 at.%Zr,suggests potential ability for reducing stress shielding and controlled degradation performance,and consequently,promising functional biodegradable materials f

关键词： Mg-Zr coatings Magnetron sputtering Nanoindentation Corrosion resistance Bone implants

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Untangling the biotic stress in the late Maastrichtian Deccan-benchmark interval of Bidart(France)

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Journal of Palaeogeography 2024年第2期13卷 181-198页

作者： Subham Patra Gerta Keller Eric Font Thierry Adatte Jahnavi Punekar Indian Institute of Technology Bombay PowaiMumbai 400076India Princeton university PrincetonNJ 08544USA Departamento de Ciencias da Terra Faculdade de Ciencias e TecnologiaUniversidade de Coimbra3000-272 CoimbraPortugal Institute of Earth Sciences University of Lausanne1015 LausanneSwitzerland

The late Maastrichtian witnessed substantial surges in Deccan volcanism,prompting the hypothesis that these voluminous pulses may have instigated repeated episodes of ocean acidification during this period.The Cretaceous-Palaeogene(K/Pg)boundary at Bidart(France)is preceded by a~0.5 m thick interval with geochemical and taphonomic vestiges of an ocean acidification event linked with Deccan volcanism.New planktic foraminifera census and morphometric data now confirm biotic stress conditions related to acidification in the Deccan benchmark interval.The absolute abundance data of larger(>150μm)heavily calcified planktic morphogroups show fluctuating populations throughout zone CF1(spanning the final~225 ky),lowest peaks within the Deccan benchmark,and a demographic collapse(>90%)at the K/Pg boundary.The analyzed species are generally reduced in size,with thinner test walls in this~0.5 m interval,indicating the likelihood of calcification stress as a contributor to the overall biotic stress.At the K/Pg boundary,maximum biotic stress is recorded in all the tested faunal proxies.A preliminary graphic correlation of zone CF1 at Bidart with the auxiliary GSSP at Elles(Tunisia)constrains the Deccan benchmark interval of high biotic stress to the final~58ky of the late Maastrichtian,culminating in the K/Pg mass extinction.The volcanogenic Hg peaks coincident with faunal and taphonomic evidence of ocean acidification strengthen the Deccan-related ocean acidification hypothesis.

关键词： Deccan volcanism K/Pg mass extinction Biotic stress Calcification stress

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Remaking a connection: molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期 1719-1720页

作者： Diogo Tomé Ramiro D.Almeida iBiMED–Institute of Biomedicine Department of Medical Sciences University of Aveiro CNC–Center for Neuroscience and Cell Biology University of Coimbra

Functional recovery from central nervous system (CNS) trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate targets.Although several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after injury.Herein,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

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Embeddings of generalised Morrey smoothness spaces

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Acta Mathematica Sinica,English Series 2024年

作者： Dorothee D.HAROSKE Zhen LIU Susana D.MOURA Leszek SKRZYPCZAK Institute of Mathematics Friedrich Schiller University Jena Faculty of Mathematics & Computer Science Adam Mickiewicz University ul.Uniwersytetu Poznańskiego 4 university of coimbra Department of MathematicsCMUC

We study embeddings between generalised Triebel-Lizorkin-Morrey spaces εφ,p,qs(Rd) and within the scales of further generalised Morrey smoothness spaces like Nφ,p,qs(Rd),Bp,qs,φ(Rd) and Fp,qs,φ(Rd).The latter have been investigated in a recent paper by the first two authors(2023),while the embeddings of the scale Nφ,p,qs(Rd) were mainly obtained in a paper of the first and last two authors(2022).Now we concentrate on the characterisation of the spaces εφ,p,qs(Rd).Our approach requires a wavelet characterisation of those spaces which we establish for the system of Daubechies’ wavelets.Then we prove necessary and sufficient conditions for the embedding εφ1,p1,q1s1(Rd)→εφ2,p2,q2s2(Rd).We can also provide some almost final answer to the question when εφ,p,qs(Rd) is embedded into C(Rd),complementing our recent findings in case of Nφ,p,qs(Rd).

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Prevalence and risk factors for acquired long QT syndrome in the emergency department:a retrospective observational study

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World Journal of Emergency Medicine 2023年第6期14卷 454-461页

作者： Diogo de Almeida Fernandes Guilherme de Freitas Camoes Diana Ferreira Carolina Queijo Carlos Fontes-Ribeiro Lino Gongalves Rui Pina Natalia Antonio Department of Cardiology Coimbra Hospital and University Centre(CHUC)Coimbra 3000-075Portugal Department of Internal Medicine Coimbra Hospital and University Centre(CHUC)Coimbra 3000-075Portugal Faculty of Medicine University of CoimbraCoimbra 3000-370Portugal Institute for Clinical and Biomedical Research Faculty of MedicineUniversity of CoimbraCoimbra 3000-548Portugal

BACKGROUND: Long QT syndrome(LQTS) is a heterogeneous syndrome that may be congenital or, more frequently, acquired. The real-world prevalence of acquired LQTS(aLQTS) in the emergency department(ED) remains to be determined. The aim of this study was to determine prevalence of aLQTS and its impact on symptoms on ED admissions.METHODS: Electrocardiograms(ECG) of 5,056 consecutively patients admitted in the ED of a tertiary hospital between January 28th and March 17th of 2020 were reviewed. All patients with aLQTS were included. Clinical data with a focus on QT prolonging drugs and clinical factors were recorded. Statistical comparison was made between the groups with and without corrected QT(QTc) interval greater than 500 ms(value that is considered severely increased).RESULTS: A total of 383 ECGs with prolonged QTc were recognized, corresponding to a prevalence of aLQTS at admission of 7.82%. Patients with aLQTS were more commonly men(53.3%) with an age of(73.49±14.79) years old and QTc interval of(505.3±32.4) ms. Only 20.4% of these patients with aLQTS were symptomatic. No ventricular arrhythmias were recorded. Patients with QT interval greater than 500 ms were more frequently female(59.5%;P<0.001) and were more frequently on QT prolonging drugs(77.3%;P=0.025). Main contributing factor was intake of antibiotics(odds ratio [OR] 4.680) followed by female gender(OR 2.473) and intake of antipsychotics(OR 1.925).CONCLUSION: aLQTS is particularly prevalent in the ED. Female patients on antibiotics and antipsychotics are at particularly high risk. Efforts must be made to avoid, detect and treat aLQTS as early as possible.

关键词： Long QT syndrome Epidemiology Drug interactions Emergency department

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Parkinson's Disease:A Multisystem Disorder

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Neuroscience Bulletin 2023年第1期39卷 113-124页

作者： Helena Nunes Costa Ana Raquel Esteves Nuno Empadinhas Sandra Morais Cardoso CNC–Center for Neuroscience and Cell Biology and CIBB–Center for Innovative Biomedicine and Biotechnology University of Coimbra3004-504CoimbraPortugal IIIUC–Institute for Interdisciplinary Research University of Coimbra3004-504CoimbraPortugal Faculty of Medicine University of Coimbra3004-504CoimbraPortugal

The way sporadic Parkinson's disease(PD)is perceived has undergone drastic changes in recent decades.For a long time,PD was considered a brain disease characterized by motor disturbances;however,the identification of several risk factors and the hypothesis that PD has a gastrointestinal onset have shed additional light.Today,after recognition of prodromal non-motor symptoms and the pathological processes driving their evolution,there is a greater understanding of the involvement of other organ systems.For this reason,PD is increasingly seen as a multiorgan and multisystemic pathology that arises from the interaction of susceptible genetic factors with a challenging environment during aging-related decline.

关键词： Parkinson's disease Gut microbiome Intestinal barrier α-Synuclein Blood-brain barrier

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Towards the automation of book typesetting

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Visual Informatics 2023年第2期7卷 1-12页

作者： Sérgio M.Rebelo Tiago Martins Diogo Ferreira Artur Rebelo university of coimbra Centre for Informatics and Systems of the University of CoimbraDepartment of Informatics EngineeringCoimbraPortugal

This paper proposes a generative approach for the automatic typesetting of books in desktop publishing.The presented system consists in a computer script that operates inside a widely used design software tool and implements a generative process based on several typographic rules,styles and principles which have been identified in the literature.The performance of the proposed system is tested through an experiment which included the evaluation of its outputs with people.The results reveal the ability of the system to consistently create varied book designs from the same input content as well as visually coherent book designs with different contents while complying with fundamental typographic principles.

关键词： Design tools Data-driven design Generative design Graphic design Typography

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Biomarkers of hypoxic-ischemic encephalopathy:a systematic review

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World Journal of Pediatrics 2023年第6期19卷 505-548页

作者： Ines Caramelo Margarida Coelho Miguel Rosado Carla M.P.Cardoso Alexandra Dinis Carlos B.Duarte Mario Graos Bruno Manadas CNC-Center for Neuroscience and Cell Biology University of Coimbra3004‑504 CoimbraPortugal PhD Programme in Experimental Biology and Biomedicine Institute for Interdisciplinary Research(IIIUC)University of CoimbraCasa Costa Alemão3030‑789 CoimbraPortugal Chemistry Department Faculty of Sciences and TechnologyUniversity of Coimbra3004‑535 CoimbraPortugal Stemlab SA 3060‑197 CantanhedePortugal Pediatric Intensive Care Unit Hospital PediátricoCentro Hospitalar E Universitário de Coimbra3000‑075 CoimbraPortugal Department of Life Sciences University of Coimbra3001‑401 CoimbraPortugal Biocant Technology Transfer Association3060‑197 CantanhedePortugal Institute for Interdisciplinary Research University of Coimbra(IIIUC)3030‑789 CoimbraPortugal

Background Current diagnostic criteria for hypoxic–ischemic encephalopathy in the early hours lack objective measurement tools.Therefore,this systematic review aims to identify putative molecules that can be used in diagnosis in daily clinical practice(PROSPERO ID:CRD42021272610).Data sources Searches were performed in PubMed,Web of Science,and Science Direct databases until November 2020.English original papers analyzing samples from newborns>36 weeks that met at least two American College of Obstetricians and Gynecologists diagnostic criteria and/or imaging evidence of cerebral damage were included.Bias was assessed by the Newcastle–Ottawa Scale.The search and data extraction were verified by two authors separately.Results From 373 papers,30 met the inclusion criteria.Data from samples collected in the first 72 hours were extracted,and increased serum levels of neuron-specific enolase and S100-calcium-binding protein-B were associated with a worse prognosis in newborns that suffered an episode of perinatal asphyxia.In addition,the levels of glial fibrillary acidic protein,ubiquitin carboxyl terminal hydrolase isozyme-L1,glutamic pyruvic transaminase-2,lactate,and glucose were elevated in newborns diagnosed with hypoxic–ischemic encephalopathy.Moreover,pathway analysis revealed insulin-like growth factor signaling and alanine,aspartate and glutamate metabolism to be involved in the early molecular response to insult.Conclusions Neuron-specific enolase and S100-calcium-binding protein-B are potential biomarkers,since they are correlated with an unfavorable outcome of hypoxic-ischemic encephalopathy newborns.However,more studies are required to determine the sensitivity and specificity of this approach to be validated for clinical practice.

关键词： Biomarker Hypoxic-ischemic encephalopathy Neonatal brain injury Newborn Neuron-specific enolase S100-calcium-binding protein-B

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