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Design of a Socially Inclusive Climate Risk Transfer Mechanism:A Case Study in La Guajira,Colombia

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International Journal of Disaster Risk Science 2024年第4期15卷 565-578页

作者： Cristian Camilo Fernández Lopera JoséManuel Mendes Eduardo Jorge Barata Centre for Social Studies Institute for Interdisciplinary ResearchUniversity of Coimbra3000-995 CoimbraPortugal Faculty of Economics Centre for Social StudiesUniversity of Coimbra3000-995 CoimbraPortugal Faculty of Economics CeBERUniversity of Coimbra3004-512 CoimbraPortugal

The primary aim of this study was to develop a model of a socially inclusive climate risk insurance(CRI) mechanism based on the differential risk transfer approach. This study focused on the department of La Guajira, Colombia, as a case *** Guajira is the department in Colombia that, due to its critical disaster risk conditions, presents the adequate configuration for implementing a climate risk transfer mechanism. The article starts by analyzing risk conditions by using secondary data. Based on fieldwork, this research explored the perspectives of the most vulnerable sectors in La Guajira Department on the socioeconomic impacts and needs they experience regarding climate-related hazards, their adaptive measures for risk reduction, and their willingness to adopt CRI. This represents the fundamental input for the formulation of the CRI model. Consequently, this research proposed an operational structure as input for future implementations of the model. The results indicate that national and local disaster risk management public policies align with the sectors' needs and priorities. Strengthening sectoral associations can enhance representation in CRI projects. In-kind indemnization is preferred for women entrepreneurs and the indigenous community. The CRI model includes a risk pool through the family compensation fund of La Guajira as a sectoral agglomerator, with contingent credit and traditional/parametric insurance. The methodology developed in this study can be applied in different contexts worldwide as a guidance for informing national and international climate risk finance initiatives.

关键词： Colombia Disaster risk fnancing Disaster risk management La Guajira Climate risk insurance Socioeconomic vulnerability

Prevalence and risk factors for acquired long QT syndrome in the emergency department:a retrospective observational study

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World Journal of Emergency Medicine 2023年第6期14卷 454-461页

作者： Diogo de Almeida Fernandes Guilherme de Freitas Camoes Diana Ferreira Carolina Queijo Carlos Fontes-Ribeiro Lino Gongalves Rui Pina Natalia Antonio Department of Cardiology Coimbra Hospital and University Centre(CHUC)Coimbra 3000-075Portugal Department of Internal Medicine Coimbra Hospital and University Centre(CHUC)Coimbra 3000-075Portugal Faculty of Medicine University of CoimbraCoimbra 3000-370Portugal Institute for Clinical and Biomedical Research Faculty of MedicineUniversity of CoimbraCoimbra 3000-548Portugal

BACKGROUND: Long QT syndrome(LQTS) is a heterogeneous syndrome that may be congenital or, more frequently, acquired. The real-world prevalence of acquired LQTS(aLQTS) in the emergency department(ED) remains to be determined. The aim of this study was to determine prevalence of aLQTS and its impact on symptoms on ED ***: Electrocardiograms(ECG) of 5,056 consecutively patients admitted in the ED of a tertiary hospital between January 28th and March 17th of 2020 were reviewed. All patients with aLQTS were included. Clinical data with a focus on QT prolonging drugs and clinical factors were recorded. Statistical comparison was made between the groups with and without corrected QT(QTc) interval greater than 500 ms(value that is considered severely increased).RESULTS: A total of 383 ECGs with prolonged QTc were recognized, corresponding to a prevalence of aLQTS at admission of 7.82%. Patients with aLQTS were more commonly men(53.3%) with an age of(73.49±14.79) years old and QTc interval of(505.3±32.4) ms. Only 20.4% of these patients with aLQTS were symptomatic. No ventricular arrhythmias were recorded. Patients with QT interval greater than 500 ms were more frequently female(59.5%;P<0.001) and were more frequently on QT prolonging drugs(77.3%;P=0.025). Main contributing factor was intake of antibiotics(odds ratio [OR] 4.680) followed by female gender(OR 2.473) and intake of antipsychotics(OR 1.925).CONCLUSION: aLQTS is particularly prevalent in the ED. Female patients on antibiotics and antipsychotics are at particularly high risk. Efforts must be made to avoid, detect and treat aLQTS as early as possible.

关键词： Long QT syndrome Epidemiology Drug interactions Emergency department

The effect of salinity on Fucus ceranoides (Ochrophyta,Phaeophyceae) in the Mondego River(Portugal)

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Journal of Oceanology and Limnology 2019年第3期37卷 881-891页

作者： COTAS Joao FIGUEIRINHA Artur PEREIRA Leonel BATISTA Teresa Department of Life Sciences University of CoimbraCoimbra 3001-456Portugal MARE-Marine and Environmental Sciences Centre Faculty of Science and TechnologyUniversity of CoimbraCoimbra 3000-548Portugal Laboratory of Pharmacognosy Faculty of PharmacyUniversity of CoimbraCoimbra 3000-548Portugal LAQV REQUIMTEFaculty of PharmacyUniversity of CoimbraCoimbra 3000-548Portugal CIEPQPF Department of Chemical EngineeringFaculty of Science and TechnologyUniversity of CoimbraCoimbra 3030-790Portugal

Algae(and their extracts)are increasingly important for pharmaceutical applications due to the diversity of useful compounds they *** genus Fucus contains one of the most studied species,Fucus *** species *** differs from the others of the genus by presenting longitudinal air-vesicles and a capacity to survive at low *** is an alga that inhabits the Mondego River estuary(Portugal),at the southern limit of its distribution,and can serve as a role model to understand the effect of a salt gradient on the production of bioactive *** assessed the phenolic content and antioxidant activity of different *** extracts(***,aqueous and polysaccharide)prepared from samples harvested from two different zones to evaluate if the adaptation of *** to different salinity levels influenced its chemical *** antioxidant activity of the extracts was determined using 1,2-diphenyl-picrylhydrazyl(DPPH)and 2.2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)(ABTS)*** assays demonstrated that the methanolic extract of lyophilized *** that grew at low salinities was the most bioactive,***(IC 50=50.39μg/mL)and ABTS(TEAC=2.42).The total phenolic content(Folin-Ciocalteu method)and the methanolic extract of the lyophilized *** collected from a low salinity habitat exhibited the highest phenolic content(PGE=49.48μg/mg of lyophilized extract)amongst those *** layer chromatography(TLC)and Fourier transform infrared spectroscopy(FTIR)were used for the identification of compounds in the *** characterization allowed confirmation that the various extracts contained almost the same compounds but with notable quantitative *** on these results,we conclude that there were differences in the quantity of the compounds due to the effect of *** drying methods used were also found to have influenced the quality of the extracted compounds.

关键词： Fucus ceranoides salinity gradient sequential extractions phenolic content dependent bioactivities spectroscopic analysis

Fluorescent probes for the detection of reactive oxygen species in human spermatozoa

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Asian Journal of Andrology 2020年第5期22卷 465-471页

作者： Sara Escada-Rebelo Francisca G Mora Ana P Sousa Teresa Almeida-Santos Artur Paiva Joao Ramalho-Santos phD Programme in Experimental Biology and Biomedicine CNC-Center for Neuroscience and Cell BiologyUniversity of CoimbraCoimbra 3004-504Portugal Biology of Reproduction and Stem Cell Group CNC-Center for Neuroscience and Cell BiologyUniversity of CoimbraCoimbra 3004-504Portugal IIIUC-Institute for Interdisciplinary Research Casa Costa AlemaoUniversity of CoimbraCoimbra 3030-789Portugal Reproductive Medicine Unit University Hospitals of CoimbraCoimbra 3004-561Portugal Faculty of Medicine University of CoimbraCoimbra 3000-370Portugal Clinical Pathology Unit University Hospitals of CoimbraCoimbra 3004-561Portugal Department of Life Sciences University of CoimbraCoimbra 3000-456Portugal

Reactive oxygen species(ROS)production is a by-product of mitochondrial activity and is necessary for the acquisition of the capacitated state,a requirement for functional ***,an increase in oxidative stress,due to an abnormal production of ROS,has been shown to be related to loss of sperm function,highlighting the importance of an accurate detection of sperm ROS,given the specific nature of this *** this work,we tested a variety of commercially available fluorescent probes to detect ROS and reactive nitrogen species(RNS)in human sperm,to define their *** both flow cytometry(FC)and fluorescence microscopy(FM),we confirmed that MitoSOX™Red and dihydroethidium(DHE)detect superoxide anion(as determined using antimycin A as a positive control),while DAF-2A detects reactive nitrogen species(namely,nitric oxide).For the first time,we also report that RedoxSensor™Red CC-1,CellROX®Orange Reagent,and MitoPYl seem to be mostly sensitive to hydrogen peroxide,but not ***,mean fluorescence intensity(and not percentage of labeled cells)is the main parameter that can be reproducibly monitored using this type of methodology.

关键词： flow cytometry fluorescent probes human spermatozoa oxidative stress reactive oxygen species

Neuropsychological features of progranulin-associated frontotemporal dementia: a nested case-control study

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Neural Regeneration Research 2021年第5期16卷 910-915页

作者： Marisa Lima Miguel Tábuas-Pereira Diana Duro João Durães Daniela Vieira Inês Baldeiras Maria Rosário Almeida Isabel Santana Neurology Department Centro Hospitalar e Universitário de CoimbraCoimbraPortugal university of coimbra Faculty of MedicineCoimbraPortugal university of coimbra Center for Neuroscience and Cell BiologyCoimbraPortugal university of coimbra Center for Research in Neuropsychology and Cognitive Behavioral Intervention(CINEICC)Faculty of Psychology and Educational SciencesCoimbraPortugal

The distinction between sporadic and genetic behavioural-variant frontotemporal dementia(bvFTD)regarding some neuropsychological(NP)features remains ***,progranulin(GRN)-associated bvFTD frequently presents with early episodic memory impairment and some degree of parietal dysfunction which are supporters of Alzheimer’s disease(AD)*** this context,we aimed to characterize the NP profile of GRN-bvFTD as compared to sporadic-bvFTD and AD in patients with mild dementia(Mini-Mental State Examination score≥17 and Clinical Dementia Rating Scale score≤*** identified 21 patients at Centro Hospitalar e Universitário de coimbra,Portugal with GRN mutations belonging to fifteen different *** our focus was bvFTD variants,FTD-related aphasic forms(3 patients)were *** remaining 18 GRN-bvFTD were further matched with 18 sporadic-bvFTD and 18 AD patients according to disease staging,age and *** patients completed the Mini-Mental State Examination,Montreal Cognitive Assessment(MoCA)and a comprehensive NP assessment *** were converted into *** between groups in individual NP measures and NP domains were assessed through non-parametric tests(Kruskal-Wallis test analysis)and eta squared(ŋ2)was calculated as a measure of effect *** comparisons show that GRN patients have worse performances on verbal retrieval processes(P=0.039,ŋ2=0.110)and visuoconstructive abilities(P=0.039,ŋ2=0.190)than sporadic bvFTD *** compared to AD,GRN patients present a higher impairment in frontal(P=0.001,ŋ2=0.211)and parietal(P=0.041,ŋ2=0.129)measures and a better performance in memory tasks(P=0.020,ŋ2=0.120).Sporadic-bvFTD forms are worse than AD in frontal measures(P=0.032,ŋ2=0.200),being better in both memory(P=0.010,ŋ2=0.131)and visuospatial skills(P=0.023,ŋ2=0.231).Considering these results,we conclude that GRN-bvFTD patients present a NP profile that associates the typical patterns of FTD and AD ***

关键词： Alzheimer’s disease behavioral variant frontotemporal dementia cognitive profile frontotemporal dementia genetics memory neuropsychology progranulin visuoconstructive ability

Repurposing a deep learning network to filter and classify volunteered photographs for land cover and land use characterization

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Geo-Spatial Information Science 2017年第3期20卷 252-268页

作者： Lukasz Tracewski Lucy Bastin Cidalia C.Fonte School of Engineering and Applied Science Aston UniversityBirminghamUK Department of Mathematics INESC CoimbraUniversity of CoimbraCoimbraPortugal

This paper extends recent research into the usefulness of volunteered photos for land cover extraction,and investigates whether this usefulness can be automatically assessed by an easily accessible,off-the-shelf neural network pre-trained on a variety of scene *** photographs are sometimes presented to volunteers as part of a game which requires them to extract relevant facts about land *** challenge is to select the most relevant photographs in order to most efficiently extract the useful information while maintaining the engagement and interests of *** repurposing an existing network which had been trained on an extensive library of potentially relevant features,we can quickly carry out initial assessments of the general value of this approach,pick out especially salient features,and identify focus areas for future neural network training and *** compare two approaches to extract land cover information from the network:a simple post hoc weighting approach accessible to non-technical audiences and a more complex decision tree approach that involves training on domain-specific features of *** approaches had reasonable success in characterizing human influence within a scene when identifying the land use types(as classified by Urban Atlas)present within a buffer around the photograph’s *** work identifies important limitations and opportunities for using volunteered photographs as follows:(1)the false precision of a photograph’s location is less useful for identifying on-the-spot land cover than the information it can give on neighbouring combinations of land cover;(2)groundacquired photographs,interpreted by a neural network,can supplement plan view imagery by identifying features which will never be discernible from above;(3)when dealing with contexts where there are very few exemplars of particular classes,an independent a posteriori weighting of existing scene attributes and categories can buffer

关键词： Land cover land use volunteered geographic information(VGI) photograph convolutional neural network machine learning

Towards the automation of book typesetting

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Visual Informatics 2023年第2期7卷 1-12页

作者： Sérgio M.Rebelo Tiago Martins Diogo Ferreira Artur Rebelo university of coimbra Centre for Informatics and Systems of the University of CoimbraDepartment of Informatics EngineeringCoimbraPortugal

This paper proposes a generative approach for the automatic typesetting of books in desktop *** presented system consists in a computer script that operates inside a widely used design software tool and implements a generative process based on several typographic rules,styles and principles which have been identified in the *** performance of the proposed system is tested through an experiment which included the evaluation of its outputs with *** results reveal the ability of the system to consistently create varied book designs from the same input content as well as visually coherent book designs with different contents while complying with fundamental typographic principles.

关键词： Design tools Data-driven design Generative design Graphic design Typography

Parkinson's Disease:A Multisystem Disorder

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Neuroscience Bulletin 2023年第1期39卷 113-124页

作者： Helena Nunes Costa Ana Raquel Esteves Nuno Empadinhas Sandra Morais Cardoso CNC–Center for Neuroscience and Cell Biology and CIBB–Center for Innovative Biomedicine and Biotechnology University of Coimbra3004-504CoimbraPortugal IIIUC–Institute for Interdisciplinary Research University of Coimbra3004-504CoimbraPortugal Faculty of Medicine University of Coimbra3004-504CoimbraPortugal

The way sporadic Parkinson's disease(PD)is perceived has undergone drastic changes in recent *** a long time,PD was considered a brain disease characterized by motor disturbances;however,the identification of several risk factors and the hypothesis that PD has a gastrointestinal onset have shed additional ***,after recognition of prodromal non-motor symptoms and the pathological processes driving their evolution,there is a greater understanding of the involvement of other organ *** this reason,PD is increasingly seen as a multiorgan and multisystemic pathology that arises from the interaction of susceptible genetic factors with a challenging environment during aging-related decline.

关键词： Parkinson's disease Gut microbiome Intestinal barrier α-Synuclein Blood-brain barrier

Carbon dioxide adsorption and cycloaddition reaction of epoxides using chitosan–graphene oxide nanocomposite as a catalyst

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Journal of Environmental Sciences 2018年第7期30卷 77-84页

作者： Santosh Kumar Mohmmad Y.Wani Joonseok Koh Joao M.Gil Abilio J.F.N.Sobral Chemistry Center Department of ChemistryUniversity of CoimbraCoimbra 3004-535Portugal Department of Organic and Nano System Engineering Konkuk UniversitySeoul 143-701Republic of Korea CFisUC Department of PhysicsUniversity of CoimbraCoimbra 3004-516Portugal

One of today＇s major challenges is to provide green materials for a cleaner environment. We have conducted studies on carbon dioxide（CO2） adsorption and conversion to valuable products by an ecofriendly approach based in chitosan/graphene oxide（CSGO） nanocomposite film. Rheological behavior indicates that the CSGO has a better solvation property than the pure chitosan. An adsorption capacity of 1.0152 mmol CO2/g of CSGO nanocomposite at4.6 bar was observed. The catalytic behavior of the CSGO nanocomposite in the presence of tetra-n-butylammonium iodide（n-Bu4 NI） as co-catalyst was evaluated for the cycloaddition of CO2 to epoxides, to give cyclic carbonates, in the absence of any solvent. These results strongly suggest that the CSGO nanocomposite may open new vistas towards the development of ecofriendly material for catalytic conversion and adsorption of CO2 on industrial scale.

关键词： Chitosan Graphene oxide Adsorption Conversion Carbon dioxide