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Journal of Traditional chinese Medical Sciences 2023年第2期10卷 127-128页

作者： Tingyu Fang Shenglou Ni Yanping Wang Xiaoli Li Liangxiao Ma Ochs Shelley School of Humanities Beijing University of Chinese MedicineBeijing102488China Periodical Center Beijing University of Chinese MedicineBeijing102488China School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing102488China Acupuncture Works LouisvilleKY40205USA

General Secretary Xi Jinping points out“traditional chinese medicine(TCM)is a treasure of the chinese *** must pro-tect,explore,develop and inherit it well.”According tothe latest in-formation,1 TCM has spread to 196 countries and regions around the world,indicating that it enjoys a good development abroad,especially the development of acupuncture and moxibustion.

关键词： medicine(TCM) acupuncture moxibustion

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BEIJING university of chinese medicine: A MAIN FORCE OF TCM PRESERVATION,INNOVATION AND PROMOTION

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World Journal of Traditional chinese medicine 2015年第4期1卷 78-79页

作者： Wu Qing Deputy Dean of School of chinese Materia Medica Beijing University of Chinese Medicine

Beijing university of chinese medicine(BUCM)was founded in 1956,and is one of the earliest established traditional chinese medical institutions for higher educat:ion in the People’s Republic of ***,BUCM has 10 schools with 2,462 staff and 27,833 students,3 affiliated hospitals with 1960 medical staff and equipped with 2200 beds average daily out-patient capacity is over7000 *** research funding is over$16.5

关键词： TCM A MAIN FORCE OF TCM PRESERVATION,INNOVATION AND PROMOTION BEIJING university of chinese medicine

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Innovation Ability of Traditional chinese medicine Graduates Cultivated by Industry-university-Research Institute Cooperation Program:A Case Study of Guangxi university of chinese medicine

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Medicinal Plant 2020年第4期11卷 98-100页

作者： Chenyan LIANG Lin JIANG Rumei LU Yunli TANG Wenya CHEN Guangxi university of chinese medicine Nanning 530200 China

Industry-university-research institute cooperation has important strategic significance and practical value for cultivating the innovation ability of graduate *** Guangxi university of chinese medicine as an example,this paper analyzed the current status of the joint cultivation of industry-university-research institute,and explored an effective way to cultivate top-notch innovative talents with innovative spirit,entrepreneurial awareness and innovative entrepreneurial ability,in order to maximally stimulate talents to create the vitality of traditional chinese medicine.

关键词： Industry-university-research institute Traditional chinese pharmacy Cultivation of graduate students Innovation ability

Shanghai university of Traditional chinese medicine Partners with Cai Tong De

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chinese medicine and Culture 2020年第1期 55-55页

A signing ceremony was held at the Cai Tong De Pharmacy in Shanghai on Nov 22nd,*** university of Traditional chinese medicine(SHUTCM) and Shanghai Cai Tong De Pharmaceutical *** an agreement on Nov 22nd to allow international students from the university to do an internship at the Cai Tong De Pharmacy in Shanghai.

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Traditional chinese medicine Workshop for International Medical Experts Held at Shanghai university of Traditional chinese medicine

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chinese medicine and Culture 2019年第4期 149-149页

The 2019 Traditional chinese medicine Workshop for Professionals from countries involved in the Belt and Road Initiative（BRI） began on Oct 14;at the Shanghai university of Traditional chinese medicine（SHUTCM）.This year, 35 goverment officials from various health departments, doctors and professors from 15 BRI countries attended the workshop.

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Tuina alleviates neuropathic pain through regulate the activation of microglia and the secretion of inflammatory cytokine in spinal cord

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Journal of Traditional chinese medicine 2024年第4期44卷 762-769页

作者： WU Zhiwei ZHU Qingguang KONG Lingjun SONG Pengfei ZHOU Xin GUO Guangxin ZHANG Shuaipan HE Tianxiang CHENG Yanbin FANG Min Yueyang Hospital of Integrated Traditional chinese and Western medicine Shanghai University of Traditional Chinese Medicine Institute of Tuina Shanghai Institute of Traditional Chinese Medicine Shuguang Hospital Shanghai University of Traditional Chinese Medicine Department of Acupuncture and Tuina Shanghai University of Traditional Chinese Medicine

OBJECTIVE: To observe the analgesic effects of Tuina on neuropathic pain(NPP) and the underlying mechanisms. METHODS: Forty-eight Sprague-Dawley(SD) rats were assigned by random into three treatment groups: sham, chronic constriction injury(CCI), and Tuina. Each group contained sixteen rats. CCI model was generated by ligating the right sciatic nerve. Behavioral changes of CCI were assessed by the paw withdrawal threshold(PWT) and paw withdrawal latency(PWL). In addition, biochemical techniques such as immunofluorescence staining, enzyme-linked immunosorbent assay(ELISA) and Western blotting were used to profile levels of microglia activation and inflammatory factors in the spinal dorsal horn(SDH) of rats. Tuina(clockwise pressing and rubbing) was performed at Chengshan(BL57) to observe the analgesic effects on CCI rats and the underlying mechanisms. RESULTS: Rats with CCI experienced significant reduction in the PWT and PWL of the right hind paw relative to CCI group at day 3. Tuina treatment rescued this situation significantly on days 10 and 14. Besides, Iba-1, microglia M1 receptor CD68, tumor necrosis factor-α(TNF-α), and interleukin-1β(IL-1β) were higher in the right SDH for CCI group compared to the sham group on day 14. As expected, Tuina partially downregulated the CCI-induced overexpressed Iba-1, CD68, TNF-α, and IL-1β in the SDH of CCI model. CONCLUSION: Tuina induces a time-dependent cumulative analgesic effect in CCI rats by inhibiting the activation of microglia and the secretion of IL-1β and TNF-α in SDH.

关键词： Tuina inflammatory cytokine microglia neuralgia spinal cord

Luteolin promotes neuronogenesis in hippocampus of chronic unpredictable mild stress rats and primary hippocampus of fetal rats

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Journal of Traditional chinese medicine 2024年第4期44卷 670-679页

作者： LIU Tongtong ZHANG Xi YANG Hui LIN Xiaoyuan LIU Jian ZHANG Xiuli GUO Dongwei ZHAO Hongqing ZOU Manshu LEI Chang LONG Hongping LUO Yan XIANG Yun GE Jinwen WANG Yuhong MENG Pan Institute of Innovation and Applied Research in chinese medicine Hunan University of Chinese Medicine the Second People's Hospital of Hunan Province The First Affiliated Hospital Hunan University of Chinese Medicine Hunan Academy of chinese medicine

OBJECTIVE: To investigate the effects of luteolin on chronic unpredictable mild stress(CUMS)-induced depressive rats and corticosterone(CORT)-induced depressive primary hippocampal neurons, and to elucidate the mechanism behind the ***: The antidepressant mechanism of luteolin was studied by using CUMS rat model and primary hippocampal neurons in fetal rats. In vivo, novelty suppressed feeding, open-field and sucrose preference tests as well as Morris water maze were evaluated. The content of brain derived neurotrophic factor(BDNF), 5-hydroxytryptamine(5-HT), norepinephrine(NE), and dopamine(DA) in serum were detected by enzyme-linked immunosorbent assay. The mechanisms of luteolin were explored based on neurotrophin and hippocampal neurogenesis, and proliferation. Survival of the septotemporal axis in hippocampus was assayed using the 5-bromo-2-deoxyuridine(BrdU), the expression of BDNF,neurotrophin-3(NT-3), and nerve growth factor(NGF) in hippocampus dentate gyrus region were measured by Western-blotting. In vitro, BDNF, NT-3, tropomyosin receptor kinase B(TrkB), and phosphorylated cyclic adenosine monophosphate responsive element binding protein(p-CREB) were detected through the high content analysis(HCA) to investigate neurotrophin and ***: Induction of CUMS in rats induced depressive symptoms, while luteolin significantly enhanced sucrose consumption, decreased feeding latency, increased locomotor activity, escape latency, distance of target quadrant and regulated the content of depressive-like biomarkers. Histology analysis revealed that luteolin increased the abundance of new born neurons that had been labeled with BrdU, BrdU + neuronal nuclear antigen,and BrdU + doublecortin in septo-temporal axis of S2(mid-septal) and T3(mid-temporal). Moreover,expression of BDNF, NT-3, and NGF increased significantly in the septo-temporal axis of S2 and T3. HCA showed increased expression of BDNF, NT-3, TrkB and p-CREB in primary hippocampal neuron

关键词： chronic unpredicted mild stress depression hippocampal neurogenesis luteolin septo-temporal axis

Sanhua Tang(三化汤) protects against ischemic stroke by preventing blood-brain barrier injury: a network pharmacology and in vivo experiments

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Journal of Traditional chinese medicine 2024年第4期44卷 794-803页

作者： LUO Shan YANG Fan CHEN Yuanchun ZHAO Ruoxi LIU Haiye GAO Fei MA Wencan GAO Weijuan YU Wentao College of Basic medicine Hebei University of Chinese Medicine Graduate School Hebei University of Chinese Medicine College of Acupuncture and Massage Hebei University of Chinese Medicine Hebei Key Laboratory of chinese medicine Research on Cardio-Cerebrovascular Diseases Hebei International Joint Research Centre for Acupuncture and Moxibustion of Traditional chinese medicine

OBJECTIVE: To assess the effect and mechanism of Sanhua Tang(三化汤, SHT) in treating ischemic stroke(IS) through the "Kaitong Xuanfu" theory by using network pharmacology and animal experiments. METHODS: The active ingredients and targets of SHT and IS were screened by public databases such as Traditional chinese medicine systems pharmacology, GeneCards, and online mendelian inheritance in man. Visual network topographies were constructed using R, Cytoscape 3.6.0, AutoDockTools, a user-sponsored molecular visualization system on an open-source foundation, and other software to analyze the correlation between targets and active ingredients. The middle cerebral artery occlusion(MCAO) model was established by operation. Animals were divided into the Sham group, MCAO group(M group), aloe-emodin(AE) group(MCAO rats treated with aloe-emodin), SHT at low dosage(SL group)(MCAO rats treated with SL), SHT at medium dosage(SM group), and SHT at high dosage(SH group). 2,3,5-triphenyl tetrazolium chloride staining was used to detect the volume of cerebral infarction; Nissl staining was used to observe the morphology of neuronal cells; transmission electron microscopy was used to observe the integrity of the blood-brain barrier(BBB); enzymelinked immunosorbent assay was used to detect the content of interleukin-6(IL-6), IL-10, tumor necrosis factor α(TNF-α) in serum. Western blot was used to detect the expression of vascular endothelial growth factor A(VEGFA) protein in the cerebral ischemic penumbra. RESULTS: Using network pharmacology and molecular docking validation, four active ingredients(lignan, naringenin, aloe-rhodopsin, and β-sitosterol), seven target proteins(protein kinase b 1, IL-6, TNF, VEGFA, TP53, jun proto-oncogene, and cysteinyl aspartate specific proteinase 3), and inflammatory signaling pathways were identified. Animal experiments showed that the SH and AE groups had fewer neurological deficits, reduced brain infarct volumes, decreased serum inflammatory factor l

关键词： Sanhua Tang blood-brain barrier inflammatory reactions ischemic stroke network pharmacology

Integration of serum pharmacochemistry with network pharmacology to reveal the potential mechanism of Yangqing Chenfei formula(养清尘肺方) for the treatment of silicosis

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Journal of Traditional chinese medicine 2024年第4期44卷 784-793页

作者： HU Yuanyuan LIU Xinguang ZHAO Peng WU Jinyan YAN Xinhua HOU Runsu WANG Xiangcheng YANG Fan TIAN Xinrong LI Jiansheng Longhua Hospital Shanghai university of Traditional chinese medicine Shanghai University of Traditional Chinese Medicine Co-construction Collaborative Innovation Center for chinese medicine and Respiratory Diseases by Henan and Education Ministry of P.R.China Henan Key Laboratory of chinese medicine for Respiratory Disease Henan University of Chinese Medicine

OBJECTIVE: To explore the mechanisms of Yangqing Chenfei formula(养清尘肺方, YCF) in the treatment of silicosis through a comprehensive strategy consisting of serum pharmacochemistry, network pharmacology analysis, and in vitro validation. METHODS: An ultrahigh-performance liquid chromatography-tandem mass spectrometry method was used to confirm the active components in YCF-medicated serum. Then, we obtained targets for active components and genes for silicosis from multiple databases. Furthermore, a protein-protein interaction network was constructed, and Kyoto Encyclopedia of Genes and Genomes pathway and biological process analyses were conducted to elucidate the mechanisms of YCF for the treatment of silicosis. Finally, we validated the important components and mechanisms in vitro. RESULTS: Altogether, 19 active components were identified from rat serum after YCF administration. We identified 724 targets for 19 components, which were mainly related to inflammation [phosphatidy linositol 3 kinase/protein kinase B, forkhead box O, hypoxia inducible factor, and T-cell receptor signaling pathway, nitric oxide biosynthetic process], fibrotic processes [vascular endothelial growth factor signaling pathway, extracellular signal regulated kinase(ERK) 1 and ERK2 cascade, smooth muscle cell proliferation], and apoptosis(negative regulation of apoptotic process). In addition, 218 genes for silicosis were identified and were mainly associated with the inflammatory response and immune process [cytokine-cytokine receptor interaction, tumor necrosis factor alpha(TNF-α), toll-like receptor, and nucleotide binding oligomerization domain-like receptor signaling pathway]. Taking an intersection of active component targets and silicosis genes, we obtained 61 common genes that were mainly related to the inflammatory response and apoptosis, such as the phosphatidylinositol-3-kinase/protein kinase B signaling pathway, mitogen activated protein kinases signaling pathway, TNF signaling pathw

关键词： Yangqing Chenfei formula network pharmacology serum pharmacochemistry silicosis validation study

Scraping therapy for knee osteoarthritis: a systematic review and Meta-analysis

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Journal of Traditional chinese medicine 2024年第4期44卷 633-641页

作者： CHEN Dandan JIN Qianhong SHEN Yuanjuan WANG Qing DAI Zhengxiang School of Nursing Guangxi University of Chinese Medicine School of Nursing Nanjing University of Chinese Medicine General Surgery Department Jiangsu Province Hospital of Chinese Medicine Hospital Infection Control Office Jiangsu Province Hospital of Chinese Medicine

OBJECTIVE: To systematically evaluate the efficacy of scraping therapy on knee osteoarthritis(KOA). METHODS: A computerized search was conducted in several databases, including PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure Database, China Science and Technology Journal Database,Wanfang, and chinese BioMedical Literature Database,from the establishment date of these databases to April 9,2023. Randomized controlled trials(RCTs) on scraping therapy for KOA were collected in accordance with the “Participants-Intervention-Control-Outcome-Study design”criteria. The methodological evaluation of the included studies was carried out using RoB 2.0, and Meta-analysis was conducted using RevMan. The Grades of Recommendations Assessment, Development and Evaluation(GRADE System) was applied to grade the quality of evidence. RESULTS: A total of 12 RCTs with 997 subjects were included in the Meta-analysis. Results indicated that compared with the control group, the scraping therapy treatment group exhibited increased Lysholm scores [mean difference(MD) = 4.96, 95% confidence intervals(CI)(3.18, 6.74), P university Osteoarthritis Index scores [MD =-6.77, 95% CI(-8.99,-4.56), P < 0.000 01)]. The quality of evidence obtained in this Meta-analysis was low according to the GRADE system. CONCLUSION: The available evidence suggests that scraping therapy may have certain clinical efficacy in the treatment of KOA. However, further high-quality RCTs are needed to confirm the findings.

关键词： Meta-analysis osteoarthritis, knee scraping systematic review