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Artificial Intelligence Based Meteorological Parameter Forecasting for Optimizing Response of Nuclear Emergency Decision Support System

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原子能科学技术 2024年第10期58卷 2068-2076页

作者： BILAL Ahmed Khan HASEEB ur Rehman QAISAR Nadeem MUHAMMAD Ahmad Naveed Qureshi JAWARIA Ahad MUHAMMAD Naveed Akhtar AMJAD Farooq MASROOR Ahmad Pakistan Institute of Engineering and applied sciences Islamabad 44000Pakistan

This paper presents a novel artificial intelligence (AI) based approach to predict crucial meteorological parameters such as temperature,pressure,and wind speed,typically calculated from computationally intensive weather research and forecasting (WRF) *** meteorological data is indispensable for simulating the release of radioactive effluents,especially in dispersion modeling for nuclear emergency decision support *** of meteorological conditions during nuclear emergencies using the conventional WRF model is very complex and ***,a new artificial neural network (ANN) based technique was proposed as a viable alternative for meteorological prediction.A multi-input multi-output neural network was trained using historical site-specific meteorological data to forecast the meteorological *** evaluation of this technique was conducted to test its performance in forecasting various parameters including atmospheric pressure,temperature,and wind speed components in both East-West and North-South *** performance of developed network was evaluated on an unknown dataset,and acquired results are within the acceptable range for all meteorological *** show that ANNs possess the capability to forecast meteorological parameters,such as temperature and pressure,at multiple spatial locations within a grid with high accuracy,utilizing input data from a single ***,accuracy is slightly compromised when predicting wind speed *** mean square error (RMSE) was utilized to report the accuracy of predicted results,with values of 1.453℃for temperature,77 Pa for predicted pressure,1.058 m/s for the wind speed of U-component and 0.959 m/s for the wind speed of *** conclusion,this approach offers a precise,efficient,and wellinformed method for administrative decision-making during nuclear emergencies.

关键词： prediction of meteorological parameters weather research and forecasting model artificial neural networks nuclear emergency support system

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Cumulative Exposure to Natural Hazards and Mental Health in China: Are Older People More Vulnerable or More Resilient Than Younger and Middle-Aged Adults?

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International Journal of Disaster Risk Science 2024年第2期15卷 277-289页

作者： Shuai Zhou Crystal Kwan Department of applied Social sciences The Hong Kong Polytechnic UniversityHong Kong 999077China

Despite the well-documented impacts of single natural hazards like earthquakes, less is known about the psychological adaptation to multiple natural hazards, particularly in rural areas. This study investigated the associations of multiple natural hazards with depression among Chinese adults. Data were retrieved from the China Family Panel Studies conducted during 2010–2018. With a sample of 11,633 Chinese adults, multilevel logistic regression was employed to examine the relationships between natural hazard exposure and depression in the total sample and different age groups. Overall, experiencing four or more natural hazards was associated with a higher risk of being depressed. Regarding hazard type, the number of hydrometeorological and biological hazards was associated with a higher likelihood of depression, whereas the number of geologic and other hazards was related to a lower risk of depression. Middle-aged adults from villages were more likely to be affected by natural hazard exposure than older and younger adults. The findings of this study show that cumulative exposure to natural hazards can generate lasting effects on depressive symptoms, particularly in middle adulthood. The findings also suggest that older adults from rural areas may have accumulated more resilience to mitigate the adverse well-being effects of hazard events. Policies and interventions should enhance disaster awareness and preparation for aging residents from multi-hazard communities.

关键词： Age differences China Depressive symptoms Multi-hazard communities Natural hazard exposure

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Modularized viromimetic polymer nanoparticle vaccines(VPNVaxs) to elicit durable and effective humoral immune responses

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National Science Review 2024年第3期11卷 200-214页

作者： Zichao Huang Xinyu Zhuang Liping Liu Jiayu Zhao Sheng Ma Xinghui Si Zhenyi Zhu Fan Wu Ningyi Jin Mingyao Tian Wantong Song Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences School of applied Chemistry and Engineering University of Science and Technology of China Changchun Veterinary Research Institute Chinese Academy of Agricultural Sciences Jilin Biomedical Polymers Engineering Laboratory State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences

Virus-like particle(VLP) vaccines had shown great potential during the COVID-19 pandemic, and was thought to be the next generation of antiviral vaccine technology due to viromimetic structures. However,the time-consuming and complicated processes in establishing a current recombinant-protein–based VLP vaccine has limited its quick launch to the out-bursting pandemic. To simplify and optimize VLP vaccine design, we herein report a kind of viromimetic polymer nanoparticle vaccine(VPNVax), with subunit receptor-binding domain(RBD) proteins conjugated to the surface of polyethylene glycol-b-polylactic acid(PEG-b-PLA) nanoparticles for vaccination against SARS-CoV-2. The preparation of VPNVax based on synthetic polymer particle and chemical post-conjugation makes it possible to rapidly replace the antigens and construct matched vaccines at the emergence of different viruses. Using this modular preparation system, we identified that VPNVax with surface protein coverage of 20%–25% had the best immunostimulatory activity, which could keep high levels of specific antibody titers over 5 months and induce virus neutralizing activity when combined with an aluminum adjuvant. Moreover, the polymer nano-vectors could be armed with more immune-adjuvant functions by loading immunostimulant agents or chemical chirality design. This VPNVax platform provides a novel kind of rapidly producing and efficient vaccine against different variants of SARS-CoV-2 as well as other viral pandemics.

关键词： vaccine polymer nanomaterials SARS-CoV-2

High-throughput computational screening and in vitro evaluation identifies 5-(4-oxo-4H-3,1-benzoxazin-2-yl)-2-[3-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]-1H-isoindole-1,3(2H)-dione(C3),as a novel EGFR—HER2 dual inhibitor in gastric tumors

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Oncology Research 2024年第2期32卷 251-259页

作者： MESFER AL SHAHRANI REEM GAHTANI MOHAMMAD ABOHASSAN MOHAMMAD ALSHAHRANI YASSER ALRAEY AYED DERA MOHAMMAD RAJEH ASIRI PRASANNA RAJAGOPALAN Department of Clinical Laboratory sciences College of Applied Medical SciencesKing Khalid UniversityAbhaSaudi Arabia

Gastric cancers are caused primarily due to the activation and amplification of the EGFR or HER2 kinases resulting in cell proliferation,adhesion,angiogenesis,and *** therapies are ineffective due to the intra-tumoral heterogeneity and concomitant genetic ***,dual inhibition strategies are recommended to increase potency and reduce *** this study,we have conducted computational high-throughput screening of the ChemBridge library followed by in vitro assays and identified novel selective inhibitors that have a dual impediment of EGFR/HER2 kinase ***-based High-throughput Virtual Screening(D-HTVS)was used to screen the whole ChemBridge small molecular library against EGFR and *** atomistic molecular dynamic simulation was conducted to understand the dynamics and stability of the protein-ligand ***/HER2 kinase enzymes,KATOIII,and Snu-5 cells were used for in vitro *** atomistic Molecular Dynamics simulations followed by solvent-based Gibbs binding free energy calculation of top molecules,identified compound C3(5-(4-oxo-4H-3,1-benzoxazin-2-yl)-2-[3-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]-1H-isoindole-1,3(2H)-dione)to have a good affinity for both EGFR and *** predicted compound,C3,was promising with better binding energy,good binding pose,and optimum interactions with the EGFR and HER2 residues.C3 inhibited EGFR and HER2 kinases with IC50 values of 37.24 and 45.83 nM,*** GI50 values of C3 to inhibit KATOIII and Snu-5 cells were 84.76 and 48.26 nM,*** on these findings,we conclude that the identified compound C3 showed a conceivable dual inhibitory activity on EGFR/HER2 kinase,and therefore can be considered as a plausible lead-like molecule for treating gastric cancers with minimal side effects,though testing in higher models with pharmacokinetic approach is required.

关键词： Dual inhibitor Drug discovery EGFR/HER2 kinase Gastric cancer High-throughput screening

Stereoselective recognition of morphine enantiomers by μ-opioid receptor

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National Science Review 2024年第3期11卷 183-191页

作者： Yibo Wang Van A.Ngo Xiaohui Wang Laboratory of Chemical Biology Changchun Institute of Applied ChemistryChinese Academy of Sciences Advanced Computing for Life sciences and Engineering Group Science Engagement Section National Center for Computational Sciences Oak Ridge National Lab School of applied Chemistry and Engineering University of Science and Technology of China Beijing National Laboratory for Molecular sciences

Stereospecific recognition of chiral molecules plays a crucial role in biological systems. The μ-opioid receptor（MOR） exhibits binding affinity towards（-）-morphine, a well-established gold standard in pain management, while it shows minimal binding affinity for the（+）-morphine enantiomer, resulting in a lack of analgesic activity. Understanding how MOR stereoselectively recognizes morphine enantiomers has remained a puzzle in neuroscience and pharmacology for over half-a-century due to the lack of direct observation techniques. To unravel this mystery, we constructed the binding and unbinding processes of morphine enantiomers with MOR via molecular dynamics simulations to investigate the thermodynamics and kinetics governing MOR's stereoselective recognition of morphine enantiomers. Our findings reveal that the binding of（-）-morphine stabilizes MOR in its activated state, exhibiting a deep energy well and a prolonged residence time. In contrast,（+）-morphine fails to sustain the activation state of ***, the results suggest that specific residues, namely D1142.50and D1473.32, are deprotonated in the active state of MOR bound to（-）-morphine. This work highlights that the selectivity in molecular recognition goes beyond binding affinities, extending into the realm of residence time.

关键词： stereoselective recognition thermodynamics and kinetics residence time morphine enantiomers μ-opioid receptor

Determination of uncertainties of geomechanical parameters of metamorphic rocks using petrographic analyses

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 345-364页

作者： Behzad Dastjerdy Ali Saeidi Shahriyar Heidarzadeh Department of applied sciences University of Quebec at ChicoutimiSaguenayQCCanada SNC-Lavalin MontrealCanada

Geomechanical parameters of intact metamorphic rocks determined from laboratory testing remain highly uncertain because of the great intrinsic variability associated with the degrees of *** aim of this paper is to develop a proper methodology to analyze the uncertainties of geomechanical characteristics by focusing on three domains,*** treatment process,schistosity angle,and ***,the variabilities of the geomechanical laboratory data of Westwood Mine(Quebec,Canada)were examined statistically by applying different data treatment techniques,through which the most suitable outlier methods were selected for each parameter using multiple decision-making criteria and engineering *** indicated that some methods exhibited better performance in identifying the possible outliers,although several others were unsuccessful because of their limitation in large sample *** well-known boxplot method might not be the best outlier method for most geomechanical parameters because its calculated confidence range was not acceptable according to engineering ***,several approaches,including adjusted boxplot,2MADe,and 2SD,worked very well in the detection of true ***,the statistical tests indicate that the best-fitting probability distribution function for geomechanical intact parameters might not be the normal distribution,unlike what is assumed in most geomechanical ***,the negative effects of schistosity angle on the uniaxial compressive strength(UCS)variabilities were reduced by excluding the samples within a specific angle range where the UCS data present the highest ***,a petrographic analysis was conducted to assess the associated uncertainties such that a logical link was found between the dispersion and the variabilities of hard and soft minerals.

关键词： Intact rock parameters Natural variabilities Outlier detection methods Uncertainties Westwood mine Mineralogy

Experimental demonstration of a photonic spiking neuron based on a DFB laser subject to side-mode optical pulse injection

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Science China(Information sciences) 2024年第3期67卷 271-280页

作者： Shuiying XIANG Shuang GAO Yuechun SHI Yuna ZHANG Ziwei SONG Xingxing GUO Yahui ZHANG Yuxin MA Xiangfei CHEN State Key Laboratory of Integrated Service Networks Xidian University Yongjiang Laboratory 3. College of Engineering and applied sciences Nanjing University

We proposed and experimentally demonstrated a simple and novel photonic spiking neuron based on a distributed feedback(DFB) laser subject to side-mode optical pulse injection(SMOPI). The DFB laser chip is designed and fabricated based on asymmetric equivalent π phase shift(π-EPS) with the reconstruction-equivalent-chirp(REC) technique. Under side-mode continuous-wave(CW) optical injection,excitability pulse was experimentally observed during the dominant mode switching process due to the injection-locked effect. Based on the transition between the excitability regime and the side-mode injection locking effect, the controllable and repeatable neuron-like spiking response can be realized when external stimulus pulses are electro-optically modulated on the CW optical carrier. The experimental results show that the spike threshold, temporal integration, and refractory period, which are important spike processing mechanisms in biological neurons, can all be achieved in the optically-injected DFB laser. The experimental findings are also verified numerically with a rate equation model that considers the SMOPI. To the best of our knowledge, this is the first experimental demonstration of a photonic spiking neuron based on a DFB laser subject to SMOPI, which holds promise for realizing large-scale photonic spiking neuron arrays for hardware photonic spiking neural network chips.

关键词： neuromorphic photonics photonic spiking neuron DFB laser side-mode optical pulse injections

Accelerated generation of holograms with ultra-low memory symmetrically high-compressed look-up table

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Chinese Physics B 2024年第4期33卷 466-471页

作者：杨燕朱建英孙敏远毕勇 applied Laser Research Center Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China university of Chinese Academy of sciences Beijing 100049China

Computer-generated holography technology has been widely applied,and as research in this field deepens,the demand for memory and computational power in small AR and VR devices continues to *** paper presents a hologram generation method,i.e.,a symmetrically high-compressed look-up table method,which can reduce memory usage by50%.In offline computing,half of the basic horizontal and vertical modulation factors are stored,halving the memory requirements without affecting inline ***,its potential extends to various holographic applications,including the production of optical diffraction elements.

关键词： computergenerated hologram look-up table holography

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Antimicrobial,antibiofilm,angiogenesis,anti-inflammatory,and wound healing activities of zinc nanoparticles green synthesized using Ferula macrecolea extract

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Asian Pacific Journal of Tropical Biomedicine 2024年第6期14卷 259-268页

作者： Sultan F.Alnomasy Department of Medical Laboratories sciences College of Applied Medical SciencesShaqra UniversityAl-Quwayiyah 19257Saudi Arabia

Objective:To assess the antimicrobial,antibiofilm,anti-inflammatory,angiogenic,and wound healing activities of zinc nanoparticles(ZNPs)green synthesized using Ferula macrecolea ***:The green synthesis was conducted using the precipitation ***,the minimum inhibitory concentration(MIC),minimum bactericidal concentration(MBC),and minimum biofilm inhibition concentration 50%(MBIC50)of ZNPs against Staphylococcus aureus(***)and Pseudomonas aeruginosa(***)were *** effects of ZNPs on the gene expressions of Staphylococcus spp.[intracellular adhesion A(icaA)and D(icaD)]and ***(rhlI and rhlR)were investigated using quantitative real-time *** addition,the effects of ZNPs on wound healing,angiogenesis,and anti-inflammatory markers were ***:The green-synthesized ZNPs demonstrated significant antimicrobial efficacy against *** and *** biofilm formation in *** and *** was also inhibited by ZNPs with MBIC50 values of 3.30μg/mL and 2.08μg/mL,***,ZNPs downregulated the expression of biofilm-related genes icaA,icaD,rhlI,and rhlR in the tested *** also demonstrated promising in vitro wound healing effects by promoting fibroblast cell proliferation and wound closure in a dose-dependent manner.A significant increase in the expression of HLA-G5 and VEGF-A genes as well as a marked decrease in the expression of NF-κB,IL-1β,and TNF-αgenes were observed in cells treated with ZNPs compared to the control group(P<0.05).Conclusions:ZNPs display promising antibacterial effects against *** and *** and wound-healing effects by inhibiting biofilm formation,inducing angiogenesis,and reducing ***,further studies must be conducted to specify the accurate mechanisms of action and toxicity of ZNPs.

关键词： Wound healing Antibacterial Angiogenesis Nanomedicine Ferula macrecolea Inflammation