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Log-normal flux distribution of bright Fermi blazars

Research in Astronomy and Astrophysics 2018年第11期18卷 111-122页

作者： Zahir Shah Nijil Mankuzhiyil Atreyee Sinha Ranjeev Misra Sunder Sahayanathan Naseer Iqbal Department Of Physics University of KashmirSrinagar-190006India Astrophysical Sciences Division Bhabha Atomic Research CentreMumbai-400085India in Inter-university Centre for Astronomy and Astrophysics Pune-411007India AstroParticule et Cosmoligie CNRS/University Paris Diderot10Rue Alice Domon et Leonie DuquetParis 75013France

We present the results of the γ-ray flux distribution study on the brightest blazars which were observed by Fermi-LAT. We selected 50 of the brightest blazars based on the maximum number of detections reported in the Third LAT AGN Catalog. We performed standard unbinned maximum likelihood analysis on the LAT data during the period between August 2008 and December 2016, in order to obtain the average monthly flux. After quality cuts, blazars for which at least 90% of the total flux had survived were selected for further study, and this included 19 FSRQs and 19 BL Lacs. The Anderson-Darling and χ2 tests suggest that the integrated monthly flux follows a log-normal distribution for all sources, except for three FSRQs for which neither a normal nor a log-normal distribution was preferred. A double log-normal flux distribution tendency was observed in these sources, though this has to be confirmed with improved statistics. We also found that the standard deviation of the log-normal flux distribution increases with the mean spectral index of the blazar, and can be fitted with a line of slope 0.24±0.04. We repeat our study on three additional brightest unclassified blazars to identify their flux distribution properties. Based on the features of their log-normal flux distribution, we infer these unclassified blazars may be closely associated with FSRQs. We also highlight that considering the lognormal behavior of the flux distribution of blazars, averaging their long term flux on a linear scale can largely underestimate the nominal flux and this discrepancy can propagate down to the estimation of source parameters through spectral modeling.

关键词： active galaxy: blazar FSRQ BL Lac gamma-rays

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New trends in colorectal surgery: Single port and natural orifice techniques

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World Journal of Gastroenterology 2014年第48期20卷 18104-18120页

作者： Ronald Daher Elie Chouillard Yves Panis Department of General and Digestive Surgery Poissy/Saint-Germain Medical Center 78300Poissy France Department of Colorectal Surgery Beaujon Hospital Assistance Publique Hopitaux de Paris University Denis Diderot (Paris VII) 75013 Clichy France

Single-incision laparoscopic surgery (SILS) and natural orifice transluminal endoscopic surgery (NOTES) have rapidly gained pace worldwide, potentially replacing conventional laparoscopic surgery (CLS) as the preferred colorectal surgery technique. Currently available data mainly consist of retrospective series analyzed in four meta-analyses. Despite conflicting results and lack of an objective comparison, SILS appears to offer cosmetic advantages over CLS. However, due to conflicting results and marked heterogeneity, present data fail to show significant differences in terms of operative time, postoperative morbidity profiles, port-site complications rates, oncological appropriateness, duration of hospitalization or cost when comparing SILS with conventional laparoscopy for colorectal procedures. The application of “pure” NOTES in humans remains limited to case reports because of unresolved issues concerning the ideal access site, distant organ reach, spatial orientation and viscera closure. Alternatively, minilaparoscopy-assisted natural orifice surgery techniques are being developed. The transanal “down-to-up” total mesorectum excision has been derived for transanal endoscopic microsurgery (TEM) and represents the most encouraging NOTES-derived technique. Preliminary experiences demonstrate good oncological and functional short-term outcomes. Large-scale randomized controlled trials are now mandatory to confirm the long-term SILS results and validate transanal TEM for the application of NOTES in humans.

关键词： Surgery Colon Rectum Cancer Laparoscopy Single-port Natural orifice transluminal endoscopic surgery

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Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy

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Translational Neurodegeneration 2018年第1期7卷 54-62页

作者： Seyedeh Maryam Alavi Naini Constantin Yanicostas Rahma Hassan-Abdi Sébastien Blondeel Mohamed Bennis Ryan J.Weiss Yitzhak Tor Jeffrey D.Esko Nadia Soussi-Yanicostas PROTECT InsermUniversitéParis DiderotSorbonne Paris CitéParisFrance Institut de Biologie paris Seine-Laboratoire Neuroscience paris Seine Inserm UMRS 1130CNRS UMR 8246UPMC UM 118UniversitéPierre et Marie CurieParisFrance Cadi Ayyad university MarrakeshMorocco Department of Chemistry and Biochemistry University of CaliforniaSan DiegoLa JollaCAUSA Department of Cellular and Molecular Medicine University of CaliforniaSan DiegoLa JollaCAUSA

Background:Tauopathies comprise a family of neurodegenerative disorders including Alzheimer’s disease for which there is an urgent and unmet need for disease-modifying *** are characterized by pathological tau hyperphosphorylation,which has been shown to correlate tightly with disease progression and memory loss in patients suffering from Alzheimer’s *** recently demonstrated an essential requirement for 3-O-sulfated heparan sulfate in pathological tau hyperphosphorylation in zebrafish,a prominent model organism for human drug ***,we investigated whether in vivo treatment with surfen or its derivatives oxalyl surfen and hemisurfen,small molecules with heparan sulfate antagonist properties,could mitigate tau hyperphosphorylation and neuronal deficits in a zebrafish model of ***:In vivo treatment of Tg[HuC::hTau^(P301L);DsRed]embryos for 2 days with surfen or oxalyl surfen significantly reduced the accumulation of the pThr181 tau phospho-epitope measured by ELISA by 30%and 51%,*** blot analysis also showed a significant decrease of pThr181 and pSer396/pSer404 in embryos treated with surfen or oxalyl *** analysis further confirmed that treatment with surfen or oxalyl surfen significantly decreased the AT8 tau epitope in spinal *** addition,in vivo treatment of Tg[HuC::hTau^(P301L);DsRed]embryos with surfen or oxalyl surfen significantly rescued spinal motoneuron axon-branching defects and,as a likely consequence,the impaired stereotypical touch-evoked escape ***,treatment with hemisurfen,a surfen derivative devoid of heparan sulfate antagonist activity,does not affect tau hyperphosphorylation,nor neuronal or behavioural deficits in Tg[HuC::hTau^(P301L);DsRed]***:Our findings demonstrate for the first time that surfen,a well-tolerated molecule in clinical settings,and its derivative,oxalyl surfen,could mitigate or delay neuronal defects

关键词： Tauopathy Zebrafish Alzheimer’s disease Tau protein Tau hyperphosphorylation Surfen Oxalyl surfen Heparan sulfate

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On a certain non-split cubic surface

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Science China Mathematics 2019年第12期62卷 2435-2446页

作者： Regis de la Breteche Kevin Destagnol Jianya Liu Jie Wu Yongqiang Zhao Institut de Mathematiques de Jussieu Universite Paris-DiderotParis 75205France IST Austria Klosterneuburg 3400Austria School of Mathematics Shandong UniversityJinan 250100China Laboratoire d'Analyse et de Mathematiques Appliquees Univer site Paris-Est CreteilCNRSUMR 8050Creteil 94010France School of Science Westlake UniversityHangzhou 310024China

This paper establishes an asymptotic formula with a power-saving error term for the number of rational points of bounded height on the singular cubic surface of P3 Qgiven by the following equation x0（x12+ x22）-x33= ... 详细信息

关键词： Manin-Peyre conjecture rational points singular cubic surface non-split toric surface descent on torsors asymptotic formula

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Structure-based Comparative Analysis and Prediction of N-linked Glycosylation Sites in Evolutionarily Distant Eukaryotes

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Genomics, Proteomics & Bioinformatics 2013年第2期11卷 96-104页

作者： Phuc Vinh Nguyen Lam Radoslav Goldman Konstantinos Karagiannis Tejas Narsule Vahan Simonyan Valerii Soika Raja Mazumder Life Sciences Department Paris Diderot University Department of Biochemistry and Molecular Biology George Washington University Medical Center Department of Oncology Georgetown University Center for Biologics Evaluation and Research Food and Drug Administration

The asparagine-X-serine/threonine （NXS/T） motif, where X is any amino acid except proline, is the consensus motif for N-linked glycosylation. Significant numbers of high-resolution crystal structures of glycosylated proteins allow us to carry out structural analysis of the N-linked glycosylation sites （NGS）. Our analysis shows that there is enough structural information from diverse glycoproteins to allow the development of rules which can be used to predict NGS. A Python-based tool was developed to investigate asparagines implicated in N-glycosylation in five species： Homo sapiens, Mus musculus, Drosophila melanogaster, Arabidopsis thaliana and Saccharo- myees cerevisiae. Our analysis shows that 78 % of all asparagines of NXS/T motif involved in N-gly- cosylation are localized in the loop/turn conformation in the human proteome. Similar distribution was revealed for all the other species examined. Comparative analysis of the occurrence of NXS/T motifs not known to be glycosylated and their reverse sequence （S/TXN） shows a similar distribu- tion across the secondary structural elements, indicating that the NXS/T motif in itself is not bio- logically relevant. Based on our analysis, we have defined rules to determine NGS. Using machine learning methods based on these rules we can predict with 93% accuracy if a particular site will be glycosylated. If structural information is not available the tool uses structural prediction results resulting in 74% accuracy. The tool was used to identify glycosylation sites in 108 human proteins with structures and 2247 proteins without structures that have acquired NXS/T site/s due to non-synonymous variation. The tool, Structure Feature Analysis Tool （SFAT）, is freely available to the public at http：//***/tools/sfat.

关键词： N-linked glycosylation Gain and loss of glycosyla-tion nsSNP nsSNV Variation

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Common Language

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Psychology Research 2017年第6期7卷 330-334页

作者： Houria Abdelouahed Universite paris-diderot Paris France

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A Formal Passage From a System of Boltzmann Equations for Mixtures Towards a Vlasov-Euler System of Compressible Fluids

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Acta Mathematicae Applicatae Sinica 2019年第1期35卷 158-173页

作者： Laurent DESVILLETTES Fran?ois GOLSE Valeria RICCI Université paris diderot Sorbonne Paris Cité Institut de Mathématiques de Jussieu-Paris Rive GaucheUMR CNRS 7586 CNRS Sorbonne Universités UPMC Univ CMLS Ecole polytechnique et CNRS Université Paris-Saclay Dipartimento di Matematica e Informatica Università degli Studi di Palermo

A formal asymptotics leading from a system of Boltzmann equations for mixtures towards either Vlasov-Navier-Stokes or Vlasov-Stokes equations of incompressible fluids was established by the same authors and Etienne Bernard in: A Derivation of the Vlasov-Navier-Stokes Model for Aerosol Flows from Kinetic Theory Commun. Math. Sci., 15: 1703–1741(2017) and A Derivation of the Vlasov-Stokes System for Aerosol Flows from the Kinetic Theory of Binary Gas Mixtures. KRM, 11: 43–69(2018). With the same starting point but with a different scaling, we establish here a formal asymptotics leading to the Vlasov-Euler system of compressible fluids. Explicit formulas for the coupling terms are obtained in two typical situations: for elastic hard spheres on one hand, and for collisions corresponding to the inelastic interaction with a macroscopic dust speck on the other hand.

关键词： Vlasov-Euler system Boltzmann equation Hydrodynamic limit Aerosols Sprays Gas mixture

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上海精神医学 2014年第4期26卷 243-244页

作者： Bruno MEGARBANE Anne-Sophie HANAK Lucie CHEVILLARD Assistance Publique–Hopitaux de paris Hopital LariboisiereLaboratoire de Toxicologie biologique Inserm U1144 Universite paris Descartes Universite paris diderot

We would like to comment on the interesting case report of lithium intoxication reported by Jing Peng.[1]An 18-year old female with mania developed confusion,trembling extremities,slurred speech,increased muscle tension,and hyperactive tendon reflexes 20 days after initiating treatment with routine dosages of lithium *** admitted to the hospital due to her acute neurological condition,her serum lithium concentration was in the therapeutic range(0.57 mmol/L).Most of her symptoms spontaneously reversed one

关键词： Serum concentration Neurotoxicity treatment

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Evaluation of antiangiogenic efficacy in advanced hepatocellular carcinoma: Biomarkers and functional imaging

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World Journal of Hepatology 2015年第20期7卷 2245-2263页

作者： Mohamed Bouattour Audrey Payancé Johanna Wassermann Department of Hepatology Beaujon University Hospital (AP-HP - Paris 7 Diderot) Department of Medical Oncology La Pitié-Salpêtrière University Hospital (AP-HP - Paris 6 Pierre et Marie Curie)

Many years after therapeutic wilderness, sorafenib finally showed a clinical benefit in patients with advanced hepatocellular carcinoma. After the primary general enthusiasm worldwide, some disappointments emerged particularly since no new treatment could exceed or at least match sorafenib in this setting. Without these new drugs, research focused on optimi-zing care of patients treated with sorafenib. One challenging research approach deals with identifying prognostic and predictive biomarkers of sorafenib in this population. The task still seems difficult; however appropriate investigations could resolve this dilemma, as observed for some malignancies where other drugs were used.

关键词： Hepatocellular carcinoma Antiangiogenic therapies

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Macroscale fluorescence imaging against autofluorescence under ambient light

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Light(Science & Applications) 2018年第1期7卷 151-162页

作者： Ruikang Zhang Raja Chouket Marie-Aude Plamont Zsolt Kelemen Agathe Espagne Alison G.Tebo Arnaud Gautier Lionel Gissot Jean-Denis Faure Ludovic Jullien Vincent Croquette Thomas Le Saux PASTEUR Département de ChimieÉcole Normale SupérieurePSL UniversitySorbonne UniversitéCNRS75005 ParisFrance Institut Jean-Pierre Bourgin INRAAgroParisTechCNRSSaclay Plant Science(SPS)UniversitéParis-SaclayVersaillesFrance Laboratoire de Physique Statistique École Normale SupérieurePSL Research UniversityUniversitéParis Diderot Sorbonne Paris-CitéSorbonne UniversitéCNRS75005 ParisFrance Institut de biologie de l’École normale supérieure(IBENS) École Normale SupérieureCNRSINSERMPSL Research University75005 ParisFrance

Macroscale fluorescence imaging is increasingly used to observe biological ***,it may suffer from spectral interferences that originate from ambient light or autofluorescence of the sample or its *** this manuscript,we built a simple and inexpensive fluorescence macroscope,which has been used to evaluate the performance of Speed OPIOM(Out of Phase Imaging after Optical Modulation),which is a reference-free dynamic contrast protocol,to selectively image reversibly photoswitchable fluorophores as labels against detrimental autofluorescence and ambient *** tuning the intensity and radial frequency of the modulated illumination to the Speed OPIOM resonance and adopting a phase-sensitive detection scheme that ensures noise rejection,we enhanced the sensitivity and the signal-to-noise ratio for fluorescence detection in blot assays by factors of 50 and 10,respectively,over direct fluorescence observation under constant ***,we overcame the strong autofluorescence of growth media that are currently used in microbiology and realized multiplexed fluorescence observation of colonies of spectrally similar fluorescent bacteria with a unique configuration of excitation and emission ***,we easily discriminated fluorescent labels from the autofluorescent and reflective background in labeled leaves,even under the interference of incident light at intensities that are comparable to *** proposed approach is expected to find multiple applications,from biological assays to outdoor observations,in fluorescence macroimaging.

关键词： ambient illumination light

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