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Risk factors for hepatocellular carcinoma associated with hepatitis C genotype 3 infection:A systematic review

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1596-1612页

作者： Hamzah Z Farooq Michael James Jane Abbott Patrick Oyibo Pip Divall Naheed Choudhry Graham R Foster Blizard Institute Queen Mary University of LondonLondon E12ATUnited Kingdom School of Health and Psychological Sciences University of LondonLondon EC1V 0HBUnited Kingdom university hospitals of leicester library University Hospitals of Leicester NHS TrustLeicester LE39QPUnited Kingdom

BACKGROUND Hepatitis C virus(HCV)is a blood-borne virus which globally affects around 79 million people and is associated with high morbidity and *** infection leads to cirrhosis in a large proportion of patients and often causes hepatocellular carcinoma(HCC)in people with *** the 6 HCV genotypes(G1-G6),genotype-3 accounts for 17.9%of *** genotype-3 responds least well to directly-acting antivirals and patients with genotype-3 infection are at increased risk of HCC even if they do not have *** To systematically review and critically appraise all risk factors for HCC secondary to HCV-G3 in all ***,we studied possible risk factors for HCC due to HCV-G3 in the literature from 1946 to *** This systematic review aimed to synthesise existing and published studies of risk factors for HCC secondary to HCV genotype-3 and evaluate their strengths and *** searched Web of Science,Medline,EMBASE,and CENTRAL for publications reporting risk factors for HCC due to HCV genotype-3 in all settings,*** Four thousand one hundred and forty-four records were identified from the four databases with 260 records removed as *** thousand eight hundred and eighty-four records were screened with 3514 *** hundred and seventy-one full-texts were assessed for eligibility with seven studies included for *** the seven studies,three studies were retrospective case-control trials,two retrospective cohort studies,one a prospective cohort study and one a cross-sectional study *** were based in hospital settings with four in Pakistan,two in South Korea and one in the United *** total number of participants were 9621 of which 167 developed HCC(1.7%).All seven studies found cirrhosis to be a risk factor for HCC secondary to HCV genotype-3 followed by higher age(five-studies),with two studies each showing male sex,high alpha feto-protein,directly-acting antivirals trea

关键词： Hepatocellular carcinoma Hepatitis C Genotype 3 Systematic review Blood-borne viruses Liver cancer

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Not in Control,but Liable?Attributing Human Responsibility for Fully Automated Vehicle Accidents

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Engineering 2024年第2期33卷 121-132页

作者： Siming Zhai Lin Wang Peng Liu Center for Psychological Sciences Zhejiang UniversityHangzhou 310063China Department of library and Information Science Incheon National UniversityIncheon 22012Republic of Korea

Human agency has become increasingly limited in complex systems with increasingly automated decision-making *** instance,human occupants are passengers and do not have direct vehicle control in fully automated cars(i.e.,driverless cars).An interesting question is whether users are responsible for the accidents of these *** ethical and legal analyses frequently argue that individuals should not bear responsibility for harm beyond their ***,we consider human judgment of responsibility for accidents involving fully automated cars through three studies with seven experiments(N=2668).We compared the responsibility attributed to the occupants in three conditions:an owner in his private fully automated car,a passenger in a driverless robotaxi,and a passenger in a conventional taxi,where none of these three occupants have direct vehicle control over the involved vehicles that cause identical pedestrian *** contrast to normative analyses,we show that the occupants of driverless cars(private cars and robotaxis)are attributed more responsibility than conventional taxi *** dilemma is robust across different contexts(e.g.,participants from China vs the Republic of Korea,participants with first-vs third-person perspectives,and occupant presence vs absence).Furthermore,we observe that this is not due to the perception that these occupants have greater control over driving but because they are more expected to foresee the potential consequences of using driverless *** findings suggest that when driverless vehicles(private cars and taxis)cause harm,their users may face more social pressure,which public discourse and legal regulations should manage appropriately.

关键词： Fully automated vehicle accidents Responsibility attribution Controllability Foreseeability

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Research on Bast Fiber Extracted from the White Bark of Three Species in the Genus Broussonetia

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Chinese Journal of Polymer Science 2024年第6期42卷 729-738页

作者： Shan-Shan Jin Si-Nong Wang Yan-Yan Huang Jing-Yu Zhang Peng Liu Hui Yu Hong-Dong Zhang Yu-Liang Yang Institute for Preservation and Conservation of Chinese Ancient Books Fudan University LibraryFudan UniversityShanghai200433China State key laboratory of Molecular Engineering of polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China

Against the backdrop of a global paper resource shortage,there is a growing need to identify fast-growing tree species capable of producing long-lasting *** plant species namely Broussonetia kazinoki,Broussonetia papyrifera and hybrid paper mulberry,belong to the Broussonetia genus,were collected from China to study their white bark suitability for pulp and *** chemical composition revealed that the holocellulose content in Broussonetia kazinoki and Broussonetia papyrifera was more than 80%.The molecular weight distribution of several holocellulose/α-cellulose is observed by GPC,which allows us to better observe the changes of various components on the molecular *** yield,lignin,whiteness,and molecular weight of the pulps obtained by NaOH treatment were *** microscope was used to characterize the fiber length-width ratio and ***,the improvement of the fiber rigidity method based on the Kratky-Porod chain model makes it more theoretical and further reveals the influencing factors of fiber *** study demonstrates the high potentiality of these three species for papermaking applications.

关键词： Broussonetia genus Cellulose Alkaline pulping Kratky-Porod chain model Fiber rigidity

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Trends in Event Understanding and Caption Generation/Reconstruction in Dense Video:A Review

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Computers, Materials & Continua 2024年第3期78卷 2941-2965页

作者： Ekanayake Mudiyanselage Chulabhaya Lankanatha Ekanayake Abubakar Sulaiman Gezawa Yunqi Lei Department of Computer Science Xiamen UniversityXiamen361005China Main library Wayamba University of Sri LankaKuliyapitiya60200Sri Lanka School of Information Engineering Sanming UniversitySanming365004China

Video description generates natural language sentences that describe the subject,verb,and objects of the targeted *** video description has been used to help visually impaired people to understand the *** is also playing an essential role in devolving human-robot *** dense video description is more difficult when compared with simple Video captioning because of the object’s interactions and event *** learning is changing the shape of computer vision(CV)technologies and natural language processing(NLP).There are hundreds of deep learning models,datasets,and evaluations that can improve the gaps in current *** article filled this gap by evaluating some state-of-the-art approaches,especially focusing on deep learning and machine learning for video caption in a dense *** this article,some classic techniques concerning the existing machine learning were *** provides deep learning models,a detail of benchmark datasets with their respective *** paper reviews various evaluation metrics,including Bilingual EvaluationUnderstudy(BLEU),Metric for Evaluation of Translation with Explicit Ordering(METEOR),WordMover’s Distance(WMD),and Recall-Oriented Understudy for Gisting Evaluation(ROUGE)with their pros and ***,this article listed some future directions and proposed work for context enhancement using key scene extraction with object detection in a particular ***,how to improve the context of video description by analyzing key frames detection through morphological image ***,the paper discusses a novel approach involving sentence reconstruction and context improvement through key frame object detection,which incorporates the fusion of large languagemodels for refining *** ultimate results arise fromenhancing the generated text of the proposedmodel by improving the predicted text and isolating objects using various *** keyframes identify dense ev

关键词： Video description video to text video caption sentence reconstruction

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Perceptions and Controversies on Cholera in the Traditional Chinese Medicine Field in the Late Qing Dynasty

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Chinese Medicine and Culture 2024年第2期7卷 143-151页

作者： GUO Shiqiang WU Haohuan WU Yinghua The Department of History College of Liberal Arts Of Jinan UniversityGuangzhou 510632China Jinan university library Jinan UniversityGuangzhou 510632China

At the beginning of the initial cholera outbreak in China,Wang Qingren(王清任),after years of clinical trials,became an early representative who discovered the infectious characteristics and observed the course of cholera in the field of traditional Chinesse medicine(TCM).Kou Langao(寇兰皋)and Xu Zimo(徐子默),both medical practitioners,constructed a diagnosis and treatment system for cholera with cold patterns under the theory of *** represented“School of Cholera with Cold Patterns”(SCCP).In the 1860s,with the influence of Wang Shixiong’s(王士雄)studies on the nature of cholera under the theory of epidemic febrile disease,the“School of Cholera with Heated Patterns”(SCHP)prevailed *** two schools complemented each other in theories and contributed to the integrity of TCM in cholera diagnosis and *** reviewing previous literature,books,clinical cases,and historical materials in medical field,this article aims 1)to summarise the influence of TCM on the cognitive development towards cholera in the late Qing dynasty;2)to explore the origin of the controversy between SCCP and SCHP from historical evidence;3)to summarize the historical lessons from the debate over cholera in TCM based on the principle of treatment based on pattern identification,and offer suggestions for the current prevention and treatment of new diseases using TCM.

关键词： Traditional Chinese medicine Cholera School of Cholera with Cold Patterns School of Cholera with Heated Patterns Wang Shixiong Xu Zimo

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Paper Analysis of Shanghai Ocean university in Bibliometric Method from Web of Science

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Journal of Applied Mathematics and Physics 2024年第2期12卷 632-638页

作者： Jia Jiang The library Shanghai Ocean University Shanghai

The data of this research was mainly collected from the Web of Science (WOS) and Incites database platform, which was filtered and cataloged according to the different platforms. For tracing the change in scientific research at Shanghai Ocean university, make use of Bibliometric analysis to get the image and table of highly cited papers and hot papers. In this study, the scientific aspects in highly cited papers and hot papers, published in the last year in the core collection of Web of Science, were taken as objects, and office software was used as the main tool to carry out bibliometric and figure analysis. From the four aspects to find the difference in these fields, the production of specific fields and cited times is inconsistent. And suggest the department and management adjust the policy and method via elastic personnel and rewards to prompt the advancement of the research fields.

关键词： Highly Cited Papers Hot Paper Shanghai Ocean university Comparison Cited Times Author

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Amend:An integrated platform of retracted papers and concerned papers

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Journal of Data and Information Science 2024年第2期9卷 41-55页

作者： Menghui Li Fuyou Chen Sichao Tong Liying Yang Zhesi Shen National Science library Chinese Academy of SciencesBeijing 100190China Department of Information Resources Management School of Economics and ManagementUniversity of Chinese Academy of SciencesBeijing 100190China

Purpose:The notable increase in retraction papers has attracted considerable attention from diverse *** sources are now offering information related to research integrity,including concerns voiced on social media,disclosed lists of paper mills,and retraction notices accessible through journal ***,despite the availability of such resources,there remains a lack of a unified platform to consolidate this information,thereby hindering efficient searching and ***,it is imperative to develop a comprehensive platform for retracted papers and related *** article aims to introduce“Amend,”a platform designed to integrate information on research integrity from diverse ***/methodology/approach:The Amend platform consolidates concerns and lists of problematic articles sourced from social media platforms(e.g.,PubPeer,For Better Science),retraction notices from journal websites,and citation databases(e.g.,Web of Science,CrossRef).Moreover,Amend includes investigation and punishment announcements released by administrative agencies(e.g.,NSFC,MOE,MOST,CAS).Each related paper is marked and can be traced back to its information source via a provided ***,the Amend database incorporates various attributes of retracted articles,including citation topics,funding details,open access status,and *** reasons for retraction are identified and classified as either academic misconduct or honest errors,with detailed subcategories provided for further ***:Within the Amend platform,a total of 32,515 retracted papers indexed in SCI,SSCI,and ESCI between 1980 and 2023 were *** these,26,620(81.87%)were associated with academic *** retraction rate stands at 6.64 per 10,000 ***,the retraction rate for non-gold open access articles significantly differs from that for gold open access articles,with this disparity progressively widening over the ***,the reasons

关键词： Research Integrity Retraction Rate Academic Misconduct Reasons for Retraction Temporal Trends

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T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1277-1292页

作者： Yuxiao Zheng Zilin Ren Ying Liu Juntang Yan Congai Chen Yanhui He Yuyu Shi Fafeng Cheng Qingguo Wang Changxiang Li Xueqian Wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina library Beijing University of Chinese MedicineBeijingChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue *** the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the *** an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune *** review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic *** found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic ***1,Th17,and M1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain ***2,Treg,and M2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke *** trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic ***,such studies have been relatively infrequent,and clinical experience is still *** summary,in ischemic stroke,T cell subsets and activated micro

关键词： brain immune inflammation interaction ischemic stroke mechanism microglia neuron secondary injury T cells

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Tendoscopic Surgery for Peroneal Tendons Instability: A Literature Review

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Open Journal of Orthopedics 2024年第3期14卷 139-148页

作者： Islam Mubark Amr Abouelela Mahmoud Elbakry Tarek El Gamal Department of Trauma and Orthopaedics University Hospitals Birmingham NHS Foundation Trust Birmingham UK Department of Trauma and Orthopaedics Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK Department of Trauma and Orthopaedics University Hospitals of Derby and Burton NHS Foundation Trust Derby UK

Introduction: There has been a surge in the use of tendoscopic surgery for treating peroneal tendons instability. The novelty of this approach demanded a literature review of its indications, limitations, and clinical outcomes. Aim: a literature review of the clinical studies reporting on tendoscopic peroneal tendon stabilisation surgery along with its outcomes and complications. Methods: We carried out a comprehensive review of the literature up until September 2022 with an extensive search of the MEDLINE, Embase and Cochrane library databases. Results: Initial search resulted in 66 articles. Four duplicate articles were removed. Further 30 articles were excluded after title and abstract screening. Eight studies satisfied the inclusion criteria and were included in this review. Articles were analysed for outcomes and complications. Conclusion: The tendoscopic technique for peroneal tendon instability is an effective and safe surgical technique with very low failure rate. Levels of Evidence: Level IV.

关键词： Peroneal Tendons Instability Tendoscopy

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Measuring drug similarity using drug–drug interactions

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Quantitative Biology 2024年第2期12卷 164-172页

作者： Ji Lv Guixia Liu Yuan Ju Houhou Huang Ying Sun College of Computer Science and Technology Jilin UniversityChangchunChina Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin UniversityChangchunChina Sichuan university library Sichuan UniversityChengduChina College of Chemistry Jilin UniversityChangchunChina Department of Respiratory Medicine The First Hospital of Jilin UniversityChangchunChina

Combination therapy is a promising approach to address the challenge of antimicrobial resistance,and computational models have been proposed for predicting drug–drug *** existing models rely on drug similarity measures based on characteristics such as chemical structure and the mechanism of *** this study,we focus on the network structure itself and propose a drug similarity measure based on drug–drug interaction *** explore the potential applications of this measure by combining it with unsupervised learning and semi-supervised learning *** unsupervised learning,drugs can be grouped based on their interactions,leading to almost monochromatic group–group *** addition,drugs within the same group tend to have similar mechanisms of action(MoA).In semi-supervised learning,the similarity measure can be utilized to construct affinity matrices,enabling the prediction of unknown drug–drug *** method exceeds existing approaches in terms of ***,our experiments demonstrate the effectiveness and practicability of the proposed similarity *** the one hand,when combined with clustering algorithms,it can be used for functional annotation of compounds with unknown *** the other hand,when combined with semi-supervised graph learning,it enables the prediction of unknown drug–drug interactions.

关键词： drug similarity drug–drug interactions drug combinations synergy effect clustering semi-supervised learning

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