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Beta-lactam antibiotic resistance among Escherichia coli isolates from patients with urinary tract infections in Vietnam:A systematic review and meta-analysis

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亚太热带医药杂志（英文版） 2024年第6期17卷 243-255,中插1-中插3页

作者： Dat T Nguyen Princess Margaret Cancer Centre University Health NetworkToronto0ntarioCanada

Objective:To investigate the evolving patterns of antimicrobial resistance against beta-lactam antibiotics in Escherichia coli isolates from urinary tract infection patients in Vietnam,covering the period from 2005 to 2022.Methods:29 Descriptive studies published between 2010 and 2022 in English and Vietnamese were included in the *** on resistance rates to beta-lactam antibiotics,including cephalosporins and carbapenems,were extracted and *** pooled resistance rates were calculated using random-effects *** trends in resistance were assessed using linear regression analysis.Results:Among the beta-lactam antibiotics studied,Escherichia coli exhibited varying levels of resistance,with cephalosporins showing higher resistance rates compared to *** pooled resistance rates were 66％for cefotaxime,65％for ceftriaxone,54％for ceftazidime,and 56％for *** contrast,carbapenems demonstrated lower resistance rates,with weighted pooled resistance rates ranging from 3％to 4％for meropenem,ertapenem,and *** rates were also observed for amoxicillin/clavulanate(35％),ticarcillin/clavulanate(26％),and piperacillin/tazobactam(12％).Significant annual increases in resistance were noted for imipenem(0.56％,P＜0.001).Conclusions:This study highlights the critical issue of antimicrobial resistance in urinary tract infections in Vietnam and emphasizes the importance of prudent antibiotic use and the regular monitoring of resistance *** insights are useful for guiding healthcare professionals in optimizing treatment strategies and for policymakers in formulating evidence-based clinical guidelines to combat antibiotic resistance effectively.

关键词： Antimicrobial resistance Urinary tract infection Vietnam

Mapping the metabolic responses to oxaliplatin-based chemotherapy with in vivo spatiotemporal metabolomics

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Journal of Pharmaceutical Analysis 2024年第2期14卷 196-210页

作者： Mariola Olkowicz Khaled Ramadan Hernando Rosales-Solano Miao Yu Aizhou Wang Marcelo Cypel Janusz Pawliszyn Department of Chemistry University of WaterlooWaterlooONCanada Jagiellonian Centre for Experimental Therapeutics(JCET) Jagiellonian UniversityKrakowPoland Latner Thoracic Surgery Research Laboratories Toronto General Hospital Research InstituteUniversity Health NetworkTorontoONCanada The Jackson Laboratory JAX Genomic MedicineFarmingtonCTUSA Division of Thoracic Surgery Department of SurgeryUniversity Health NetworkUniversity of TorontoToronto Lung Transplant ProgramTorontoONCanada

Adjuvant chemotherapy improves the survival outlook for patients undergoing operations for lung metastases caused by colorectal cancer (CRC). However, a multidisciplinary approach that evaluates several factors related to patient and tumor characteristics is necessary for managing chemotherapy treatment in metastatic CRC patients with lung disease, as such factors dictate the timing and drug regimen, which may affect treatment response and prognosis. In this study, we explore the potential of spatial metabolomics for evaluating metabolic phenotypes and therapy outcomes during the local delivery of the anticancer drug, oxaliplatin, to the lung. 12 male Yorkshire pigs underwent a 3 h left lung in vivo lung perfusion (IVLP) with various doses of oxaliplatin (7.5, 10, 20, 40, and 80 mg/L), which were administered to the perfusion circuit reservoir as a bolus. Biocompatible solid-phase microextraction (SPME) microprobes were combined with global metabolite profiling to obtain spatiotemporal information about the activity of the drug, determine toxic doses that exceed therapeutic efficacy, and conduct a mechanistic exploration of associated lung injury. Mild and subclinical lung injury was observed at 40 mg/L of oxaliplatin, and significant compromise of the hemodynamic lung function was found at 80 mg/L. This result was associated with massive alterations in metabolic patterns of lung tissue and perfusate, resulting in a total of 139 discriminant compounds. Uncontrolled inflammatory response, abnormalities in energy metabolism, and mitochondrial dysfunction next to accelerated kynurenine and aldosterone production were recognized as distinct features of dysregulated metabolipidome. Spatial pharmacometabolomics may be a promising tool for identifying pathological responses to chemotherapy.

关键词： Pulmonary metastases Colorectal cancer Adjuvant chemotherapy In vivo lung chemo-perfusion Solid-phase microextraction(SPME)microprobes Spatial metabolomics

Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack W.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

Effects of Lycium barbarum polysaccharide on cytokines in adolescents with subthreshold depression:a randomized controlled study

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Neural Regeneration Research 2024年第9期19卷 2036-2040页

作者： Xiaoyue Li Tao Liu Xuan Mo Runhua Wang Xueyan Kong Robin Shao Roger S.Mclntyre Kwok-Fai So Kangguang Lin Department of Affective Disorders The Affiliated Brain Hospital of Guangzhou Medical University(Guangzhou Huiai Hospital)GuangzhouGuangdong ProvinceChina Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Psychiatry The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Mood Disorders Psychopharmacology Unit Poul Hansen Family Centre for DepressionUniversity Health NetworkTorontoONCanada Department of Psychiatry University of TorontoTorontoONCanada Brain and Cognition Discovery Foundation TorontoCanada Ministry of Education Joint International Research Laboratory of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Strong evidence has accumulated to show a correlation between depression symptoms and inflammatory ***,anti-inflammatory treatment has shown partial effectiveness in alleviating depression *** barbarum polysaccharide(LBP),derived from Goji berries,exhibits notable antioxidative and anti-inflammatory *** our recent double-blinded randomized placebo-controlled trial,we found that LBP significantly reduced depressive symptoms in adolescents with subthreshold *** is presumed that the antidepressant effect of LBP may be associated with its influence on inflammatory *** the double-blinded randomized controlled trial,we enrolled 29 adolescents with subthreshold depression and randomly divided them into an LBP group and a placebo *** the LBP group,adolescents were given 300 mg/d LBP.A 6-week follow up was completed by 24 adolescents,comprising 14 adolescents from the LBP group(15.36±2.06 years,3 men and 11 women)and 10 adolescents from the placebo group(14.9±1.6 years,2 men and 8 women).Our results showed that after 6 weeks of treatment,the interleukin-17A level in the LBP group was lower than that in the placebo *** analysis showed that LBP reduced the correlations and connectivity between inflammatory factors,which were associated with the improvement in depressive *** findings suggest that 6-week administration of LBP suppresses the immune response by reducing interleukin-17A level,thereby exerting an antidepressant effect.

关键词： adolescents cytokines efficacy Goji berry inflammatory responses interleukin-17A Lycium barbarum polysaccharide randomized controlled study subthreshold depression

Modulated symbol-based one-time pad secure transmission scheme using physical layer keys

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Science China(Information Sciences) 2024年第1期67卷 221-239页

作者： Xiaoyan HU Zheng WAN Kaizhi HUANG Liang JIN Mengyao YAN Yajun CHEN Jinmei YANG Information Engineering university Purple Mountain Laboratories for network and Communication Security

This paper proposes a novel modulated symbols-based one-time pad(SOTP) secure transmission scheme using physical layer *** classical physical layer key generation and exclusive OR(XOR)encryption in the discrete binary space,we design a framework for modulated symbols-based one-time pad(OTP) encryption,where the cryptographic primitive and mathematical model of SOTP is given to build a practical cryptographic *** with existing physical layer encryption(PLE) schemes,we provide rigorous proof that the framework can meet perfect secrecy and correctness *** addition,we provide a specific scheme of physical layer OTP secure transmission for quadrature amplitude modulation(QAM) and phase-shift keying(PSK) symbols based on physical layer *** scheme realizes the unification of bit encryption and symbol encryption,which can adaptively select the quantization level according to the signal-to-noise ratio(SNR) to minimize the symbol error rate(SER).Further,we analyze the performance quantitatively and derive the closed-form expressions of SER,which indicates that the proposed scheme has a lower ***,simulation results verify that the proposed symbol-wise OTP secure transmission scheme can achieve perfect secrecy and high reliability.

关键词： physical layer security one-time pad wireless channel physical layer encryption perfect secrecy

Sexual and Reproductive Service Interventions for Menstrual Regulation, Safe Abortion, and Post-abortion Care and Their Effectiveness During Disaster Response: A Global Systematic Review

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International Journal of Disaster Risk Science 2024年第3期15卷 359-373页

作者： Nibedita S.Ray-Bennett Winifred Ekezie Isha Biswas Nimra Iqbal Choudhary David Cowie Lasith Dissanayake Lauren Macleod Azukaeogo Nnaji Madhulika Sahoo School of Business University of Leicester Avoidable Deaths network University of Leicester Diabetes Research Centre Leicester General Hospital University of Leicester School of Social Sciences and Humanities Aston University Lifespan and Population health School of Medicine University of Nottingham School of Public health and Interdisciplinary Studies Auckland University of Technology Faculty of Life Sciences and Education University of South Wales West African Regional ECHO (WARE) APIN Public Health Initiatives Department of Anthropology Kalahandi University

Sexual and reproductive health(SRH) services are crucial for women especially during disasters, to reduce maternal mortality and morbidity from miscarriages, unsafe abortions, and post-abortion complications. This study explored the SRH interventions provided during disaster response. A systematic review was conducted to identify what menstrual regulation(MR), safe abortion(SA), and post-abortion care(PAC) approaches/interventions exist to promote resilience in the health system in disaster settings; what intervention components were most eff ective; and challenges and opportunities to meeting SRH rights. Five electronic databases were searched, resulting in 4194 records. Following the screening process, seven publications were included. The intervention-related information in each publication was assessed based on availability,accessibility, acceptability, and quality. Two SRH approaches/interventions were found. The eff ectiveness of intervention components could not be conducted due to the limited number of relevant studies. Challenges were found at facility and community levels, and opportunities included overcoming them, making MR, SA, and PAC integral to the mitigation phase,and policy change to overcome barriers related to unaff ordability and inaccessibility. Recommendations are provided to encourage research and policy towards improving neglected SRH in disaster settings to realize Sustainable Development Goal 3 and the Global Strategy and Sendai Framework's priority to promote disaster-resilient health systems.

关键词： Abortion Disasters Sendai framework Sexual and reproductive health Sustainable development goal

Coexistence of noise-like pulse and dark pulse in an Er/Yb co-doped fiber laser

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Chinese Optics Letters 2024年第5期22卷 68-74页

作者：李婧王春灿王鹏 Key Laboratory of All Optical network and Advanced Telecommunication network Ministry of EducationInstitute of Lightwave TechnologyBeijing Jiaotong UniversityBeijing 100044China

The coexistence of a noise-like pulse(NLP)and a dark pulse was experimentally demonstrated in a net-anomalous dispersion Er/Yb co-doped fiber(EYDF)laser,for the first time,to our *** cavity was mode-locked by nonlinear polarization rotation(NPR)***,a Sagnac loop with a section of polarization-maintaining fiber(PMF)was used as a comb filter to enable multiwavelength pulse *** the PMF length was 0.3 m,an asymmetric two-peak spectrum with central wavelengths of 1565.3 and 1594.2 nm was obtained by adjusting polarization controllers(PCs).It is a composite state of NLP and dark pulse due to the cross-phase modulation between the two different wavelength components along orthogonal polarization *** two pulses are synchronized with a repetition rate of 7.53 *** adjusting the PC in the Sagnac loop,the spectral ranges of NLPs and dark pulses can be tuned from 1560 to 1577.8 nm and from 1581.8 to 1605.4 nm,*** addition,the pulse characteristics were investigated by incorporating the PMF with different lengths,where the coexistence patterns can be generated when the PMF lengths were 0.2 and 0.3 m.A longer PMF can lead to a narrowband comb filtering,which causes a larger loss and is not favorable for stable operation of the coexistence *** fiber laser demonstrates an interesting operation regime and has significant potential for numerous practical applications.

关键词： coexistence state mode-locked fiber laser Sagnac loop tunable wavelength

Off-Grid Compressed Channel Estimation with Parallel Interference Cancellation for Millimeter Wave Massive MIMO

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China Communications 2024年第3期21卷 51-65页

作者： Liu Jinru Tian Yongqing Liu Danpu Zhang Zhilong Beijing Laboratory of Advanced Information network Beijing Key Laboratory of Network System Architecture and ConvergenceBeijing University of Posts and TelecommunicationsBeijing100876China

Millimeter wave(mmWave)massive multiple-input multiple-output(MIMO)plays an important role in the fifth-generation(5G)mobile communications and beyond wireless communication systems owing to its potential of high ***,channel estimation has become very challenging due to the use of massive MIMO antenna ***,the mmWave channel has strong sparsity in the spatial angle domain,and the compressed sensing technology can be used to convert the original channel matrix into the sparse matrix of discrete angle *** the high-dimensional channel matrix estimation is transformed into a sparse recovery problem with greatly reduced computational ***,the path angle in the actual scene appears randomly and is unlikely to be completely located on the quantization angle grid,thus leading to the problem of power ***,multiple paths with the random distribution of angles will bring about serious interpath interference and further deteriorate the performance of channel *** address these off-grid issues,we propose a parallel interference cancellation assisted multi-grid matching pursuit(PIC-MGMP)algorithm in this *** proposed algorithm consists of three stages,including coarse estimation,refined estimation,and inter-path cyclic iterative inter-ference *** specifically,the angular resolution can be improved by locally refining the grid to reduce power leakage,while the inter-path interference is eliminated by parallel interference cancellation(PIC),and the two together improve the estimation *** results show that compared with the traditional orthogonal matching pursuit(OMP)algorithm,the normalized mean square error(NMSE)of the proposed algorithm decreases by over 14dB in the case of 2 paths.

关键词： channel estimation compressed sensing inter-path interference millimeter wave massive MIMO off-grid parallel interference cancellation

Coherence analysis of noise-like pulses generated by an erbium-doped fiber mode-locked laser

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Optoelectronics Letters 2024年第4期20卷 205-210页

作者： ZHANG Ziyi WANG Chuncan LI Jing WANG Peng Key Laboratory of All Optical network and Advanced Telecommunication network Ministry of EducationInstitute of Lightwave TechnologyBeijing Jiaotong university Beijing 100044China

The noise-like pulses(NLPs)with tunable fraction of the pedestal height in the whole intensity autocorrelation(AC)trace are numerically demonstrated in the designed erbium-doped fiber(EDF)mode-locked laser,which contains the saturable absorber(SA)with nonlinear polarization rotation(NPR),sinusoidal-shaped or Gaussian-shaped filter,two segments of EDFs,and two pieces of single-mode fibers(SMFs)with normal dispersion and anomalous dispersion,*** pedestal ratio of the intensity AC trace can be tuned by changing the gain saturation energies of *** results show that when the net cavity dispersion is 1.06 ps^(2),the tuning range of the pedestal ratio for the NLPs can reach its maximum values,which are 0.51—0.89 and 0.58—0.88 for the sinusoidal-shaped and Gaussian-shaped filters,*** addition,an appropriate choice of filter bandwidth is also conducive to obtain a wide range of the tuning pedestal ratio for the intensity AC trace.

关键词： fiber tuning polarization