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Gut-liver axis in sepsis-associated liver injury:Epidemiology,challenges and clinical practice

World Journal of Gastroenterology 2025年第1期31卷 163-166页

作者： Fabiana Andréa Moura Aryana Isabelle de Almeida Neves Siqueira College of Nutrition Federal University of AlagoasMaceio 57072-970AlagoasBrazil College of Medicine Federal University of AlagoasMaceio 57072-970AlagoasBrazil

Although the liver has a remarkable regenerative capacity,sepsis-associated liver injury(SLI)is a complication often seen in intensive care *** to its role in immune and inflammatory regulation,the liver is particularly vulnerable during severe *** the global prevalence,causes,and management of SLI is essential to improve outcomes and reduce healthcare *** paper aims to explore these factors,with an emphasis on identifying effective strategies for clinical *** et al’s bibliometric analysis of 787 publications(745 original articles and 42 reviews,mostly in animal models)from 2000 to 2023 highlights the growing interest in SLI,focusing on oxidative stress,gut microbiota,and inflammatory *** components such as nuclear factor-kappa B and the NOD-like receptor thermal protein domain associated protein 3 inflammasome pathway,along with their links to gut microbiota imbalance and oxidative stress,are crucial for understanding SLI *** gut-liver axis,particularly the role of intestinal permeability and bacterial translocation in liver inflammation,is *** this context,bacterial translocation is especially relevant for critically ill patients,as it can exacerbate liver *** findings underscore the need for integrated care in intensive care units,prioritizing gut health and careful antibiotic use to prevent *** extensive research,there remains a lack of clinical trials to validate therapeutic *** abundance of experimental studies highlights potential therapeutic targets,stressing the need for high-quality randomized clinical trials to translate these findings into clinical practice.

关键词： Dysbiosis Oxidative stress Inflammation Microbiota Sepsis-associated liver injury

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Brain scarring in infants:immunological insights from a neonatal hypoxic-ischemic encephalopathy model

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Neural Regeneration Research 2025年第10期20卷 2909-2910页

作者： Pedro Moreno Pimentel-Coelho Carlos Chagas Filho Biophysics Institute Federal University of Rio de JaneiroRio de JaneiroBrazil

Neonatal hypoxic-ischemic encephalopathy(HIE)is a significant cause of disability in *** brain function and accelerating neurological recovery may require a combination of neuroprotective and pro-regenerative treatments at different stages of *** the first hours after the neonatal insult are the most critical period for neuroprotection,the existence of secondary and tertiary mechanisms of brain injury offers the possibility of preventing delayed neurodegeneration in the subsequent days,weeks,or months(Levison et al.,2022).

关键词： neonatal protective hypoxic

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Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

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Neural Regeneration Research 2025年第2期20卷 343-353页

作者： Ana Milena Silva Olaya Fernanda Martins Almeida Ana Maria Blanco Martinez Suelen Adriani Marques PhD Program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomedical Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological Anatomy(PPGAP/UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical ***,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord *** of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional *** the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in *** article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were ***,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

关键词： bioengineering biomaterials cell therapy humans non-human primates spinal cord injury stem cell therapy

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Ni/Al Intermetallics Plasma Transferred Arc Processing

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材料热处理学报 2004年第05B期25卷 948-951页

作者： Veronica A. B. Almeida Ana Sofia C. M. D'Oliveira Master student - PIPE Federal University of Parana Curitiba/BrazilMechanical Engineering Department Federal University of Parana Curitiba/Brazil

In-situ alloy development during surface processing allows for a limitless materials selection to protect components exposed to severe service conditions. In fact surface alloying offers the possibility to strengthen surface components with alloys that would not be possible to process otherwise. This work used Plasma transferred arc (PTA) hardfacing for surface alloying. Different amounts of aluminium powder, 5-25%, were added to a Ni based superalloy, from Hastealloy C family, in the atomized form. The mixture was homogeneized in a ball mill and PTA deposited on carbon steel substrate. The influence of different processing parameters on the final surface alloy was evaluated as current intensity and depositing velocity were varied. Coatings were characterized by optical and scanning electronic microscopy, X-ray diffraction and Vickers microhardness profiles, under a 500g load. Results showed that PTA hardfacing is an adequate surface alloying. For the conditions tested increasing hardness was obtained by solid solution for the lower amounts of Al added and due to the new intermetallic phases for the richer Al mixture.

关键词： PTA合金等离子转移电弧 Ni/Al金属互化物表面处理

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Optimizing the evolution of strength for lime-stabilized rammed soil

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第4期11卷 882-891页

作者： Jair de Jesus Arrieta Baldovino Ronaldo Luis dos Santos Izzo Eclesielter Batista Moreira Juliana Lundgren Rose Department of Civil Construction Federal University of Technology-Parana

In the present study,unconfined compressive strength(qu)values of two lime-treated soils(soil 1 and 2)with curing times of 28 d,90 d and 360 d were *** influence of void/lime ratio was represented by the porosity/volumetric lime content ratio(η/Liv)as the main parameter.η/Liv represents the volume of void influenced by compaction effort and lime *** evolution of qu was analyzed for each soil using the coefficient of determination as the optimization *** at providing adjustments to the mechanical resistance values,the η/Liv parameter was modified to η/LivC using the adjustment exponent C(to make qu-η/Liv variation rates compatible).The results show that with the decrease of η/*** increases potentially and the optimized values of C were *** mechanical resistance data show similar trends between qu and η/LivC for the studied silty soil-ground lime mixtures,which were cured at ambient temperature(23±2)℃ with different curing times of 28-360 ***,optimized equations were presented using the normalized strengths and the proposed optimization model,which show 6% error and 95% acceptability on average.

关键词： Lime-treated soil Void/lime ratio Ground improvement

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Improving the Thermal Efficiency and Performance of Refrigeration Systems:Numerical-Experimental Analysis of Minimization of Frost Formation

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Energy Engineering 2022年第5期119卷 1771-1788页

作者： Felipe Mercês Biglia Raquel da Cunha Ribeiro da Silva Fátima deMoraes Lino Kamal Abdel Radi Ismail Thiago Antonini Alves federal university of Technology-parana(UTFPR) CuritibaBrazil federal university of Technology-parana(UTFPR) GuarapuavaBrazil university of Campinas(UNICAMP) CampinasBrazil federal university of Technology-parana(UTFPR) Ponta GrossaBrazil

The frost growth on cold surfaces in evaporators is an undesirable phenomenon which becomes a problem for the thermal efficiency of the refrigeration systems because the ice layer acts as a thermal insulation,drastically reducing the rate of heat transfer in the *** accumulation implies an increase in energy demand and a decrease in the performance of various components involved in the refrigeration process,reducing its efficiency and making it necessary to periodically remove the frost,resulting in expenses for the defrost *** the present work,a numerical-experimental analysis was performed in order to understand the formation process of porous ice in flat plates with different surface treatments and *** understanding is of utmost importance to minimize the formation of porous ice on cold surfaces and improve equipment efficiency and *** this context,a low-cost experimental apparatus was developed,enabling an experimental analysis of the phenomenon under *** environmental conditions evaluated are the temperature of the cold surface,roomtemperature,humidity,and air *** material of the surfaces under study are aluminum,copper,and brass with different surface finishes,designated as smooth,grooved(hydrophilic),and varnished(hydrophobic).The numerical-experimental analysis demonstrates measurements and simulations of the thickness,surface temperature,and growth rate of the porous ice layer as a function of the elapsed *** numerical results were in good agreement with the experimental results,indicating that the varnished surface,with hydrophobic characteristics,presents greater difficulty in providing the ***,the results showed that application of a coating allowed a significant reduction on the frost formation process contributing to the improvement of thermal efficiency and performance of refrigeration systems.

关键词： Frost layer growth frost thickness minimization of frost hydrophobic surface refrigeration systems

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Micropropagation of Eucalyptus grandis×*** AEC 224 clone

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Journal of Forestry Research 2017年第1期28卷 29-39页

作者： Cassiana de Oliveira Juliana Degenhardt-Goldbach Gisela Manuela de Franca Bettencourt Erika Amano Luziane Franciscon Marguerite Quoirin Department of Plant Science Federal University of Parana1540Rua dos FuneionariosCuritibaParanaBrazil Embrapa-Forest 111Estrada da RibeiraColomboParanaBrazil Department of Technology Federal University of Parana210avenida CelFrancisco Heraiclito dos SantosCuritibaParanaBrazil Department of Botany Federal University of Parana210avenida CelFrancisco Heraiclito dos SantosCuritibaParanaBrazil

Genetic transformation systems require protocols that allow regenerating transgenic plants from transformed tissues. This study aimed to establish a protocol for indirect organogenesis in leaf explants of a Eucalyptus grandis x E. urophylla AEC 224 clone. During callogenesis stage, several concentrations of NAA and then NAA or 2,4-D combined with TDZ were tested in JADS culture medium for 30 days, followed by subculture of the explants in the regeneration medium, containing 5.0 μM BA and 0.5 μM NAA for another 30 days. In these media, the explant oxidation rate was high （95 %）. Thus, in order to reduce oxidation, different ;culture media were compared： WPM, MS, JADS and modified QL, followed by explant transfer onto regeneration medium. The highest percentage of regeneration and the lowest oxidation rate were achieved on WPM medium. Then, NAA and 2,4-D were tested in combination with TDZ and also TDZ and BA combined with NAA in WPM medium. The most efficient culture media in terms of shoot regeneration were WPM supplemented with 0.25 μM TDZ and 0.1μM NAA during 30 days for callus induction and then with 5.0 μM BA and 0.5 μM NAA for another 30 days. This protocol yielded a regeneration rate of 43 %, with a low oxidation of tissues. A rooting experiment was conducted using half strength MS medium and comparing three concentrations of IBA （2.46, 4.90 and 7.35μM）. The highest rooting percentage （35 %） was obtained on medium containing 2.46μM IBA. Once the shoots were rooted, acclimatization in a greenhouse was not challenging and plant survival reached 100 %.

关键词： Callogenesis Eucalyptus urograndis Organogenesis WPM culture medium

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Serological surveillance for SARS-CoV-2 antibodies among students,faculty and staff within a large university system during the pandemic

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World Journal of Virology 2025年第1期14卷 99-107页

作者： Marcos G Pinheiro Gabriela G O Alves Maria Eduarda R Conde Sofia L Costa Regina C S Sant’Anna Isa M F Antunes Mônica C Carneiro Fabio S Ronzei Julia C Scaffo Felipe R Pinheiro Lialyz S Andre Helvecio C Povoa Valéria T Baltar Fabíola Giordani Eduarda S Hemerly Gisele C Alexandre Karla C de Paula Márcio Watanabe Antonio Claudio L da Nóbrega Jackeline Christiane P Lobato Fabio Aguiar-Alves Laboratory of Molecular Epidemiology and Biotechnology Rodolpho Albino University LaboratoryFluminense Federal UniversityNiterói 24241000Rio de JaneiroBrazil Estácio de Sáuniversity Nova Friburgo 28611135Rio de JaneiroBrazil Pathology Program Medicine schoolFluminense Federal UniversityNiterói 24070090Rio de JaneiroBrazil Department of Pharmaceutical Sciences Lloyd L.Gregory School of PharmacyPalm Beach Atlantic UniversityWest Palm BeachFL 33401United States Health Institute of Nova Friburgo Fluminense Federal UniversityNova Friburgo 28613001Rio de JaneiroBrazil Department of Epidemiology and Biostatistics Institute of Collective Health(ISC)Fluminense Federal UniversityNiterói 24033900Rio de JaneiroBrazil Institute of Physical Education Fluminense Federal UniversityNiterói 24020005Rio de JaneiroBrazil Department of Statistics Fluminense Federal UniversityNiterói 24210200Rio de JaneiroBrazil Department of Physiology and Pharmacology Fluminense Federal UniversityNiterói 24210130Rio de JaneiroBrazil

BACKGROUND At the end of December 2019,the world faced severe acute respiratory syndrome-coronavirus 2(SARS-CoV-2),which led to the outbreak of coronavirus disease 2019(COVID-19),associated with respiratory *** virus has shown significant challenges,especially for senior citizens,patients with other underlying illnesses,or those with a sedentary *** tests conducted early on have helped identify how the virus is transmitted and how to curb its *** study hypothesis was that the rapid serological test for SARS-CoV-2 antibodies could indicate the immunoreactive profile during the COVID-19 pandemic in a university *** To conduct active surveillance for serological expression of anti-SARS-CoV-2 antibodies in individuals within a university setting during the COVID-19 *** This sectional study by convenience sampling was conducted in a large university in Niteroi-RJ,Brazil,from March 2021 to July *** study population consisted of students,faculty,and administrative staff employed by the university.A total of 3433 faculty members,60703 students,and 3812 administrative staff were invited to *** were gathered through rapid serological tests to detect immunoglobulin(Ig)M and IgG against ***χ²or Fisher's exact test was used to conduct statistical analysis.A 0.20 significance level was adopted for variable selection in a multiple logistic regression model to evaluate *** A total of 1648 individuals were enrolled in the *** proportion of COVID-19 positivity was 164/1648(9.8%).The adjusted logistic model indicate a positive association between the expression of IgM or IgG and age[odds ratio(OR)=1.16,95%CI:1.02-1.31](P<0.0024),individuals who had been in contact with a COVID-19-positive case(OR=3.49,95%CI:2.34-5.37)(P<0.001),those who had received the COVID-19 vaccine(OR=2.33,95%CI:1.61-3.35)(P<0.001)and social isolation(OR=0.59,95%CI:0.41-0.84)(P<0.004).The likelihood of sho

关键词： Serological surveillance SARS-CoV-2 antibodies COVID-19 Serological rapid test Risk factors for COVID-19

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King's College criteria and the Clichy-Villejuif criteria require adjustments for assessing acute liver failure due to yellow fever

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World Journal of Transplantation 2025年第1期15卷 124-134页

作者： Bruno da Silva Athanasio Antonio Marcio de Faria Andrade Vivian Vasconcelos Costa Juliano Felix Castro Silverio Leonardo Macedo Garcia Mauro Martins Teixeira Daniele da Gloria Souza Paula Vieira Teixeira Vidigal Cristiano Xavier Lima Department of Surgery Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Liver Transplantation Unit Felicio Rocho HospitalBelo Horizonte 30110-934Minas GeraisBrazil Department of Morphology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Biochemistry and Immunology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Pathology Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Acute liver failure(ALF)is a severe condition characterized by rapid deterioration of liver function in individuals without preexisting liver *** transplantation(LT)is the most impactful *** fever(YF)is an infectious disease that primarily affects the liver and has a high mortality ***,LT can be a viable option for treating rare cases with extensive liver ***,the criteria for assessing the severity of ALF and determining the indications for transplantation have not been specifically validated for cases caused by *** To present necessary adjustments to established scoring systems for ALF secondary to *** This was an observational,retrospective,single-center *** consecutive patients with confirmed ALF due to YF were monitored in the intensive care unit by a specialized liver transplant team during a three-month epidemic outbreak in *** hospitalization,general supportive therapeutic measures were implemented,and the patients were regularly assessed using the King's College criteria and the Clichy-Villejuif criteria to determine the severity of liver *** is considered a viable measure for patients with signs of end-stage liver *** Eight of 14(57%)patients developed severe neurological alterations within the first 96 hours after hospital *** patients underwent emergency LT,and despite a moderate viral infection of the graft after transplantation,the 5-year survival rate was 50%.Although the King's College criteria and the Clichy-Villejuif criteria are the main scoring systems for ALF,they are insufficient for predicting the risk of mortality in this context,primarily because of low serum bilirubin levels in the final stage of the disease and significant disparities between coagulation abnormalities and patient *** To ensure good applicability in cases of YF-induced ALF,the authors suggest adaptations to the King's College and Clichy-Vill

关键词： Yellow fever Acute liver failure Liver transplantation King's College criteria Clichy-Villejuif criteria

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Experimental Thermal Performance of Different Capillary Structures for Heat Pipes

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Energy Engineering 2021年第1期118卷 1-14页

作者： L.Krambeck G.A.Bartmeyer D.O.Souza D.Fusão P.H.D.Santos T.Antonini Alves federal university of Technology—parana(UTFPR) Ponta Grossa84.017-220Brazil federal university of Technology-parana(UTFPR) Curitiba81.280-340Brazil

The temperature control in electronic packaging is the key in numerous applications,to avoid overheating and hardware *** to high capability of heat transfer,good temperature uniformity,and no power consumption,heat pipes can be widely used for heat dissipation of electronic *** paper reports an experimental thermal analysis of different capillary structures for heat *** wicks considered are metal screens,axial microgrooves,and sintered metal *** heat pipes are made of copper,a 200 mm length tube and a 9.45 mm external *** fluid used was distilled *** devices are investigated in three positions:0,90,and 270°to the horizontal under powers of 5 up to 45 *** results show that in horizontal(0°)and with the evaporator under the condenser(270°),the heat pipes showed similar ***,in the reverse condition(the position against the gravity with the evaporator above the condenser,90°),the heat pipe with sintered wick presented the best thermal performance,as it has the lowest thermal resistance and supported a higher *** that,the sintered powder capillary structure demonstrates the most homogeneous thermal behavior for every position,making the most suitable for applications susceptible to diverse inclinations.

关键词： Heat pipes capillary structure thermal performance sintered wick

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