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Efficacy of combined psychological and physical nursing in preventing peripherally inserted central catheter-related thrombosis in gastric cancer patients

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World Journal of Gastrointestinal surgery 2025年第3期17卷 206-212页

作者： Wei-Jing Ni Yu-Xiu Xi Yong-Chao Zhou Venous Therapy Nursing clinic Affiliated Hospital of Jiangnan UniversityWuxi 214000Jiangsu ProvinceChina

BACKGROUND Long-term chemotherapy for patients with gastric cancer(GC),facilitated by peripherally inserted central catheter(PICC)catheterization,reduces vascular damage and enhances drug delivery efficiency but carries risks of catheter-related complications.A combination of group psychological nursing and physical mo-vement care significantly mitigates the risk of venous thrombosis and improves psychological well-being,and enhances motor function,underscoring its clinical *** To assess group psychological and physical movement nursing in preventing venous thrombosis in patients with PICC *** Sixty-five GC patients with PICC,admitted from January 2022 to January 2023,were randomly divided into two groups using the lottery method:A control group(n=35,routine nursing)and an observation group(n=30,routine nursing plus psychological nursing and physical movement nursing).Both groups re-ceived continuous care for 2 ***-nursing and post-nursing data on psycho-logical state,physical function,chemotherapy-related thrombosis incidence,and cancer-related fatigue were analyzed using SPSS 26.0 and GraphPad Prism *** After nursing,both groups showed reduced Hamilton Anxiety Scale scores and increased General Perceived Self-Efficacy Scale scores,with the observation group performing better(P<0.05).The Functional Comprehensive Assessment score for the observation group after nursing was(65.42±2.35)points,lower than the control group’s(62.19±4.33)points(P<0.05).Although no significant difference was observed in the incidence of venous thrombosis between the two groups(χ2=0.815,P=0.367),the observation group had lower *** groups showed decreased Revised Piper Fatigue Scale scores,with the observation group scoring lower(P<0.05).CONCLUSION Group psychological and physical movement nursing for patients with PICC reduces venous thrombosis risk,improves psychological well-being,cancer-related fatigue,and physical function,making it highly prom

关键词： Group psychological nursing Physical movement nursing Peripherally inserted central catheter Gastric cancer Venous thrombosis Cancer-related fatigue

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Retrospective analysis of factors influencing the self-healing of patients with enterocutaneous fistulas receiving conservative treatment

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 104-112页

作者： Zhuo-Nan Zhuang Rui Zhao Yuan-Xin Li Department of Gastrointestinal Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Department of General surgery Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Enterocutaneous(EC)fistula incidence has been increasing in China,along with increases in the volume and complexity of *** conservative treatment strategy has been analyzed to improve the treatment outcomes for patients with EC fistulas and reduce the need for *** To analyze the clinical data of patients undergoing conservative treatment for EC fistulas and identify the factors that promote *** findings provide a reference for improving the clinical cure rate of EC fistulas with conservative *** The clinical data of 91 patients with EC fistulas who underwent conservative treatment were *** relationships between the cure rate and characteristics such as age,sex,body mass index,albumin level,primary disease,cause of the fistula,location of the fistula,number of fistulas,nature of the fistula,infection status,diagnostic methods,nutritional support methods,somatostatin therapy,growth hormone therapy,and fibrin glue therapy were *** A comparison of the basic patient characteristics between the two groups revealed statistically significant differences in primary disease(P=0.044),location of the fistula(P=0.006),number of fistulas(P=0.007),and use of adhesive sealing(χ2=12.194,P<0.001)between the uncured and cured *** use of fibrin glue was a significant factor associated with a cure for fistulas(odds ratio=5.459,95%CI:1.958-15.219,P=0.01).CONCLUSION The cure rate of patients with a single EC fistula can be effectively improved via conservative treatment combined with the use of biological fibrin glue to seal the fistula.

关键词： Enterocutaneous fistula Conservative treatment Fibrin glue Fistula sealing Cure rate

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Nasal Tip-Columella Subunits Infrastructural Reconstruction: 10th Rib Cartilage Graft Operative Technique

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International Journal of Otolaryngology and Head & Neck surgery 2025年第1期14卷 47-56页

作者： Wenbo Huang Takkun Chow Sikkuen Chow Yangliu Liao Division of Plastic and Reconstructive surgery Department of Surgery The University of Hong Kong-Shenzhen Hospital Shenzhen China Department of surgery The University of Hong Kong Hong Kong China Hong Kong Holistic Cleft Lip & Palate Center Hong Kong China

Background: Reconstruction of Nasal Tip Columella (NTC) subunits is one of the most challenging aspects in functional aesthetic rhinoplasty. Moreover, racial variation for Asian nose rhinoplasty could even demand sophistication of tip and columella strut graft infrastructure enhancement. Various autogenous graft options such as 6th costal cartilage, septal cartilage and conchal cartilage are very commonly considered whilst the 10th costal cartilage is scarcely reported. Objective and Method: The purpose of this manuscript is to illustrate the detailed operative steps to harvest the 10th costal cartilage for infrastructural grafting at NTC subunits by a case illustration. The pros and cons of different cartilage options will be discussed, particularly its application in cleft nose rhinoplasty in Chinese patient. We have adopted the 10th rib as the key option for NTC reconstruction in 11 cases of Chinese cleft secondary rhinoplasty since 2019 and have achieved good and stable results without complications. Conclusion: The 10th costal cartilage is one of the best options in Nasal Tip Columella subunits reconstruction, particularly in complex cleft nose or failure revision aesthetic rhinoplasty cases, due to its safety of harvesting, and the sufficient quality and quantity of grafting materials it provides for simultaneous adjunctive augmentation purpose.

关键词： Nasal Tip Columella Rhinoplasty 10th Rib Cartilage Cleft Chinese

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Pigmented Villonodular Synovitis of the Spine: Two Case Reports and a Literature Review

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Open Journal of Orthopedics 2025年第1期15卷 31-40页

作者： Kazumasa Nakamura Hiroshi Takahashi Katsunori Fukutake Keiji Hasegawa Akihito Wada Department of Orthopedic surgery School of Medicine Toho University Tokyo Japan

Introduction: Pigmented villonodular synovitis (PVNS) of the spine is a rare condition, with only a limited number of cases documented in the medical literature. In this study, we review imaging findings of two cases of PVNS arising in the spine. Case 1: A 52-year-old male presented with right thigh pain of unclear etiology. His condition subsequently deteriorated and he was referred to our hospital. MRI revealed a spinal tumor with high intensity on T1-weighted imaging (T1WI) and iso-intensity on T2WI in the right L2/3 intervertebral foramen. The tumor exhibited heterogeneous enhancement on contrast-enhanced MRI. Computed tomography (CT) myelography showed the presence of an epidural tumor within the right L2/3 intervertebral foramen, situated externally to the spinal canal and compressing the dura mater. Notable scalloping was observed in the posterior margin of the L2 vertebral body on CT images. Case 2: A 78-year-old male presented with a complaint of muscle weakness of the left upper limb. His gait gradually deteriorated, which led to suspicion of cervical myelopathy. A tumor was observed on plain MRI and exhibited low to iso-intensity on T1WI and high intensity on T2WI. The tumor was in the left C7/T1 intervertebral segment and the spinal cord was compressed from the left side. CT showed destruction of the medial aspect of the left C7 vertebral arch. Conclusion: In spinal PVNS, the signal intensity on MRI is dependent on the timing of hemorrhage within the tumor, and there are no distinctive features. However, if an extradural tumor is suspected and CT shows bone erosion, scalloping or osteolytic changes, PVNS should be considered as a differential diagnosis.

关键词： Spinal Pigmented Villonodular Synovitis Imaging Diagnosis Computed Tomography Magnetic Resonance Imaging

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Rat models of frozen shoulder:Classification and evaluation

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Animal Models and Experimental Medicine 2025年第1期8卷 92-101页

作者： Hezirui Gu Wenqing Xie Hengzhen Li Shuguang Liu Yusheng Li Department of Orthopedics Xiangya HospitalCentral South UniversityChangshaChina Xiangya School of Medicine Central South UniversityChangshaChina National clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaChina Department of Joint surgery Honghui HospitalXi'an Jiaotong UniversityXi'anChina

Frozen shoulder(FS),also known as adhesive capsulitis,is a condition that causes contraction and stiffness of the shoulder joint *** main symptoms are per-sistent shoulder pain and a limited range of motion in all *** symp-toms and poor prognosis affect people's physical health and quality of ***,the specific mechanisms of FS remain unclear,and there is variability in treatment methods and their ***,the early symptoms of FS are difficult to distinguish from those of other shoulder diseases,complicating early diagnosis and ***,it is necessary to develop and utilize animal models to under-stand the pathogenesis of FS and to explore treatment strategies,providing insights into the prevention and treatment of human *** paper reviews the rat models available for FS research,including external immobilization models,surgical internal immobilization models,injection modeling models,and endocrine modeling *** introduces the basic procedures for these models and compares and analyzes the advantages,disadvantages,and applicability of each modeling ***,our paper summarizes the common methods for evaluating FS rat models.

关键词： endocrine modeling injection rat model surgical internal immobilization

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Human iPSC-derived mesenchymal stem cells relieve high blood pressure in spontaneously hypertensive rats via splenic nerve activated choline acetyltransferase-positive cells

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Science China(Life Sciences) 2025年第2期68卷 502-514页

作者： Zhen Zhang Weijun Huang Xiaoran Zhang Zhecun Wang Manting Xie Bingbing Xie Yiling Wang Xiaoyong Chen Andy Peng Xiang Qiuling Xiang Center for Stem Cell Biology and Tissue Engineering Key Laboratory for Stem Cells and Tissue EngineeringMinistry of EducationSun Yat-sen UniversityGuangzhou 510080China Department of Physiology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Department of Vascular surgery the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510062China

Despite substantial advancements in modern medicine,the management of hypertension remains a major *** cell-based therapies have recently demonstrated remarkable efficacy in treating cardiovascular diseases,including ***,the antihypertensive mechanism of mesenchymal stem cells(MSCs)has not been extensively *** study aimed to investigate the role of injected MSCs in regulating blood pressure *** previous study demonstrated that human induced pluripotent stem cellderived mesenchymal stem cells(hiPSC-MSCs)are functional and homogeneous sources for MSC-based *** the injection of hiPSCMSCs,a significant reduction in blood pressure and end target organ inflammation were observed in spontaneously hypertensive rats(SHRs).Cell tracking assays demonstrated that the injected hiPSC-MSCs accumulated in the spleens of the *** injected hiPSC-MSCs accumulated adjacent to the splenic nerve,potentially contributing to the antihypertensive ***,the hiPSC-MSCs released abundant glutamate,which acts as a neuromodulator to activate the splenic sympathetic *** inhibition of glutamate synthesis by siRNA,the ability of hiPSC-MSCs to activate sympathetic nerves was significantly *** addition,the antihypertensive effects of hiPSC-MSCs were eliminated after splenic nerve denervation(SND),underscoring the critical role of the splenic ***,activation of the splenic nerve resulted in increased release of norepinephrine(NE),which increased the number of choline acetyltransferase-positive(ChAT^(+))cells in the spleen and peripheral ***,the acetylcholine(ACh)produced by elevated ChAT+cells could act as a vasodilator,lowering blood pressure and mitigating inflammation in end target *** summary,our findings indicate that hiPSC-MSCs effectively lower blood pressure in hypertension by influencing the splenic nerves and regulating ChAT+*** connection between blood pressur

关键词： hiPSC-MSCs hypertension splenic nerve ChAT+cells

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Metastasizing to the colon from triple-negative breast cancer:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 443-455页

作者： Ben-Quan Wang Xing-Gui Fang Ben-Hong Xiang Xiao-Jiao Wang Ming Cao Cheng-Le Zhuang Zhong-Chen Liu Zheng Wang Department of Gastrointestinal surgery The First People’s Hospital of WuhuWuhu 241000Anhui ProvinceChina Department of Breast surgery The First People’s Hospital of WuhuWuhu 241000Anhui ProvinceChina Department of Pathology The First People’s Hospital of WuhuWuhu 241000Anhui ProvinceChina Department of Gastrointestinal surgery Colorectal Cancer CenterShanghai Tenth People’s Hospital Affiliated to Tongji UniversityShanghai 200000China

BACKGROUND Breast cancer(BC)metastasis to the gastrointestinal tract is uncommon,colonic metastasis from BC(CMBC)is even *** SUMMARY This report describes a 44-year-old female patient with metastatic triple-negative BC in the ascending colon who underwent laparoscopic radical right *** patient had undergone left modified radical mastectomy only 15 months ago and stopped chemotherapy just 3 months *** diagnosis of CMBC was made based on the previous history of BC and positive results of several specific immunohistochemical markers(gross cystic disease fluid protein 15,mammaglobin,GATA-binding protein 3,and cytokeratin 7)for breast *** CMBC should be highly cautious in patients with a previous history of BC,especially triple-negative BC,and further examination to aid in diagnosis.

关键词： Breast cancer Colon metastasis Colonoscopy Pathology surgery Review Case report

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Three-dimensional location approach with silk thread guided hepatectomy for liver tumor

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World Journal of Gastroenterology 2025年第8期31卷 66-71页

作者： Zhi-Hong Zhang Qing-Bo Feng Chuang Jiang Ji-Wei Huang Jia-Xin Li Division of Liver surgery Department of General Surgery and Laboratory of Liver Surgeryand State Key Laboratory of Biotherapy and Collaborative Innovation Center of BiotherapyWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Intraoperative determination of resection margin and adequate residual liver parenchyma are the key points of hepatectomy for the treatment of liver *** ultrasound and indocyanine green fluorescence navigation are the most commonly used methods at present,but the technical barriers limit their *** To evaluate the value of the three-dimensional location approach with silk thread(3D-LAST)in precise resection of liver *** From September 2020 to January 2022,8 patients with liver tumors including hepatocellular carcinoma,intrahepatic cholangiocarcinoma,hilar cholangiocar-cinoma,and gastric cancer liver metastasis were included in this *** patients underwent 3D-LAST in precise resection of liver *** All patients(8/8,100%)underwent the operation successfully without any *** the mean follow-up of 8.7 months,all patients survived without tumor *** In conclusion,the 3D-LAST is a safe and effective new method for liver intraop-erative navigation,which is practical and easy to *** Tip:The aim of this study is to evaluate the value of the three-dimensional location approach with silk thread(3D-LAST)in precise resection of liver *** patients with liver tumors including hepatocellular carcinoma,intrahepatic cholangiocarcinoma,hilar cholangiocarcinoma,and gastric cancer liver metastasis underwent the operation successfully without any *** the mean follow-up of 8.7 months,all patients survived without tumor *** conclusion,the 3D-LAST is a safe and effective new method for liver intraoperative navigation,which is practical and easy to *** Hepatectomy is widely used for the treatment of liver *** recent decades,the concept and practice of hepatectomy have developed from irregular,regular and anatomical to the current precise *** assistive technologies have enabled these *** ultraso

关键词： Hepatectomy Laparoscopy Liver tumor Three dimensional Silk thread

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A Review of Bicuspid Aortic Valve Anomaly

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International Journal of clinical Medicine 2025年第1期16卷 112-126页

作者： Wei Hu Rubing Wang Yan Zhang Yuxin Qi Jibin Xu Jingjing Wang Junnan Wang Weiqing Pu Yufeng Zhang Zhinong Wang Yudi Liu Department of Cardiothoracic surgery Changzheng Hospital Naval Medical University Shanghai China

Bicuspid aortic valve (BAV) is a common congenital heart valve disease, often accompanied by aortic valve stenosis or regurgitation, infective endocarditis, and aortic diseases such as aortic dilation and dissection. This article aims to review the definition, pathogenesis and genetic basis, classification methods, clinical features and current status of research and treatment and prognosis of BAV, and provide reference for the diagnosis and treatment of BAV. The content and structure of this article are as follows: The first part introduces the definition of BAV;The second part introduces the etiology and classification methods of BAV;The third part briefly describes the clinical manifestations and diagnosis of BAV;The fourth part discusses the treatment strategies and prognosis prediction of BAV;Finally, the article summarizes and looks forward to the future research directions.

关键词： Bicuspid Aortic Valve Congenital Heart Disease Aortic Valve Disease Transcatheter Aortic Valve Replacement

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