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Rising incidence of acute hepatitis A among adults and clinical characteristics in a tertiary care center of Pakistan

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World Journal of Virology 2025年第1期14卷 73-82页

作者： Yumna Shahid Amna Subhan Butt Iqra Jamali Faisal Wasim Ismail Division of Gastroenterology Department of MedicineAga Khan University HospitalKarachi 74800Pakistan Department of Medicine Aga Khan University HospitalKarachi 74800Pakistan

BACKGROUND For decades,hepatitis A virus(HAV)has been a leading cause of acute hepatitis among children and was less prevalent among ***,recently a paradigm shift has been observed in the epidemiology of HAV,as evident by cases of acute hepatitis due to HAV among *** To estimate frequency of HAV in acute viral hepatitis and compare characteristics in HAV and hepatitis E virus(HEV)*** This was a trend analysis conducted at Aga Khan university hospital Karachi(Sindh,Pakistan)from February 2024 to May *** aged 18 years and older diagnosed with acute viral hepatitis attributed to hepatotropic viruses in 2024 were *** compare the trend patients admitted with acute hepatitis during 2019-2023 were also *** regarding clinical and laboratory parameters were *** yearly trend of acute hepatitis due to HAV and HEV was analyzed,and comparative analysis was done between HAV and HEV cases among *** A total of 396 patients were found to have acute hepatitis during our study *** was diagnosed in 234 patients(59%)while 157 patients(39.6%)were found to have acute HEV ***,acute hepatitis B virus infection was identified in 3 patients(0.7%),whereas acute hepatitis C virus infection was found in 2(0.5%)cases of acute *** trends showed increasing occurrence of HAV infection among adults over last 5 *** patients with acute HAV were younger than patients with HEV(28 years±8 years vs 30 years±8 years;Phygiene,and adult hepatitis A vaccination programs.

关键词： Acute hepatitis Hepatitis A virus Hepatitis E virus Acute liver failure Hepatotropic virus Vaccination

Genetic variants of innate immune receptors and infections after liver transplantation

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World Journal of Gastroenterology 2014年第32期20卷 11116-11130页

作者： Gemma Sanclemente Asuncion Moreno Miquel Navasa Francisco Lozano Carlos Cervera Department of Infectious Diseases Hospital Clinic of BarcelonaIDIBAPS University of Barcelona Liver Transplant Unit Hospital Clinic of Barcelona IDIBAPS University of Barcelona Immunology Hospital Clinic of BarcelonaIDIBAPS University of Barcelona

Infection is the leading cause of complication after liver transplantation, causing morbidity and mortality in the first months after surgery. Allograft rejection is mediated through adaptive immunological responses, and thus immunosuppressive therapy is necessary after transplantation. In this setting, the presence of genetic variants of innate immunity receptors may increase the risk of post-transplant infection, in comparison with patients carrying wild-type alleles. Numerous studies have investigated the role of genetic variants of innate immune receptors and the risk of complication after liver transplantation, but their results are discordant. Tolllike receptors and mannose-binding lectin are arguably the most important studied molecules; however, many other receptors could increase the risk of infection after transplantation. In this article, we review the published studies analyzing the impact of genetic variants in the innate immune system on the development of infectious complications after liver transplantation.

关键词： Innate immunity Genetic variants Single nucleotide polymorphisms Liver transplantation Post-transplant infections Toll-like receptors Mannose-binding lectin

Suspicious brush cytology is an indication for liver transplantation evaluation in primary sclerosing cholangitis

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World Journal of Gastroenterology 2017年第33期23卷 6147-6154页

作者： Sonja Boyd Marko Vannas Kalle Jokelainen Helena Isoniemi Heikki Makisalo Martti A Farkkila Johanna Arola Department of Pathology University of Helsinki and Helsinki University Hospital Transplantation and Liver Surgery clinic University of Helsinki and Helsinki University Hospital clinic of Gastroenterology University of Helsinki and Helsinki University Hospital

AIM To investigate markers for high-grade dysplasia for the optimal timing of liver transplantation in patients with primary sclerosing cholangitis(PSC).METHODS Earlier data support a dysplasia-carcinoma sequence,even low-to high-grade dysplasia,in PSC-associated cholangiocarcinoma(CCA). Surveillance using endoscopic retrograde cholangiography(ERC) and brush cytology aims to detect cases of biliary dysplasia,and liver transplantation is an option in cases with suspicion of malignancy in brushing. This study investigated markers to identify patients with highgrade biliary dysplasia for optimal timing in early liver transplantation. Patients undergoing surveillance using ERC and brush cytology during 2008-2014 and who were diagnosed with biliary dysplasia in explanted liver or CCA until February 2016 were included in the study. Demographic data,cholangiography findings,laboratory values,cytological morphology and DNA ploidy were *** Thirty PSC patients had biliary neoplasia in the explanted liver during the study period. Sixteen of these patients had low-grade dysplasia,10 patients had high-grade dysplasia,and 4 patients had CCA. Fifteen PSC patients diagnosed with CCA were not transplanted. Patients with low-grade dysplasia were younger. Alkaline phosphatase or carcinoembryonic antigen values did not differ between groups during surveillance,but carbohydrate antigen 19-9 was higher in CCA patients. No difference in PSC duration,ERC scores,suspicious cytology,or ploidy analysis was found between groups. No difference was observed between fibrosis stage in explanted livers. Low-and high-grade dysplasia could not be differentiated before liver transplantation based on liver enzymes,tumour markers,ERC scores,brush cytology or DNA *** Repeated suspicion of neoplasia in brush cytology should be an indication for evaluations of liver transplantation prior to the development of CCA.

关键词： Endoscopic retrograde cholangiography Brush cytology Cholangiocarcinoma Biliary dysplasia

Protein-based functional hydrogel improves cutaneous nerve repair and diabetic wound healing

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Nano Research 2025年第1期18卷 586-596页

作者： Hanzhi Lu Mingrui Cui Yi Wang Xinran Du Xinyi Zhou Yuhan Fang Xiaoyan Gao Ying Peng Jianyong Zhu Guang Yang Fulun Li Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine College of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620China clinical Laboratory Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

Cutaneous nerve regeneration in diabetic wounds remains a challenge for current clinical ***,a natural protein-based functional hydrogel is developed using keratin as the sole matrix,and protocatechuic aldehyde(PA)and zinc ions as the building blocks through dual-dynamic crosslinking reactions of thiol-aldehyde addition and catecholzinc ions *** unique structural design endows the hydrogel with excellent injectability,skin adhesion,self-healing and antibacterial ability,and *** addition,this hydrogel acts as a drug carrier for the loading and sustained release of phellopterin(PP),a natural compound extracted from traditional Chinese medicine Angelica *** findings demonstrate that the PP-loaded hydrogel promotes cutaneous nerve regeneration,angiogenesis and tissue remodeling in the full-thickness wounds in both db/db and streptozotocin-induced C57BL/6 diabetic mice,notably by the synergistic effect of zinc ions and PP,showing a great potential in diabetic wound therapy.

关键词： functional hydrogel cutaneous nerve regeneration dynamic crosslinking diabetic wounds

The impact of male overweight on semen quality and outcome of assisted reproduction

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Asian Journal of Andrology 2014年第5期16卷 749-754,I0010页

作者： Lise Thomsen Peter Humaidan Leif Bungum Mona Bungum The Fertility clinic Viborg Hospital Skive Aarhus university Faculty of Health Aarhus N The Fertility clinic Herlev Hospital Herlev Denmark Reproductive Medicine Centre Skanes University Hospital Malmo Sweden

It is well-documented that male overweight and obesity causes endocrine disorders that might diminish the male reproductive capacity; however, reports have been conflicting regarding the influence of male body mass index （BMI） on semen quality and the outcome of assisted reproductive technology （ART）. The aim of this study was to investigate whether increased male BMI affects sperm quality and the outcome of assisted reproduction in couples with an overweight or obese man and a non-obese partner. Data was prospectively collected from 612 infertile couples undergoing ART at a Danish fertility center. Self-reported information on paternal height and weight were recorded and BMI was calculated. The men were divided into four BMI categories： underweight BMI 〈 20 kgm^-2, normal BMI 20-24.9 kg m^-2, overweight BMI 25-29.9 kgm^-2 and obese BMI 〉 30 kgm^-2. Conventional semen analysis was performed according to the World Health Organization guideline and sperm DNA integrity was analyzed by the Sperm Chromatin Structure Assay （SCSA）. No statistically significant effect of male BMI was seen on conventional semen parameters （sperm concentration, total sperm count, seminal volume and motility） or on SCSA-results. Furthermore, the outcome of ART regarding fertilization rate, number of good quality embryos （GQE）, implantation and pregnancy outcome was not influenced by the increasing male BMIo

关键词： assisted reproductive technology body mass index male obesity sperm chromatin structure assay sperm quality

New case of HIV cure:joined forces of haploidentical stem cells and HLA-mismatched cord blood

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3198-3199页

作者： David Peterhoff Institute for clinical Microbiology and hygiene University Hospital RegensburgRegensburgGermany

Recently,Hsu et *** the remission and possible cure of HIV-1 infection in the context of an allogeneic hematopoietic stem cell transplant for the treatment of acute myeloid leukemia(AML).1 This is the fourth case of a potential cure for HIV infection ever,the first in a woman,the first in a person of mixed race,and the first in which a CCR5Δ32/Δ32 haplo-cord transplant was used.

关键词： al. infection acute

Molecular diagnostic approaches for enteric parasites: an issue of relevance for deployed soldiers?

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Military Medical Research 2023年第3期10卷 415-417页

作者： Hagen Frickmann Department of Microbiology and hospital hygiene Bundeswehr Hospital Hamburg22529 HamburgGermany Institute for Microbiology Virology and HygieneUniversity Medicine Rostock18057 RostockGermany

Dear Editor,Recently, Lindrose et al.[1] have conducted a retrospective assessment over 6 years on enteric helminth infections in United States(US)soldiers and their relatives to provide epidemiological insights into ... 详细信息

关键词： enteric neglected

Comparison of visual acuity, refractive results and complications of femtosecond laser with mechanical microkeratome in LASIK

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International Journal of Ophthalmology(English edition) 2013年第3期6卷 350-355页

作者： Cemile Banu Cosar Tansu Gonen Murat Moray Asim Bozkurt Sener Department of Ophthalmology Acibadem University Department of Ophthalmology Namlk Kemal University Eye clinic Acibadem Bursa Hospital Eye clinic Acibadem Maslak Hospital

AIM: To compare the outcomes of laser in situ keratomileusis (LASIK) performed with a femtosecond laser (Femtec, Technolas Perfect Vision GmbH, Germany) versus a mechanical microkeratome (Hansatome, Bausch and Lomb, USA) for the correction of myopia and astigmatism. ·METHODS: In this retrospective study, patients who had undergone LASIK using the 80 -kHz Femtec femtosecond laser were compared to age- and refraction- matched patients in whom the Hansatome microkeratome was used. Refractive and visual results 1 month and 3 months postoperatively, and complication rates were compared between the two groups. ·RESULTS: A total of 280 eyes were analyzed (140 in each group). At 3 months postoperatively in the Femtec vs Hansatome group, spherical equivalent refraction was within ±1.00D of emmetropia in 140 vs 138 eyes (P = 0.498), the cylinder was within ±0.50D in 137 vs 139 eyes (P =0.622), and the UDVA was 20/20 or better in 136 vs 137 eyes (P =0.724), respectively. There was no statistically significant difference in the complication rates between the two groups (P =0.099). ·CONCLUSION: LASIK performed both with Femtec femtosecond laser and Hansatome microkeratome achieved satisfactory refractive and visual results at 3 months postoperatively, without significant differences in efficacy, safety, and complication rates between the two procedures.

关键词： laser in situ keratomileusis femtosecond laser Femtec microkeratome Hansatome

Colorectal cancer:Current imaging methods and future perspectives for the diagnosis, staging and therapeutic response evaluation

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World Journal of Gastroenterology 2013年第46期19卷 8502-8514页

作者： Maka Kekelidze Luigia D'Errico Michele Pansini Anthony Tyndall Joachim Hohmann clinic of Radiology and Nuclear Medicine University Hospital Basel University of Basel

In the last 10 years the mortality rate of colorectal cancer(CRC)has decreased by more than 20%due to the rising developments in diagnostic techniques and optimization of surgical,neoadjuvant and palliative *** methods currently used in the evaluation of CRC are heterogeneous and can vary within the countries and the *** article aims to discuss in depth currently applied imaging modalities such as virtual computed tomography colonoscopy,endorectal ultrasound,computed tomography(CT)and magnetic resonance imaging(MRI)in the diagnosis of *** focus is put on the potential of recent diagnostic developments as diffusion weighted imaging MRI,MRI biomarkers(dynamic enhanced MRI),positron emission tomography with 2-(fluorine-18)-fluoro-2-deoxy-D-glucose(FDG-PET)combined with computed tomography(PET/CT)and new hepatobiliary MRI contrast *** precise role,advantage and disadvantages of these modalities are evaluated controversially in local staging,metastatic spread and treatment monitoring of ***,the authors will touch upon the future perspectives in functional imaging evaluating the role of integrated FDG-PET/CT with perfusion CT,MRI spectroscopy of primary CRC and hepatic transit time analysis using contrast enhanced ultrasound and MRI in the detection of liver *** of these newer imaging techniques may lead to significant improvements in the management of patients with colorectal cancer.

关键词： Colorectal cancer Imaging Staging Computed tomography Magnetic resonance imaging Diffusion weighted imaging Contrast enhanced ultrasound