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Space aquatic chemistry:A roadmap for drinking water treatment in microgravity

Environmental Science and Ecotechnology 2024年第3期19卷 26-28页

作者： Baiwen Ma Yaohui Bai Chengzhi Hu Beizhen Xie Junya Zhang Mathias Ulbricht Libing Zheng Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China Lehrstuhl für Technische Chemie II Universität Duisburg-EssenEssen45117Germany Institute of Environmental Biology and Life Support Technology School of Biological Science and Medical EngineeringBeihang UniversityBeijing100191China Department of Water Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China Department of Isotope Biogeochemistry Helmholtz Centre for Environmental Research-UFZLeipzig04318Germany

Rapid advancement in aerospace technology has successfully enabled long-term life and economic activities in space,particularly in Low Earth Orbit(LEO),extending up to 2000 km from the mean sea ***,the sustainance of the LEO Economy and its Environmental Control and Life Support System(ECLSS)still relies on a regular cargo supply of essential commodities(e.g.,water,food)from Earth,for which there still is a lack of adequate and sustainable *** key challenge in this context is developing water treatment technologies and standards that can perform effectively under microgravity *** this technical challenge will be a milestone in providing a scientific basis and the necessary support mechanisms for establishing permanent bases in outer space and *** identify clues towards solving this challenge,we looked back at relevant scientific research exploring novel technologies and standards for deep space exploration,also considering feedback for enhancing these technologies on *** our findings,we share our outlook for the future of drinking water treatment in *** also bring up a new concept for space aquatic chemistry,considering the closed environment of engineered systems operating in microgravity.

关键词： Microgravity Drinking water treatment Water quality Challenges Strategies

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SETD3-mediated histidine methylation of MCM7 regulates DNA replication by facilitating chromatin loading of MCM

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Science China Life sciences 2024年

作者： Hong-Guo Duan Shuang Wang Wen-Jie Shu Yong-Jia Tong Hai-Zhen Long Guo-Hong Li Hai-Ning Du Meng-Jie Zhao Hubei Key Laboratory of Cell Homeostasis College of Life SciencesTaiKang Center for Life and Medical SciencesFrontier Science Center for Immunology and MetabolismEmergency CenterZhongnan Hospital of Wuhan UniversityRNA InstituteWuhan University The Institute for Advanced Studies Wuhan University Shenzhen Bay Laboratory Hubei Key Laboratory of Cell Homeostasis College of Life Sciences TaiKang Center for Life and Medical Sciences Frontier Science Center for Immunology and Metabolism Wuhan University

The minichromosome maintenance complex(MCM) DNA helicase is an important replicative factor during DNA replication. The proper chromatin loading of MCM is a key step to ensure replication initiation during S phase. Because replication initiation is regulated by multiple biological cues, additional changes to MCM may provide better understanding towards this event. Here, we report that histidine methyltransferase SETD3 promotes DNA replication in a manner dependent on enzymatic activity. Nascent-strand sequencing(NS-seq)shows that SETD3 regulates replication initiation, as depletion of SETD3 attenuates early replication origins firing. Biochemical studies reveal that SETD3 binds MCM mainly during S phase, which is required for the CDT1-mediated chromatin loading of MCM. This MCM loading relies on histidine-459 methylation(H459me) on MCM7 which is catalyzed by SETD3. Impairment of H459 methylation attenuates DNA synthesis and chromatin loading of MCM. Furthermore, we show that CDK2 phosphorylates SETD3 at Serine-21 during the G1/S phase,which is required for DNA replication and cell cycle progression. These findings demonstrate a novel mechanism by which SETD3 methylates MCM to regulate replication initiation.

关键词： histidine methylation SETD3 DNA replication MCM replication origin firing

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Exploiting viral vectors to deliver genome editing reagents in plants

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aBIOTECH 2024年第2期5卷 247-261页

作者： Yilin Shen Tao Ye Zihan Li Torotwa Herman Kimutai Hao Song Xiaoou Dong Jianmin Wan State Key Laboratory of Crop Genetics and Germplasm Enhancement and Utilization Jiangsu Collaborative Innovation Centre for Modern Crop ProductionJiangsu Engineering Research Center for Plant Genome EditingNanjing Agricultural UniversityNanjing 210095China Zhongshan biological Breeding Laboratory Nanjing 210014China Hainan Seed Industry Laboratory Sanya 572025China State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Genome editing holds great promise for the molecular breeding of plants,yet its application is hindered by the shortage of simple and effective means of delivering genome editing reagents into *** plant transformation-based methods for delivery of genome editing reagents into plants often involve prolonged tissue culture,a labor-intensive and technically challenging process for many elite crop *** this review,we describe various virus-based methods that have been employed to deliver genome editing reagents,including components of the CRISPR/Cas machinery and donor DNA for precision editing in *** update the progress in these methods with recent successful examples of genome editing achieved through virus-based delivery in different plant species,highlight the advantages and limitations of these delivery approaches,and discuss the remaining challenges.

关键词： Plant genome engineering Genome editing CRISPR/Cas Virus-based delivery

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Spatial search weighting information contained in cell velocity distribution

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Chinese Physics B 2024年第2期33卷 522-528页

作者：马一凯李娜陈唯 State Key Laboratory of Surface Physics and Department of Physics Fudan UniversityShanghai 200438China China National center for Bioinformation Beijing 100101China National Genomics Data center Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China

Cell migration plays a significant role in physiological and pathological *** the characteristics of cell movement is crucial for comprehending biological processes such as cell functionality,cell migration,and cell–cell *** of the fundamental characteristics of cell movement is the specific distribution of cell speed,containing valuable information that still requires comprehensive *** article investigates the distribution of mean velocities along cell trajectories,with a focus on optimizing the efficiency of cell food search in the context of the entire *** confirm that the specific velocity distribution in the experiments corresponds to an optimal search efficiency when spatial weighting is *** simulation results indicate that the distribution of average velocity does not align with the optimal search efficiency when employing average spatial ***,when considering the distribution of central spatial weighting,the specific velocity distribution in the experiment is shown to correspond to the optimal search *** simulations reveal that for any given distribution of average velocity,a specific central spatial weighting can be identified among the possible central spatial weighting that aligns with the optimal search ***,our work presents a method for determining the spatial weights embedded in the velocity distribution of cell *** results have provided new avenues for further investigation of significant topics,such as relationship between cell behavior and environmental conditions throughout their evolutionary history,and how cells achieve collective cooperation through cell-cell communication.

关键词： cell migration foraging efficiency random walk spatial search weight

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Morphological and molecular analyses of a Philine kinglipini outbreak in summer of 2022 in Jiaozhou Bay,China

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Journal of Oceanology and Limnology 2024年第3期42卷 831-848页

作者： Zelin DUAN Yanan YU Jing WANG Junlong ZHANG Nansheng CHEN CAS Key Laboratory of Marine Ecology and Environmental sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laboratory of Marine Ecology and Environmental Science Laoshan LaboratoryQingdao 266237China center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Laboratory of Marine Organism Taxonomy and Phylogeny Qingdao Key Laboratory of Marine Biodiversity and ConservationInstitute of OceanologyChinese Academy of SciencesQingdao 266071China Marine biological Museum Chinese Academy of SciencesQingdao 266071China Department of Molecular Biology and Biochemistry Simon Fraser UniversityBurnabyBritish ColumbiaV5A 1S6Canada

A sudden and unprecedented outbreak of molluscan Philine kinglipini occurred in summer 2022 in Jiaozhou Bay,Shandong,China,causing substantial damage to local mariculture industry of the Manila clam Ruditapes *** *** has been found in many coastal regions of China,the molecular research of *** has not been extensively studied,making it difficult to accurately identify and track *** samples in field using molecular *** were collected during the outbreak and their morphological features and molecular sequences were *** show that the causative species of the outbreak was *** mitochondrial genome(mt DNA)of *** was constructed for the first time,based on which phylogenetic analysis of the mt DNAs of *** and related species in the order Cephalaspidea was carried *** revealed by metabarcoding analysis of 18S rDNA V4,the seasonal change of *** and closely related Philine species was striking with peaks between April and ***,metabarcoding analysis is applicable tool for monitoring the bloom development of *** and related *** study generated for the first time essential molecular marker sequences and mtDNA of ***,which provided a reference for future characterization and monitoring of its outbreaks and for phylogenetic analysis of Philine species.

关键词： marine species outbreaks metabarcoding analysis mitochondrial genome Philine kinglipini phylogenetics spatial-temporal dynamics

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LSD1调控颗粒细胞自噬并抑制Wt1参与FSH调节的有腔卵泡形成

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Science Bulletin 2024年第8期69卷 1122-1136页

作者：朱子健何美娜张拓赵庭秦韶刚高萌王文基郑文影陈子琦刘龙萍郝明周波张华王建斌王凤超夏国良王超 State Key Laboratory of Farm Animal Biotech Breeding College of Biological SciencesChina Agricultural UniversityBeijing 100193China College of Basic Medicine Guizhou Medical UniversityGuiyang 550025China Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Department of PhysiologyCollege of Basic MedicineGuizhou Medical UniversityGuiyang 550025China School of Life sciences Taizhou UniversityTaizhou 318000China School of Life sciences Tsinghua UniversityBeijing 100084China Transgenic Animal center National Institute of Biological SciencesBeijing 102206China Key Laboratory of Ministry of Education for Conservation and Utilization of Special biological Resources in the Western China College of Life ScienceNingxia UniversityYinchuan 750021China

In a growing follicle,the survival and maturation of the oocyte largely depend on support from somatic cells to facilitate FSH-induced mutual signaling and chemical *** apoptosis and autophagy in somatic cells are involved in the process of FSH-induced follicular development,the underlying mechanisms require substantial *** to our study,along with FSH-induced antral follicles(AFs)formation,both lysine-specific demethylase 1(LSD1)protein levels and autophagy increased simultaneously in granulosa cells(GCs)in a time-dependent manner,we therefore evaluated the importance of LSD upon facilitating the formation of AFs correlated to autophagy in *** knockout of Lsdl in GCs resulted in significantly decreased AF number and subfertility in females,accompanied by marked suppression of the autophagy in *** the one hand,depletion of Lsd1 resulted in accumulation of Wilms tumor 1 homolog(WT1),at both the protein and mRNA ***1 prevented the expression of FSH receptor(Fshr)in GCs and thus reduced the responsiveness of the secondary follicles to FSH *** the other hand,depletion of LSD1 resulted in suppressed level of autophagy by upregulation of ATG16L2 in *** finally approved that LSD1 contributed to these sequential activities in GCs through its H3K4me2 demethylase ***,the importance of LSD1 in GCs is attributable to its roles in both accelerating autophagy and suppressing WT1 expression to ensure the responsiveness of GCs to FSH during AFs formation.

关键词： LSD1 Autophagy H3K4me2 WT1 Follicle formation Follicle stimulating hormone

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Molecular docking-aided AIEgen design: concept, synthesis and applications

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Science China Chemistry 2024年第8期67卷 2614-2628页

作者： Jian-Qing Zhang Xiao-Yu Xu Fu-Sheng Liu Shu-Qiang Cao Yu-Xin Gui Yi-Wen Su Xiao-Yu He Ji-Yuan Liang You-Quan Zou Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of EducationWuhan UniversityWuhan 430071China Tai Kang center for Life and Medical sciences Wuhan UniversityWuhan 430071China Department of Hepatobiliary Pancreatic SurgeryZhongnan Hospital of Wuhan UniversityWuhan 430071China

Aggregate-induced emission luminogens(AIEgens) have been widely used in biological imaging, chemical sensing, and disease treatments. The rational design and construction of AIEgens have received considerable research interests during the last few years. Herein, molecular docking-aided AIEgen design has been reasonably proposed and AIEgen TBQZY with excellent ~1O_(2) generation ability has been synthesized. The newly developed TBQZY could efficiently kill S. epidermidis and methicillinresistant S. epidermidis(MRSE) by tightly binding to bacteria and triggering the accumulation of ~1O_(2) in bacteria. TBQZY specifically regulated the immune system and polarized macrophages from M1 to M2 to accelerate the elimination of biofilm in vivo. In addition, healing acceleration was observed in chronic wounds treated with TBQZY, and side effects were ***, TBQZY had extraordinary potential for combating drug-resistant bacteria in the clinical setting. This research not only provided new concepts for the design of AIEgens, but also shed some lights on the discovery of drugs against drug-resistant bacteria.

关键词： AIEgen molecular docking drug-resistant bacteria biofilm chronic wounds healing

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Scalable production of mesoporous titanium nanoparticles through sequential flash nanocomplexation

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Chinese Chemical Letters 2024年第4期35卷 303-309页

作者： Feng Cui Fangman Chen Xiaochun Xie Chenyang Guo Kai Xiao Ziping Wu Yinglu Chen Junna Lu Feixia Ruanb Chuanxu Cheng Chao Yang Dan Shao School of Biomedical sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou 511442China Institutes for Life sciences School of MedicineSouth China University of TechnologyGuangzhou 510006China School of Biology and biological Engineering South China University of TechnologyGuangzhou 510006China Department of Orthopedics Academy of Orthopedics-Guangdong ProvinceOrthopedic Hospital of Guangdong ProvinceGuangdong Provincial Key Laboratory of Bone and Joint Degenerative DiseasesThe Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510665China National Engineering Research center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou 510006China

Mesoporous titanium nanoparticles(MTNs) have emerged as an important porous semiconductor owning to their large surface area and unique electronic/optical properties. However, the fundamental research for rational manufacturing MTNs in a highly scalable manner remains a challenge. In this study, we report a two-step flash nanocomplexation(FNC) approach to large-scalable generate MTNs through the sequential combination of two multi-inlet vortex mixers. By optimizing the concentrated titanium precursor,polyethylene glycol(PEG)-functionalized silane amount and p H, we have been able to produce MTNs with small particle size(31.5 nm), larger surface area(416.9 m^(2)/g) and pore volume(0.59 cm^(3)/g). Different from the traditional MTNs bulk, FNC-produced MTNs exhibited well-controlled manner and exceptional photocatalytic and antibacterial properties. Importantly, the optimized MTNs outperformed commercial P25 not only in protecting ultraviolet A(UVA)-exposed skin, but also in treating P. aeruginosa-infected wound. We believe that the high controllability and scalability of sequential flash nanocomplexation method offers great opportunities in enhancing the performance of mesoporous titanium nanoparticles.

关键词： Mesoporous titanium nanoparticles Flash nanocomplexation Photocatalytic Antibacterial Sequential

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Single-cell transcriptomic Atlas of aging macaque ocular outflow tissues

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Protein & Cell 2024年第8期15卷 594-611页

作者： Jian Wu Chaoye Wang Shuhui Sun Tianmin Ren Lijie Pan Hongyi Liu Simeng Hou Shen Wu Xuejing Yan Jingxue Zhang Xiaofang Zhao Weihai Liu Sirui Zhu Shuwen Wei Chi Zhang Xu Jia Qi Zhang Ziyu Yu Yehong Zhuo Qi Zhao Chenlong Yang Ningli Wang Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual SciencesBeijing 100730China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Department of Neurosurgery Peking University Third HospitalCenter for Precision Neurosurgery and Oncology of Peking University Health Science CenterBeijing 100191China Spencer center for Vision Research Byers Eye InstituteSchool of MedicineStanford UniversityPalo AltoCA 94304USA

The progressive degradation in the trabecular meshwork(TM)is related to age-related ocular diseases like primary open-angle ***,the molecular basis and biological significance of the aging process in TM have not been fully ***,we established a dynamic single-cell transcriptomic landscape of aged macaque TM,wherein we classified the outflow tissue into 12 cell subtypes and identified mitochondrial dysfunction as a prominent feature of TM ***,we divided TM cells into 13 clusters and performed an in-depth analysis on cluster O,which had the highest aging score and the most significant changes in cell proportions between the two ***,we found that the APOE gene was an important differentially expressed gene in cluster O during the aging process,highlighting the close relationship between cell migration and extracellular matrix regulation,and TM *** work further demonstrated that silencing the APOE gene could increase migration and reduce apoptosis by releasing the inhibition on the PI3K-AKT pathway and downregulating the expression of extracellular matrix components,thereby increasing the aqueous outflow rate and maintaining intraocular pressure within the normal *** work provides valuable insights for future clinical diagnosis and treatment of glaucoma.

关键词： single-cell transcriptomic atlas macaque trabecular meshwork ocular outflow tissue aging

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The RNA binding protein EHD6 recruits the m^(6)A reader YTH07 and sequesters OsCOL4 mRNA into phase-separated ribonucleoprotein condensates to promote rice flowering

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Molecular Plant 2024年第6期17卷 935-954页

作者： Song Cui Peizhe Song Chaolong Wang Saihua Chen Benyuan Hao Zhuang Xu Liang Cai Xu Chen Shanshan Zhu Xiangchao Gan Hui Dong Yuan Hu Liang Zhou Haigang Hou Yunlu Tian Xi Liu Liangming Chen Shijia Liu Ling Jiang Haiyang Wang Guifang Jia Shirong Zhou Jianmin Wan State Key Laboratory for Crop Genetics&Germplasm Enhancement and Utilization Zhongshan Biological Breeding LaboratoryNational Observation and Research Station of Rice Germplasm ResourcesNanjing Agricultural UniversityNanjing 210095China State Key Laboratory for Crop Gene Resources and Breeding Institute of Crop ScienceChinese Academy of Agricultural SciencesBeijing 100081China Synthetic and Functional Biomolecules center Beijing National Laboratory for Molecular SciencesKey Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking-Tsinghua Center for Life SciencesBeijing Advanced Center of RNA BiologyPeking UniversityBeijingChina Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding Agricultural College of Yangzhou UniversityYangzhou 225009China Max Planck Institute for Plant Breeding Research Carl-von-Linne´-Weg 1050829 KolnGermany

N6-Methyladenosine(m^(6)A)is one of the most abundant modifications of eukaryotic mRNA,but its comprehensive biological functionality remains further *** this study,we identified and characterized a new flowering-promoting gene,EARLY HEADING DATE6(EHD6),in ***6 encodes an RNA recognition motif(RRM)-containing RNA binding protein that is localized in the non-membranous cytoplasm ribonucleoprotein(RNP)granules and can bind both m^(6)A-modified RNA and unmodified RNA *** found that EHD6 can physically interact with YTH07,a YTH(YT521-B homology)domain-containing m^(6)A *** showed that their interaction enhances the binding of an m^(6)A-modified RNA and triggers relocation of a portion of YTH07 from the cytoplasm into RNP granules through phase-separated *** these condensates,the mRNA of a rice flowering repressor,CONSTANS-like 4(OsCOL4),becomes sequestered,leading to a reduction in its protein abundance and thus accelerated flowering through the Early heading date 1 *** together,these results not only shed new light on the molecular mechanism of efficient m^(6)A recognition by the collaboration between an RNA binding protein and YTH family m^(6)A reader,but also uncover the potential for m^(6)A-mediated translation regulation through phaseseparated ribonucleoprotein condensation in rice.

关键词： N6-methyladenosine m^(6)A EHD6 YTH domain-containing protein phase separation heading date

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