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Cellular & Molecular Immunology 2013年第3期10卷 213-221页

作者： Hedi Harizi Laboratory of Immunology Mixed Research Unit 5540 Bordeaux 2 University Bordeaux France

The reciprocal activating crosstalk between dendritic cells （DCs） and natural killer （NK） cells plays a pivotal role in regulating immune defense against viruses and tumors. The cytokine-producing capacity, Th-cell polarizing ability and chemokine expression, migration and stimulatory functions of DCs are regulated by activated NK cells. Conversely, the innate and effector functions of NK cells require close interactions with activated DCs. Cell membrane-associated molecules and soluble mediators, including cytokines and prostaglandins （PGs）, contribute to the bidirectional crosstalk between DCs and NK cells. One of the most well-known and well-studied PGs is PGE2. Produced by many cell types, PG E2 has been shown to affect various aspects of the immune and inflammatory responses by acting on all components of the immune system. There is emerging evidence that PGE2 plays crucial roles in DC and NK cell biology. Several studies have shown that DCs are not only a source of PGE2, but also a target of its immunomodulatory action in normal immune response and during immune disorders. Although NK cells appear to be unable to produce PGE2, they are described as powerful PGE2-responding cells, as they express all PGE2 E-prostanoid （EP） receptors. Several NK cell functions （lysis, migration, proliferation, cytokine production） are influenced by PGE2. This review highlights the effects of PGE2 on DC- NK cell crosstalk and its subsequent impact on immune regulations in normal and immunopathological processes.

关键词： DC-NK cell crosstalk immunopathology NSAIDs PGE2

A red wine polyphenolic extract reduces the activation phenotype of cultured human liver myofibroblasts

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World Journal of Gastroenterology 2008年第14期14卷 2194-2199页

作者： Véronique Neaud Jean Rosenbaum INSERM U889 Bordeaux F-33076 France university Victor Segalen bordeaux 2 Bordeaux F-33076 France

AIM: To test the effect of a standardized red wine polyphenolic extract (RWPE) on the phenotype of human liver myofibroblasts in culture. METHODS: Human myofibroblasts grown from liver explants were used in this study. Cell proliferation was measured with the 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) assay. Signaling events were analyzed by western blot with phosphospecific antibodies. Matrix-metalloproteinase activity was measured with gel zymography. RESULTS: We found that cell proliferation was dose-dependently decreased by up to 90% by RWPE while cell viability was not affected. Exposure to RWPE also greatly decreased the phosphorylation of ERK1/ERK2 and Akt in response to stimulation by the mitogenic factor platelet-derived growth factor BB (PDGF-BB). Finally, RWPE affected extracellular matrix remodeling by decreasing the secretion by myofibroblasts of matrix-metalloproteinase-2 and of tissue inhibitor of matrix- ***: Altogether, RWPE decreases the activation state of liver myofibroblasts. The identification of the active compounds in RWPE could offer new therapeutic strategies against liver fibrosis.

关键词： Liver fibrosis Myofibroblasts Hepatic stellate cells Wine Phosphorylation Proliferation

Optical coherence tomography angiography at the acute phase of optic disc edema

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Eye and Vision 2018年第1期5卷 144-150页

作者： Marie-Bénédicte Rougier Mélanie Le Goff Jean-François Korobelnik Service d’Ophtalmologie CHU de BordeauxBordeauxFrance bordeaux Population Health Research Center Team LEHAUniversity BordeauxINSERMUMR 1219F-33000 BordeauxFrance

Background:The differential diagnosis of optic disc edema at the acute phase can be *** angiography(OCTA)is a new technology allowing the visualization of the peripapillary vascular network and optic disc *** peripapillary network alterations of glaucoma and chronic non-arteritic anterior ischemic optic neuropathy(NAION)were ***,no OCTA studies on acute optic disc edema from various *** aim of this project was to use OCTA to demonstrate the vascular changes the optic nerve head of various types of optic disc edema at the acute ***:In this retrospective study,patients with non-arteritic anterior ischemic optic neuropathy(NAION),papillitis or papilledema were *** patient was imaged using the AngioPlex^(TM)CIRRUS^(TM)HD-OCT device(model 5000,Carl Zeiss Meditec,Inc.,Dublin,USA)with a scanning area of 6×6 mm^(2) centered on the optic disc.A morphological analysis of the peripapillary network was *** some patients with unilateral optic disc edema,a quantitative analysis was performed using a swept-source OCT-A system(PLEX®Elite 9000,Carl Zeiss Meditec,Inc.,Dublin,USA).Vessel perfusion density and flux index of the peripapillary area were ***:Eight eyes with NAION(4 patients),12 eyes with papillitis(6 patients)and 25 eyes with papilledema(13 patients)were *** apparent disappearance or moderate pattern alteration of the peripapillary capillary vessels were observed in patients with NAION or papillitis,*** papilledema,the capillaries at the surface of the optic disc were dilated and tortuous,but no peripapillary network pattern changes were *** quantitative analysis did not show any difference of peripapillary network between NAION and healthy *** papillitis,the flux index was higher in inflammatory eyes compared to the healthy eyes in average(p=0.03).Conclusion:At the acute phase,the morphological analysis of OCT-A appeared to be more useful than the q

关键词： Optical coherence tomography angiography Optic nerve head Edema NAION Microvascular network And morphology

INVARIANCE AND STABILITY OF THE PROFILE EQUATIONS OF GEOMETRIC OPTICS

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Acta Mathematica Scientia 2011年第6期31卷 2141-2158页

作者： Guy Mtivier Jeffrey Rauch Institut de Mathmatiques de bordeaux Universit de Bordeaux Department of Mathematics University of Michigan

The profile equations of geometric optics are described in a form invariant under the natural transformations of first order systems of partial differential equations. This allows us to prove that various strategies for computing profile equations are equivalent. We prove that if L generates an evolution on L2 the same is true of the profile equations. We prove that the characteristic polynomial of the profile equations is the localization of the characteristic polynomial of the background operator at （y, dφ（y）） where φ is the background phase. We prove that the propagation cones of the profile equations are subsets of the propagation cones of the background operator.

关键词： geometric optics profile equation localisation vector bundles propagation cones

Evaluation of left atrial remodelling following percutaneous left atrial appendage closure

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Journal of Geriatric Cardiology 2017年第8期14卷 496-500页

作者： Zakaria Jalal Xavier Iriart Marie-Lou Dinet Olivier Comeloup Xavier Pillois Hubert Cochet Jean-Benoit Thambo Department of Paediatric and Adult Congenital Cardiology Bordeaux University Hospital Pessac France Electrophysiology and Heart Modeling Institute IHU Lirye Fondation Bordeaux UniversitO Pessac-Bordeaux France Centre de recherche Cardio-Thoracique de bordeaux INSERM Bordeaux France Department of Radiology Bordeaux University Hospital Pessac France

Atrial fibrillation prevalence is increasing with age, reaching up to 5% of patients older than 65 years, and is associated with 20%-30% of stroke episodes in that population.

关键词： Atrial fibrillation Left atrial appendage Left atrial remodeling Percutaneous closure

A New Simulation of Track Structure of Low-Energy Electrons in Liquid Water:Considering the Condensed-Phase Effect on Electron Elastic Scattering

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Chinese Physics Letters 2016年第9期33卷 35-38页

作者：刘玮谭震宇 C.Champion School of Electrical Engineering Shandong University Centre d 'Etudes Nucleaires de bordeaux Gradignan Universite de Bordeaux

A new Monte Carlo simulation of the track structure of low-energy electrons （〈10keV） in liquid water is presented. The feature of the simulation is taken into consideration of the condensed-phase effect of liquid water on electron elastic scattering with the use of the Champion model, while the dielectric response formalism incorporating the optical-data model developed by Emfietzoglou et al. is applied for calculating the electron inelastic scattering. The spatial distributions of energy deposition and inelastic scattering events of low-energy electrons with different primary energies in liquid water are calculated and compared with other theoretical evaluations. The present work shows that the condensed-phase effect of liquid water on electron elastic scattering may be of the influence on the fraction of absorbed energy and distribution of inelastic scattering events at lower primary energies, which also indicate potential effects on the DNA damage induced by low-energy electrons.

关键词： of as in A New Simulation of Track Structure of Low-Energy Electrons in Liquid Water:Considering the Condensed-Phase Effect on Electron Elastic Scattering for CCPI on is

Edge Computing Based Applications in Vehicular Environments:Comparative Study and Main Issues

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Journal of Computer Science & Technology 2019年第4期34卷 869-886页

作者： Leo Mendiboure Mohamed-Aymen Chalouf Francine Krief LaBRI Laboratory University of BordeauxTalence 33400France IRISA Laboratory University of Rennes 1Lannion 22300France LaBRI Laboratory Bordeaux INPTalence 33400France

Despite the expanded efforts,the vehicular ad-hoc networks(VANETs)are still facing many challenges such as network performances,network scalability and *** solutions have been proposed to overcome these obstacles,and the edge computing,an extension of the cloud computing,is one of *** edge computing,communication,storage and computational capabilities are brought closer to end *** could offer many benefits to the global vehicular network including,for example,lower latency,network off-loading and context-awareness(location,environment factors,etc.).Different approaches of edge computing have been developed:mobile edge computing(MEC),fog computing(FC)and cloudlet are the main *** introducing the vehicular environment background,this paper aims to study and compare these different *** that purpose their main features are compared and the state-of-the-art applications in VANETs are *** addition,MEC,FC,and cloudlet are classified and their suitability level is debated for different types of vehicular ***,some challenges and future research directions in the fields of edge computing and VANETs are discussed.

关键词： cloud computing edge computing fog computing cloudlet vehicular network

VETA:Visual eye-tracking analytics for the exploration of gaze patterns and behaviours

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Visual Informatics 2022年第2期6卷 1-13页

作者： Sarah Goodwin Arnaud Prouzeau Ryan Whitelock-Jones Christophe Hurter Lee Lawrence Umair Afzal Tim Dwyer Monash university ClaytonAustralia Inria&LaBRI(university of bordeaux CNRSBordeaux-INP)BordeauxFrance ENAC UniversitédeToulouseToulouseFrance Swinburne university of Technology MelbourneAustralia

Eye tracking is growing in popularity for multiple application areas,yet analysing and exploring the large volume of complex data remains difficult for most *** present a comprehensive eye tracking visual analytics system to enable the exploration and presentation of eye-tracking data across time and space in an efficient *** application allows the user to gain an overview of general patterns and perform deep visual analysis of local gaze *** ability to link directly to the video of the underlying scene allows the visualisation insights to be verified on the *** system was motivated by the need to analyse eye-tracking data collected from an‘in the wild’study with energy network operators and has been further evaluated via interviews with 14 eye-tracking experts in multiple *** suggest that,thanks to state-of-the-art visualisation techniques and by providing context with videos,our system could enable an improved analysis of eye-tracking data through interactive exploration,facilitating comparison between different participants or conditions,thus enhancing the presentation of complex data analysis to *** research paper provides four contributions:(1)analysis of a motivational use case demonstrating the need for rich visual-analytics workflow tools for eye-tracking data;(2)a highly dynamic system to visually explore and present complex eye-tracking data;(3)insights from our applied use case evaluation and interviews with experienced users demonstrating the potential for the system and visual analytics for the wider eye-tracking community.

关键词： Eye tracking Visual analytics Spatial-temporal visualisation

Anatomical and electrophysiological plasticity of locomotor networks following spinal transection in the salamander

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Neuroscience Bulletin 2013年第4期29卷 467-476页

作者： Jean-Marie Cabelguen Stéphanie Chevallier Ianina Amontieva-Potapova Céline Philippe Neurocentre Magendie INSERM U 862 - Bordeaux University

Recovery of locomotor behavior following spinal cord injury can occur spontaneously in some vertebrates, such as fish, urodele amphibians, and certain reptiles. This review provides an overview of the current status of our knowledge on the anatomical and electrophysiological changes occurring within the spinal cord that lead to, or are associated with the [e-expression of locomotion in spinally-transected salamanders. A better understanding of these processes will help to devise strategies for restoring locomotor function in mammals, including humans.

关键词： salamander spinal cord locomotor recovery regeneration

Proteomic and metabolomic profiling underlines the stage- and time-dependent effects of high temperature on grape berry metabolism

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Journal of Integrative Plant Biology 2020年第8期62卷 1132-1158页

作者： David Lecourieux Christian Kappel Stéphane Claverol Philippe Pieri Regina Feil John E.Lunn Marc Bonneu Lijun Wang Eric Gomès Serge Delrot Fatma Lecourieux UMR1287 EGFV INRAEBordeaux Sciences AgroBordeaux UniversityISVV33140 Villenave d'OrnonFrance Institut of Biochemistry and Biology Potsdam UniversityD-14476 PotsdamGermany Proteome Platform Bordeaux Functional Genomic CenterBordeaux University33076 BordeauxFrance Max Planck Institute of Molecular Plant Physiology 14476 PotsdamGolmGermany Institute of Botany the Chinese Academy of SciencesBeijing 100093China UMR1287 EGFV CNRSINRAEBordeaux Sciences AgroBordeaux UniversityISVV33140 Villenave d'OrnonFrance

Climate change scenarios predict an increase in mean air temperatures and in the frequency,intensity,and length of extreme temperature events in many wine-growing regions *** elevated temperature has detrimental effects on berry growth and composition,it threatens the economic and environmental sustainability of wine *** Cabernet Sauvignon fruit-bearing cuttings,we investigated the effects of high temperature(HT)on grapevine berries through a label-free shotgun proteomic analysis coupled to a complementary metabolomic *** the 2,279 proteins identified,592 differentially abundant proteins were found in berries exposed to *** gene ontology categories“stress,”“protein,”“secondary metabolism,”and“cell wall”were predominantly altered under *** temperatures strongly impaired carbohydrate and energy metabolism,and the effects depended on the stage of development and duration of *** amounts correlated poorly with protein expression levels in HT berries,highlighting the value of proteomic studies in the context of heat ***,this work reveals that HT alters key proteins driving berry development and ***,we provide a list of differentially abundant proteins that can be considered as potential markers for developing or selecting grape varieties that are better adapted to warmer climates or extreme heat waves.

关键词： metabolism extreme high