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Neural Regeneration Research 2024年第4期19卷 788-799页

作者： R.Scott Duncan Sean M.Riordan Matthew C.Gernon Peter Koulen Department of Ophthalmology School of MedicineUniversity of Missouri Department of Biomedical Sciences School of MedicineUniversity of Missouri

Cannabinoids are lipophilic substances derived from Cannabis sativa that can exert a variety of effects in the human *** have been studied in cellular and animal models as well as in human clinical trials for their therapeutic benefits in several human *** of these include central nervous system(CNS)diseases and dysfunctions such as forms of epilepsy,multiple sclerosis,Parkinson’s disease,pain and neuropsychiatric *** addition,the endogenously produced cannabinoid lipids,endocannabinoids,are critical for normal CNS function,and if controlled or modified,may represent an additional therapeutic avenue for CNS *** review discusses in vitro cellular,ex vivo tissue and in vivo animal model studies on cannabinoids and their utility as therapeutics in multiple CNS *** addition,the review provides an overview on the use of cannabinoids in human clinical trials for a variety of CNS *** and endocannabinoids hold promise for use as disease modifiers and therapeutic agents for the prevention or treatment of neurodegenerative diseases and neurological disorders.

关键词： anandamide cannabidiol cannabinoid endocannabinoid epilepsy multiple sclerosis neurodegeneration neuroprotection tetrahydrocannabinol

GREENSKY:A fair energy-aware optimization model for UAVs in next-generation wireless networks

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Green Energy and Intelligent Transportation 2024年第1期3卷 16-24页

作者： Pratik Thantharate Anurag Thantharate Atul Kulkarni School of Computing and Engineering University of MissouriKansas CityMOUSA

Unmanned Aerial Vehicles(UAVs)offer a strategic solution to address the increasing demand for cellular connectivity in rural,remote,and disaster-hit regions lacking traditional ***,UAVs’limited onboard energy storage necessitates optimized,energy-efficient communication strategies and intelligent energy expenditure to maximize *** work proposes a novel joint optimization model to coordinate charging operations across multiple UAVs functioning as aerial base *** model optimizes charging station assignments and trajectories to maximize UAV flight time and minimize overall energy *** leveraging both static ground base stations and mobile supercharging stations for opportunistic charging while considering battery chemistry constraints,the mixed integer linear programming approach reduces energy usage by 9.1%versus conventional greedy *** key results provide insights into separating charging strategies based on UAV mobility patterns,fully utilizing all available infrastructure through balanced distribution,and strategically leveraging existing base stations before deploying dedicated charging *** to myopic localized decisions,the globally optimized solution extends battery life and enhances ***,this work marks a significant advance in UAV energy management by consolidating multiple improvements within a unified coordination framework focused on joint charging optimization across UAV *** model lays a critical foundation for energy-efficient aerial network deployments to serve the connectivity needs of the future.

关键词： 5G new radio Unmanned aerial vehicles(UAV) UAV battery life Energy efficiency Unmanned aircraft systems(UAS)UAV scheduling Cellular networks Linear programming Joint UAV charging optimization

Roles of fibroblast growth factors in the treatment of diabetes

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World Journal of Diabetes 2024年第3期15卷 392-402页

作者： Chun-Ye Zhang Ming Yang Bond Life Sciences Center University of MissouriColumbiaMO 65211United States Department of Surgery University of MissouriColumbiaMO 65212United States NextGen Precision Health Institution University of MissouriColumbiaMO 65212United States

Diabetes affects about 422 million people worldwide,causing 1.5 million deaths each ***,the incidence of diabetes is increasing,including several types of *** 1 diabetes(5%-10%of diabetic cases)and type 2 diabetes(90%-95%of diabetic cases)are the main types of diabetes in the *** evidence shows that the fibroblast growth factor(FGF)family plays important roles in many metabolic disorders,including type 1 and type 2 *** consists of 23 family members(FGF-1-23)in ***,we review current findings of FGFs in the treatment of diabetes and management of diabetic *** FGFs(e.g.,FGF-15,FGF-19,and FGF-21)have been broadly investigated in preclinical studies for the diagnosis and treatment of diabetes,and their therapeutic roles in diabetes are currently under investigation in clinical ***,the roles of FGFs in diabetes and diabetic complications are involved in numerous ***,FGF intervention can prevent high-fat diet-induced obesity and insulin resistance and reduce the levels of fasting blood glucose and triglycerides by regulating lipolysis in adipose tissues and hepatic glucose ***,modulation of FGF expression can inhibit renal and cardiac fibrosis by regulating the expression of extracellular matrix components,promote diabetic wound healing process and bone repair,and inhibit cancer cell proliferation and ***,FGFs can regulate the activation of glucoseexcited neurons and the expression of thermogenic genes.

关键词： Fibroblast growth factors Type 1 diabetes Type 2 diabetes Metabolic disorders Treatment Clinical trials

Centennial Analysis of Human Activity Intensity and Associated Historical Events in Heilongjiang River Sino-Russo Watershed

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Chinese Geographical Science 2024年第2期34卷 280-293页

作者： SONG Chaoxue LI Xiaoling HE Hongshi Michael SUNDE School of Geographical Sciences Northeast Normal UniversityChangchun 130024China School of Natural Resources University of MissouriColumbia 65211USA

Human activities in a transborder watershed are complex under the influence of domestic policies,international relations,and global *** the forces driving human activity change is important for the development of transborder *** this study,we used global historical land cover data,the hemeroby index model,and synthesized major historical events to analyze how human activity intensity changed in the Heilongjiang River(Amur River in Russia)watershed(HLRW).The results showed that there was a strong spatial heterogeneity in the variation of human activity intensity in the HLRW over the past century(1900-2016).On the Chinese side,the human activity intensity change shifted from the plain areas for agricultural reclamation to the mountainous areas for timber *** the Russian side,human activity intensity changes mostly concentrated along the Trans-Siberian Railway and the Baikal-Amur *** variation of human activity intensity tended to respond to regional events while regionalized variation tends to reflect national policy change or broad international *** similarities and differences between China and Russia in policies and positions in international events resulted in synchronous and asynchronous changes in human activity ***,policy shifts were often confined by the natural features of the *** results reveal the historical origins and fundamental connotations of watershed development and contribute to formulating regional management policies that coordinate population,eco-nomic,social,and environmental activities.

关键词： human activity intensity changes hemeroby index centennial scale Heilongjiang River(Amur River in Russia)watershed China Russia

Anti-oxidative stress treatment and current clinical trials

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World Journal of Hepatology 2024年第2期16卷 294-299页

作者： Chun-Ye Zhang Ming Yang Bond Life Sciences Center University of MissouriColumbiaMO 65211United States Department of Surgery University of MissouriColumbiaMO 65212United States

Oxidative stress disturbs the balance between the production of reactive oxygen species(ROS)and the detoxification biological *** plays an important role in the development and progression of many chronic *** exposure to oxidative stress or the inducers of ROS,the cellular nucleus undergoes some biological processes via different signaling pathways,such as stress adaption through the forkhead box O signaling pathway,inflammatory response through the IκB kinase/nuclear factor-κB signaling pathway,hypoxic response via the hypoxia-inducible factor/prolyl hydroxylase domain proteins pathway,DNA repair or apoptosis through the p53 signaling pathway,and antioxidant response through the Kelch-like ECH-associated protein 1/nuclear factor E2-related factor 2 signaling *** processes are involved in many ***,oxidative stress has gained more attraction as a targeting process for disease ***,anti-oxidative stress agents have been widely explored in pre-clinical ***,only limited clinical trials are performed to evaluate the efficacy of anti-oxidative stress agents or antioxidants in *** this letter,we further discuss the current clinical trials related to anti-oxidative stress treatment in different *** pre-clinical studies and clinical trials are expected to use anti-oxidative stress strategies as disease treatment or dietary supplementation to improve disease treatment outcomes.

关键词： Anti-oxidative stress treatment Clinical trials Drugs Dietary invention Reactive oxygen species

Influence of Local Cation Order on Electronic Structure and Optical Properties of Cation-Disordered Semiconductor AgBiS_(2)

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Chinese Physics Letters 2024年第10期41卷 61-69页

作者： Xiaoyu Wang Muhammad Faizan Yuhao Fu Kun Zhou Yilin Zhang Xin He David J.Singh Lijun Zhang State Key Laboratory of Superhard Materials College of PhysicsJilin UniversityChangchun 130012China State Key Laboratory of Integrated Optoelectronics Key Laboratory of Automobile Materials of MOECollege of Materials Science and EngineeringJilin UniversityChangchun 130012China Department of Physics and Astronomy University of MissouriColumbiaMissouri 65211-7010USA

Site disorder exists in some practical semiconductors and can significantly impact their intrinsic properties both beneficially and ***,the uncertain local order and structure pose a challenge for experimental and theoretical ***,it hinders the investigation of the effects of the diverse local atomic environments resulting from the site *** employ the special quasi-random structure method to perform first-principles research on connection between local site disorder and electronic/optical properties,using cationdisordered AgBiS_(2)(rock salt phase)as an *** predict that cation-disordered AgBiS_(2)has a bandgap ranging from 0.6 to 0.8 eV without spin-orbit coupling and that spin-orbit coupling reduces this by approximately 0.3 *** observe the effects of local structural features in the disordered lattice,such as the one-dimensional chain-like aggregation of cations that results in formation of doping energy bands near the band edges,formation and broadening of band-tail states,and the disturbance in the local electrostatic potential,which significantly reduces the bandgap and *** influence of these ordered features on the optical properties is confined to alterations in the bandgap and does not markedly affect the joint density of states or optical *** study provides a research roadmap for exploring the electronic structure of site-disordered semiconductor materials,suggests that the ordered chain-like aggregation of cations is an effective way to regulate the bandgap of AgBiS_(2),and provides insight into how variations in local order associated with processing can affect properties.

关键词： stability. structure ordered

Climate-change habitat shifts for the vulnerable endemic oak species(Quercus arkansana Sarg.)

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Journal of Forestry Research 2024年第1期35卷 117-127页

作者： Suresh Chandra Subedi Seth Drake Binaya Adhikari Mark V.Coggeshall Department of Biological Sciences Arkansas Tech UniversityRussellvilleARUSA Department of Biology University of KentuckyLexingtonKYUSA School of Natural Resources University of Missouri203 ABNR BuildingColumbiaMO 65211USA

Quercus arkansana(Arkansas oak)is at risk of becoming endangered,as the total known population size is represented by a few isolated *** potential impact of climate change on this species in the near future is high,yet knowledge of its predicted effects is *** study utilized the biomod2 R package to develop habi-tat suitability ensemble models based on bioclimatic and topographic environmental variables and the known loca-tions of current distribution of *** predicted suitable habitats across three climate change scenarios(SSP1-2.6,SSP2-4.5,and SSP5-8.5)for 2050,2070,and *** findings reveal that the current suitable habitat for *** is approximately 127,881 km^(2) across seven states(Texas,Arkansas,Alabama,Louisiana,Mississippi,Georgia,and Florida);approximately 9.5%is encompassed within state and federally managed protected *** models predict that all current suitable habitats will disap-pear by 2050 due to climate change,resulting in a northward shift into new regions such as Tennessee and *** large extent of suitable habitat outside protected areas sug-gests that a species-specific action plan incorporating pro-tected areas and other areas may be crucial for its ***,protection of *** habitat against climate change may require locally and regionally focused conservation policies,adaptive management strategies,and educational outreach among local people.

关键词： Biomod2 Climate change Conservation Habitat loss Habitat shift Species distribution modeling Oak species

Inferring the Effects of Protein Variants on Protein-Protein Interactions with Interpretable Transformer Representations

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Research 2024年第2期2023卷 473-489页

作者： Zhe Liu Wei Qian Wenxiang Cai Weichen Song Weidi Wang Dhruba Tara Maharjan Wenhong Cheng Jue Chen Han Wang Dong Xu Guan Ning Lin Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineSchool of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Psychotic Disorders ShanghaiChina School of Information Science and Technology Institute of Computational BiologyNortheast Normal UniversityChangchunChina Department of Electrical Engineering and Computer Science University of MissouriColumbiaMO 65211USA Christopher S.Bond Life Sciences Center University of MissouriColumbiaMO 65211USA

Identifying pathogenetic variants and inferring their impact on protein-protein interactions sheds light on their functional consequences on *** by the availability of experimental data on the consequences of protein interaction,most existing methods focus on building models to predict changes in protein binding ***,we introduced MIPPI,an end-to-end,interpretable transformer-based deep learning model that learns features directly from sequences by leveraging the interaction data from *** was specifically trained to determine the types of variant impact(increasing,decreasing,disrupting,and no effect)on protein-protein *** demonstrate the accuracy of MIPPI and provide interpretation through the analysis of learned attention weights,which exhibit correlations with the amino acids interacting with the ***,we showed the practicality of MIPPI in prioritizing de novo mutations associated with complex neurodevelopmental disorders and the potential to determine the pathogenic and driving ***,we experimentally validated the functional impact of several variants identified in patients with such ***,MIPPI emerges as a versatile,robust,and interpretable model,capable of effectively predicting mutation impacts on protein-protein interactions and facilitating the discovery of clinically actionable variants.

关键词： consequences weights versatile

Enhanced termination of zinc and cadmium ions from wastewater employing plain and chitosan-modified mxenes: synthesis, characterization,and adsorption performance

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Green Chemical Engineering 2024年第3期5卷 339-347页

作者： Njood R.Azeez Suhaib S.Salih Mohammed Kadhom Harith N.Mohammed Tushar K.Ghosh Department of Chemical Engineering College of Engineering University of Tikrit Department of Environmental Science College of Energy and Environmental Science Al-Karkh University of Science Department of Nuclear Science & Engineering Institute University of Missouri-Columbia

Zinc and cadmium pollutants cause a significant environmental effect that cannot be ignored. Due to their considerable amount in an aqueous environment, industries are seeking suitable adsorbents that are environmentally friendly and inexpensive for removing metals from wastewater before disposing of them in surface waters. This research employed original MXene(MX) and chitosan-modified MXene(CSMX) to extract zinc(Zn(Ⅱ)) and cadmium(Cd(Ⅱ)) metal ions from water-based solutions. The composite material produced was analyzed using techniques such as X-ray Diffraction(XRD), Scanning Electron Microscopy(SEM), Fourier Transform Infrared Spectroscopy(FTIR), and Brunauer-Emmett-Teller(BET). The effects of contact duration, p H of the solution, and initial concentration of metal ions on the adsorption process of Zn(Ⅱ) and Cd(Ⅱ) onto both MX and CSMX composites were investigated. MX and prepared CSMX composite presented a high adsorption capacity for both studied heavy metals, which were 91.55 and 73.82 mg/g for Zn(Ⅱ) and Cd(Ⅱ) onto MX, 106.84 and 93.07 mg/g for Cd(Ⅱ) and Zn(Ⅱ) onto CSMX composite, respectively. Furthermore, the maximum competitive adsorption capacities for Zn(Ⅱ) onto MX and CSMX composites are 77.29 and 93.47 mg/g, and for are Cd(Ⅱ)60.30 and 79.66 mg/g, respectively. Hence, the removal capacities for both single and competitive metal ions were superior to CSMX composite. However, the adsorption capacities after five successive regeneration sequences were only dropped by 13.2% for Zn(Ⅱ) and 17.4% for Cd(Ⅱ) onto the CSMX composite compared to the first cycle. These results confirm that both metals could be efficiently terminated from wastewater, which makes the prepared CSMX composite a favorable candidate adsorbent in practical applications.

关键词： Adsorption Chitosan MXene Zn(II) Cd(II) Wastewater

Simultaneous improving luminescence intensity and stability of CsPbBr_(3):SCN−@Eu/Zr-Uio-66-NH_(2) with tunable emissions from blue to green and applications in indoor photovoltaics

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Nano Research 2024年第8期17卷 6879-6887页

作者： Minze Li Yao Sun Honglai Lu Peifen Zhu Ruihong Wang Guofeng Wang Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080China Department of Electrical Engineering and Computer Science University of MissouriColumbiaMO 65211USA

The construction of stable and efficient materials that emit blue and green light remains a *** the blue light materials reported,metal-organic framework(MOF)materials are rarely reported as blue phosphors due to their weak luminescence *** on the construction of CsPbBr_(3)@MOF(CPB@MOF),an innovative idea was proposed to simultaneously enhance the green luminescence of CPB and the blue luminescence of MOF through the interaction between CPB and MOF for the first *** expected,the blue luminescence from CPB:7%SCN−@0.5%MOF:Eu as well as the green luminescence from 5%CPB:7%SCN−@MOF:Eu was sufficient to construct high-performance light-emitting diode(LED)devices and further excite solar cells to generate stable photoelectric *** white LED(WLED)device with excellent color quality(color rendering index(CRI)=96.2)and correlated color temperature(CCT=9688 K)can be constructed by using the obtained blue-emitting CPB:7%SCN-@0.5%MOF:Eu,green-emitting 5%CPB:7%SCN−@MOF:Eu,and red-emitting PPB:30%Mn^(2+).The density functional theory(DFT)theoretical calculation results indicate that the p orbital of Pb plays the major role in the conduction band,and the p orbital of Br plays the major role in the valance band of CPB and CPB:SCN−.While the p orbital of O plays the major role in both the conduction band and valance band of *** heat capacity of CPB and CPB:SCN−separately reaches the Dulong–Petit limit at 200 and 400 K,indicating that the thermal stability of CsPbBr_(3)increases after SCN−doping.

关键词： CsPbBr_(3):SCN−@Uio-66-NH_(2) composites luminescence stability white light-emitting diodes(WLEDs) indoor photovoltaics density functional theory(DFT)calculation